Doxycycline (monohydrate)_MIA PaCa-2 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Doxycycline (monohydrate) perturbation in MIA PaCa-2 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Doxycycline (monohydrate)_MIA PaCa-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
DST dystonin 0.0358737
CENPF centromere protein F, 350/400kDa 0.0139771
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0127542
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.0127044
SLK STE20-like kinase 0.0121835
TSC22D1 TSC22 domain family, member 1 0.0118925
MKI67 marker of proliferation Ki-67 0.0111208
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 0.0107107
PDE10A phosphodiesterase 10A 0.00967148
TOP2A topoisomerase (DNA) II alpha 170kDa 0.00965909
UBE2E3 ubiquitin-conjugating enzyme E2E 3 0.00949127
CAPRIN2 caprin family member 2 0.00927603
NUP58 nucleoporin 58 0.00925336
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.00905228
CFAP299 cilia and flagella associated protein 299 0.00893874
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0088929
FXR1 fragile X mental retardation, autosomal homolog 1 0.00883232
RAB27B RAB27B, member RAS oncogene family 0.00840774
RPS12 ribosomal protein S12 0.0083492
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.00773405
SFPQ splicing factor proline/glutamine-rich 0.00760516
TPM3 tropomyosin 3 0.00723493
CAMTA1 calmodulin binding transcription activator 1 0.00715636
AHCTF1 AT hook containing transcription factor 1 0.00708407
NCKAP1 NCK-associated protein 1 0.00707806
RPS7 ribosomal protein S7 0.00700436
WDR43 WD repeat domain 43 0.00699375
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.00697913
STAT1 signal transducer and activator of transcription 1, 91kDa 0.00682167
BIRC2 baculoviral IAP repeat containing 2 0.00673885
MYH9 myosin, heavy chain 9, non-muscle 0.00670575
KLC1 kinesin light chain 1 0.00664152
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.00660508
COL5A2 collagen, type V, alpha 2 0.00658147
MACF1 microtubule-actin crosslinking factor 1 0.00640606
RPL3 ribosomal protein L3 0.00629827
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.00629224
ATP13A3 ATPase type 13A3 0.00626652
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 0.00625105
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.00623562
MSN moesin 0.00616221
EFNA5 ephrin-A5 0.00614254
SRSF11 serine/arginine-rich splicing factor 11 0.00612088
TRIP12 thyroid hormone receptor interactor 12 0.00610684
CCNL1 cyclin L1 0.00606208
ECPAS Ecm29 proteasome adaptor and scaffold 0.00598791
RTTN rotatin 0.00590309
BCLAF1 BCL2-associated transcription factor 1 0.00584065
SDK1 sidekick cell adhesion molecule 1 0.0058123
SPTBN1 spectrin, beta, non-erythrocytic 1 0.00575768
PUM2 pumilio RNA-binding family member 2 0.00574286
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.00572745
FNIP1 folliculin interacting protein 1 0.00563037
SCAF4 SR-related CTD-associated factor 4 0.00552017
PDE4D phosphodiesterase 4D, cAMP-specific 0.00548667
RAPH1 Ras association (RalGDS/AF-6) and pleckstrin homology domains 1 0.00548342
WARS1 tryptophanyl-tRNA synthetase 1 0.00545079
WAC WW domain containing adaptor with coiled-coil 0.00541461
XPO1 exportin 1 0.00538628
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0053316
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) 0.00532106
SS18 synovial sarcoma translocation, chromosome 18 0.00526535
USP12 ubiquitin specific peptidase 12 0.00520902
SMC4 structural maintenance of chromosomes 4 0.00515468
SRSF4 serine/arginine-rich splicing factor 4 0.00508201
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.00508094
CADM2 cell adhesion molecule 2 0.00496232
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 0.00494934
PAPOLA poly(A) polymerase alpha 0.00494835
HNRNPM heterogeneous nuclear ribonucleoprotein M 0.00489284
HSPA4 heat shock 70kDa protein 4 0.00483603
DIAPH3 diaphanous-related formin 3 0.00480362
MAT2A methionine adenosyltransferase II, alpha 0.00479467
ANKRD36 ankyrin repeat domain 36 0.00479392
RFFL ring finger and FYVE-like domain containing E3 ubiquitin protein ligase 0.00477956
FERMT1 fermitin family member 1 0.00477033
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.00474706
FUBP1 far upstream element (FUSE) binding protein 1 0.00472988
PANK3 pantothenate kinase 3 0.00471091
APOLD1 apolipoprotein L domain containing 1 0.00467561
UBA6 ubiquitin-like modifier activating enzyme 6 0.00466982
SLC35F5 solute carrier family 35, member F5 0.00466607
TBL1X transducin (beta)-like 1X-linked 0.00465238
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.00464831
CNBP CCHC-type zinc finger, nucleic acid binding protein 0.00461013
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 0.00459239
CKAP5 cytoskeleton associated protein 5 0.00458843
RBM26 RNA binding motif protein 26 0.00458555
CSMD3 CUB and Sushi multiple domains 3 0.00449426
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.00443836
RYK receptor-like tyrosine kinase 0.00441528
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.00440102
HNRNPA3 heterogeneous nuclear ribonucleoprotein A3 0.00437831
RAD23B RAD23 homolog B (S. cerevisiae) 0.00432922
TPX2 TPX2, microtubule-associated 0.00428477
ZNF160 zinc finger protein 160 0.00427974
HNRNPH3 heterogeneous nuclear ribonucleoprotein H3 (2H9) 0.00425742
ZFAND3 zinc finger, AN1-type domain 3 0.00422798
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.00412455
ADAM10 ADAM metallopeptidase domain 10 0.00412163

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.286254
VIM vimentin -0.116814
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0736853
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0715328
TMSB10 thymosin beta 10 -0.0529988
MT2A metallothionein 2A -0.0445586
TMSB4X thymosin beta 4, X-linked -0.0408614
TM4SF1 transmembrane 4 L six family member 1 -0.0400845
ACTG1 actin gamma 1 -0.0372962
LOC112694756 uncharaterized LOC112694756 -0.02937
CD44 CD44 molecule (Indian blood group) -0.0288371
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0284705
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0268197
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0247639
DLG1 discs, large homolog 1 (Drosophila) -0.024733
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0245679
TXNRD1 thioredoxin reductase 1 -0.0245174
RAB7A RAB7A, member RAS oncogene family -0.0239274
EIF1 eukaryotic translation initiation factor 1 -0.0233615
FTL ferritin, light polypeptide -0.0232108
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0217149
CANX calnexin -0.0216222
AHNAK AHNAK nucleoprotein -0.0211364
RUNX1 runt-related transcription factor 1 -0.0194578
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0189606
MT1X metallothionein 1X -0.018788
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0179301
UBC ubiquitin C -0.0176952
LDHA lactate dehydrogenase A -0.0174035
PTMA prothymosin, alpha -0.0168883
JMJD1C jumonji domain containing 1C -0.0168212
SRGN serglycin -0.0163731
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0162275
HDLBP high density lipoprotein binding protein -0.0157474
S100A10 S100 calcium binding protein A10 -0.0157252
RPL8 ribosomal protein L8 -0.0155451
TNFRSF10D tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain -0.0154955
GCLM glutamate-cysteine ligase, modifier subunit -0.0151276
RPLP1 ribosomal protein, large, P1 -0.0149289
HMGA1 high mobility group AT-hook 1 -0.0149145
JUN jun proto-oncogene -0.0147609
TPT1 tumor protein, translationally-controlled 1 -0.0143982
GNAS GNAS complex locus -0.0141474
SEPTIN7 septin 7 -0.0139713
EMP1 epithelial membrane protein 1 -0.0138665
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.013809
MT1E metallothionein 1E -0.0137444
LMAN1 lectin, mannose-binding, 1 -0.0136468
FBXO11 F-box protein 11 -0.0132286
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.013006
EGR1 early growth response 1 -0.0128512
ANXA2 annexin A2 -0.0126679
AP2B1 adaptor-related protein complex 2, beta 1 subunit -0.0126642
PKM pyruvate kinase, muscle -0.0126359
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0125175
FUS FUS RNA binding protein -0.0122573
APP amyloid beta (A4) precursor protein -0.0122484
H1-0 H1.0 linker histone -0.0119252
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.011817
BPTF bromodomain PHD finger transcription factor -0.0117065
TFRC transferrin receptor -0.0115093
NPR2 natriuretic peptide receptor 2 -0.0114702
PDIA3 protein disulfide isomerase family A, member 3 -0.0112139
RPS23 ribosomal protein S23 -0.0109858
MORF4L2 mortality factor 4 like 2 -0.0108482
MYOF myoferlin -0.0107309
SQSTM1 sequestosome 1 -0.0105631
RGS4 regulator of G-protein signaling 4 -0.0103319
EHBP1 EH domain binding protein 1 -0.0103087
IARS1 isoleucyl-tRNA synthetase 1 -0.010278
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0101661
SLC38A1 solute carrier family 38, member 1 -0.010136
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 -0.0100724
RPL19 ribosomal protein L19 -0.010038
AKAP9 A kinase (PRKA) anchor protein 9 -0.00986341
TPI1 triosephosphate isomerase 1 -0.00984993
KPNB1 karyopherin (importin) beta 1 -0.00981969
RSL1D1 ribosomal L1 domain containing 1 -0.00981796
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.00979778
TRIO trio Rho guanine nucleotide exchange factor -0.00977715
USP34 ubiquitin specific peptidase 34 -0.00973695
PRDX1 peroxiredoxin 1 -0.00954302
NDRG1 N-myc downstream regulated 1 -0.00950191
EZR ezrin -0.00948375
RPS24 ribosomal protein S24 -0.00948196
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.00944019
RERE arginine-glutamic acid dipeptide (RE) repeats -0.00937555
WDR45B WD repeat domain 45B -0.00936879
ZMYND8 zinc finger, MYND-type containing 8 -0.00934152
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.00934107
FMNL2 formin-like 2 -0.00926804
GLG1 golgi glycoprotein 1 -0.00915493
TOP1 topoisomerase (DNA) I -0.00904153
SGK1 serum/glucocorticoid regulated kinase 1 -0.00900266
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 -0.00900194
LOXL2 lysyl oxidase-like 2 -0.00898315
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) -0.00882342
RPS6 ribosomal protein S6 -0.0086509
CLIP2 CAP-GLY domain containing linker protein 2 -0.00862298
RPS15 ribosomal protein S15 -0.008585