| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Doxycycline (monohydrate) perturbation in HepG2/C3A cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Doxycycline (monohydrate)_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| IGF2 | insulin-like growth factor 2 | 0.332653 |
| C3 | complement component 3 | 0.0862721 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | 0.0812003 |
| APOB | apolipoprotein B | 0.0718506 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0579262 |
| LRMDA | leucine rich melanocyte differentiation associated | 0.0535338 |
| GPAM | glycerol-3-phosphate acyltransferase, mitochondrial | 0.0483289 |
| GPC6 | glypican 6 | 0.0441856 |
| MAML2 | mastermind-like 2 (Drosophila) | 0.0429938 |
| FAT1 | FAT atypical cadherin 1 | 0.0415387 |
| ITGAV | integrin, alpha V | 0.0387466 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0387333 |
| SESTD1 | SEC14 and spectrin domains 1 | 0.0340407 |
| SOX5 | SRY (sex determining region Y)-box 5 | 0.0339233 |
| TNFAIP3 | tumor necrosis factor, alpha-induced protein 3 | 0.0317146 |
| LRRTM4 | leucine rich repeat transmembrane neuronal 4 | 0.0310847 |
| DENND4A | DENN/MADD domain containing 4A | 0.0307347 |
| ARHGAP9 | Rho GTPase activating protein 9 | 0.0271684 |
| A2M | alpha-2-macroglobulin | 0.0270577 |
| EML4 | echinoderm microtubule associated protein like 4 | 0.027047 |
| VPS54 | vacuolar protein sorting 54 homolog (S. cerevisiae) | 0.0269744 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0263691 |
| DNAH17 | dynein, axonemal, heavy chain 17 | 0.0252097 |
| NKD1 | naked cuticle homolog 1 (Drosophila) | 0.0251312 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | 0.0240524 |
| PEG3 | paternally expressed 3 | 0.0231609 |
| KDM7A | lysine (K)-specific demethylase 7A | 0.0223158 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0219603 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | 0.0219089 |
| FCHSD2 | FCH and double SH3 domains 2 | 0.0218569 |
| ASAP2 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 | 0.0215122 |
| MTUS1 | microtubule associated tumor suppressor 1 | 0.0212323 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0207691 |
| SLC23A1 | solute carrier family 23 (ascorbic acid transporter), member 1 | 0.020584 |
| CDK6 | cyclin-dependent kinase 6 | 0.0198709 |
| MLLT10 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 | 0.0195063 |
| TXNRD1 | thioredoxin reductase 1 | 0.0192667 |
| NIPBL | Nipped-B homolog (Drosophila) | 0.0192542 |
| TCF12 | transcription factor 12 | 0.0190648 |
| SOX9 | SRY (sex determining region Y)-box 9 | 0.018929 |
| ACSS3 | acyl-CoA synthetase short-chain family member 3 | 0.0185746 |
| TNFRSF19 | tumor necrosis factor receptor superfamily, member 19 | 0.0185177 |
| PTBP3 | polypyrimidine tract binding protein 3 | 0.0184927 |
| VMP1 | vacuole membrane protein 1 | 0.0180384 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0174627 |
| DST | dystonin | 0.017208 |
| SRPK1 | SRSF protein kinase 1 | 0.0170701 |
| DOCK4 | dedicator of cytokinesis 4 | 0.0167942 |
| APOA2 | apolipoprotein A-II | 0.0165473 |
| RELL1 | RELT-like 1 | 0.016525 |
| SLC38A2 | solute carrier family 38, member 2 | 0.0161855 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0161523 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0160142 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.0158948 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0158854 |
| ARID1B | AT rich interactive domain 1B (SWI1-like) | 0.0158678 |
| TLK1 | tousled-like kinase 1 | 0.0156545 |
| TMEM51 | transmembrane protein 51 | 0.0155 |
| ARHGAP5 | Rho GTPase activating protein 5 | 0.0153493 |
| KRT8 | keratin 8, type II | 0.0151245 |
| FBXL17 | F-box and leucine-rich repeat protein 17 | 0.015057 |
| RNF19A | ring finger protein 19A, RBR E3 ubiquitin protein ligase | 0.0148686 |
| NFIA | nuclear factor I/A | 0.014835 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | 0.0148052 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0146085 |
| SNTB1 | syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) | 0.0145638 |
| ENAH | enabled homolog (Drosophila) | 0.0145538 |
| NXN | nucleoredoxin | 0.0144722 |
| FHIT | fragile histidine triad | 0.0144465 |
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | 0.0143844 |
| KRT18 | keratin 18, type I | 0.014348 |
| SREBF2 | sterol regulatory element binding transcription factor 2 | 0.0141172 |
| FOXO1 | forkhead box O1 | 0.0139761 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0139053 |
| GCC2 | GRIP and coiled-coil domain containing 2 | 0.0138392 |
| NPAS2 | neuronal PAS domain protein 2 | 0.0137903 |
| MAPK14 | mitogen-activated protein kinase 14 | 0.0137306 |
| PTPRG | protein tyrosine phosphatase, receptor type, G | 0.0136909 |
| RAPGEF5 | Rap guanine nucleotide exchange factor (GEF) 5 | 0.0136751 |
| SOS1 | son of sevenless homolog 1 (Drosophila) | 0.0136422 |
| EPB41 | erythrocyte membrane protein band 4.1 | 0.0136329 |
| NUP98 | nucleoporin 98kDa | 0.0135935 |
| SYN3 | synapsin III | 0.0135435 |
| ELF2 | E74-like factor 2 (ets domain transcription factor) | 0.0133892 |
| AK1 | adenylate kinase 1 | 0.0132454 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | 0.0132339 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.0132288 |
| TPM4 | tropomyosin 4 | 0.0132099 |
| DDI2 | DNA-damage inducible 1 homolog 2 (S. cerevisiae) | 0.0131619 |
| FNBP1L | formin binding protein 1-like | 0.0130854 |
| PSMD1 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 1 | 0.0130265 |
| MSI2 | musashi RNA-binding protein 2 | 0.0129596 |
| AFF4 | AF4/FMR2 family, member 4 | 0.0128507 |
| DNAJB1 | DnaJ (Hsp40) homolog, subfamily B, member 1 | 0.0127968 |
| LMTK2 | lemur tyrosine kinase 2 | 0.0127147 |
| PKP4 | plakophilin 4 | 0.0126801 |
| GK | glycerol kinase | 0.0126343 |
| MEMO1 | mediator of cell motility 1 | 0.0125564 |
| SOX6 | SRY (sex determining region Y)-box 6 | 0.0124479 |
| FGG | fibrinogen gamma chain | 0.0123529 |
| Symbol | Name | Standardized Value |
|---|---|---|
| MT2A | metallothionein 2A | -0.111277 |
| RPS12 | ribosomal protein S12 | -0.0985321 |
| RPS6 | ribosomal protein S6 | -0.0778753 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.0725502 |
| ENO1 | enolase 1, (alpha) | -0.0659952 |
| RPL37A | ribosomal protein L37a | -0.0638913 |
| RPS8 | ribosomal protein S8 | -0.0616238 |
| CCL20 | chemokine (C-C motif) ligand 20 | -0.0612558 |
| RPS19 | ribosomal protein S19 | -0.0600197 |
| RPS27A | ribosomal protein S27a | -0.0578423 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0562587 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0547016 |
| RPS3 | ribosomal protein S3 | -0.0516368 |
| RPL26 | ribosomal protein L26 | -0.0488161 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0475272 |
| RACK1 | receptor for activated C kinase 1 | -0.0459634 |
| SDC4 | syndecan 4 | -0.0434901 |
| RPL34 | ribosomal protein L34 | -0.043357 |
| DSPP | dentin sialophosphoprotein | -0.0427587 |
| RPL11 | ribosomal protein L11 | -0.0423672 |
| RPLP1 | ribosomal protein, large, P1 | -0.0415476 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0406891 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.0391527 |
| DDIT4 | DNA-damage-inducible transcript 4 | -0.0379569 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.037751 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0371576 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | -0.0370315 |
| RPL35A | ribosomal protein L35a | -0.0369306 |
| AFDN | afadin, adherens junction formation factor | -0.0365434 |
| FAM107B | family with sequence similarity 107, member B | -0.0348394 |
| RPL23 | ribosomal protein L23 | -0.0337828 |
| RPL12 | ribosomal protein L12 | -0.0334645 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0333973 |
| RPLP2 | ribosomal protein, large, P2 | -0.0332346 |
| RPL18 | ribosomal protein L18 | -0.0329258 |
| LOC112694756 | uncharaterized LOC112694756 | -0.031907 |
| FBF1 | Fas (TNFRSF6) binding factor 1 | -0.030364 |
| RPL17-C18ORF32 | RPL17-C18orf32 readthrough | -0.0294714 |
| LDHA | lactate dehydrogenase A | -0.0280564 |
| PDGFB | platelet-derived growth factor beta polypeptide | -0.0279586 |
| GPC3 | glypican 3 | -0.0278137 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0274297 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0267264 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0264265 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | -0.0264104 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | -0.0263866 |
| ASPH | aspartate beta-hydroxylase | -0.0263033 |
| FLNB | filamin B, beta | -0.0256571 |
| GOLGA4 | golgin A4 | -0.0253414 |
| RPLP0 | ribosomal protein, large, P0 | -0.0252864 |
| RPL19 | ribosomal protein L19 | -0.0252136 |
| PSMA7 | proteasome (prosome, macropain) subunit, alpha type, 7 | -0.0239635 |
| EPAS1 | endothelial PAS domain protein 1 | -0.0238884 |
| RPL5 | ribosomal protein L5 | -0.0232448 |
| ACSL4 | acyl-CoA synthetase long-chain family member 4 | -0.0231222 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0230849 |
| DHRS2 | dehydrogenase/reductase (SDR family) member 2 | -0.0228016 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0225944 |
| SQSTM1 | sequestosome 1 | -0.0225673 |
| UBC | ubiquitin C | -0.0224533 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0223157 |
| S100A9 | S100 calcium binding protein A9 | -0.0219212 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0215986 |
| RPL9 | ribosomal protein L9 | -0.0212789 |
| DLC1 | DLC1 Rho GTPase activating protein | -0.0211402 |
| RLF | rearranged L-myc fusion | -0.0210397 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.0209365 |
| B2M | beta-2-microglobulin | -0.0208528 |
| SLC25A6 | solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6 | -0.0208394 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.0208202 |
| ATP5F1E | ATP synthase F1 subunit epsilon | -0.0207715 |
| ATP1A4 | ATPase, Na+/K+ transporting, alpha 4 polypeptide | -0.0206748 |
| RPS14 | ribosomal protein S14 | -0.0201982 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0198604 |
| NACA | nascent polypeptide-associated complex alpha subunit | -0.0198549 |
| CPE | carboxypeptidase E | -0.0195377 |
| RPS24 | ribosomal protein S24 | -0.0194741 |
| APOC1 | apolipoprotein C-I | -0.019422 |
| BRD4 | bromodomain containing 4 | -0.0193412 |
| BHLHE40 | basic helix-loop-helix family, member e40 | -0.0193351 |
| RPS16 | ribosomal protein S16 | -0.0191885 |
| RPS25 | ribosomal protein S25 | -0.0190473 |
| RPS21 | ribosomal protein S21 | -0.0189999 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0188132 |
| RPN2 | ribophorin II | -0.0186334 |
| TUT4 | terminal uridylyl transferase 4 | -0.0185832 |
| DOCK5 | dedicator of cytokinesis 5 | -0.0184653 |
| RPS27 | ribosomal protein S27 | -0.0184083 |
| NPR2 | natriuretic peptide receptor 2 | -0.0182848 |
| GDF15 | growth differentiation factor 15 | -0.0180657 |
| GNAS | GNAS complex locus | -0.0179169 |
| RPL38 | ribosomal protein L38 | -0.0178543 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | -0.0178197 |
| RPL30 | ribosomal protein L30 | -0.0177942 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | -0.0176615 |
| PRAG1 | PEAK1 related, kinase-activating pseudokinase 1 | -0.0176546 |
| SPSB1 | splA/ryanodine receptor domain and SOCS box containing 1 | -0.0174778 |
| RPS2 | ribosomal protein S2 | -0.0174096 |
| APOA1 | apolipoprotein A-I | -0.0173899 |
| RPL10A | ribosomal protein L10a | -0.0172265 |
