Doxycycline (monohydrate)_HT-29 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Doxycycline (monohydrate) perturbation in HT-29 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Doxycycline (monohydrate)_HT-29 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
TXNRD1 thioredoxin reductase 1 0.0771142
EXT1 exostosin glycosyltransferase 1 0.0693121
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.0682226
KDM6A lysine (K)-specific demethylase 6A 0.0635798
KMT2C lysine (K)-specific methyltransferase 2C 0.0578237
EPS8 epidermal growth factor receptor pathway substrate 8 0.0543472
MBNL2 muscleblind-like splicing regulator 2 0.0518865
USP3 ubiquitin specific peptidase 3 0.045743
ZFAND3 zinc finger, AN1-type domain 3 0.0443273
WAC WW domain containing adaptor with coiled-coil 0.0427168
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0420705
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 0.0370866
IARS1 isoleucyl-tRNA synthetase 1 0.0362776
FNDC3B fibronectin type III domain containing 3B 0.0358629
ANKRD11 ankyrin repeat domain 11 0.035498
ADAM17 ADAM metallopeptidase domain 17 0.0353077
RICTOR RPTOR independent companion of MTOR, complex 2 0.0353016
TRA2A transformer 2 alpha homolog (Drosophila) 0.035292
PUM2 pumilio RNA-binding family member 2 0.0351715
PDS5B PDS5 cohesin associated factor B 0.0343987
GCLC glutamate-cysteine ligase, catalytic subunit 0.0342917
TOP1 topoisomerase (DNA) I 0.0341768
ZNF292 zinc finger protein 292 0.0340382
CCNL1 cyclin L1 0.0339557
PAN3 PAN3 poly(A) specific ribonuclease subunit 0.0339303
JMJD1C jumonji domain containing 1C 0.0337715
TSC22D2 TSC22 domain family, member 2 0.0332591
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0326466
BIRC6 baculoviral IAP repeat containing 6 0.032522
FAM91A1 family with sequence similarity 91, member A1 0.0323341
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0321394
PCCA propionyl CoA carboxylase, alpha polypeptide 0.0321149
COG5 component of oligomeric golgi complex 5 0.0319683
OGA O-GlcNAcase 0.0318959
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0311555
NCKAP1 NCK-associated protein 1 0.0310003
SBF2 SET binding factor 2 0.0309818
DSCAM Down syndrome cell adhesion molecule 0.0304505
ARHGAP26 Rho GTPase activating protein 26 0.0296429
HELZ helicase with zinc finger 0.029592
LCORL ligand dependent nuclear receptor corepressor-like 0.029513
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase 0.0293656
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0293567
RAB3GAP1 RAB3 GTPase activating protein subunit 1 (catalytic) 0.0291921
ZFAND6 zinc finger, AN1-type domain 6 0.028686
TMEM41B transmembrane protein 41B 0.0285251
XPO1 exportin 1 0.0282398
SLMAP sarcolemma associated protein 0.0279547
PARD3 par-3 family cell polarity regulator 0.0279249
PAWR PRKC, apoptosis, WT1, regulator 0.0277915
TES testin LIM domain protein 0.027552
CUL3 cullin 3 0.0275332
TMEM65 transmembrane protein 65 0.0275118
PDIA3 protein disulfide isomerase family A, member 3 0.0274706
GSK3B glycogen synthase kinase 3 beta 0.0270894
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0270246
LGR4 leucine-rich repeat containing G protein-coupled receptor 4 0.0267375
FAM135A family with sequence similarity 135, member A 0.0265126
CHD1 chromodomain helicase DNA binding protein 1 0.0262095
NUP58 nucleoporin 58 0.0262033
UBE2D3 ubiquitin-conjugating enzyme E2D 3 0.0260687
RNF145 ring finger protein 145 0.0260194
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha 0.025933
MED13L mediator complex subunit 13-like 0.025493
USP9X ubiquitin specific peptidase 9, X-linked 0.025194
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0251799
YTHDC1 YTH domain containing 1 0.0251365
NSMCE2 non-SMC element 2, MMS21 homolog (S. cerevisiae) 0.0246416
RBM39 RNA binding motif protein 39 0.0245434
TCEA1 transcription elongation factor A (SII), 1 0.0244823
MARCHF6 membrane associated ring-CH-type finger 6 0.0244371
USP12 ubiquitin specific peptidase 12 0.0243744
NEK7 NIMA-related kinase 7 0.0239476
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.0239119
SUCO SUN domain containing ossification factor 0.0238914
IPO7 importin 7 0.0237041
AFF1 AF4/FMR2 family, member 1 0.0234589
SND1 staphylococcal nuclease and tudor domain containing 1 0.0231818
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit 0.023178
MATR3 matrin 3 0.0230575
ZMYM2 zinc finger, MYM-type 2 0.023049
CAMTA1 calmodulin binding transcription activator 1 0.0229002
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0225858
PICALM phosphatidylinositol binding clathrin assembly protein 0.0224169
ZNF207 zinc finger protein 207 0.0219424
GGNBP2 gametogenetin binding protein 2 0.0218743
SPRED2 sprouty-related, EVH1 domain containing 2 0.0217402
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0214538
CDK8 cyclin-dependent kinase 8 0.0214106
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.021164
ATP13A3 ATPase type 13A3 0.0209938
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) 0.0207915
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.020726
SEL1L sel-1 suppressor of lin-12-like (C. elegans) 0.0205497
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0204529
BIRC3 baculoviral IAP repeat containing 3 0.0203516
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0203214
VAPA VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa 0.0197752
UBN2 ubinuclein 2 0.0196077
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0195954

decreased expression

Symbol Name Standardized Value
AHNAK AHNAK nucleoprotein -0.134394
FTL ferritin, light polypeptide -0.118087
MYH14 myosin, heavy chain 14, non-muscle -0.109592
SLC45A4 solute carrier family 45, member 4 -0.101901
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 -0.0965417
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0925898
KRT20 keratin 20, type I -0.0913468
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.082596
RPS3 ribosomal protein S3 -0.0792375
EZR ezrin -0.0764413
ANXA2 annexin A2 -0.0703589
RPLP1 ribosomal protein, large, P1 -0.0661294
ITPKC inositol-trisphosphate 3-kinase C -0.0624
TPT1 tumor protein, translationally-controlled 1 -0.0606582
LMO7 LIM domain 7 -0.0600032
RPL35A ribosomal protein L35a -0.0593226
NDRG1 N-myc downstream regulated 1 -0.0591302
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 -0.0584389
PGK1 phosphoglycerate kinase 1 -0.0569542
PTMA prothymosin, alpha -0.0569178
RPS8 ribosomal protein S8 -0.0564036
RPS19 ribosomal protein S19 -0.054628
ACTN4 actinin, alpha 4 -0.0529373
RPS12 ribosomal protein S12 -0.0527832
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0526568
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 -0.052573
RPLP2 ribosomal protein, large, P2 -0.0523372
PLAUR plasminogen activator, urokinase receptor -0.0510968
KRT18 keratin 18, type I -0.0507821
TMSB10 thymosin beta 10 -0.0505133
LYZ lysozyme -0.050486
NECTIN2 nectin cell adhesion molecule 2 -0.0502595
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.049081
ZMYND8 zinc finger, MYND-type containing 8 -0.0487012
RRBP1 ribosome binding protein 1 -0.0480465
ST14 suppression of tumorigenicity 14 (colon carcinoma) -0.0471323
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0461616
JUN jun proto-oncogene -0.0460495
LOC112694756 uncharaterized LOC112694756 -0.0458755
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 -0.0447863
RPL37A ribosomal protein L37a -0.0444967
POF1B premature ovarian failure, 1B -0.0431744
RPL18 ribosomal protein L18 -0.042348
FRY furry homolog (Drosophila) -0.0420325
RPS6 ribosomal protein S6 -0.0419108
RPL19 ribosomal protein L19 -0.0413911
LDHA lactate dehydrogenase A -0.0408479
RPL26 ribosomal protein L26 -0.0406553
TJP1 tight junction protein 1 -0.040291
GSN gelsolin -0.0400096
RPL31 ribosomal protein L31 -0.039899
MYO1E myosin IE -0.0396465
KLF3 Kruppel-like factor 3 (basic) -0.0394746
RPL12 ribosomal protein L12 -0.0393662
BCAS1 breast carcinoma amplified sequence 1 -0.0392599
LAMA4 laminin, alpha 4 -0.0388322
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0380856
EIF1 eukaryotic translation initiation factor 1 -0.0379412
ETV6 ets variant 6 -0.036929
MMP7 matrix metallopeptidase 7 -0.0366873
RPL13A ribosomal protein L13a -0.0353643
MAML3 mastermind-like 3 (Drosophila) -0.0351393
MKI67 marker of proliferation Ki-67 -0.0349969
WASF2 WAS protein family, member 2 -0.0348913
PRR5L proline rich 5 like -0.0348318
RPS13 ribosomal protein S13 -0.0347933
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0345666
LMNA lamin A/C -0.0330693
SQSTM1 sequestosome 1 -0.0323134
RNF213 ring finger protein 213 -0.0322987
LAMB3 laminin, beta 3 -0.0321494
JUP junction plakoglobin -0.031542
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) -0.0310687
ENO1 enolase 1, (alpha) -0.0306705
ITGA1 integrin, alpha 1 -0.0304727
RPS27A ribosomal protein S27a -0.030044
RPLP0 ribosomal protein, large, P0 -0.0297412
FAT1 FAT atypical cadherin 1 -0.0296436
ACTG1 actin gamma 1 -0.0295454
RPL27A ribosomal protein L27a -0.0294236
KRT8 keratin 8, type II -0.0293122
KRT19 keratin 19, type I -0.0289098
TMC5 transmembrane channel-like 5 -0.0288446
PTPRK protein tyrosine phosphatase, receptor type, K -0.0287839
EGR1 early growth response 1 -0.0281894
BPTF bromodomain PHD finger transcription factor -0.0279893
NIBAN2 niban apoptosis regulator 2 -0.0279807
TPI1 triosephosphate isomerase 1 -0.0278151
PTPRF protein tyrosine phosphatase, receptor type, F -0.0277599
TRIB1 tribbles pseudokinase 1 -0.0276902
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase -0.0275775
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -0.0275604
IQGAP1 IQ motif containing GTPase activating protein 1 -0.0274139
ZBTB20 zinc finger and BTB domain containing 20 -0.0273648
NPC1 Niemann-Pick disease, type C1 -0.027316
CTBP2 C-terminal binding protein 2 -0.0273018
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 -0.0271846
SULT2B1 sulfotransferase family, cytosolic, 2B, member 1 -0.0271599
BAIAP2L1 BAI1-associated protein 2-like 1 -0.0270009
RPL23 ribosomal protein L23 -0.0267199