| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Doxycycline (monohydrate) perturbation in NCI-H661 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Doxycycline (monohydrate)_NCI-H661 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 0.0378292 |
| ARHGAP15 | Rho GTPase activating protein 15 | 0.0372189 |
| MED13L | mediator complex subunit 13-like | 0.0348134 |
| PCBP2 | poly(rC) binding protein 2 | 0.032294 |
| ELF2 | E74-like factor 2 (ets domain transcription factor) | 0.0286521 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0285076 |
| CTNNA2 | catenin (cadherin-associated protein), alpha 2 | 0.0232128 |
| PGAP1 | post-GPI attachment to proteins 1 | 0.0217447 |
| KDM5B | lysine (K)-specific demethylase 5B | 0.0205267 |
| TSC22D2 | TSC22 domain family, member 2 | 0.0203527 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.0197328 |
| ATP11B | ATPase, class VI, type 11B | 0.0197139 |
| TMBIM6 | transmembrane BAX inhibitor motif containing 6 | 0.0193781 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0182636 |
| FER | fer (fps/fes related) tyrosine kinase | 0.018236 |
| CALCR | calcitonin receptor | 0.0181396 |
| CCDC102B | coiled-coil domain containing 102B | 0.0179513 |
| LAMP2 | lysosomal-associated membrane protein 2 | 0.0179121 |
| CAPZA2 | capping protein (actin filament) muscle Z-line, alpha 2 | 0.0178359 |
| TCERG1 | transcription elongation regulator 1 | 0.0177382 |
| CFL2 | cofilin 2 (muscle) | 0.0176977 |
| NLGN1 | neuroligin 1 | 0.0176578 |
| KIF1B | kinesin family member 1B | 0.0173887 |
| COL8A1 | collagen, type VIII, alpha 1 | 0.017299 |
| MYO10 | myosin X | 0.0172239 |
| WDR43 | WD repeat domain 43 | 0.0171817 |
| ADGRV1 | adhesion G protein-coupled receptor V1 | 0.0171678 |
| PPP4R1 | protein phosphatase 4, regulatory subunit 1 | 0.0169772 |
| GTF2A1 | general transcription factor IIA, 1, 19/37kDa | 0.016855 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.0168506 |
| SIK3 | SIK family kinase 3 | 0.0168267 |
| BTBD9 | BTB (POZ) domain containing 9 | 0.016603 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0165053 |
| ASCC3 | activating signal cointegrator 1 complex subunit 3 | 0.0163544 |
| HNRNPH3 | heterogeneous nuclear ribonucleoprotein H3 (2H9) | 0.0160044 |
| MYO6 | myosin VI | 0.0159759 |
| TBC1D12 | TBC1 domain family, member 12 | 0.0159622 |
| SS18 | synovial sarcoma translocation, chromosome 18 | 0.0157715 |
| CMSS1 | cms1 ribosomal small subunit homolog (yeast) | 0.0156669 |
| EXOC4 | exocyst complex component 4 | 0.0155762 |
| SMARCAD1 | SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1 | 0.01557 |
| GSK3B | glycogen synthase kinase 3 beta | 0.0155166 |
| MSN | moesin | 0.015471 |
| RIGI | RNA sensor RIG-I | 0.0152792 |
| SMARCA1 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 | 0.0152678 |
| NCOR2 | nuclear receptor corepressor 2 | 0.0151666 |
| USP12 | ubiquitin specific peptidase 12 | 0.0148554 |
| GASK1B | golgi associated kinase 1B | 0.0148519 |
| DST | dystonin | 0.0148424 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | 0.0146632 |
| RPL3 | ribosomal protein L3 | 0.014468 |
| RAPH1 | Ras association (RalGDS/AF-6) and pleckstrin homology domains 1 | 0.0144153 |
| DENND4C | DENN/MADD domain containing 4C | 0.0143728 |
| CEP135 | centrosomal protein 135kDa | 0.0143115 |
| POSTN | periostin, osteoblast specific factor | 0.0142824 |
| SLMAP | sarcolemma associated protein | 0.0142736 |
| SLC35F5 | solute carrier family 35, member F5 | 0.0142417 |
| FBXO11 | F-box protein 11 | 0.0142181 |
| RERG | RAS-like, estrogen-regulated, growth inhibitor | 0.0142045 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | 0.0141001 |
| YAP1 | Yes-associated protein 1 | 0.0139079 |
| ERBIN | erbb2 interacting protein | 0.0138966 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | 0.0138423 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | 0.0138208 |
| ZFC3H1 | zinc finger, C3H1-type containing | 0.0137853 |
| CCDC14 | coiled-coil domain containing 14 | 0.0135532 |
| IPO7 | importin 7 | 0.0135418 |
| VMP1 | vacuole membrane protein 1 | 0.0135283 |
| CBFB | core-binding factor, beta subunit | 0.0135028 |
| FIP1L1 | factor interacting with PAPOLA and CPSF1 | 0.0134974 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | 0.0133191 |
| FEM1C | fem-1 homolog c (C. elegans) | 0.0132525 |
| PIK3CA | phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha | 0.0132486 |
| CD109 | CD109 molecule | 0.0131685 |
| R3HDM1 | R3H domain containing 1 | 0.0131572 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0131108 |
| CWC22 | CWC22 spliceosome-associated protein | 0.0131059 |
| NPTN | neuroplastin | 0.0129745 |
| SEL1L | sel-1 suppressor of lin-12-like (C. elegans) | 0.0129571 |
| NRIP1 | nuclear receptor interacting protein 1 | 0.0128807 |
| CFAP20 | cilia and flagella associated protein 20 | 0.0128487 |
| ZNF608 | zinc finger protein 608 | 0.0128224 |
| MB21D2 | Mab-21 domain containing 2 | 0.012737 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0126151 |
| SPICE1 | spindle and centriole associated protein 1 | 0.0125829 |
| CLINT1 | clathrin interactor 1 | 0.0125191 |
| MTF2 | metal response element binding transcription factor 2 | 0.0123922 |
| ZDBF2 | zinc finger, DBF-type containing 2 | 0.0123815 |
| APPL1 | adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1 | 0.0123702 |
| ARL15 | ADP-ribosylation factor-like 15 | 0.0123474 |
| ARID1B | AT rich interactive domain 1B (SWI1-like) | 0.0123174 |
| ARMH3 | armadillo like helical domain containing 3 | 0.0123058 |
| FOXN3 | forkhead box N3 | 0.0122087 |
| FBXW7 | F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase | 0.0121605 |
| HLTF | helicase-like transcription factor | 0.0121266 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0120154 |
| RALB | v-ral simian leukemia viral oncogene homolog B | 0.0119847 |
| PRKAR1A | protein kinase, cAMP-dependent, regulatory, type I, alpha | 0.0119624 |
| EFR3A | EFR3 homolog A (S. cerevisiae) | 0.0119377 |
| LYST | lysosomal trafficking regulator | 0.011931 |
| Symbol | Name | Standardized Value |
|---|---|---|
| VIM | vimentin | -0.22163 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.138258 |
| PTMA | prothymosin, alpha | -0.12767 |
| TMSB10 | thymosin beta 10 | -0.112554 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0960598 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.093478 |
| RPS16 | ribosomal protein S16 | -0.093153 |
| PCDH9 | protocadherin 9 | -0.0855451 |
| ACTG1 | actin gamma 1 | -0.083467 |
| CDH6 | cadherin 6, type 2, K-cadherin (fetal kidney) | -0.0833136 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.074691 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0735346 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.071141 |
| RPS8 | ribosomal protein S8 | -0.0707118 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0688843 |
| CDH10 | cadherin 10, type 2 (T2-cadherin) | -0.0663585 |
| RPLP1 | ribosomal protein, large, P1 | -0.0661968 |
| TMSB4X | thymosin beta 4, X-linked | -0.0659764 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.061335 |
| RPL11 | ribosomal protein L11 | -0.0580343 |
| MYL12B | myosin, light chain 12B, regulatory | -0.057326 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0569307 |
| GNAS | GNAS complex locus | -0.0562469 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.0551739 |
| RPS6 | ribosomal protein S6 | -0.0527015 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0485011 |
| THBS1 | thrombospondin 1 | -0.0479371 |
| COL11A1 | collagen, type XI, alpha 1 | -0.0475661 |
| BMPR2 | bone morphogenetic protein receptor, type II (serine/threonine kinase) | -0.0467688 |
| ERBB4 | erb-b2 receptor tyrosine kinase 4 | -0.0465983 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0452031 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0445698 |
| RPS21 | ribosomal protein S21 | -0.04413 |
| PCLO | piccolo presynaptic cytomatrix protein | -0.043646 |
| MRPS30 | mitochondrial ribosomal protein S30 | -0.043102 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.042786 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0418777 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0409378 |
| IRF2BP2 | interferon regulatory factor 2 binding protein 2 | -0.0408334 |
| RFPL4B | ret finger protein-like 4B | -0.0390606 |
| SRP72 | signal recognition particle 72kDa | -0.0390277 |
| NCOR1 | nuclear receptor corepressor 1 | -0.037347 |
| DEK | DEK proto-oncogene | -0.0368906 |
| RLF | rearranged L-myc fusion | -0.0365915 |
| HS3ST5 | heparan sulfate (glucosamine) 3-O-sulfotransferase 5 | -0.0360107 |
| SNX6 | sorting nexin 6 | -0.0359012 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.035299 |
| RPS24 | ribosomal protein S24 | -0.0352679 |
| BACH2 | BTB and CNC homology 1, basic leucine zipper transcription factor 2 | -0.0347041 |
| ADGRL2 | adhesion G protein-coupled receptor L2 | -0.0346566 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0344255 |
| RPS3 | ribosomal protein S3 | -0.0343589 |
| MDK | midkine (neurite growth-promoting factor 2) | -0.0342951 |
| CALR | calreticulin | -0.0340829 |
| RPS19 | ribosomal protein S19 | -0.0337048 |
| RPL12 | ribosomal protein L12 | -0.0336542 |
| RSL1D1 | ribosomal L1 domain containing 1 | -0.0334252 |
| SF3B2 | splicing factor 3b, subunit 2, 145kDa | -0.0329619 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0328998 |
| RPS12 | ribosomal protein S12 | -0.0328027 |
| H1-0 | H1.0 linker histone | -0.0326658 |
| HMGB2 | high mobility group box 2 | -0.0324102 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | -0.0321438 |
| FOXP2 | forkhead box P2 | -0.0319307 |
| TPR | translocated promoter region, nuclear basket protein | -0.0315761 |
| CADM2 | cell adhesion molecule 2 | -0.0314414 |
| MKI67 | marker of proliferation Ki-67 | -0.0309343 |
| RPL31 | ribosomal protein L31 | -0.0308607 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0306536 |
| RPL19 | ribosomal protein L19 | -0.0305459 |
| IGF1R | insulin-like growth factor 1 receptor | -0.030466 |
| RPL37 | ribosomal protein L37 | -0.0298214 |
| COL3A1 | collagen, type III, alpha 1 | -0.0295239 |
| RACK1 | receptor for activated C kinase 1 | -0.0291125 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | -0.028909 |
| TNRC6B | trinucleotide repeat containing 6B | -0.0288032 |
| GPC3 | glypican 3 | -0.0287214 |
| PTGES3 | prostaglandin E synthase 3 (cytosolic) | -0.0284076 |
| PEG10 | paternally expressed 10 | -0.0283698 |
| KIF5B | kinesin family member 5B | -0.0283129 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0280724 |
| TPM4 | tropomyosin 4 | -0.0279859 |
| CNRIP1 | cannabinoid receptor interacting protein 1 | -0.0279513 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0273671 |
| RPS25 | ribosomal protein S25 | -0.0272762 |
| ARF1 | ADP-ribosylation factor 1 | -0.0271917 |
| MAP4 | microtubule-associated protein 4 | -0.0267966 |
| NIPBL | Nipped-B homolog (Drosophila) | -0.0266228 |
| BAZ1A | bromodomain adjacent to zinc finger domain, 1A | -0.0265498 |
| ANKRD12 | ankyrin repeat domain 12 | -0.026438 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0264059 |
| KIF4A | kinesin family member 4A | -0.0263853 |
| RPL38 | ribosomal protein L38 | -0.0258658 |
| CXADR | coxsackie virus and adenovirus receptor | -0.0258293 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0256111 |
| KHDRBS1 | KH domain containing, RNA binding, signal transduction associated 1 | -0.0255454 |
| FBL | fibrillarin | -0.0255313 |
| RPL32 | ribosomal protein L32 | -0.0255229 |
| PAFAH1B1 | platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) | -0.0254582 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | -0.0254383 |
