Doxycycline (monohydrate)_NCI-H23 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Doxycycline (monohydrate) perturbation in NCI-H23 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Doxycycline (monohydrate)_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 0.184464
ZFAND3 zinc finger, AN1-type domain 3 0.101032
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0974207
GRAMD1B GRAM domain containing 1B 0.0906463
ERRFI1 ERBB receptor feedback inhibitor 1 0.085348
UBE2H ubiquitin-conjugating enzyme E2H 0.0798149
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0750579
TXNRD1 thioredoxin reductase 1 0.0723698
PTK2 protein tyrosine kinase 2 0.0705704
CAMTA1 calmodulin binding transcription activator 1 0.0698446
TPM3 tropomyosin 3 0.0670212
RTN4 reticulon 4 0.0658963
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.057789
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0569297
PUM2 pumilio RNA-binding family member 2 0.0547626
KDM3A lysine (K)-specific demethylase 3A 0.0542419
SRPK2 SRSF protein kinase 2 0.0538034
KTN1 kinectin 1 (kinesin receptor) 0.0529234
ENO1 enolase 1, (alpha) 0.0498402
CSDE1 cold shock domain containing E1, RNA-binding 0.0496069
TFG TRK-fused gene 0.0493478
CDK17 cyclin-dependent kinase 17 0.0487113
RAB6A RAB6A, member RAS oncogene family 0.0483078
FMNL2 formin-like 2 0.0477457
PHIP pleckstrin homology domain interacting protein 0.0473416
NUP58 nucleoporin 58 0.0470278
TRIM33 tripartite motif containing 33 0.045385
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0447102
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.0441349
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0430819
MACF1 microtubule-actin crosslinking factor 1 0.0422609
KMT2C lysine (K)-specific methyltransferase 2C 0.041594
TNPO3 transportin 3 0.0412952
BBX bobby sox homolog (Drosophila) 0.0407555
FAM168A family with sequence similarity 168, member A 0.0405646
MKI67 marker of proliferation Ki-67 0.0395149
CDCP1 CUB domain containing protein 1 0.0390675
ANKRD11 ankyrin repeat domain 11 0.0389352
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0388371
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0388253
IFI6 interferon, alpha-inducible protein 6 0.0385814
IGF2 insulin-like growth factor 2 0.0383726
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0382909
NCKAP1 NCK-associated protein 1 0.0376149
TM4SF1 transmembrane 4 L six family member 1 0.0372769
RBM33 RNA binding motif protein 33 0.0366917
ANKRD28 ankyrin repeat domain 28 0.0362673
WSB1 WD repeat and SOCS box containing 1 0.0362568
MIS18BP1 MIS18 binding protein 1 0.0357355
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 0.035635
RNF38 ring finger protein 38 0.0354473
SMAD3 SMAD family member 3 0.0353327
ADAM17 ADAM metallopeptidase domain 17 0.0353235
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0350128
ARID2 AT rich interactive domain 2 (ARID, RFX-like) 0.0348221
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0346735
YES1 YES proto-oncogene 1, Src family tyrosine kinase 0.0345301
IGF1R insulin-like growth factor 1 receptor 0.0343864
EEF2 eukaryotic translation elongation factor 2 0.0342895
USP34 ubiquitin specific peptidase 34 0.0335916
RICTOR RPTOR independent companion of MTOR, complex 2 0.0334385
UBE2V1 ubiquitin-conjugating enzyme E2 variant 1 0.0332852
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0331458
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.0330232
RAB10 RAB10, member RAS oncogene family 0.0330123
THSD4 thrombospondin, type I, domain containing 4 0.0325432
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) 0.0324696
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0322991
KPNA1 karyopherin alpha 1 (importin alpha 5) 0.0321844
SENP6 SUMO1/sentrin specific peptidase 6 0.0320079
MNAT1 MNAT CDK-activating kinase assembly factor 1 0.0319732
PPM1B protein phosphatase, Mg2+/Mn2+ dependent, 1B 0.031714
OGA O-GlcNAcase 0.0317132
MEMO1 mediator of cell motility 1 0.0315913
NUMB numb homolog (Drosophila) 0.0314794
WNK1 WNK lysine deficient protein kinase 1 0.0314603
EML4 echinoderm microtubule associated protein like 4 0.0313643
BIRC6 baculoviral IAP repeat containing 6 0.0312435
UBE2K ubiquitin-conjugating enzyme E2K 0.0311159
BRWD3 bromodomain and WD repeat domain containing 3 0.0310822
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0310362
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0310081
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0309181
SNX9 sorting nexin 9 0.0308891
JMJD1C jumonji domain containing 1C 0.0308183
LUC7L2 LUC7-like 2 (S. cerevisiae) 0.0306168
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.0305762
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 0.0303671
MED13 mediator complex subunit 13 0.0302329
NUP153 nucleoporin 153kDa 0.0301591
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 0.0299586
SINHCAF SIN3-HDAC complex associated factor 0.0297486
GSK3B glycogen synthase kinase 3 beta 0.029639
SPPL3 signal peptide peptidase like 3 0.0295237
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0295126
NR6A1 nuclear receptor subfamily 6, group A, member 1 0.0292668
ANXA5 annexin A5 0.0292663
CDYL chromodomain protein, Y-like 0.0291729
UBA2 ubiquitin-like modifier activating enzyme 2 0.0287517
GOLGA4 golgin A4 0.0285677

decreased expression

Symbol Name Standardized Value
NABP1 nucleic acid binding protein 1 -0.0624145
MCL1 myeloid cell leukemia 1 -0.0572589
RPS8 ribosomal protein S8 -0.053136
INTS6 integrator complex subunit 6 -0.0507499
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0506054
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0459319
RPL35A ribosomal protein L35a -0.0447115
AEBP2 AE binding protein 2 -0.0439699
RAD51B RAD51 paralog B -0.0427048
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 -0.040517
RPL23 ribosomal protein L23 -0.0392326
WNT2B wingless-type MMTV integration site family, member 2B -0.0391709
RPS12 ribosomal protein S12 -0.0375052
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0354458
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0348314
RPL26 ribosomal protein L26 -0.0345961
MORF4L2 mortality factor 4 like 2 -0.0340868
SLC38A2 solute carrier family 38, member 2 -0.0334807
RPS3 ribosomal protein S3 -0.0323118
RPLP1 ribosomal protein, large, P1 -0.0319072
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0311162
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0309671
RPL12 ribosomal protein L12 -0.0308874
RACK1 receptor for activated C kinase 1 -0.0302594
RPL9 ribosomal protein L9 -0.0297358
TPT1 tumor protein, translationally-controlled 1 -0.0294749
RPL19 ribosomal protein L19 -0.0285
VCL vinculin -0.0284868
KIAA1328 KIAA1328 -0.0262956
LOC112694756 uncharaterized LOC112694756 -0.0257141
SQSTM1 sequestosome 1 -0.0256775
EGR1 early growth response 1 -0.0254756
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 -0.0252844
STYK1 serine/threonine/tyrosine kinase 1 -0.0250564
MT2A metallothionein 2A -0.0244744
DDIT3 DNA-damage-inducible transcript 3 -0.0239699
NAP1L1 nucleosome assembly protein 1-like 1 -0.0238411
PTBP1 polypyrimidine tract binding protein 1 -0.0237585
ELL2 elongation factor, RNA polymerase II, 2 -0.0233967
NFE2L2 nuclear factor, erythroid 2-like 2 -0.0231404
RPS6 ribosomal protein S6 -0.023118
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0229743
RPL34 ribosomal protein L34 -0.0227779
GOLGB1 golgin B1 -0.0226289
AKAP9 A kinase (PRKA) anchor protein 9 -0.022477
DOCK1 dedicator of cytokinesis 1 -0.0223088
GPATCH2L G patch domain containing 2-like -0.0220073
ACTG1 actin gamma 1 -0.0219715
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0219339
TRIM59 tripartite motif containing 59 -0.0219261
CALD1 caldesmon 1 -0.0217049
PDLIM5 PDZ and LIM domain 5 -0.0216171
RPL13A ribosomal protein L13a -0.0215178
ATRX alpha thalassemia/mental retardation syndrome X-linked -0.0214333
EGFR epidermal growth factor receptor -0.0214189
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0213253
CRK v-crk avian sarcoma virus CT10 oncogene homolog -0.0210409
BPTF bromodomain PHD finger transcription factor -0.0210279
VIM vimentin -0.0206787
FTL ferritin, light polypeptide -0.0199966
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0198663
RPS27A ribosomal protein S27a -0.0198412
LOC102724023 ES1 protein homolog, mitochondrial -0.0196404
PDIA4 protein disulfide isomerase family A, member 4 -0.0196159
NEK10 NIMA-related kinase 10 -0.0194506
ATF6 activating transcription factor 6 -0.0194431
MSRB3 methionine sulfoxide reductase B3 -0.0192465
RARS1 arginyl-tRNA synthetase 1 -0.0188809
HMGA2 high mobility group AT-hook 2 -0.0188608
R3HDM2 R3H domain containing 2 -0.0188595
DCAF8 DDB1 and CUL4 associated factor 8 -0.0185419
EIF1 eukaryotic translation initiation factor 1 -0.0180643
TBCA tubulin folding cofactor A -0.0179607
RPLP2 ribosomal protein, large, P2 -0.0178173
STPG4 sperm-tail PG-rich repeat containing 4 -0.0178111
NR4A1 nuclear receptor subfamily 4, group A, member 1 -0.0178043
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 -0.0175147
PRELID2 PRELI domain containing 2 -0.0172598
HDAC4 histone deacetylase 4 -0.0172459
FBXO11 F-box protein 11 -0.0171996
RPS16 ribosomal protein S16 -0.0171644
NPAS2 neuronal PAS domain protein 2 -0.0170048
GNAS GNAS complex locus -0.0169221
NACA nascent polypeptide-associated complex alpha subunit -0.0169219
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) -0.016904
FLRT2 fibronectin leucine rich transmembrane protein 2 -0.0168285
MYSM1 Myb-like, SWIRM and MPN domains 1 -0.0168281
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0168082
ZRANB2 zinc finger, RAN-binding domain containing 2 -0.016795
SON SON DNA binding protein -0.0167325
C6ORF62 chromosome 6 open reading frame 62 -0.0167314
RPL5 ribosomal protein L5 -0.0164951
PPP1R10 protein phosphatase 1, regulatory subunit 10 -0.016117
CFAP44 cilia and flagella associated protein 44 -0.016108
ARHGEF10 Rho guanine nucleotide exchange factor (GEF) 10 -0.0160965
SPIDR scaffolding protein involved in DNA repair -0.015992
RPS20 ribosomal protein S20 -0.0158013
TMEM263 transmembrane protein 263 -0.0156753
RBM19 RNA binding motif protein 19 -0.0156115
TFPI2 tissue factor pathway inhibitor 2 -0.0154921