| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Doxycycline (monohydrate) perturbation in HEC-1-A cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Doxycycline (monohydrate)_HEC-1-A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | 0.101089 |
| ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) | 0.0922991 |
| ZNF292 | zinc finger protein 292 | 0.0810958 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 0.0756228 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.0754665 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0712344 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0704406 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.068169 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.0607339 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.059578 |
| LRRFIP2 | leucine rich repeat (in FLII) interacting protein 2 | 0.0585528 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0580665 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0566726 |
| CCNL1 | cyclin L1 | 0.0565916 |
| MATR3 | matrin 3 | 0.0558366 |
| UGCG | UDP-glucose ceramide glucosyltransferase | 0.0554527 |
| SNX9 | sorting nexin 9 | 0.0544107 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0534675 |
| DHX9 | DEAH (Asp-Glu-Ala-His) box helicase 9 | 0.0526751 |
| APP | amyloid beta (A4) precursor protein | 0.0498737 |
| PUM1 | pumilio RNA-binding family member 1 | 0.0498707 |
| DHX15 | DEAH (Asp-Glu-Ala-His) box helicase 15 | 0.0491231 |
| NCKAP1 | NCK-associated protein 1 | 0.0490254 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0483869 |
| POTEF | POTE ankyrin domain family, member F | 0.048268 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0472623 |
| SMAD3 | SMAD family member 3 | 0.0472097 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0469855 |
| RAD23B | RAD23 homolog B (S. cerevisiae) | 0.046129 |
| ACTR3 | ARP3 actin-related protein 3 homolog (yeast) | 0.0460175 |
| PKM | pyruvate kinase, muscle | 0.0448026 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | 0.0441339 |
| PCBP2 | poly(rC) binding protein 2 | 0.0439338 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0426988 |
| RNF145 | ring finger protein 145 | 0.041504 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0404448 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.0403559 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 0.0401497 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0394006 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0382448 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0376498 |
| DIAPH1 | diaphanous-related formin 1 | 0.0363283 |
| PTP4A2 | protein tyrosine phosphatase type IVA, member 2 | 0.0359784 |
| USP3 | ubiquitin specific peptidase 3 | 0.0357563 |
| SPAG9 | sperm associated antigen 9 | 0.0352884 |
| AFDN | afadin, adherens junction formation factor | 0.0349808 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | 0.0344452 |
| NFKB1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | 0.0340175 |
| WDR43 | WD repeat domain 43 | 0.0337184 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0330343 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | 0.0325135 |
| RYBP | RING1 and YY1 binding protein | 0.0317819 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | 0.0317185 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.0313725 |
| RBM39 | RNA binding motif protein 39 | 0.0301183 |
| MIER1 | mesoderm induction early response 1, transcriptional regulator | 0.029911 |
| PTK2 | protein tyrosine kinase 2 | 0.0297625 |
| MEF2A | myocyte enhancer factor 2A | 0.0297247 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0296093 |
| SPOPL | speckle-type POZ protein-like | 0.029547 |
| VAPA | VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa | 0.0293562 |
| ACTN4 | actinin, alpha 4 | 0.0293412 |
| TRA2B | transformer 2 beta homolog (Drosophila) | 0.0291297 |
| QKI | QKI, KH domain containing, RNA binding | 0.0290695 |
| SET | SET nuclear proto-oncogene | 0.0290023 |
| FLNA | filamin A, alpha | 0.0289958 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.0289489 |
| TCERG1 | transcription elongation regulator 1 | 0.0287277 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0282968 |
| CNOT4 | CCR4-NOT transcription complex, subunit 4 | 0.0281585 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | 0.0281177 |
| ZNF207 | zinc finger protein 207 | 0.0277995 |
| TOP2B | topoisomerase (DNA) II beta 180kDa | 0.0277895 |
| SMG7 | SMG7 nonsense mediated mRNA decay factor | 0.0277868 |
| CDC73 | cell division cycle 73 | 0.0277325 |
| TNFAIP2 | tumor necrosis factor, alpha-induced protein 2 | 0.0275703 |
| PPP2CA | protein phosphatase 2, catalytic subunit, alpha isozyme | 0.0275366 |
| SEPTIN7 | septin 7 | 0.027394 |
| RPS2 | ribosomal protein S2 | 0.0270852 |
| ANP32B | acidic (leucine-rich) nuclear phosphoprotein 32 family, member B | 0.0269816 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0267708 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0266231 |
| PSMD14 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 | 0.0263903 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | 0.026362 |
| TPM3 | tropomyosin 3 | 0.0263233 |
| ANXA11 | annexin A11 | 0.0263128 |
| RASA2 | RAS p21 protein activator 2 | 0.0262852 |
| PTMA | prothymosin, alpha | 0.0260688 |
| UBQLN1 | ubiquilin 1 | 0.0259745 |
| HNRNPD | heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) | 0.0259367 |
| NPEPPS | aminopeptidase puromycin sensitive | 0.0258936 |
| FAM168A | family with sequence similarity 168, member A | 0.0256356 |
| PACSIN2 | protein kinase C and casein kinase substrate in neurons 2 | 0.025589 |
| RLF | rearranged L-myc fusion | 0.0254871 |
| HNRNPH3 | heterogeneous nuclear ribonucleoprotein H3 (2H9) | 0.0254531 |
| NRIP1 | nuclear receptor interacting protein 1 | 0.0249461 |
| ANKRD28 | ankyrin repeat domain 28 | 0.0247587 |
| PER1 | period circadian clock 1 | 0.0247394 |
| RPS6 | ribosomal protein S6 | 0.0245753 |
| CLDN4 | claudin 4 | 0.0245492 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.195459 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.121447 |
| MT2A | metallothionein 2A | -0.0737851 |
| LIMCH1 | LIM and calponin homology domains 1 | -0.0707705 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | -0.0561927 |
| CANX | calnexin | -0.0544194 |
| CREB5 | cAMP responsive element binding protein 5 | -0.0544137 |
| DLC1 | DLC1 Rho GTPase activating protein | -0.0540853 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.049984 |
| TTC3 | tetratricopeptide repeat domain 3 | -0.047584 |
| PAX8 | paired box 8 | -0.0474778 |
| GOLGA4 | golgin A4 | -0.0433449 |
| EGFR | epidermal growth factor receptor | -0.0400348 |
| BICD1 | bicaudal D homolog 1 (Drosophila) | -0.0396921 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | -0.0395313 |
| FLNB | filamin B, beta | -0.0389863 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.038742 |
| FNIP1 | folliculin interacting protein 1 | -0.0371126 |
| FTL | ferritin, light polypeptide | -0.0353905 |
| SBF2 | SET binding factor 2 | -0.0348758 |
| MBD5 | methyl-CpG binding domain protein 5 | -0.0341162 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.032878 |
| SEC24D | SEC24 family member D | -0.0319609 |
| CDK13 | cyclin-dependent kinase 13 | -0.0317295 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0306233 |
| MBNL2 | muscleblind-like splicing regulator 2 | -0.0306026 |
| GOLGB1 | golgin B1 | -0.0296717 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.029248 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0292087 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0290804 |
| PDIA5 | protein disulfide isomerase family A, member 5 | -0.0289059 |
| TNIK | TRAF2 and NCK interacting kinase | -0.0288631 |
| LAMC2 | laminin, gamma 2 | -0.0287398 |
| ARHGAP29 | Rho GTPase activating protein 29 | -0.0284504 |
| MINDY2 | MINDY lysine 48 deubiquitinase 2 | -0.0284448 |
| RHEX | regulator of hemoglobinization and erythroid cell expansion | -0.028379 |
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | -0.0283787 |
| KAZN | kazrin, periplakin interacting protein | -0.0281451 |
| TMSB4X | thymosin beta 4, X-linked | -0.0275516 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0274039 |
| N4BP2L2 | NEDD4 binding protein 2-like 2 | -0.0271282 |
| NFX1 | nuclear transcription factor, X-box binding 1 | -0.0268114 |
| VCAN | versican | -0.0265154 |
| DSCAML1 | Down syndrome cell adhesion molecule like 1 | -0.0263797 |
| FRAS1 | Fraser extracellular matrix complex subunit 1 | -0.026128 |
| ARHGEF10 | Rho guanine nucleotide exchange factor (GEF) 10 | -0.0259378 |
| SSH2 | slingshot protein phosphatase 2 | -0.0259309 |
| LARP1B | La ribonucleoprotein domain family, member 1B | -0.025872 |
| GCC2 | GRIP and coiled-coil domain containing 2 | -0.0256038 |
| RPS6KA2 | ribosomal protein S6 kinase, 90kDa, polypeptide 2 | -0.0255801 |
| HDLBP | high density lipoprotein binding protein | -0.0253189 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0252107 |
| HMGA2 | high mobility group AT-hook 2 | -0.0249588 |
| DOCK3 | dedicator of cytokinesis 3 | -0.024912 |
| LDHA | lactate dehydrogenase A | -0.0242735 |
| CALR | calreticulin | -0.0239391 |
| PATJ | PATJ crumbs cell polarity complex component | -0.0235336 |
| CCDC138 | coiled-coil domain containing 138 | -0.0234888 |
| DOCK4 | dedicator of cytokinesis 4 | -0.0233324 |
| EXOC4 | exocyst complex component 4 | -0.0232608 |
| PTPN4 | protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte) | -0.0232416 |
| CDK12 | cyclin-dependent kinase 12 | -0.0232145 |
| COPB1 | coatomer protein complex, subunit beta 1 | -0.0231346 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0231319 |
| NUFIP2 | nuclear fragile X mental retardation protein interacting protein 2 | -0.0230095 |
| ARHGEF28 | Rho guanine nucleotide exchange factor (GEF) 28 | -0.0229469 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0226151 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0223542 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.0222805 |
| LARS1 | leucyl-tRNA synthetase 1 | -0.0222569 |
| COA1 | cytochrome c oxidase assembly factor 1 homolog (S. cerevisiae) | -0.0219809 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0217757 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0217324 |
| ATG7 | autophagy related 7 | -0.0216667 |
| NSRP1 | nuclear speckle splicing regulatory protein 1 | -0.0216232 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0215483 |
| LITAF | lipopolysaccharide-induced TNF factor | -0.0214756 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0212419 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0211487 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0208424 |
| GTF2IRD1 | GTF2I repeat domain containing 1 | -0.0204343 |
| CHD9 | chromodomain helicase DNA binding protein 9 | -0.0202815 |
| FER | fer (fps/fes related) tyrosine kinase | -0.0201954 |
| SPDYA | speedy/RINGO cell cycle regulator family member A | -0.020098 |
| GNL3 | guanine nucleotide binding protein-like 3 (nucleolar) | -0.020085 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0197488 |
| THOC2 | THO complex 2 | -0.0196634 |
| HKDC1 | hexokinase domain containing 1 | -0.0195339 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | -0.0193127 |
| MCTP1 | multiple C2 domains, transmembrane 1 | -0.0192789 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0186659 |
| NR6A1 | nuclear receptor subfamily 6, group A, member 1 | -0.0186467 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0185859 |
| NDUFAF2 | NADH dehydrogenase (ubiquinone) complex I, assembly factor 2 | -0.0184626 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0183416 |
| ARFGEF3 | ARFGEF family member 3 | -0.0182835 |
| TASOR2 | transcription activation suppressor family member 2 | -0.0182698 |
| SEC63 | SEC63 homolog (S. cerevisiae) | -0.0182078 |
| PARP4 | poly (ADP-ribose) polymerase family, member 4 | -0.0178873 |
| ZNF609 | zinc finger protein 609 | -0.0177359 |
