Doxycycline (monohydrate)_LOX-IMVI Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Doxycycline (monohydrate) perturbation in LOX-IMVI cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Doxycycline (monohydrate)_LOX-IMVI drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
DTNA dystrobrevin, alpha 0.109419
ASPH aspartate beta-hydroxylase 0.100878
EFNA5 ephrin-A5 0.0896818
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 0.0796632
PRKG1 protein kinase, cGMP-dependent, type I 0.0741805
PBX3 pre-B-cell leukemia homeobox 3 0.0716091
PTPRG protein tyrosine phosphatase, receptor type, G 0.0708788
LSAMP limbic system-associated membrane protein 0.0701552
PTK2 protein tyrosine kinase 2 0.0693316
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 0.0632255
NALF1 NALCN channel auxiliary factor 1 0.0614288
CDH13 cadherin 13 0.0546733
GPC6 glypican 6 0.0546576
EXT1 exostosin glycosyltransferase 1 0.0540189
NAV1 neuron navigator 1 0.0524274
KIAA1549L KIAA1549-like 0.0513009
MAPKAP1 mitogen-activated protein kinase associated protein 1 0.0512549
FNDC3B fibronectin type III domain containing 3B 0.0499432
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0498872
MMP12 matrix metallopeptidase 12 0.0476486
SDCCAG8 serologically defined colon cancer antigen 8 0.0475818
PHACTR1 phosphatase and actin regulator 1 0.0471915
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0463627
MYO10 myosin X 0.0461246
SAMD3 sterile alpha motif domain containing 3 0.0456402
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 0.0430285
MACF1 microtubule-actin crosslinking factor 1 0.0424661
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0421896
KIAA1217 KIAA1217 0.0412542
SAMD4A sterile alpha motif domain containing 4A 0.0402673
DST dystonin 0.0398965
MSN moesin 0.0382619
ZEB1 zinc finger E-box binding homeobox 1 0.0367926
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0367734
ANK3 ankyrin 3, node of Ranvier (ankyrin G) 0.0360384
USP34 ubiquitin specific peptidase 34 0.0358316
FMNL2 formin-like 2 0.0357855
KDM4C lysine (K)-specific demethylase 4C 0.0339505
DSCAM Down syndrome cell adhesion molecule 0.0330074
NTM neurotrimin 0.0325399
PLEKHA5 pleckstrin homology domain containing, family A member 5 0.0324325
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.030376
EEF2 eukaryotic translation elongation factor 2 0.0301139
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0301012
ITGA6 integrin, alpha 6 0.0300561
ERRFI1 ERBB receptor feedback inhibitor 1 0.0297077
CDK14 cyclin-dependent kinase 14 0.0292997
HMGA2 high mobility group AT-hook 2 0.0292268
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0288322
ZNF804A zinc finger protein 804A 0.0285669
TRIO trio Rho guanine nucleotide exchange factor 0.0281937
NUP58 nucleoporin 58 0.02793
UBA6 ubiquitin-like modifier activating enzyme 6 0.0279095
EPB41L2 erythrocyte membrane protein band 4.1-like 2 0.0278124
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 0.0278025
PCBP2 poly(rC) binding protein 2 0.0276366
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0269789
PTPRD protein tyrosine phosphatase, receptor type, D 0.0268807
RUNX1 runt-related transcription factor 1 0.0265713
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0262767
DOCK4 dedicator of cytokinesis 4 0.0260933
GLS2 glutaminase 2 (liver, mitochondrial) 0.025886
AKAP12 A kinase (PRKA) anchor protein 12 0.0258001
ASCC3 activating signal cointegrator 1 complex subunit 3 0.0257703
SBF2 SET binding factor 2 0.0256425
PRKCE protein kinase C, epsilon 0.0255529
PICALM phosphatidylinositol binding clathrin assembly protein 0.0253647
ANTXR2 anthrax toxin receptor 2 0.0253258
RBMS3 RNA binding motif, single stranded interacting protein 3 0.0252527
ADAM19 ADAM metallopeptidase domain 19 0.0251705
JARID2 jumonji, AT rich interactive domain 2 0.0251488
HDAC9 histone deacetylase 9 0.0249891
RAD51B RAD51 paralog B 0.0249837
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0249068
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.024574
LPP LIM domain containing preferred translocation partner in lipoma 0.024446
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.0243592
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0243187
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0241214
CDK6 cyclin-dependent kinase 6 0.0241168
POTEF POTE ankyrin domain family, member F 0.0239617
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.0232714
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.023215
ENKUR enkurin, TRPC channel interacting protein 0.0229561
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0225396
SFPQ splicing factor proline/glutamine-rich 0.0224364
ZNF292 zinc finger protein 292 0.0221683
MCL1 myeloid cell leukemia 1 0.0220485
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) 0.0218942
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase 0.0215068
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0213953
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.021263
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0211252
PARD3 par-3 family cell polarity regulator 0.0209009
MBD5 methyl-CpG binding domain protein 5 0.0204202
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0203764
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0202889
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0201545
TPM3 tropomyosin 3 0.0200969
FRMD6 FERM domain containing 6 0.0200806

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.243714
TMSB10 thymosin beta 10 -0.0763201
VIM vimentin -0.0752401
RPS6 ribosomal protein S6 -0.0677428
TPT1 tumor protein, translationally-controlled 1 -0.0609232
ACTG1 actin gamma 1 -0.0595354
FTL ferritin, light polypeptide -0.0592446
RPL35A ribosomal protein L35a -0.0581595
RPLP1 ribosomal protein, large, P1 -0.0493229
MT2A metallothionein 2A -0.0487596
PTMA prothymosin, alpha -0.0485342
RPS19 ribosomal protein S19 -0.0442507
RPL23 ribosomal protein L23 -0.0398364
EIF1 eukaryotic translation initiation factor 1 -0.0394034
RPL12 ribosomal protein L12 -0.038794
RPL37A ribosomal protein L37a -0.0354513
RPS8 ribosomal protein S8 -0.0337446
RPLP2 ribosomal protein, large, P2 -0.0329626
RPLP0 ribosomal protein, large, P0 -0.0308511
RPL36 ribosomal protein L36 -0.0305413
RPL26 ribosomal protein L26 -0.0302584
RPL19 ribosomal protein L19 -0.0301515
RPS24 ribosomal protein S24 -0.0301246
RPL11 ribosomal protein L11 -0.0300681
RPL34 ribosomal protein L34 -0.0289506
LOC112694756 uncharaterized LOC112694756 -0.0285791
YBX3 Y box binding protein 3 -0.0271635
RPS21 ribosomal protein S21 -0.0270294
BTG1 B-cell translocation gene 1, anti-proliferative -0.0269958
RPL30 ribosomal protein L30 -0.0268376
RPL8 ribosomal protein L8 -0.0266657
RPS13 ribosomal protein S13 -0.0263269
RPL38 ribosomal protein L38 -0.0258263
RPS3 ribosomal protein S3 -0.0257377
RPL13A ribosomal protein L13a -0.024247
H1-0 H1.0 linker histone -0.0230823
CAVIN1 caveolae associated protein 1 -0.0213184
RPS12 ribosomal protein S12 -0.0208832
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0207884
RPL36A ribosomal protein L36a -0.0206603
RPS25 ribosomal protein S25 -0.0201404
RIGI RNA sensor RIG-I -0.019919
RPL32 ribosomal protein L32 -0.0198432
RPL37 ribosomal protein L37 -0.0197437
RPL5 ribosomal protein L5 -0.0196985
RPL31 ribosomal protein L31 -0.0195523
RPS20 ribosomal protein S20 -0.0191528
VDAC1 voltage-dependent anion channel 1 -0.0185932
RPL35 ribosomal protein L35 -0.0182965
OSMR oncostatin M receptor -0.0177099
GNAS GNAS complex locus -0.0176443
STC1 stanniocalcin 1 -0.0170915
IFI16 interferon, gamma-inducible protein 16 -0.0170233
RPL18 ribosomal protein L18 -0.0166416
IER3 immediate early response 3 -0.0165735
RPS16 ribosomal protein S16 -0.0163925
RPS14 ribosomal protein S14 -0.0162901
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0153118
TPI1 triosephosphate isomerase 1 -0.0152053
KPNB1 karyopherin (importin) beta 1 -0.0151205
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0151068
RPL7 ribosomal protein L7 -0.0150837
RPL27 ribosomal protein L27 -0.0149874
RPS27 ribosomal protein S27 -0.0149418
RACK1 receptor for activated C kinase 1 -0.0149227
LIMA1 LIM domain and actin binding 1 -0.0148547
LMNA lamin A/C -0.0146829
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0145139
ANXA2 annexin A2 -0.0145042
RPL9 ribosomal protein L9 -0.0144981
NACA nascent polypeptide-associated complex alpha subunit -0.0143955
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0137717
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0137024
RPS29 ribosomal protein S29 -0.0136712
HLA-E major histocompatibility complex, class I, E -0.013661
RPL6 ribosomal protein L6 -0.0136594
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0135995
IGFBP3 insulin-like growth factor binding protein 3 -0.013567
RPS23 ribosomal protein S23 -0.0135195
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0135186
RPS17 ribosomal protein S17 -0.0134952
RPL27A ribosomal protein L27a -0.013481
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0134295
CFAP251 cilia and flagella associated protein 251 -0.0130373
HMGB1 high mobility group box 1 -0.0127574
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0127542
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0127018
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0125984
CD44 CD44 molecule (Indian blood group) -0.0123862
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) -0.0123234
RPS11 ribosomal protein S11 -0.0122656
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0122126
KLF6 Kruppel-like factor 6 -0.0121688
RPL7A ribosomal protein L7a -0.0121485
RPL4 ribosomal protein L4 -0.0120808
CSTB cystatin B (stefin B) -0.0120382
RPS5 ribosomal protein S5 -0.0118873
GLIPR1 GLI pathogenesis-related 1 -0.0117278
BZW1 basic leucine zipper and W2 domains 1 -0.0117004
LMAN1 lectin, mannose-binding, 1 -0.0116514