Doxycycline (monohydrate)_Hs 766T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Doxycycline (monohydrate) perturbation in Hs 766T cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Doxycycline (monohydrate)_Hs 766T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FLNB filamin B, beta 0.0681144
NAMPT nicotinamide phosphoribosyltransferase 0.065152
CEMIP cell migration inducing protein, hyaluronan binding 0.0534462
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0526839
RICTOR RPTOR independent companion of MTOR, complex 2 0.0483659
TRIO trio Rho guanine nucleotide exchange factor 0.0478165
MEF2A myocyte enhancer factor 2A 0.0470526
KIAA1217 KIAA1217 0.0428696
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2 0.0418062
SMAD3 SMAD family member 3 0.0391308
RIN2 Ras and Rab interactor 2 0.0387923
ITCH itchy E3 ubiquitin protein ligase 0.0374985
KDM6A lysine (K)-specific demethylase 6A 0.035953
SULF1 sulfatase 1 0.0333623
FNDC3B fibronectin type III domain containing 3B 0.0332999
ESYT2 extended synaptotagmin-like protein 2 0.0331348
NEK7 NIMA-related kinase 7 0.0317854
BCL2L1 BCL2-like 1 0.0317526
ANKRD33B ankyrin repeat domain 33B 0.0296175
FOXO1 forkhead box O1 0.029477
DOCK5 dedicator of cytokinesis 5 0.0293653
PDK3 pyruvate dehydrogenase kinase, isozyme 3 0.0288099
ZNF292 zinc finger protein 292 0.028798
MYOF myoferlin 0.0283694
HERC3 HECT and RLD domain containing E3 ubiquitin protein ligase 3 0.0272621
OGA O-GlcNAcase 0.0270415
LNPEP leucyl/cystinyl aminopeptidase 0.0264291
KLF7 Kruppel-like factor 7 (ubiquitous) 0.026251
NRG1 neuregulin 1 0.0260356
RBM39 RNA binding motif protein 39 0.0259572
PRELID2 PRELI domain containing 2 0.0257958
DHRS3 dehydrogenase/reductase (SDR family) member 3 0.0255692
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0253047
MSN moesin 0.0252341
ARHGAP29 Rho GTPase activating protein 29 0.025094
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0249745
KMT2E lysine (K)-specific methyltransferase 2E 0.0242959
SBF2 SET binding factor 2 0.0240421
DLG1 discs, large homolog 1 (Drosophila) 0.0239012
SMG7 SMG7 nonsense mediated mRNA decay factor 0.0238819
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) 0.0236641
HYCC2 hyccin PI4KA lipid kinase complex subunit 2 0.0235416
RNF145 ring finger protein 145 0.0235348
SLCO4A1 solute carrier organic anion transporter family, member 4A1 0.0232749
PLEKHA1 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 0.023119
GOLGA4 golgin A4 0.023094
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0230803
MYO10 myosin X 0.022934
NBAS neuroblastoma amplified sequence 0.0227584
ADAM9 ADAM metallopeptidase domain 9 0.022287
CUL4B cullin 4B 0.0220279
HELZ helicase with zinc finger 0.0209108
NCOA3 nuclear receptor coactivator 3 0.0208289
METTL15 methyltransferase like 15 0.020763
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) 0.0207247
SUCO SUN domain containing ossification factor 0.0205785
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0205248
MYH9 myosin, heavy chain 9, non-muscle 0.0202648
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0199333
COG5 component of oligomeric golgi complex 5 0.0193552
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 0.01913
HIBADH 3-hydroxyisobutyrate dehydrogenase 0.0189538
EZR ezrin 0.0189452
FAR1 fatty acyl CoA reductase 1 0.0189259
ARRDC3 arrestin domain containing 3 0.018741
PCCA propionyl CoA carboxylase, alpha polypeptide 0.0185259
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0183909
RNF19B ring finger protein 19B 0.0183856
TGM2 transglutaminase 2 0.0183397
PTBP2 polypyrimidine tract binding protein 2 0.0181669
DIDO1 death inducer-obliterator 1 0.0179018
TNFRSF10D tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain 0.0178636
CD47 CD47 molecule 0.0178632
USP12 ubiquitin specific peptidase 12 0.0177416
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase) 0.0177351
NUP58 nucleoporin 58 0.0177293
ANO6 anoctamin 6 0.0176282
GATA6 GATA binding protein 6 0.017501
SPAG9 sperm associated antigen 9 0.0174648
MARCHF6 membrane associated ring-CH-type finger 6 0.017404
USP9X ubiquitin specific peptidase 9, X-linked 0.0173805
ALDH3A1 aldehyde dehydrogenase 3 family, member A1 0.0173285
NPEPPS aminopeptidase puromycin sensitive 0.0172539
CTNND1 catenin (cadherin-associated protein), delta 1 0.0172209
PHF21A PHD finger protein 21A 0.017188
PPP4R1 protein phosphatase 4, regulatory subunit 1 0.0171731
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0171319
ADAM17 ADAM metallopeptidase domain 17 0.0169392
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0167527
LAMA5 laminin, alpha 5 0.0166654
TFG TRK-fused gene 0.0164882
ARHGAP12 Rho GTPase activating protein 12 0.0164037
EHF ets homologous factor 0.0163235
BRWD3 bromodomain and WD repeat domain containing 3 0.0163209
SLTM SAFB-like, transcription modulator 0.016199
RB1CC1 RB1-inducible coiled-coil 1 0.0161114
ATP13A3 ATPase type 13A3 0.016103
VAPA VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa 0.0160955
USP3 ubiquitin specific peptidase 3 0.0159821
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0158725

decreased expression

Symbol Name Standardized Value
TIMP3 TIMP metallopeptidase inhibitor 3 -0.291518
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.221912
TPT1 tumor protein, translationally-controlled 1 -0.140138
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.100172
MT2A metallothionein 2A -0.0964727
RPS8 ribosomal protein S8 -0.0939703
B2M beta-2-microglobulin -0.0897908
PDLIM5 PDZ and LIM domain 5 -0.0860309
LMO7 LIM domain 7 -0.0858752
TMSB10 thymosin beta 10 -0.0841469
RPS6 ribosomal protein S6 -0.0829645
PTMA prothymosin, alpha -0.0814785
INTS6 integrator complex subunit 6 -0.0805912
RPS21 ribosomal protein S21 -0.0794724
ALCAM activated leukocyte cell adhesion molecule -0.0751367
SLC35F3 solute carrier family 35, member F3 -0.0712948
RPLP2 ribosomal protein, large, P2 -0.0694946
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0694452
MTSS1 metastasis suppressor 1 -0.0677099
RPS3 ribosomal protein S3 -0.0670055
RPS13 ribosomal protein S13 -0.0659357
HLA-B major histocompatibility complex, class I, B -0.0644378
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0636025
RPL11 ribosomal protein L11 -0.0634274
RPS25 ribosomal protein S25 -0.062008
TMSB4X thymosin beta 4, X-linked -0.0605894
RPL12 ribosomal protein L12 -0.0586596
RPLP1 ribosomal protein, large, P1 -0.0586121
RPS12 ribosomal protein S12 -0.0584809
RPL35A ribosomal protein L35a -0.0581513
RPL37 ribosomal protein L37 -0.0581103
STC1 stanniocalcin 1 -0.0572695
AHNAK AHNAK nucleoprotein -0.0554911
S100A10 S100 calcium binding protein A10 -0.0553645
IFITM3 interferon induced transmembrane protein 3 -0.0547717
LDHA lactate dehydrogenase A -0.0540935
PDE4D phosphodiesterase 4D, cAMP-specific -0.053887
RPS19 ribosomal protein S19 -0.053573
RPS24 ribosomal protein S24 -0.0531957
RPL37A ribosomal protein L37a -0.0516823
RPL34 ribosomal protein L34 -0.0514099
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.05131
ABI3BP ABI family, member 3 (NESH) binding protein -0.0500169
PALM2AKAP2 PALM2 and AKAP2 fusion -0.0500086
PRSS23 protease, serine, 23 -0.046619
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0465234
RASAL2 RAS protein activator like 2 -0.045795
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0443154
RALY RALY heterogeneous nuclear ribonucleoprotein -0.0442911
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0441147
SQSTM1 sequestosome 1 -0.0439675
IFITM1 interferon induced transmembrane protein 1 -0.0438304
RPL26 ribosomal protein L26 -0.0435724
PALLD palladin, cytoskeletal associated protein -0.0435582
RPL23 ribosomal protein L23 -0.0429192
FTL ferritin, light polypeptide -0.0427386
ANO1 anoctamin 1, calcium activated chloride channel -0.0416032
RPL31 ribosomal protein L31 -0.0413022
ENO1 enolase 1, (alpha) -0.0412217
VCL vinculin -0.0403767
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0402267
RPS27A ribosomal protein S27a -0.0397202
EXT1 exostosin glycosyltransferase 1 -0.0389282
RABGAP1L RAB GTPase activating protein 1-like -0.0386724
LAMC2 laminin, gamma 2 -0.0383763
RPS14 ribosomal protein S14 -0.0382881
S100A9 S100 calcium binding protein A9 -0.037985
GNAS GNAS complex locus -0.0379113
ZMYND8 zinc finger, MYND-type containing 8 -0.0376437
HLA-E major histocompatibility complex, class I, E -0.0376149
ST3GAL6 ST3 beta-galactoside alpha-2,3-sialyltransferase 6 -0.0374242
RPL7A ribosomal protein L7a -0.0372478
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0366715
RPL19 ribosomal protein L19 -0.0365061
RPS27 ribosomal protein S27 -0.0360531
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0359829
RPS16 ribosomal protein S16 -0.035966
SULF2 sulfatase 2 -0.0359046
RPL36A ribosomal protein L36a -0.0356263
LMNA lamin A/C -0.0354506
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0350654
RPL36 ribosomal protein L36 -0.0349584
CSTB cystatin B (stefin B) -0.0344219
RAI14 retinoic acid induced 14 -0.0342815
RPL30 ribosomal protein L30 -0.0342076
RPLP0 ribosomal protein, large, P0 -0.0340269
RCOR1 REST corepressor 1 -0.033738
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0336061
IFI6 interferon, alpha-inducible protein 6 -0.0333495
RPS29 ribosomal protein S29 -0.0333351
IFI27 interferon, alpha-inducible protein 27 -0.0329824
HMGA2 high mobility group AT-hook 2 -0.0329693
S100A6 S100 calcium binding protein A6 -0.0325227
RIGI RNA sensor RIG-I -0.0324045
KLF5 Kruppel-like factor 5 (intestinal) -0.0321396
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0321165
RPL8 ribosomal protein L8 -0.0320221
RPL27A ribosomal protein L27a -0.0319822
RACK1 receptor for activated C kinase 1 -0.031837
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 -0.031823