Doxycycline (monohydrate)_HS-578T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Doxycycline (monohydrate) perturbation in HS-578T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Doxycycline (monohydrate)_HS-578T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
COL6A3 collagen, type VI, alpha 3 0.0498452
EXT1 exostosin glycosyltransferase 1 0.0447283
ATP13A3 ATPase type 13A3 0.0442074
CDH13 cadherin 13 0.04352
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0384213
HMGA2 high mobility group AT-hook 2 0.0342591
ANTXR2 anthrax toxin receptor 2 0.0340955
NALF1 NALCN channel auxiliary factor 1 0.0318422
DPYD dihydropyrimidine dehydrogenase 0.0315465
FNDC3B fibronectin type III domain containing 3B 0.0282354
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 0.0250642
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0235893
ZFPM2 zinc finger protein, FOG family member 2 0.0226733
MYH9 myosin, heavy chain 9, non-muscle 0.02262
COL5A1 collagen, type V, alpha 1 0.0222872
GLIS3 GLIS family zinc finger 3 0.0217218
TRPS1 trichorhinophalangeal syndrome I 0.0213616
FAT1 FAT atypical cadherin 1 0.0200775
NAV2 neuron navigator 2 0.0199889
MACF1 microtubule-actin crosslinking factor 1 0.0192904
PLEC plectin 0.0190742
ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 0.018422
SMAD3 SMAD family member 3 0.0174423
MAML2 mastermind-like 2 (Drosophila) 0.0167409
EFNA5 ephrin-A5 0.0166179
PTK2 protein tyrosine kinase 2 0.0165014
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0163955
LPP LIM domain containing preferred translocation partner in lipoma 0.0161471
UBE2E2 ubiquitin-conjugating enzyme E2E 2 0.015903
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 0.0154381
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0153809
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0153403
DST dystonin 0.0153284
CNTN5 contactin 5 0.0152507
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0146067
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 0.0143019
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0142038
PDE4D phosphodiesterase 4D, cAMP-specific 0.0142013
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0141984
NKAIN3 Na+/K+ transporting ATPase interacting 3 0.0140347
ATXN1 ataxin 1 0.0139993
CAMTA1 calmodulin binding transcription activator 1 0.013894
ZFAND3 zinc finger, AN1-type domain 3 0.0136154
VEGFC vascular endothelial growth factor C 0.0135776
MTSS1 metastasis suppressor 1 0.0135667
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) 0.013498
RFX8 RFX family member 8, lacking RFX DNA binding domain 0.0130255
LHFPL2 lipoma HMGIC fusion partner-like 2 0.0123937
WWTR1 WW domain containing transcription regulator 1 0.0123698
FBXL13 F-box and leucine-rich repeat protein 13 0.0122602
MYO10 myosin X 0.0122215
DPYSL3 dihydropyrimidinase-like 3 0.0120232
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0118625
SPSB1 splA/ryanodine receptor domain and SOCS box containing 1 0.0114376
COL3A1 collagen, type III, alpha 1 0.0112873
RASA2 RAS p21 protein activator 2 0.0112172
PAPPA pregnancy-associated plasma protein A, pappalysin 1 0.0111999
ZEB1 zinc finger E-box binding homeobox 1 0.0111821
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0110559
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.0109978
NAV1 neuron navigator 1 0.010975
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0109409
RABGAP1L RAB GTPase activating protein 1-like 0.0108448
FER fer (fps/fes related) tyrosine kinase 0.0107694
ECT2 epithelial cell transforming 2 0.0107197
BBS9 Bardet-Biedl syndrome 9 0.0106652
SOCS5 suppressor of cytokine signaling 5 0.0106554
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0105222
MAP3K5 mitogen-activated protein kinase kinase kinase 5 0.0103968
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0103066
AOPEP aminopeptidase O (putative) 0.0102707
ZBTB20 zinc finger and BTB domain containing 20 0.0102705
CLIC4 chloride intracellular channel 4 0.0101234
ACSL3 acyl-CoA synthetase long-chain family member 3 0.0101152
KLC1 kinesin light chain 1 0.00997991
BCAR3 breast cancer anti-estrogen resistance 3 0.00995738
ADAM12 ADAM metallopeptidase domain 12 0.00987485
FAF1 Fas (TNFRSF6) associated factor 1 0.00984903
LTBP1 latent transforming growth factor beta binding protein 1 0.00982146
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.00978108
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A 0.00976066
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.00966815
MSRB3 methionine sulfoxide reductase B3 0.00964447
TBC1D5 TBC1 domain family, member 5 0.00960418
TRAPPC9 trafficking protein particle complex 9 0.00959983
SLC22A23 solute carrier family 22, member 23 0.00955534
AGFG1 ArfGAP with FG repeats 1 0.00947132
IRAK2 interleukin-1 receptor-associated kinase 2 0.00926324
AMPD3 adenosine monophosphate deaminase 3 0.0091438
DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila) 0.0091432
NAV3 neuron navigator 3 0.00910137
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.00909272
STK38L serine/threonine kinase 38 like 0.00897274
CENPE centromere protein E, 312kDa 0.00896704
NFE2L1 nuclear factor, erythroid 2-like 1 0.0089028
SDC2 syndecan 2 0.00885291
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.00879116
HSPA8 heat shock 70kDa protein 8 0.00878327
PALM2AKAP2 PALM2 and AKAP2 fusion 0.00877666
PTPRG protein tyrosine phosphatase, receptor type, G 0.00876174

decreased expression

Symbol Name Standardized Value
IGFBP3 insulin-like growth factor binding protein 3 -0.235441
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.208321
VIM vimentin -0.199614
NDRG1 N-myc downstream regulated 1 -0.187232
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.135546
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.13202
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.118676
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0889599
TMSB10 thymosin beta 10 -0.0760541
MT2A metallothionein 2A -0.0739496
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0732236
COL1A1 collagen, type I, alpha 1 -0.066726
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0624609
ENO1 enolase 1, (alpha) -0.056511
FTL ferritin, light polypeptide -0.0541555
FN1 fibronectin 1 -0.0532872
TGFBI transforming growth factor, beta-induced, 68kDa -0.0518547
IER3 immediate early response 3 -0.049177
RPS6 ribosomal protein S6 -0.0473132
COL1A2 collagen, type I, alpha 2 -0.0451557
RPS8 ribosomal protein S8 -0.0448135
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0393893
CALR calreticulin -0.039011
LDHA lactate dehydrogenase A -0.0386611
ACTG1 actin gamma 1 -0.0382873
PTMA prothymosin, alpha -0.0380831
UBC ubiquitin C -0.0379937
LMAN1 lectin, mannose-binding, 1 -0.0373594
LOX lysyl oxidase -0.03722
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0365807
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0329502
ANXA2 annexin A2 -0.032858
HLA-B major histocompatibility complex, class I, B -0.0317347
PDIA3 protein disulfide isomerase family A, member 3 -0.0316879
TPM4 tropomyosin 4 -0.0315129
CANX calnexin -0.0315086
EIF1 eukaryotic translation initiation factor 1 -0.0311305
S100A9 S100 calcium binding protein A9 -0.031032
HILPDA hypoxia inducible lipid droplet-associated -0.0307799
B2M beta-2-microglobulin -0.0307148
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0291435
RPL8 ribosomal protein L8 -0.028503
RPL11 ribosomal protein L11 -0.0281268
TMSB4X thymosin beta 4, X-linked -0.0280804
PSD3 pleckstrin and Sec7 domain containing 3 -0.0279277
RPL35A ribosomal protein L35a -0.027926
S100A10 S100 calcium binding protein A10 -0.0277514
MTDH metadherin -0.0275193
PGK1 phosphoglycerate kinase 1 -0.0270908
ADM adrenomedullin -0.0267652
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0265576
RPL19 ribosomal protein L19 -0.0259722
TMEM158 transmembrane protein 158 (gene/pseudogene) -0.025933
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0250668
YBX1 Y box binding protein 1 -0.0250064
LOC112694756 uncharaterized LOC112694756 -0.0246691
RACK1 receptor for activated C kinase 1 -0.024582
IFI6 interferon, alpha-inducible protein 6 -0.0243952
RPL12 ribosomal protein L12 -0.0240505
LIMS1 LIM and senescent cell antigen-like domains 1 -0.0239302
RPLP1 ribosomal protein, large, P1 -0.0238979
SEPTIN7 septin 7 -0.0237298
PKM pyruvate kinase, muscle -0.0233191
RPS19 ribosomal protein S19 -0.0230635
CD44 CD44 molecule (Indian blood group) -0.0228419
RPL28 ribosomal protein L28 -0.0226859
EGR1 early growth response 1 -0.0225335
CYB5R3 cytochrome b5 reductase 3 -0.0221112
MAP1B microtubule-associated protein 1B -0.0219412
CADM1 cell adhesion molecule 1 -0.0215206
RRBP1 ribosome binding protein 1 -0.0213184
PFN1 profilin 1 -0.0212809
RPL23 ribosomal protein L23 -0.0208604
VEGFA vascular endothelial growth factor A -0.0208524
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0207713
DSTN destrin (actin depolymerizing factor) -0.0207365
GOLGB1 golgin B1 -0.0206377
RPL30 ribosomal protein L30 -0.0206133
TRAM1 translocation associated membrane protein 1 -0.0201438
IFITM3 interferon induced transmembrane protein 3 -0.0201253
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0200973
RPS5 ribosomal protein S5 -0.0196249
PDIA6 protein disulfide isomerase family A, member 6 -0.0195586
TPI1 triosephosphate isomerase 1 -0.0194145
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3 -0.0187645
RPLP0 ribosomal protein, large, P0 -0.0186861
GNAS GNAS complex locus -0.0183606
TPM2 tropomyosin 2 (beta) -0.0182577
MT1X metallothionein 1X -0.0181759
S100A6 S100 calcium binding protein A6 -0.018013
SP100 SP100 nuclear antigen -0.0179822
RPLP2 ribosomal protein, large, P2 -0.0179254
WASF2 WAS protein family, member 2 -0.0179175
TPT1 tumor protein, translationally-controlled 1 -0.0176756
RPL5 ribosomal protein L5 -0.0176365
RPL26 ribosomal protein L26 -0.0175098
RPS14 ribosomal protein S14 -0.0173543
HIP1 huntingtin interacting protein 1 -0.0172373
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0167843
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0166721