Doxycycline (monohydrate)_NCI-H2347 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Doxycycline (monohydrate) perturbation in NCI-H2347 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Doxycycline (monohydrate)_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
POTEF POTE ankyrin domain family, member F 0.118816
FNDC3B fibronectin type III domain containing 3B 0.0829521
MYO6 myosin VI 0.075321
LPP LIM domain containing preferred translocation partner in lipoma 0.0716004
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0493787
ADAM9 ADAM metallopeptidase domain 9 0.0476699
ERBIN erbb2 interacting protein 0.0445413
MSN moesin 0.0444004
COPA coatomer protein complex, subunit alpha 0.0434992
GRB10 growth factor receptor-bound protein 10 0.0400558
PTK2 protein tyrosine kinase 2 0.0398665
AKAP13 A kinase (PRKA) anchor protein 13 0.0394636
CCNL1 cyclin L1 0.03839
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0375885
ITCH itchy E3 ubiquitin protein ligase 0.0370702
VEGFA vascular endothelial growth factor A 0.0367254
LIMCH1 LIM and calponin homology domains 1 0.035494
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0351054
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) 0.0350099
PDLIM5 PDZ and LIM domain 5 0.0346299
RNF145 ring finger protein 145 0.033766
TSC22D2 TSC22 domain family, member 2 0.033077
PCBP2 poly(rC) binding protein 2 0.0326156
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0321469
TRIO trio Rho guanine nucleotide exchange factor 0.0317069
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0315217
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2 0.0314757
TFG TRK-fused gene 0.0303448
STRN3 striatin, calmodulin binding protein 3 0.0302749
ENO2 enolase 2 (gamma, neuronal) 0.0296129
LDHA lactate dehydrogenase A 0.0292921
FXR1 fragile X mental retardation, autosomal homolog 1 0.0291005
PICALM phosphatidylinositol binding clathrin assembly protein 0.0290159
KMT2C lysine (K)-specific methyltransferase 2C 0.0285107
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0281586
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0280949
ZFAND3 zinc finger, AN1-type domain 3 0.0280634
MACF1 microtubule-actin crosslinking factor 1 0.0279619
TMF1 TATA element modulatory factor 1 0.0278222
MYH9 myosin, heavy chain 9, non-muscle 0.0275987
SEC23A Sec23 homolog A (S. cerevisiae) 0.0273968
KDM6A lysine (K)-specific demethylase 6A 0.027332
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.025397
PPP4R1 protein phosphatase 4, regulatory subunit 1 0.0250093
MCU mitochondrial calcium uniporter 0.0243253
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.024179
WAC WW domain containing adaptor with coiled-coil 0.0238177
KMT2E lysine (K)-specific methyltransferase 2E 0.0238117
ZSWIM6 zinc finger, SWIM-type containing 6 0.0234101
APLP2 amyloid beta (A4) precursor-like protein 2 0.022934
PARD3 par-3 family cell polarity regulator 0.0228671
TPM3 tropomyosin 3 0.0226357
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.022117
WASF2 WAS protein family, member 2 0.0219128
RCOR1 REST corepressor 1 0.0219073
RAI14 retinoic acid induced 14 0.0218386
ZNF148 zinc finger protein 148 0.0216931
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0213187
PDS5A PDS5 cohesin associated factor A 0.0212323
KDM5B lysine (K)-specific demethylase 5B 0.0212199
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0210397
MXD1 MAX dimerization protein 1 0.0210029
MBNL1 muscleblind-like splicing regulator 1 0.020984
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) 0.0209143
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 0.0209064
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0208978
GPBP1 GC-rich promoter binding protein 1 0.020887
PLS3 plastin 3 0.0208713
UBA6 ubiquitin-like modifier activating enzyme 6 0.0207863
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.0203245
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.0202776
UBE2E1 ubiquitin-conjugating enzyme E2E 1 0.0202328
SETD5 SET domain containing 5 0.0201971
HELZ helicase with zinc finger 0.0201269
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0198602
FAM13A family with sequence similarity 13, member A 0.0196463
ZFP36L1 ZFP36 ring finger protein-like 1 0.019595
AKAP9 A kinase (PRKA) anchor protein 9 0.0194562
SRPK2 SRSF protein kinase 2 0.0190234
CCND1 cyclin D1 0.0188972
PUM1 pumilio RNA-binding family member 1 0.0186552
SLMAP sarcolemma associated protein 0.018617
CD47 CD47 molecule 0.0186026
UBE2H ubiquitin-conjugating enzyme E2H 0.018455
KDM2A lysine (K)-specific demethylase 2A 0.0184102
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0183905
ATXN2 ataxin 2 0.0182552
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0181209
BBX bobby sox homolog (Drosophila) 0.0180306
PDIA6 protein disulfide isomerase family A, member 6 0.0177882
RNASE3 ribonuclease, RNase A family, 3 0.0177674
ZNF207 zinc finger protein 207 0.0177632
RAB1A RAB1A, member RAS oncogene family 0.0177221
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0177207
ITGAV integrin, alpha V 0.0176159
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.0175927
MIER1 mesoderm induction early response 1, transcriptional regulator 0.0175594
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 0.0175194
HNRNPM heterogeneous nuclear ribonucleoprotein M 0.0173911
RHOA ras homolog family member A 0.0172685

decreased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.286326
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.146171
FTL ferritin, light polypeptide -0.131843
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.122422
LAMB3 laminin, beta 3 -0.100643
TPT1 tumor protein, translationally-controlled 1 -0.081214
RPL35A ribosomal protein L35a -0.0793116
MT2A metallothionein 2A -0.0716162
RPLP1 ribosomal protein, large, P1 -0.0675051
RPS8 ribosomal protein S8 -0.066362
RPL34 ribosomal protein L34 -0.0633777
S100A6 S100 calcium binding protein A6 -0.06251
TMSB10 thymosin beta 10 -0.0596047
RPS3 ribosomal protein S3 -0.057568
RPL23 ribosomal protein L23 -0.0570174
RPS19 ribosomal protein S19 -0.0558829
ACTG1 actin gamma 1 -0.0535957
NDRG1 N-myc downstream regulated 1 -0.0509174
RACK1 receptor for activated C kinase 1 -0.0508794
EIF1 eukaryotic translation initiation factor 1 -0.0482812
RPL12 ribosomal protein L12 -0.0452248
RPLP2 ribosomal protein, large, P2 -0.0450867
PTMA prothymosin, alpha -0.0450427
LAMC2 laminin, gamma 2 -0.0449885
SDC4 syndecan 4 -0.0439573
RPL30 ribosomal protein L30 -0.0418818
RPL9 ribosomal protein L9 -0.041037
RPL11 ribosomal protein L11 -0.0392401
RPS6 ribosomal protein S6 -0.0392325
NAMPT nicotinamide phosphoribosyltransferase -0.0389414
BHLHE40 basic helix-loop-helix family, member e40 -0.0382672
ELL2 elongation factor, RNA polymerase II, 2 -0.0374345
SLC38A1 solute carrier family 38, member 1 -0.037037
RPLP0 ribosomal protein, large, P0 -0.0361707
RPS29 ribosomal protein S29 -0.0356858
AHNAK AHNAK nucleoprotein -0.0346319
SQSTM1 sequestosome 1 -0.0345515
RPS27A ribosomal protein S27a -0.0344004
RPL37A ribosomal protein L37a -0.0343944
TMSB4X thymosin beta 4, X-linked -0.0342269
RPL37 ribosomal protein L37 -0.0333374
RPL19 ribosomal protein L19 -0.0333125
LOC112694756 uncharaterized LOC112694756 -0.0331734
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0317204
NAP1L1 nucleosome assembly protein 1-like 1 -0.0298113
RPL31 ribosomal protein L31 -0.0292489
RPS27 ribosomal protein S27 -0.0289826
RPL26 ribosomal protein L26 -0.0284282
RPL8 ribosomal protein L8 -0.0283634
RPS13 ribosomal protein S13 -0.0282733
HMGB2 high mobility group box 2 -0.0279606
RPL36 ribosomal protein L36 -0.0276132
RPS17 ribosomal protein S17 -0.0273492
RPL32 ribosomal protein L32 -0.0265528
FN1 fibronectin 1 -0.0265357
RPL35 ribosomal protein L35 -0.0263998
RPS12 ribosomal protein S12 -0.0261381
RPS16 ribosomal protein S16 -0.0261361
DUSP6 dual specificity phosphatase 6 -0.0257675
RAD21 RAD21 homolog (S. pombe) -0.0255359
RPL27A ribosomal protein L27a -0.0248929
RPS21 ribosomal protein S21 -0.0246713
RPS20 ribosomal protein S20 -0.0244858
HMGA1 high mobility group AT-hook 1 -0.0236598
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) -0.0234621
RPL4 ribosomal protein L4 -0.0233452
S100A9 S100 calcium binding protein A9 -0.0231014
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.0225893
RPS24 ribosomal protein S24 -0.0225314
RPS14 ribosomal protein S14 -0.0224167
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0224004
C15ORF48 chromosome 15 open reading frame 48 -0.0222458
RPL38 ribosomal protein L38 -0.022118
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase -0.0217578
G0S2 G0/G1 switch 2 -0.0217223
S100A10 S100 calcium binding protein A10 -0.0214062
RPL18 ribosomal protein L18 -0.0213925
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0213311
RPL27 ribosomal protein L27 -0.0211885
ISG15 ISG15 ubiquitin-like modifier -0.0211454
IFITM3 interferon induced transmembrane protein 3 -0.0210264
KLF6 Kruppel-like factor 6 -0.0210005
ATP5F1E ATP synthase F1 subunit epsilon -0.0207225
TUBB4B tubulin, beta 4B class IVb -0.0206605
YBX1 Y box binding protein 1 -0.0205638
ENO1 enolase 1, (alpha) -0.0201789
RPL28 ribosomal protein L28 -0.0198573
KIAA1217 KIAA1217 -0.0196911
RPL36A ribosomal protein L36a -0.0195874
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0195832
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.019332
RRBP1 ribosome binding protein 1 -0.0192896
NME2 NME/NM23 nucleoside diphosphate kinase 2 -0.0190902
IFITM1 interferon induced transmembrane protein 1 -0.0189079
CCNI cyclin I -0.0185633
ARF1 ADP-ribosylation factor 1 -0.0184897
RPS5 ribosomal protein S5 -0.0184108
GPX4 glutathione peroxidase 4 -0.0183845
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0183529
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0182173