Doxycycline (monohydrate)_NCI-H1792 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Doxycycline (monohydrate) perturbation in NCI-H1792 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Doxycycline (monohydrate)_NCI-H1792 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 0.0617723
SDK1 sidekick cell adhesion molecule 1 0.0534152
CDH13 cadherin 13 0.0514988
WAC WW domain containing adaptor with coiled-coil 0.0440306
FNDC3B fibronectin type III domain containing 3B 0.0433457
ATP13A3 ATPase type 13A3 0.0415522
PARD3 par-3 family cell polarity regulator 0.040316
GRB10 growth factor receptor-bound protein 10 0.0396437
MTSS1 metastasis suppressor 1 0.0377465
RICTOR RPTOR independent companion of MTOR, complex 2 0.0364953
USP3 ubiquitin specific peptidase 3 0.0363476
FN1 fibronectin 1 0.0361138
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0343743
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0338318
ZFAND3 zinc finger, AN1-type domain 3 0.0336223
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0331367
CAMK1D calcium/calmodulin-dependent protein kinase ID 0.0326257
ANKRD11 ankyrin repeat domain 11 0.0325384
KDM3A lysine (K)-specific demethylase 3A 0.0313301
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0310656
SOD2 superoxide dismutase 2, mitochondrial 0.0305395
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.030504
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0282389
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0272913
LRRFIP2 leucine rich repeat (in FLII) interacting protein 2 0.0266592
FAM13A family with sequence similarity 13, member A 0.0265007
CXCL8 chemokine (C-X-C motif) ligand 8 0.0259585
AKAP13 A kinase (PRKA) anchor protein 13 0.0254566
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 0.0251166
NUP58 nucleoporin 58 0.0249322
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.02487
SPAG9 sperm associated antigen 9 0.0246887
RNF145 ring finger protein 145 0.0238192
PTK2 protein tyrosine kinase 2 0.0237392
PIAS2 protein inhibitor of activated STAT, 2 0.0237188
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.0233855
MSRB3 methionine sulfoxide reductase B3 0.0230673
NRG1 neuregulin 1 0.0229912
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0229039
HELZ helicase with zinc finger 0.0227611
UBA6 ubiquitin-like modifier activating enzyme 6 0.0227545
MACF1 microtubule-actin crosslinking factor 1 0.0224037
MYO1B myosin IB 0.0219225
SIK3 SIK family kinase 3 0.0217251
DENND4A DENN/MADD domain containing 4A 0.0210306
RIOK3 RIO kinase 3 0.0208412
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0207688
CCNY cyclin Y 0.0199674
EPS8 epidermal growth factor receptor pathway substrate 8 0.0196206
TRIO trio Rho guanine nucleotide exchange factor 0.0195156
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.0188646
CDC73 cell division cycle 73 0.0187789
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0184085
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0182837
NCKAP1 NCK-associated protein 1 0.0182812
PICALM phosphatidylinositol binding clathrin assembly protein 0.018261
COG5 component of oligomeric golgi complex 5 0.0180629
AP3S1 adaptor-related protein complex 3, sigma 1 subunit 0.0180509
SSBP2 single-stranded DNA binding protein 2 0.0180365
RAB8B RAB8B, member RAS oncogene family 0.0177106
SMG7 SMG7 nonsense mediated mRNA decay factor 0.0177021
UBE2E2 ubiquitin-conjugating enzyme E2E 2 0.0175696
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0174308
MARCHF6 membrane associated ring-CH-type finger 6 0.0174165
ITCH itchy E3 ubiquitin protein ligase 0.0172391
MEF2A myocyte enhancer factor 2A 0.0171846
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0170887
CDK14 cyclin-dependent kinase 14 0.0170267
GALNT18 polypeptide N-acetylgalactosaminyltransferase 18 0.0168165
PAPOLA poly(A) polymerase alpha 0.0167277
MAML3 mastermind-like 3 (Drosophila) 0.0160544
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0159381
CACNA2D3 calcium channel, voltage-dependent, alpha 2/delta subunit 3 0.0158669
NUMB numb homolog (Drosophila) 0.0157297
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0157012
WDR43 WD repeat domain 43 0.0156747
FAR1 fatty acyl CoA reductase 1 0.0156333
SEPTIN9 septin 9 0.0156003
STRN3 striatin, calmodulin binding protein 3 0.015335
DENND1A DENN/MADD domain containing 1A 0.0152829
AADAC arylacetamide deacetylase 0.0151636
MYO10 myosin X 0.0150796
QKI QKI, KH domain containing, RNA binding 0.015076
DPYD dihydropyrimidine dehydrogenase 0.0150642
ADAM9 ADAM metallopeptidase domain 9 0.0149597
MEMO1 mediator of cell motility 1 0.0148605
DST dystonin 0.0148049
FBN1 fibrillin 1 0.014616
ARHGAP32 Rho GTPase activating protein 32 0.014488
PEAK1 pseudopodium-enriched atypical kinase 1 0.0144517
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0144365
PGK1 phosphoglycerate kinase 1 0.014383
KDM6A lysine (K)-specific demethylase 6A 0.0143234
BCAT1 branched chain amino-acid transaminase 1, cytosolic 0.0142683
GARS1 glycyl-tRNA synthetase 1 0.0141211
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0141035
TFPI2 tissue factor pathway inhibitor 2 0.0140853
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0140733
SNX9 sorting nexin 9 0.0140153
FMNL2 formin-like 2 0.0139858

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.105821
TMSB10 thymosin beta 10 -0.0808612
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0779808
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.072193
CD44 CD44 molecule (Indian blood group) -0.064676
MT2A metallothionein 2A -0.0572556
AKAP12 A kinase (PRKA) anchor protein 12 -0.0545269
RPLP1 ribosomal protein, large, P1 -0.0437439
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0430701
RPL35A ribosomal protein L35a -0.0388519
RPS19 ribosomal protein S19 -0.0373255
FTL ferritin, light polypeptide -0.0368971
RPS6 ribosomal protein S6 -0.0350195
C15ORF48 chromosome 15 open reading frame 48 -0.0348163
EIF1 eukaryotic translation initiation factor 1 -0.0339035
OSMR oncostatin M receptor -0.0329993
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0327113
RPS8 ribosomal protein S8 -0.0323036
NCOA7 nuclear receptor coactivator 7 -0.0318578
NAMPT nicotinamide phosphoribosyltransferase -0.0314072
RPS12 ribosomal protein S12 -0.0286167
RPLP2 ribosomal protein, large, P2 -0.0281059
PTMA prothymosin, alpha -0.0280996
AKAP9 A kinase (PRKA) anchor protein 9 -0.0278839
ZMYND8 zinc finger, MYND-type containing 8 -0.0269177
BASP1 brain abundant, membrane attached signal protein 1 -0.026891
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0256916
NPC1 Niemann-Pick disease, type C1 -0.0255886
RPL12 ribosomal protein L12 -0.0245362
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0241092
RPL34 ribosomal protein L34 -0.0240183
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0235542
RPL37A ribosomal protein L37a -0.0234693
NRP1 neuropilin 1 -0.023256
RPL36 ribosomal protein L36 -0.0228482
RPL23 ribosomal protein L23 -0.0227659
RPS3 ribosomal protein S3 -0.0225859
RPS29 ribosomal protein S29 -0.0220007
S100A6 S100 calcium binding protein A6 -0.0219353
IER3 immediate early response 3 -0.0216231
EGR1 early growth response 1 -0.0213975
RPS21 ribosomal protein S21 -0.0210855
LMAN1 lectin, mannose-binding, 1 -0.0207676
GCC2 GRIP and coiled-coil domain containing 2 -0.0204313
HAS2 hyaluronan synthase 2 -0.0201909
IFI16 interferon, gamma-inducible protein 16 -0.0201481
SPRED2 sprouty-related, EVH1 domain containing 2 -0.0201225
RPL11 ribosomal protein L11 -0.0199697
RPL31 ribosomal protein L31 -0.0198712
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0193044
RPS16 ribosomal protein S16 -0.0191967
RPL9 ribosomal protein L9 -0.0188585
SYAP1 synapse associated protein 1 -0.018394
CANX calnexin -0.0180944
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0179795
ZBTB20 zinc finger and BTB domain containing 20 -0.0179759
RPL18 ribosomal protein L18 -0.0179195
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0177797
RPL32 ribosomal protein L32 -0.0169325
NIPBL Nipped-B homolog (Drosophila) -0.0167529
ANGPTL4 angiopoietin-like 4 -0.0163779
SEC61G Sec61 gamma subunit -0.016262
BTG1 B-cell translocation gene 1, anti-proliferative -0.0161461
RPL19 ribosomal protein L19 -0.0160447
S100A9 S100 calcium binding protein A9 -0.0160017
CTNND1 catenin (cadherin-associated protein), delta 1 -0.0159517
IGFBP3 insulin-like growth factor binding protein 3 -0.0158739
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.015751
RB1CC1 RB1-inducible coiled-coil 1 -0.0154978
RPS13 ribosomal protein S13 -0.0154965
PTPRR protein tyrosine phosphatase, receptor type, R -0.0151795
BPTF bromodomain PHD finger transcription factor -0.0149548
B2M beta-2-microglobulin -0.0149181
ACBD3 acyl-CoA binding domain containing 3 -0.0146231
SQSTM1 sequestosome 1 -0.014502
RACK1 receptor for activated C kinase 1 -0.0144617
RPS27 ribosomal protein S27 -0.0144007
ATP5MC2 ATP synthase membrane subunit c locus 2 -0.0143709
H1-0 H1.0 linker histone -0.0143057
RPS24 ribosomal protein S24 -0.0141635
RPS17 ribosomal protein S17 -0.0140871
RPS25 ribosomal protein S25 -0.0140747
SLC38A1 solute carrier family 38, member 1 -0.0139321
RPL37 ribosomal protein L37 -0.0139256
ETV6 ets variant 6 -0.0136411
CALU calumenin -0.013621
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0135491
KLF6 Kruppel-like factor 6 -0.0135469
IFITM3 interferon induced transmembrane protein 3 -0.0135068
RPLP0 ribosomal protein, large, P0 -0.0134254
CDCP1 CUB domain containing protein 1 -0.0133872
HM13 histocompatibility (minor) 13 -0.0132888
RPL38 ribosomal protein L38 -0.0132685
NDRG1 N-myc downstream regulated 1 -0.013266
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.0132295
TPT1 tumor protein, translationally-controlled 1 -0.0132288
HLA-B major histocompatibility complex, class I, B -0.0131358
FBXL13 F-box and leucine-rich repeat protein 13 -0.0130799
RBM25 RNA binding motif protein 25 -0.012985
XRN1 5'-3' exoribonuclease 1 -0.0129686