| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Doxycycline (monohydrate) perturbation in NCI-H1573 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Doxycycline (monohydrate)_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0833727 |
| TXNRD1 | thioredoxin reductase 1 | 0.082111 |
| TOP1 | topoisomerase (DNA) I | 0.0766137 |
| ANKRD10 | ankyrin repeat domain 10 | 0.0669305 |
| SPAG9 | sperm associated antigen 9 | 0.0619787 |
| CES1 | carboxylesterase 1 | 0.060964 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.0607884 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0572521 |
| RUNX1 | runt-related transcription factor 1 | 0.0540463 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0537257 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0526894 |
| AGO2 | argonaute RISC catalytic component 2 | 0.0512837 |
| PUM2 | pumilio RNA-binding family member 2 | 0.0504953 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0492253 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.0490139 |
| MKI67 | marker of proliferation Ki-67 | 0.0470743 |
| UVRAG | UV radiation resistance associated | 0.0469095 |
| HOOK2 | hook microtubule-tethering protein 2 | 0.0458958 |
| CAPZA2 | capping protein (actin filament) muscle Z-line, alpha 2 | 0.045656 |
| CAMTA1 | calmodulin binding transcription activator 1 | 0.0454934 |
| ATP13A3 | ATPase type 13A3 | 0.0443668 |
| RBM39 | RNA binding motif protein 39 | 0.0439734 |
| RNF145 | ring finger protein 145 | 0.0437256 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.0436574 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.043293 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0425233 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0419053 |
| PGK1 | phosphoglycerate kinase 1 | 0.0418135 |
| USP34 | ubiquitin specific peptidase 34 | 0.0416739 |
| ARRDC3 | arrestin domain containing 3 | 0.0414924 |
| HELZ | helicase with zinc finger | 0.0407496 |
| ARID2 | AT rich interactive domain 2 (ARID, RFX-like) | 0.0398002 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.0395424 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0394095 |
| NPTN | neuroplastin | 0.0382436 |
| NUP58 | nucleoporin 58 | 0.0380969 |
| TFG | TRK-fused gene | 0.0379419 |
| DTNA | dystrobrevin, alpha | 0.037302 |
| OGT | O-linked N-acetylglucosamine (GlcNAc) transferase | 0.0372195 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0367505 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | 0.0364007 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0363062 |
| DNAJC3 | DnaJ (Hsp40) homolog, subfamily C, member 3 | 0.035598 |
| ZFC3H1 | zinc finger, C3H1-type containing | 0.0351717 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | 0.0351208 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0344418 |
| INTS6 | integrator complex subunit 6 | 0.0344367 |
| ECT2 | epithelial cell transforming 2 | 0.0336421 |
| GSK3B | glycogen synthase kinase 3 beta | 0.0327532 |
| FNIP1 | folliculin interacting protein 1 | 0.0327279 |
| DENND4A | DENN/MADD domain containing 4A | 0.0326993 |
| ZC3H11A | zinc finger CCCH-type containing 11A | 0.0323038 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0322264 |
| UBE2D3 | ubiquitin-conjugating enzyme E2D 3 | 0.0312049 |
| CYLD | cylindromatosis (turban tumor syndrome) | 0.0309108 |
| GPAT3 | glycerol-3-phosphate acyltransferase 3 | 0.0307581 |
| STRN3 | striatin, calmodulin binding protein 3 | 0.030057 |
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | 0.0294208 |
| KANSL1 | KAT8 regulatory NSL complex subunit 1 | 0.0290454 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0289773 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | 0.0288591 |
| VOPP1 | vesicular, overexpressed in cancer, prosurvival protein 1 | 0.0285416 |
| AP1G1 | adaptor-related protein complex 1, gamma 1 subunit | 0.0282794 |
| SMG1 | SMG1 phosphatidylinositol 3-kinase-related kinase | 0.0278858 |
| ANXA5 | annexin A5 | 0.0278537 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0277814 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0277582 |
| PAPOLA | poly(A) polymerase alpha | 0.0277437 |
| MON2 | MON2 homolog (S. cerevisiae) | 0.0276211 |
| AP1S3 | adaptor-related protein complex 1, sigma 3 subunit | 0.027567 |
| BTAF1 | BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa | 0.0271794 |
| ZNF292 | zinc finger protein 292 | 0.027124 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0265449 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | 0.0261887 |
| DHX15 | DEAH (Asp-Glu-Ala-His) box helicase 15 | 0.0261572 |
| UBC | ubiquitin C | 0.0261497 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0260228 |
| CNOT1 | CCR4-NOT transcription complex, subunit 1 | 0.0260197 |
| NBAS | neuroblastoma amplified sequence | 0.0259469 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0258498 |
| SCFD1 | sec1 family domain containing 1 | 0.0256189 |
| CDC73 | cell division cycle 73 | 0.0255579 |
| HBP1 | HMG-box transcription factor 1 | 0.0254637 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0254499 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.025234 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0250478 |
| ARL8B | ADP-ribosylation factor-like 8B | 0.0248037 |
| PPTC7 | PTC7 protein phosphatase homolog (S. cerevisiae) | 0.0247946 |
| PCBP2 | poly(rC) binding protein 2 | 0.0243901 |
| HOMER1 | homer scaffolding protein 1 | 0.0240198 |
| NGLY1 | N-glycanase 1 | 0.0239929 |
| NCKAP1 | NCK-associated protein 1 | 0.0239073 |
| PPP1R15B | protein phosphatase 1, regulatory subunit 15B | 0.0238087 |
| RTN4 | reticulon 4 | 0.0238065 |
| SMC4 | structural maintenance of chromosomes 4 | 0.0236001 |
| MYO5B | myosin VB | 0.0235594 |
| GPATCH2L | G patch domain containing 2-like | 0.0235505 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0234755 |
| HAPSTR1 | HUWE1 associated protein modifying stress responses | 0.0234557 |
| TSC22D2 | TSC22 domain family, member 2 | 0.0233557 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TMSB10 | thymosin beta 10 | -0.145387 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.126115 |
| MT2A | metallothionein 2A | -0.119891 |
| CAV1 | caveolin 1, caveolae protein, 22kDa | -0.112302 |
| LAMC2 | laminin, gamma 2 | -0.111444 |
| LMO7 | LIM domain 7 | -0.100641 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0974712 |
| EGFR | epidermal growth factor receptor | -0.0916711 |
| CEACAM6 | carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) | -0.0723163 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0718175 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0716432 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.068409 |
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 | -0.06688 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | -0.0643342 |
| LAMA4 | laminin, alpha 4 | -0.0565422 |
| RPS3 | ribosomal protein S3 | -0.0556939 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0553369 |
| EGR1 | early growth response 1 | -0.0544835 |
| AHNAK | AHNAK nucleoprotein | -0.0542622 |
| OSMR | oncostatin M receptor | -0.0541765 |
| EFNA5 | ephrin-A5 | -0.0539069 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0537365 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0520681 |
| RNF213 | ring finger protein 213 | -0.0516888 |
| KRT18 | keratin 18, type I | -0.0516635 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0467813 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0462611 |
| SEC61G | Sec61 gamma subunit | -0.0445135 |
| DDX17 | DEAD (Asp-Glu-Ala-Asp) box helicase 17 | -0.0437264 |
| STC1 | stanniocalcin 1 | -0.0430731 |
| RPS12 | ribosomal protein S12 | -0.0430631 |
| IGFBP5 | insulin-like growth factor binding protein 5 | -0.0430598 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0427253 |
| RPL35A | ribosomal protein L35a | -0.0426671 |
| CCND1 | cyclin D1 | -0.0425552 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.0403567 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0400655 |
| LDHA | lactate dehydrogenase A | -0.0393717 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0393221 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0389016 |
| ANXA2 | annexin A2 | -0.0386015 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | -0.0383769 |
| SCEL | sciellin | -0.0382819 |
| FOXP1 | forkhead box P1 | -0.038184 |
| MT1X | metallothionein 1X | -0.037533 |
| ASPH | aspartate beta-hydroxylase | -0.0362618 |
| KRT7 | keratin 7, type II | -0.0351317 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | -0.0349906 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | -0.0347654 |
| TRIM56 | tripartite motif containing 56 | -0.0345298 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0342378 |
| ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) | -0.0337976 |
| RPL12 | ribosomal protein L12 | -0.0329568 |
| B2M | beta-2-microglobulin | -0.0329273 |
| DSPP | dentin sialophosphoprotein | -0.0328651 |
| GNAS | GNAS complex locus | -0.0328488 |
| CSTB | cystatin B (stefin B) | -0.0323436 |
| TPM4 | tropomyosin 4 | -0.0317506 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0314108 |
| DOCK5 | dedicator of cytokinesis 5 | -0.0313267 |
| PKM | pyruvate kinase, muscle | -0.030858 |
| GRAMD1B | GRAM domain containing 1B | -0.0308106 |
| CAV2 | caveolin 2 | -0.0304522 |
| ABCC3 | ATP-binding cassette, sub-family C (CFTR/MRP), member 3 | -0.0303988 |
| ACTG1 | actin gamma 1 | -0.0301114 |
| RPL34 | ribosomal protein L34 | -0.0300665 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0298456 |
| FTL | ferritin, light polypeptide | -0.0297478 |
| S100A6 | S100 calcium binding protein A6 | -0.0295729 |
| CCSER1 | coiled-coil serine-rich protein 1 | -0.0294981 |
| AHNAK2 | AHNAK nucleoprotein 2 | -0.0292431 |
| ANKRD12 | ankyrin repeat domain 12 | -0.029137 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | -0.0287433 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | -0.0282826 |
| PACS1 | phosphofurin acidic cluster sorting protein 1 | -0.0280065 |
| MYOF | myoferlin | -0.0278666 |
| EHBP1 | EH domain binding protein 1 | -0.027649 |
| CIB1 | calcium and integrin binding 1 (calmyrin) | -0.027462 |
| DSG2 | desmoglein 2 | -0.0267295 |
| RPLP1 | ribosomal protein, large, P1 | -0.0266136 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | -0.0264742 |
| RPL37A | ribosomal protein L37a | -0.0262742 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0260407 |
| RAB27B | RAB27B, member RAS oncogene family | -0.0259639 |
| LAMB3 | laminin, beta 3 | -0.0257974 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0257698 |
| RALGAPA2 | Ral GTPase activating protein, alpha subunit 2 (catalytic) | -0.0256322 |
| BZW1 | basic leucine zipper and W2 domains 1 | -0.0255339 |
| SMYD3 | SET and MYND domain containing 3 | -0.0254457 |
| ID1 | inhibitor of DNA binding 1, dominant negative helix-loop-helix protein | -0.0254267 |
| RPS8 | ribosomal protein S8 | -0.025337 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.024522 |
| LIMCH1 | LIM and calponin homology domains 1 | -0.0244772 |
| H1-0 | H1.0 linker histone | -0.0243277 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0242978 |
| MAP3K5 | mitogen-activated protein kinase kinase kinase 5 | -0.0242291 |
| MYO9A | myosin IXA | -0.0237977 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0237926 |
| ANXA1 | annexin A1 | -0.0237816 |
| TBC1D5 | TBC1 domain family, member 5 | -0.0236276 |
