| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Doxycycline (monohydrate) perturbation in NCI-H2030 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Doxycycline (monohydrate)_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0181917 |
| NPC1 | Niemann-Pick disease, type C1 | 0.012446 |
| FLNB | filamin B, beta | 0.012046 |
| TPM3 | tropomyosin 3 | 0.0109248 |
| MTX2 | metaxin 2 | 0.00892948 |
| RPS12 | ribosomal protein S12 | 0.00831877 |
| SLC35F5 | solute carrier family 35, member F5 | 0.00802477 |
| SSRP1 | structure specific recognition protein 1 | 0.0078506 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.00765328 |
| SP3 | Sp3 transcription factor | 0.00759108 |
| RPL21 | ribosomal protein L21 | 0.0074549 |
| PGM3 | phosphoglucomutase 3 | 0.0072798 |
| TM9SF3 | transmembrane 9 superfamily member 3 | 0.00722599 |
| PDXDC1 | pyridoxal-dependent decarboxylase domain containing 1 | 0.00708442 |
| FAT1 | FAT atypical cadherin 1 | 0.0069836 |
| BARD1 | BRCA1 associated RING domain 1 | 0.00663754 |
| MSN | moesin | 0.00661943 |
| NCAPG2 | non-SMC condensin II complex, subunit G2 | 0.00659553 |
| FSIP2 | fibrous sheath interacting protein 2 | 0.00658006 |
| RIOK1 | RIO kinase 1 | 0.00635781 |
| AMOTL1 | angiomotin like 1 | 0.00612748 |
| FAM3C | family with sequence similarity 3, member C | 0.00611154 |
| CHURC1 | churchill domain containing 1 | 0.00606759 |
| YEATS2 | YEATS domain containing 2 | 0.00602882 |
| ARRDC3 | arrestin domain containing 3 | 0.00598986 |
| CHIC2 | cysteine-rich hydrophobic domain 2 | 0.00595361 |
| VRK1 | vaccinia related kinase 1 | 0.00589128 |
| NTM | neurotrimin | 0.00588272 |
| GART | phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase | 0.0058679 |
| AZIN1 | antizyme inhibitor 1 | 0.00586254 |
| FBXL5 | F-box and leucine-rich repeat protein 5 | 0.00584644 |
| EIF5AL1 | eukaryotic translation initiation factor 5A-like 1 | 0.00583103 |
| ECPAS | Ecm29 proteasome adaptor and scaffold | 0.00580554 |
| RPS3A | ribosomal protein S3A | 0.00574384 |
| MTHFD2 | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase | 0.00572972 |
| FOSL1 | FOS-like antigen 1 | 0.00567864 |
| SLC39A11 | solute carrier family 39, member 11 | 0.00567187 |
| TMEM106B | transmembrane protein 106B | 0.00566516 |
| DDX18 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 18 | 0.00563224 |
| IBTK | inhibitor of Bruton agammaglobulinemia tyrosine kinase | 0.00558183 |
| DGKD | diacylglycerol kinase, delta 130kDa | 0.00557876 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.00554673 |
| SHOC1 | shortage in chiasmata 1 | 0.00552911 |
| RANGAP1 | Ran GTPase activating protein 1 | 0.00546172 |
| PVR | poliovirus receptor | 0.00545577 |
| ARID3B | AT rich interactive domain 3B (BRIGHT-like) | 0.00543005 |
| FOXM1 | forkhead box M1 | 0.00539563 |
| CTTNBP2NL | CTTNBP2 N-terminal like | 0.00538621 |
| BMP6 | bone morphogenetic protein 6 | 0.00537967 |
| DHRS7 | dehydrogenase/reductase (SDR family) member 7 | 0.00537852 |
| RIPK1 | receptor (TNFRSF)-interacting serine-threonine kinase 1 | 0.00536795 |
| SHCBP1 | SHC SH2-domain binding protein 1 | 0.005365 |
| PCMTD2 | protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2 | 0.00535867 |
| NT5C3A | 5'-nucleotidase, cytosolic IIIA | 0.00535783 |
| CSRP1 | cysteine and glycine-rich protein 1 | 0.00535728 |
| ATXN1 | ataxin 1 | 0.00534936 |
| ASRGL1 | asparaginase like 1 | 0.00528979 |
| MAX | MYC associated factor X | 0.00528819 |
| KLRC3 | killer cell lectin-like receptor subfamily C, member 3 | 0.0052841 |
| CDCP1 | CUB domain containing protein 1 | 0.00528092 |
| POLR2B | polymerase (RNA) II (DNA directed) polypeptide B, 140kDa | 0.00527382 |
| MMADHC | methylmalonic aciduria (cobalamin deficiency) cblD type, with homocystinuria | 0.0052404 |
| PRCC | papillary renal cell carcinoma (translocation-associated) | 0.005206 |
| SLC30A7 | solute carrier family 30 (zinc transporter), member 7 | 0.00520045 |
| SSBP1 | single-stranded DNA binding protein 1, mitochondrial | 0.0051321 |
| KIF1C | kinesin family member 1C | 0.00510924 |
| THUMPD2 | THUMP domain containing 2 | 0.00509565 |
| DCAF13 | DDB1 and CUL4 associated factor 13 | 0.00507202 |
| ZNF410 | zinc finger protein 410 | 0.00506318 |
| DLG5 | discs, large homolog 5 (Drosophila) | 0.00505086 |
| PSMD11 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 11 | 0.00499645 |
| ESPL1 | extra spindle pole bodies homolog 1 (S. cerevisiae) | 0.00499141 |
| TNFAIP8 | tumor necrosis factor, alpha-induced protein 8 | 0.00498513 |
| ARFGAP1 | ADP-ribosylation factor GTPase activating protein 1 | 0.00498132 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | 0.00497932 |
| VIRMA | vir like m6A methyltransferase associated | 0.00495264 |
| DNAJC7 | DnaJ (Hsp40) homolog, subfamily C, member 7 | 0.00495199 |
| RBMS2 | RNA binding motif, single stranded interacting protein 2 | 0.00494999 |
| HNRNPUL2 | heterogeneous nuclear ribonucleoprotein U-like 2 | 0.00493841 |
| PRELID2 | PRELI domain containing 2 | 0.00493177 |
| DEDD | death effector domain containing | 0.00487671 |
| KIF14 | kinesin family member 14 | 0.00484276 |
| FBXL4 | F-box and leucine-rich repeat protein 4 | 0.0048048 |
| B4GALT3 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 3 | 0.00478802 |
| CBLL1 | Cbl proto-oncogene-like 1, E3 ubiquitin protein ligase | 0.00478768 |
| ZNF121 | zinc finger protein 121 | 0.00477935 |
| CCNC | cyclin C | 0.00476728 |
| MICU2 | mitochondrial calcium uptake 2 | 0.00476382 |
| VOPP1 | vesicular, overexpressed in cancer, prosurvival protein 1 | 0.00474432 |
| CCDC18 | coiled-coil domain containing 18 | 0.00473299 |
| RNPS1 | RNA binding protein S1, serine-rich domain | 0.00471599 |
| PRDM4 | PR domain containing 4 | 0.00470154 |
| DDX1 | DEAD (Asp-Glu-Ala-Asp) box helicase 1 | 0.00469885 |
| COPG1 | coatomer protein complex, subunit gamma 1 | 0.00469456 |
| NKD1 | naked cuticle homolog 1 (Drosophila) | 0.00468872 |
| SDE2 | SDE2 telomere maintenance homolog (S. pombe) | 0.00468417 |
| POLE2 | polymerase (DNA directed), epsilon 2, accessory subunit | 0.00466432 |
| FBRS | fibrosin | 0.00465246 |
| FBXO45 | F-box protein 45 | 0.00464456 |
| ANXA5 | annexin A5 | 0.00463462 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.385152 |
| FTL | ferritin, light polypeptide | -0.174093 |
| MT2A | metallothionein 2A | -0.160086 |
| TMSB10 | thymosin beta 10 | -0.14647 |
| VIM | vimentin | -0.134924 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.132854 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.104513 |
| ACTG1 | actin gamma 1 | -0.0879155 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0827461 |
| RPL19 | ribosomal protein L19 | -0.0797258 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.0693603 |
| IER3 | immediate early response 3 | -0.0689384 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0656261 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0626905 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0614774 |
| S100A6 | S100 calcium binding protein A6 | -0.0580548 |
| PARD3 | par-3 family cell polarity regulator | -0.0566295 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0528603 |
| S100A10 | S100 calcium binding protein A10 | -0.0521123 |
| RBM39 | RNA binding motif protein 39 | -0.0516675 |
| RPL23 | ribosomal protein L23 | -0.0509122 |
| RPS4Y1 | ribosomal protein S4, Y-linked 1 | -0.0509082 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0504499 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0504105 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0503837 |
| TXNRD1 | thioredoxin reductase 1 | -0.0490143 |
| RPLP1 | ribosomal protein, large, P1 | -0.0458231 |
| PTK2 | protein tyrosine kinase 2 | -0.0456536 |
| PTMA | prothymosin, alpha | -0.0434413 |
| UBC | ubiquitin C | -0.042251 |
| AP2B1 | adaptor-related protein complex 2, beta 1 subunit | -0.0420256 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0402731 |
| DENND4A | DENN/MADD domain containing 4A | -0.0397215 |
| ANXA2 | annexin A2 | -0.0394683 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0392925 |
| RPL8 | ribosomal protein L8 | -0.0387667 |
| RPS21 | ribosomal protein S21 | -0.0386259 |
| CAVIN1 | caveolae associated protein 1 | -0.0374392 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0373095 |
| GNAS | GNAS complex locus | -0.0372357 |
| GRAMD1B | GRAM domain containing 1B | -0.0352617 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.0347866 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0346999 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | -0.0337543 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0335137 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0334574 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0332201 |
| NOP58 | NOP58 ribonucleoprotein | -0.0329724 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | -0.0328289 |
| BASP1 | brain abundant, membrane attached signal protein 1 | -0.0325763 |
| RPS5 | ribosomal protein S5 | -0.03206 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0317846 |
| RPS16 | ribosomal protein S16 | -0.0315636 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0314543 |
| TPI1 | triosephosphate isomerase 1 | -0.0308492 |
| DSCAM | Down syndrome cell adhesion molecule | -0.0308342 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0308281 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0307533 |
| RPS23 | ribosomal protein S23 | -0.0305693 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | -0.0303085 |
| RPLP0 | ribosomal protein, large, P0 | -0.0302072 |
| PKM | pyruvate kinase, muscle | -0.030179 |
| RHOA | ras homolog family member A | -0.0299278 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | -0.029866 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0296895 |
| IGF2 | insulin-like growth factor 2 | -0.0294389 |
| AHNAK | AHNAK nucleoprotein | -0.0293944 |
| RPS25 | ribosomal protein S25 | -0.0291662 |
| CYRIB | CYFIP related Rac1 interactor B | -0.0286678 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | -0.0284332 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.0283525 |
| SLC38A1 | solute carrier family 38, member 1 | -0.028345 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0281623 |
| APP | amyloid beta (A4) precursor protein | -0.0280475 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.0278483 |
| RPL11 | ribosomal protein L11 | -0.0275861 |
| FUS | FUS RNA binding protein | -0.0275307 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.0274641 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0274546 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0272519 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0272028 |
| RPL4 | ribosomal protein L4 | -0.0270592 |
| RPS15 | ribosomal protein S15 | -0.0266251 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | -0.0263719 |
| C15ORF48 | chromosome 15 open reading frame 48 | -0.0263257 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | -0.0261456 |
| LDHA | lactate dehydrogenase A | -0.0260823 |
| ASPH | aspartate beta-hydroxylase | -0.0259944 |
| CSGALNACT1 | chondroitin sulfate N-acetylgalactosaminyltransferase 1 | -0.0253448 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0251634 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | -0.0251069 |
| STAU1 | staufen double-stranded RNA binding protein 1 | -0.0250922 |
| B2M | beta-2-microglobulin | -0.0248113 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | -0.0247981 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0247846 |
| RPL26 | ribosomal protein L26 | -0.0246628 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.0246434 |
| MYOF | myoferlin | -0.0245762 |
| NQO1 | NAD(P)H dehydrogenase, quinone 1 | -0.0242195 |
| RPL37 | ribosomal protein L37 | -0.0239814 |
