Doxycycline (monohydrate)_LS 180 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Doxycycline (monohydrate) perturbation in LS 180 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Doxycycline (monohydrate)_LS 180 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
NPSR1 neuropeptide S receptor 1 0.0691287
EREG epiregulin 0.0627181
NALF1 NALCN channel auxiliary factor 1 0.057147
MUC6 mucin 6, oligomeric mucus/gel-forming 0.0568463
MUC5AC mucin 5AC, oligomeric mucus/gel-forming 0.0547638
ZFAND3 zinc finger, AN1-type domain 3 0.0467861
FAT1 FAT atypical cadherin 1 0.0449916
FLNB filamin B, beta 0.0443626
BCAT1 branched chain amino-acid transaminase 1, cytosolic 0.0413555
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B 0.0392618
ITGA6 integrin, alpha 6 0.0370172
PTPRK protein tyrosine phosphatase, receptor type, K 0.0364479
GREB1L growth regulation by estrogen in breast cancer-like 0.0346221
TTC3 tetratricopeptide repeat domain 3 0.0345285
KMT2C lysine (K)-specific methyltransferase 2C 0.031519
GRB10 growth factor receptor-bound protein 10 0.0308094
CALB1 calbindin 1, 28kDa 0.0297602
ANKRD11 ankyrin repeat domain 11 0.0294011
BIRC6 baculoviral IAP repeat containing 6 0.0289593
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0280206
RNF217 ring finger protein 217 0.0273852
LMO7 LIM domain 7 0.0272322
PSD3 pleckstrin and Sec7 domain containing 3 0.0266215
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0266182
NAB1 NGFI-A binding protein 1 (EGR1 binding protein 1) 0.0258278
ANTXR2 anthrax toxin receptor 2 0.0256945
CCNY cyclin Y 0.0252671
ALCAM activated leukocyte cell adhesion molecule 0.0252337
PARD3 par-3 family cell polarity regulator 0.0248282
WDR43 WD repeat domain 43 0.024718
KDM6A lysine (K)-specific demethylase 6A 0.0246988
PTK2 protein tyrosine kinase 2 0.0246215
MBNL2 muscleblind-like splicing regulator 2 0.024536
GCC2 GRIP and coiled-coil domain containing 2 0.0237767
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0237568
RNF145 ring finger protein 145 0.0234778
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.0233562
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0232179
RCOR1 REST corepressor 1 0.0229655
ASCC3 activating signal cointegrator 1 complex subunit 3 0.0229039
KMT2E lysine (K)-specific methyltransferase 2E 0.0224418
MON2 MON2 homolog (S. cerevisiae) 0.0222809
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) 0.0222644
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0219212
NCOR1 nuclear receptor corepressor 1 0.0219077
GLS2 glutaminase 2 (liver, mitochondrial) 0.0218591
COG5 component of oligomeric golgi complex 5 0.0218149
NCOR2 nuclear receptor corepressor 2 0.0214476
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0214467
PUM2 pumilio RNA-binding family member 2 0.0214453
MSI2 musashi RNA-binding protein 2 0.0209624
ANKRD17 ankyrin repeat domain 17 0.0209616
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0205249
LIMS1 LIM and senescent cell antigen-like domains 1 0.0205046
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 0.0203246
MAML3 mastermind-like 3 (Drosophila) 0.020265
SLMAP sarcolemma associated protein 0.0202035
ARHGAP21 Rho GTPase activating protein 21 0.0201126
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit 0.0194882
ARHGAP6 Rho GTPase activating protein 6 0.0193609
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0193369
SLC35F3 solute carrier family 35, member F3 0.0190832
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2 0.0190827
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase 0.0190735
PAPOLA poly(A) polymerase alpha 0.0189483
FNDC3A fibronectin type III domain containing 3A 0.0188202
RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5 0.0188058
MYO5B myosin VB 0.0187972
CNOT4 CCR4-NOT transcription complex, subunit 4 0.0185345
SMG7 SMG7 nonsense mediated mRNA decay factor 0.0185
SND1 staphylococcal nuclease and tudor domain containing 1 0.0183794
AFDN afadin, adherens junction formation factor 0.0182949
SENP6 SUMO1/sentrin specific peptidase 6 0.0182904
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 0.0182614
MUC17 mucin 17, cell surface associated 0.0182082
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.0181874
BBX bobby sox homolog (Drosophila) 0.017994
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0177774
EWSR1 EWS RNA-binding protein 1 0.0173809
NCKAP1 NCK-associated protein 1 0.0173457
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 0.0172841
EHBP1 EH domain binding protein 1 0.0172826
ESYT2 extended synaptotagmin-like protein 2 0.0172251
GARS1 glycyl-tRNA synthetase 1 0.0171498
FAM13A family with sequence similarity 13, member A 0.0169776
FRYL FRY-like 0.0167566
GSK3B glycogen synthase kinase 3 beta 0.0167399
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like 0.0167395
BRWD1 bromodomain and WD repeat domain containing 1 0.0166722
SRRM2 serine/arginine repetitive matrix 2 0.0166599
WAC WW domain containing adaptor with coiled-coil 0.0165863
TES testin LIM domain protein 0.0165712
AHR aryl hydrocarbon receptor 0.016516
LAMA4 laminin, alpha 4 0.0164898
PDS5B PDS5 cohesin associated factor B 0.0164885
RBM39 RNA binding motif protein 39 0.0164179
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0164143
NCOA2 nuclear receptor coactivator 2 0.0164021
KDM3A lysine (K)-specific demethylase 3A 0.0163971
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.01638

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.467021
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.229271
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.146108
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 -0.144886
PTMA prothymosin, alpha -0.111662
NDRG1 N-myc downstream regulated 1 -0.0699722
RPS6 ribosomal protein S6 -0.0683768
TPT1 tumor protein, translationally-controlled 1 -0.0638871
AHNAK AHNAK nucleoprotein -0.0610049
RPLP1 ribosomal protein, large, P1 -0.0573864
H1-0 H1.0 linker histone -0.0551678
FTL ferritin, light polypeptide -0.0534849
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0534768
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0504139
TXNIP thioredoxin interacting protein -0.0491169
RNF43 ring finger protein 43 -0.0480529
TNS4 tensin 4 -0.0474593
ACTG1 actin gamma 1 -0.0472832
CEMIP cell migration inducing protein, hyaluronan binding -0.0445265
RPLP0 ribosomal protein, large, P0 -0.0442277
S100A10 S100 calcium binding protein A10 -0.0441896
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0431377
RPL23 ribosomal protein L23 -0.0399047
CD44 CD44 molecule (Indian blood group) -0.0389169
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0376867
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.0372767
LOC112694756 uncharaterized LOC112694756 -0.0370045
PDIA3 protein disulfide isomerase family A, member 3 -0.035897
ANXA2 annexin A2 -0.0356305
EIF1 eukaryotic translation initiation factor 1 -0.0348019
RPL8 ribosomal protein L8 -0.0340865
RPL34 ribosomal protein L34 -0.0337231
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0335995
FHIT fragile histidine triad -0.0334663
ONECUT3 one cut homeobox 3 -0.0332837
RPS19 ribosomal protein S19 -0.0327273
FTH1 ferritin, heavy polypeptide 1 -0.0325994
LDHA lactate dehydrogenase A -0.0319494
LOC102724023 ES1 protein homolog, mitochondrial -0.0318075
PTBP3 polypyrimidine tract binding protein 3 -0.0313477
RPL9 ribosomal protein L9 -0.0312769
RPL11 ribosomal protein L11 -0.0310462
VCL vinculin -0.0310333
PDIA4 protein disulfide isomerase family A, member 4 -0.0309161
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.030434
KLF6 Kruppel-like factor 6 -0.030424
RPS8 ribosomal protein S8 -0.030164
RPL19 ribosomal protein L19 -0.0300342
RPL12 ribosomal protein L12 -0.0295482
SPTBN1 spectrin, beta, non-erythrocytic 1 -0.0290573
KRT19 keratin 19, type I -0.028013
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0279743
RPL32 ribosomal protein L32 -0.0276025
TRIM2 tripartite motif containing 2 -0.0274865
TMSB10 thymosin beta 10 -0.0274832
RPLP2 ribosomal protein, large, P2 -0.0274671
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) -0.0261479
CALR calreticulin -0.0258571
S100A9 S100 calcium binding protein A9 -0.0252216
TPM4 tropomyosin 4 -0.0247537
EGR1 early growth response 1 -0.0245296
RPS13 ribosomal protein S13 -0.0243887
RPL36 ribosomal protein L36 -0.0242675
SMYD3 SET and MYND domain containing 3 -0.0242155
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0239776
CANX calnexin -0.02388
UBC ubiquitin C -0.0238788
TMTC2 transmembrane and tetratricopeptide repeat containing 2 -0.0237883
RPL35A ribosomal protein L35a -0.0237738
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0235598
MT1X metallothionein 1X -0.0233949
DEK DEK proto-oncogene -0.0231701
ABLIM1 actin binding LIM protein 1 -0.0231308
CCND1 cyclin D1 -0.02303
AGR2 anterior gradient 2 -0.0225399
RPL31 ribosomal protein L31 -0.0221348
JUN jun proto-oncogene -0.02182
MT2A metallothionein 2A -0.0218139
ENO1 enolase 1, (alpha) -0.02133
MYO1E myosin IE -0.0211252
LGALS4 lectin, galactoside-binding, soluble, 4 -0.0210143
RPS21 ribosomal protein S21 -0.0209978
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.020525
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0205063
PKP2 plakophilin 2 -0.0204572
RPS20 ribosomal protein S20 -0.020411
RPS27A ribosomal protein S27a -0.0203794
RPS15 ribosomal protein S15 -0.0202333
HMGB1 high mobility group box 1 -0.0201768
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0201348
CEMIP2 cell migration inducing hyaluronidase 2 -0.0200872
RPS11 ribosomal protein S11 -0.0199273
PARP4 poly (ADP-ribose) polymerase family, member 4 -0.0198587
EXPH5 exophilin 5 -0.019512
IER3 immediate early response 3 -0.0194151
MYO1D myosin ID -0.0191971
FHL2 four and a half LIM domains 2 -0.0191235
PRSS3 protease, serine, 3 -0.019006
CDCP1 CUB domain containing protein 1 -0.0190046
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0188549