Doxycycline (monohydrate)_NCI-H460 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Doxycycline (monohydrate) perturbation in NCI-H460 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Doxycycline (monohydrate)_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0801415
NAMPT nicotinamide phosphoribosyltransferase 0.0719002
SPAG9 sperm associated antigen 9 0.0688065
KDM6A lysine (K)-specific demethylase 6A 0.0461063
FNDC3B fibronectin type III domain containing 3B 0.0437893
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0427316
KMT2C lysine (K)-specific methyltransferase 2C 0.0397655
NUP58 nucleoporin 58 0.0388552
ESYT2 extended synaptotagmin-like protein 2 0.0386209
AGFG1 ArfGAP with FG repeats 1 0.0374635
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0335837
KMT2E lysine (K)-specific methyltransferase 2E 0.0330092
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.031956
ATP13A3 ATPase type 13A3 0.0305581
WDR43 WD repeat domain 43 0.0303164
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0298608
USP3 ubiquitin specific peptidase 3 0.0297118
FAM13A family with sequence similarity 13, member A 0.0296318
NCKAP1 NCK-associated protein 1 0.0293166
SOD2 superoxide dismutase 2, mitochondrial 0.029142
ADAM17 ADAM metallopeptidase domain 17 0.0291413
UBA6 ubiquitin-like modifier activating enzyme 6 0.0289371
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0278452
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.0273548
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0272285
CAMTA1 calmodulin binding transcription activator 1 0.026811
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0262345
CDC73 cell division cycle 73 0.0256733
RNF145 ring finger protein 145 0.0255834
NBAS neuroblastoma amplified sequence 0.0253274
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9 0.0250719
HELZ helicase with zinc finger 0.0240263
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0236733
WAC WW domain containing adaptor with coiled-coil 0.0235084
PUM2 pumilio RNA-binding family member 2 0.0230481
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0227361
TNIP1 TNFAIP3 interacting protein 1 0.0222415
ANXA5 annexin A5 0.021693
USP9X ubiquitin specific peptidase 9, X-linked 0.0216416
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0212555
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0211096
AHCTF1 AT hook containing transcription factor 1 0.0210434
RTN4 reticulon 4 0.0206212
TSC22D2 TSC22 domain family, member 2 0.02053
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0202593
CHD1 chromodomain helicase DNA binding protein 1 0.0198315
TRIO trio Rho guanine nucleotide exchange factor 0.0196758
TFG TRK-fused gene 0.0196647
ECPAS Ecm29 proteasome adaptor and scaffold 0.019584
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0191614
ZNF292 zinc finger protein 292 0.0189668
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.018958
PDPK1 3-phosphoinositide dependent protein kinase 1 0.0183833
ADAM9 ADAM metallopeptidase domain 9 0.018021
MCL1 myeloid cell leukemia 1 0.0177496
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0172853
MSN moesin 0.0169761
PTK2 protein tyrosine kinase 2 0.016956
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0168517
ANKRD11 ankyrin repeat domain 11 0.0168326
ZFAND3 zinc finger, AN1-type domain 3 0.0166787
CXCL8 chemokine (C-X-C motif) ligand 8 0.016603
GRB10 growth factor receptor-bound protein 10 0.0165736
NCAM1 neural cell adhesion molecule 1 0.0165345
ARRDC3 arrestin domain containing 3 0.0165068
CTBP2 C-terminal binding protein 2 0.0165006
LRRFIP2 leucine rich repeat (in FLII) interacting protein 2 0.0164134
SUCO SUN domain containing ossification factor 0.0163453
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.0162792
OLA1 Obg-like ATPase 1 0.0161673
AHR aryl hydrocarbon receptor 0.0160928
MATR3 matrin 3 0.0160892
ERRFI1 ERBB receptor feedback inhibitor 1 0.0160567
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.015969
NGLY1 N-glycanase 1 0.0157912
HOOK2 hook microtubule-tethering protein 2 0.0156488
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.015204
MYO1B myosin IB 0.0150687
SRPK2 SRSF protein kinase 2 0.0150312
RBM39 RNA binding motif protein 39 0.0148624
TPD52 tumor protein D52 0.014729
CCNL1 cyclin L1 0.0147169
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0147148
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 0.0144609
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0144123
RAD23B RAD23 homolog B (S. cerevisiae) 0.0142421
PCBP2 poly(rC) binding protein 2 0.013994
CNOT4 CCR4-NOT transcription complex, subunit 4 0.0138096
CHD1L chromodomain helicase DNA binding protein 1-like 0.0137821
DPY19L1 dpy-19-like 1 (C. elegans) 0.0137404
RASA2 RAS p21 protein activator 2 0.0137397
RICTOR RPTOR independent companion of MTOR, complex 2 0.0136498
DIAPH1 diaphanous-related formin 1 0.0135428
EGLN1 egl-9 family hypoxia-inducible factor 1 0.0135386
USP12 ubiquitin specific peptidase 12 0.0134912
PIK3C3 phosphatidylinositol 3-kinase, catalytic subunit type 3 0.0134889
DENND4A DENN/MADD domain containing 4A 0.0134776
TRA2A transformer 2 alpha homolog (Drosophila) 0.0134503
FAR1 fatty acyl CoA reductase 1 0.0134486
SMG7 SMG7 nonsense mediated mRNA decay factor 0.0134365

decreased expression

Symbol Name Standardized Value
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.258986
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.196821
PDE4D phosphodiesterase 4D, cAMP-specific -0.15049
VIM vimentin -0.140828
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.1283
TMSB10 thymosin beta 10 -0.119221
GDA guanine deaminase -0.105123
FTL ferritin, light polypeptide -0.0964997
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0939948
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0926416
RPS6 ribosomal protein S6 -0.0924987
TPT1 tumor protein, translationally-controlled 1 -0.0918388
RPLP1 ribosomal protein, large, P1 -0.0916791
PTMA prothymosin, alpha -0.0888289
PM20D1 peptidase M20 domain containing 1 -0.0801278
RPS8 ribosomal protein S8 -0.079124
RPL12 ribosomal protein L12 -0.0780872
FN1 fibronectin 1 -0.0742609
RPL35A ribosomal protein L35a -0.0741147
PDE10A phosphodiesterase 10A -0.0732713
P3H2 prolyl 3-hydroxylase 2 -0.0703348
RPL26 ribosomal protein L26 -0.070205
SMYD3 SET and MYND domain containing 3 -0.0684287
RPL31 ribosomal protein L31 -0.0681078
RPS12 ribosomal protein S12 -0.0679241
RPL37A ribosomal protein L37a -0.0649679
BASP1 brain abundant, membrane attached signal protein 1 -0.0607088
RPL19 ribosomal protein L19 -0.0604456
RPS24 ribosomal protein S24 -0.0603932
MT2A metallothionein 2A -0.05894
PDLIM5 PDZ and LIM domain 5 -0.0579309
KYNU kynureninase -0.057783
RPS19 ribosomal protein S19 -0.0577149
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) -0.0555273
TFPI2 tissue factor pathway inhibitor 2 -0.0554382
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 -0.0548741
S100A6 S100 calcium binding protein A6 -0.0545441
EIF1 eukaryotic translation initiation factor 1 -0.053038
RPS3 ribosomal protein S3 -0.0528908
NPAS2 neuronal PAS domain protein 2 -0.0526573
DST dystonin -0.0513441
RPS27A ribosomal protein S27a -0.0508347
VCL vinculin -0.0499574
RPLP0 ribosomal protein, large, P0 -0.0484328
RPL23 ribosomal protein L23 -0.0481436
RPL36A ribosomal protein L36a -0.0480915
RPL34 ribosomal protein L34 -0.0478546
COL5A2 collagen, type V, alpha 2 -0.0472867
RPL7A ribosomal protein L7a -0.0463307
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0450475
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 -0.044712
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0446518
PLEKHA5 pleckstrin homology domain containing, family A member 5 -0.0444253
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0443348
RPL9 ribosomal protein L9 -0.0443135
PSD3 pleckstrin and Sec7 domain containing 3 -0.0442481
RPLP2 ribosomal protein, large, P2 -0.0430616
RPS23 ribosomal protein S23 -0.0429502
RPL36 ribosomal protein L36 -0.0423835
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.042183
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0414483
NCOA7 nuclear receptor coactivator 7 -0.0410509
ACTG1 actin gamma 1 -0.0410399
RPS27 ribosomal protein S27 -0.0408157
GNAS GNAS complex locus -0.0406125
RGS2 regulator of G-protein signaling 2 -0.0404741
TM4SF1 transmembrane 4 L six family member 1 -0.0397407
SOX4 SRY (sex determining region Y)-box 4 -0.03951
RPL11 ribosomal protein L11 -0.0394707
RACK1 receptor for activated C kinase 1 -0.0390079
COL8A1 collagen, type VIII, alpha 1 -0.0382267
CANX calnexin -0.0380748
MYOF myoferlin -0.0376895
RPS14 ribosomal protein S14 -0.0369097
RPS21 ribosomal protein S21 -0.036855
RPL37 ribosomal protein L37 -0.0364209
INHBA inhibin, beta A -0.0361679
TGFBI transforming growth factor, beta-induced, 68kDa -0.0361409
SLC38A2 solute carrier family 38, member 2 -0.0359967
NT5C2 5'-nucleotidase, cytosolic II -0.0353388
DPP10 dipeptidyl-peptidase 10 (non-functional) -0.0351948
RPS29 ribosomal protein S29 -0.0349248
RPS4X ribosomal protein S4, X-linked -0.0347729
PDE3A phosphodiesterase 3A, cGMP-inhibited -0.0343794
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0343219
RPL35 ribosomal protein L35 -0.0341392
SH3KBP1 SH3-domain kinase binding protein 1 -0.0340034
RPL13A ribosomal protein L13a -0.0338912
AGTPBP1 ATP/GTP binding protein 1 -0.033784
IGFBP3 insulin-like growth factor binding protein 3 -0.0337091
NTN4 netrin 4 -0.0336066
RPS16 ribosomal protein S16 -0.0331577
COL4A5 collagen, type IV, alpha 5 -0.0326784
RPS13 ribosomal protein S13 -0.0325027
PRKN parkin RBR E3 ubiquitin protein ligase -0.0325016
HLA-B major histocompatibility complex, class I, B -0.0324906
CDH13 cadherin 13 -0.0322182
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 -0.0322048
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0320037
ANTXR1 anthrax toxin receptor 1 -0.0318095