| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Doxycycline (monohydrate) perturbation in HOP62 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Doxycycline (monohydrate)_HOP62 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.112724 |
| FAM13A | family with sequence similarity 13, member A | 0.100974 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0929099 |
| JARID2 | jumonji, AT rich interactive domain 2 | 0.0905512 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0892257 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0885022 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0808261 |
| PTK2 | protein tyrosine kinase 2 | 0.0713625 |
| ZNF292 | zinc finger protein 292 | 0.0657592 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0653183 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0647778 |
| MT2A | metallothionein 2A | 0.0639136 |
| DTNA | dystrobrevin, alpha | 0.0563622 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.055907 |
| ASPH | aspartate beta-hydroxylase | 0.0527565 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0524547 |
| PLAUR | plasminogen activator, urokinase receptor | 0.0520292 |
| RNF145 | ring finger protein 145 | 0.0512732 |
| COL6A1 | collagen, type VI, alpha 1 | 0.0506337 |
| MYO10 | myosin X | 0.0456253 |
| ENO1 | enolase 1, (alpha) | 0.0454138 |
| PGK1 | phosphoglycerate kinase 1 | 0.0451911 |
| RUNX1 | runt-related transcription factor 1 | 0.0444413 |
| NUP58 | nucleoporin 58 | 0.0439374 |
| KHDRBS3 | KH domain containing, RNA binding, signal transduction associated 3 | 0.0423898 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0420426 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | 0.0413448 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0394681 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0391891 |
| MSN | moesin | 0.0387876 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0376337 |
| PSMD14 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 | 0.0375453 |
| USP3 | ubiquitin specific peptidase 3 | 0.0365438 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0363854 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0362591 |
| ATP13A3 | ATPase type 13A3 | 0.036167 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0358969 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0358175 |
| PKM | pyruvate kinase, muscle | 0.0336276 |
| NGLY1 | N-glycanase 1 | 0.0336089 |
| SDK1 | sidekick cell adhesion molecule 1 | 0.0331273 |
| TMSB10 | thymosin beta 10 | 0.0330152 |
| BCAT1 | branched chain amino-acid transaminase 1, cytosolic | 0.0326095 |
| CENPF | centromere protein F, 350/400kDa | 0.0319169 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0313314 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0310481 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.030959 |
| MYO1B | myosin IB | 0.030747 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | 0.0307336 |
| NAV2 | neuron navigator 2 | 0.0302251 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0298851 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | 0.0298151 |
| PTPN14 | protein tyrosine phosphatase, non-receptor type 14 | 0.0296738 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | 0.029554 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0293894 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0291208 |
| VEGFA | vascular endothelial growth factor A | 0.028656 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | 0.0282053 |
| VAPA | VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa | 0.0281702 |
| SP3 | Sp3 transcription factor | 0.0278845 |
| HPCAL1 | hippocalcin-like 1 | 0.027863 |
| DIAPH2 | diaphanous-related formin 2 | 0.0277384 |
| NALF1 | NALCN channel auxiliary factor 1 | 0.0275587 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.027461 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0272483 |
| ZNF148 | zinc finger protein 148 | 0.0267549 |
| SPAG9 | sperm associated antigen 9 | 0.0267209 |
| TFG | TRK-fused gene | 0.026614 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | 0.0262833 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0260193 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0258613 |
| FOXJ3 | forkhead box J3 | 0.0258051 |
| FAM162A | family with sequence similarity 162, member A | 0.0256983 |
| HNRNPDL | heterogeneous nuclear ribonucleoprotein D-like | 0.0256718 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | 0.0255301 |
| RPS6 | ribosomal protein S6 | 0.0254554 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | 0.0253412 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | 0.0252952 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.0252409 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0250065 |
| MEF2A | myocyte enhancer factor 2A | 0.0248034 |
| LIMS1 | LIM and senescent cell antigen-like domains 1 | 0.0246101 |
| NCKAP1 | NCK-associated protein 1 | 0.0243925 |
| HELZ | helicase with zinc finger | 0.0243781 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0242099 |
| INSIG2 | insulin induced gene 2 | 0.0241897 |
| AXL | AXL receptor tyrosine kinase | 0.0241358 |
| QKI | QKI, KH domain containing, RNA binding | 0.0241023 |
| CLEC1B | C-type lectin domain family 1, member B | 0.0239953 |
| PCBP2 | poly(rC) binding protein 2 | 0.0239268 |
| TOP2B | topoisomerase (DNA) II beta 180kDa | 0.0237977 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0236734 |
| DHX15 | DEAH (Asp-Glu-Ala-His) box helicase 15 | 0.0236004 |
| NBAS | neuroblastoma amplified sequence | 0.0235166 |
| XPO1 | exportin 1 | 0.0234074 |
| TPM3 | tropomyosin 3 | 0.0231261 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.023108 |
| HERC3 | HECT and RLD domain containing E3 ubiquitin protein ligase 3 | 0.0230761 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0229863 |
| ARRDC3 | arrestin domain containing 3 | 0.0229438 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.518722 |
| FN1 | fibronectin 1 | -0.288869 |
| CD44 | CD44 molecule (Indian blood group) | -0.149794 |
| HMGA2 | high mobility group AT-hook 2 | -0.115389 |
| VCL | vinculin | -0.105134 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.103206 |
| LOX | lysyl oxidase | -0.0955123 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0932947 |
| AHNAK | AHNAK nucleoprotein | -0.0893473 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0858654 |
| CANX | calnexin | -0.0631368 |
| EGR1 | early growth response 1 | -0.0599135 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0585934 |
| ANKRD28 | ankyrin repeat domain 28 | -0.057918 |
| OSMR | oncostatin M receptor | -0.0525207 |
| CCND1 | cyclin D1 | -0.0494565 |
| HDLBP | high density lipoprotein binding protein | -0.0487147 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.048246 |
| ACTG1 | actin gamma 1 | -0.0456301 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | -0.0451023 |
| TNNC1 | troponin C type 1 (slow) | -0.0450195 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0446508 |
| GOLGB1 | golgin B1 | -0.0417054 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0416519 |
| RRBP1 | ribosome binding protein 1 | -0.0379973 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | -0.0376844 |
| DUSP6 | dual specificity phosphatase 6 | -0.0372059 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0363098 |
| NECTIN2 | nectin cell adhesion molecule 2 | -0.0360246 |
| BPTF | bromodomain PHD finger transcription factor | -0.0354265 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0350131 |
| KPNA4 | karyopherin alpha 4 (importin alpha 3) | -0.0342045 |
| EGFR | epidermal growth factor receptor | -0.0339791 |
| NABP1 | nucleic acid binding protein 1 | -0.0323044 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0318009 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0317193 |
| FBXL2 | F-box and leucine-rich repeat protein 2 | -0.0313578 |
| BASP1 | brain abundant, membrane attached signal protein 1 | -0.0308904 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0303868 |
| CAVIN1 | caveolae associated protein 1 | -0.0303808 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0301237 |
| IER3 | immediate early response 3 | -0.0298137 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0290465 |
| RAI14 | retinoic acid induced 14 | -0.0289483 |
| PALLD | palladin, cytoskeletal associated protein | -0.0287856 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | -0.0280186 |
| LOXL2 | lysyl oxidase-like 2 | -0.0267735 |
| TMEM263 | transmembrane protein 263 | -0.0265195 |
| CALU | calumenin | -0.0260212 |
| MORF4L2 | mortality factor 4 like 2 | -0.025717 |
| P4HA2 | prolyl 4-hydroxylase, alpha polypeptide II | -0.0256681 |
| ANXA2 | annexin A2 | -0.025629 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.025288 |
| ARF1 | ADP-ribosylation factor 1 | -0.0250908 |
| STC1 | stanniocalcin 1 | -0.0238279 |
| BICD1 | bicaudal D homolog 1 (Drosophila) | -0.0236696 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | -0.0227549 |
| ZBTB38 | zinc finger and BTB domain containing 38 | -0.0226429 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | -0.0225519 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.022174 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | -0.0220311 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0219583 |
| ENPP1 | ectonucleotide pyrophosphatase/phosphodiesterase 1 | -0.0216258 |
| NLK | nemo-like kinase | -0.0209505 |
| GFPT2 | glutamine-fructose-6-phosphate transaminase 2 | -0.0207264 |
| ACTN4 | actinin, alpha 4 | -0.0205583 |
| COL4A2 | collagen, type IV, alpha 2 | -0.0204261 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0203983 |
| RND3 | Rho family GTPase 3 | -0.0200426 |
| COPB1 | coatomer protein complex, subunit beta 1 | -0.0197728 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0197435 |
| CLIC4 | chloride intracellular channel 4 | -0.0196141 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0191556 |
| SLC6A6 | solute carrier family 6 (neurotransmitter transporter), member 6 | -0.0187787 |
| FNIP1 | folliculin interacting protein 1 | -0.0186682 |
| HM13 | histocompatibility (minor) 13 | -0.0185125 |
| FSTL1 | follistatin-like 1 | -0.0184376 |
| PCBP3 | poly(rC) binding protein 3 | -0.0181825 |
| UBC | ubiquitin C | -0.0181081 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0179988 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | -0.0178513 |
| MAPK8 | mitogen-activated protein kinase 8 | -0.0176982 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | -0.0176279 |
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | -0.0175057 |
| PPP1R10 | protein phosphatase 1, regulatory subunit 10 | -0.017434 |
| TTC3 | tetratricopeptide repeat domain 3 | -0.017429 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | -0.0172922 |
| S100A10 | S100 calcium binding protein A10 | -0.017275 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0171172 |
| F2RL1 | coagulation factor II (thrombin) receptor-like 1 | -0.0170557 |
| TBCA | tubulin folding cofactor A | -0.016982 |
| RAP1B | RAP1B, member of RAS oncogene family | -0.0168834 |
| TBX3 | T-box 3 | -0.0168119 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0166022 |
| ACTN1 | actinin, alpha 1 | -0.0165694 |
| ANKUB1 | ankyrin repeat and ubiquitin domain containing 1 | -0.0165399 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | -0.0165074 |
| GLG1 | golgi glycoprotein 1 | -0.0164705 |
| NF1 | neurofibromin 1 | -0.0164675 |
| SENP5 | SUMO1/sentrin specific peptidase 5 | -0.0164437 |
