Doxycycline (monohydrate)_NCI-H2122 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Doxycycline (monohydrate) perturbation in NCI-H2122 cell line (Tahoe Therapeutics)
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Genes

154 genes differentially expressed following the Doxycycline (monohydrate)_NCI-H2122 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) 0.166575
NDRG1 N-myc downstream regulated 1 0.123672
PTMA prothymosin, alpha 0.0897042
UBC ubiquitin C 0.0780764
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0770009
RSAD2 radical S-adenosyl methionine domain containing 2 0.0767216
ASPH aspartate beta-hydroxylase 0.0743823
BRIP1 BRCA1 interacting protein C-terminal helicase 1 0.0727799
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0711045
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0689406
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0662878
KYNU kynureninase 0.0654117
HOOK2 hook microtubule-tethering protein 2 0.0575338
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0568785
ITGA6 integrin, alpha 6 0.0561675
TRIO trio Rho guanine nucleotide exchange factor 0.0525774
IER3 immediate early response 3 0.0520335
CA12 carbonic anhydrase XII 0.0519459
RPL26 ribosomal protein L26 0.0509669
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2 0.0509666
FNDC3B fibronectin type III domain containing 3B 0.0497961
SPTBN1 spectrin, beta, non-erythrocytic 1 0.046615
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) 0.0462395
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.045664
SYT1 synaptotagmin I 0.0456283
RPS3 ribosomal protein S3 0.0453005
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.0451819
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0422369
NKD1 naked cuticle homolog 1 (Drosophila) 0.0406398
RPLP1 ribosomal protein, large, P1 0.0373099
SPAG9 sperm associated antigen 9 0.0336875
EIF4A3 eukaryotic translation initiation factor 4A3 0.0321366
MATR3 matrin 3 0.0316774
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0307358
JUN jun proto-oncogene 0.0296858
ISG20 interferon stimulated exonuclease gene 20kDa 0.0296557
SRRM2 serine/arginine repetitive matrix 2 0.0284975
ENO1 enolase 1, (alpha) 0.0276793
H3-3B H3.3 histone B 0.02736
RNF149 ring finger protein 149 0.0247861
DSPP dentin sialophosphoprotein 0.0239251
LIFR leukemia inhibitory factor receptor alpha 0.0236328
PDLIM5 PDZ and LIM domain 5 0.0231672
OGA O-GlcNAcase 0.0217823
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0202268
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.019249
LDHA lactate dehydrogenase A 0.019143
SQSTM1 sequestosome 1 0.0186066
EZR ezrin 0.0174306
SDC4 syndecan 4 0.0150423
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0139779
KRT17 keratin 17, type I 0.0134392
UBN2 ubinuclein 2 0.0131806
GOLGA4 golgin A4 0.0129587
VIM vimentin 0.0124165
RPL35A ribosomal protein L35a 0.00976462
RPL37A ribosomal protein L37a 0.00953233
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.00930141
RPS6 ribosomal protein S6 0.00878621
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.00833389
PKM pyruvate kinase, muscle 0.0078623
CLASP1 cytoplasmic linker associated protein 1 0.00765041
WAC WW domain containing adaptor with coiled-coil 0.00713432
KTN1 kinectin 1 (kinesin receptor) 0.00641411
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.00632609
RUNX1 runt-related transcription factor 1 0.00609423
PICALM phosphatidylinositol binding clathrin assembly protein 0.0058657
MINDY2 MINDY lysine 48 deubiquitinase 2 0.00522233
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.00522111
KMT2C lysine (K)-specific methyltransferase 2C 0.00511381
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.00475677
PTBP3 polypyrimidine tract binding protein 3 0.00470418
KDM6A lysine (K)-specific demethylase 6A 0.00461579
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 8.82325E-4
GPBP1 GC-rich promoter binding protein 1 7.11028E-4

decreased expression

Symbol Name Standardized Value
GRB10 growth factor receptor-bound protein 10 -0.151807
ATOSA atos homolog A -0.12428
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.123854
LMO7 LIM domain 7 -0.113993
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type -0.111498
FN1 fibronectin 1 -0.103057
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.101672
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) -0.0956081
PARD3 par-3 family cell polarity regulator -0.0954129
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0950293
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 -0.0878042
SVIL supervillin -0.0868902
MYO1E myosin IE -0.0864665
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0855045
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 -0.0837397
BACE2 beta-site APP-cleaving enzyme 2 -0.0830263
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 -0.0826794
IGFBP3 insulin-like growth factor binding protein 3 -0.0791369
NPEPPS aminopeptidase puromycin sensitive -0.0755217
PDE4D phosphodiesterase 4D, cAMP-specific -0.0739642
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0716757
SAMD4A sterile alpha motif domain containing 4A -0.0681245
DSCAM Down syndrome cell adhesion molecule -0.0666948
TXNRD1 thioredoxin reductase 1 -0.0655259
SLC38A1 solute carrier family 38, member 1 -0.0630135
PRELID2 PRELI domain containing 2 -0.0611695
AHNAK AHNAK nucleoprotein -0.0545282
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.0534806
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0513374
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b -0.0448646
AKAP13 A kinase (PRKA) anchor protein 13 -0.0400826
AKAP9 A kinase (PRKA) anchor protein 9 -0.0393348
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 -0.0357113
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0350567
KANSL1 KAT8 regulatory NSL complex subunit 1 -0.0346017
FTH1 ferritin, heavy polypeptide 1 -0.0312422
TENT5A terminal nucleotidyltransferase 5A -0.0311011
USP15 ubiquitin specific peptidase 15 -0.0309072
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase -0.0294897
FBXO11 F-box protein 11 -0.0294179
B2M beta-2-microglobulin -0.0290202
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0285942
RACK1 receptor for activated C kinase 1 -0.027493
PRRC2C proline-rich coiled-coil 2C -0.0274478
FTL ferritin, light polypeptide -0.0250593
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like -0.0236535
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.022825
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0225558
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0219687
PCBP2 poly(rC) binding protein 2 -0.0204044
KDM3A lysine (K)-specific demethylase 3A -0.0201122
LAMB3 laminin, beta 3 -0.0194765
ZMYND8 zinc finger, MYND-type containing 8 -0.0192258
TPT1 tumor protein, translationally-controlled 1 -0.0175929
ATP2C2 ATPase, Ca++ transporting, type 2C, member 2 -0.0170185
POTEF POTE ankyrin domain family, member F -0.0168256
ESYT2 extended synaptotagmin-like protein 2 -0.0159719
TAS2R14 taste receptor, type 2, member 14 -0.0158016
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0148352
LUC7L3 LUC7-like 3 (S. cerevisiae) -0.0143548
PRAG1 PEAK1 related, kinase-activating pseudokinase 1 -0.0132265
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.0123611
RAB11FIP1 RAB11 family interacting protein 1 (class I) -0.0110924
CANX calnexin -0.0110066
SBF2 SET binding factor 2 -0.0107519
LRBA LPS-responsive vesicle trafficking, beach and anchor containing -0.0101833
ANXA2 annexin A2 -0.00964436
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.00937787
FAM13A family with sequence similarity 13, member A -0.0090258
MAML2 mastermind-like 2 (Drosophila) -0.00811286
MT2A metallothionein 2A -0.00564817
RERE arginine-glutamic acid dipeptide (RE) repeats -0.00535853
TMSB10 thymosin beta 10 -0.00476042
RBM39 RNA binding motif protein 39 -0.00431442
ZBTB20 zinc finger and BTB domain containing 20 -0.00383106
IFIH1 interferon induced with helicase C domain 1 -0.00357202
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.00153819
MACF1 microtubule-actin crosslinking factor 1 -1.96736E-4
PDIA3 protein disulfide isomerase family A, member 3 -1.88677E-4