| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Doxycycline (monohydrate) perturbation in RPMI-7951 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Doxycycline (monohydrate)_RPMI-7951 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| FN1 | fibronectin 1 | 0.104344 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0989213 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.0673536 |
| CENPF | centromere protein F, 350/400kDa | 0.0472889 |
| PGK1 | phosphoglycerate kinase 1 | 0.0422158 |
| ZNF292 | zinc finger protein 292 | 0.0411062 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0400149 |
| PTPN14 | protein tyrosine phosphatase, non-receptor type 14 | 0.0381631 |
| ATP13A3 | ATPase type 13A3 | 0.0377958 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0374537 |
| ECT2 | epithelial cell transforming 2 | 0.0365502 |
| CD44 | CD44 molecule (Indian blood group) | 0.036016 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | 0.0354491 |
| MSN | moesin | 0.0352493 |
| GSK3B | glycogen synthase kinase 3 beta | 0.034528 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0338419 |
| TFG | TRK-fused gene | 0.0336422 |
| XPO1 | exportin 1 | 0.0319589 |
| TGM2 | transglutaminase 2 | 0.0315599 |
| POTEF | POTE ankyrin domain family, member F | 0.0312023 |
| LRRFIP2 | leucine rich repeat (in FLII) interacting protein 2 | 0.0304378 |
| GPCPD1 | glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) | 0.0303466 |
| DIAPH3 | diaphanous-related formin 3 | 0.0298945 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0294875 |
| PTBP2 | polypyrimidine tract binding protein 2 | 0.0287083 |
| ZFAND6 | zinc finger, AN1-type domain 6 | 0.028324 |
| ZNF148 | zinc finger protein 148 | 0.0283042 |
| CDCP1 | CUB domain containing protein 1 | 0.028022 |
| MKI67 | marker of proliferation Ki-67 | 0.0279996 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0278352 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0276593 |
| YEATS2 | YEATS domain containing 2 | 0.0271627 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.0267431 |
| NRIP1 | nuclear receptor interacting protein 1 | 0.0267208 |
| THBS1 | thrombospondin 1 | 0.0263123 |
| SMC4 | structural maintenance of chromosomes 4 | 0.0259707 |
| WWTR1 | WW domain containing transcription regulator 1 | 0.0255205 |
| RAD23B | RAD23 homolog B (S. cerevisiae) | 0.0254442 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0253086 |
| NUP58 | nucleoporin 58 | 0.0248851 |
| PUM2 | pumilio RNA-binding family member 2 | 0.0248808 |
| BCLAF1 | BCL2-associated transcription factor 1 | 0.0246913 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0246714 |
| FKBP1A | FK506 binding protein 1A, 12kDa | 0.0246019 |
| NAV2 | neuron navigator 2 | 0.0235147 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0234995 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.0234473 |
| TXNRD1 | thioredoxin reductase 1 | 0.0232246 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.0232219 |
| SPRED1 | sprouty-related, EVH1 domain containing 1 | 0.0231813 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0227661 |
| ANKRD28 | ankyrin repeat domain 28 | 0.022633 |
| ASPM | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) | 0.0225484 |
| ITGAV | integrin, alpha V | 0.021612 |
| AFAP1 | actin filament associated protein 1 | 0.0215921 |
| GOLGA4 | golgin A4 | 0.0211516 |
| DHX15 | DEAH (Asp-Glu-Ala-His) box helicase 15 | 0.020949 |
| NCKAP1 | NCK-associated protein 1 | 0.0209417 |
| OGT | O-linked N-acetylglucosamine (GlcNAc) transferase | 0.0208158 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0203143 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0201286 |
| RNF145 | ring finger protein 145 | 0.0199918 |
| PHC2 | polyhomeotic homolog 2 (Drosophila) | 0.0199325 |
| ARHGAP11A | Rho GTPase activating protein 11A | 0.0198553 |
| HNRNPDL | heterogeneous nuclear ribonucleoprotein D-like | 0.0198084 |
| PDPK1 | 3-phosphoinositide dependent protein kinase 1 | 0.0197222 |
| FLNB | filamin B, beta | 0.0196879 |
| PIAS1 | protein inhibitor of activated STAT, 1 | 0.0196575 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0194472 |
| CKAP5 | cytoskeleton associated protein 5 | 0.0194438 |
| CLTC | clathrin, heavy chain (Hc) | 0.0194183 |
| ATP2C1 | ATPase, Ca++ transporting, type 2C, member 1 | 0.0193998 |
| ITCH | itchy E3 ubiquitin protein ligase | 0.0193508 |
| KIF4A | kinesin family member 4A | 0.0192328 |
| TMEM39A | transmembrane protein 39A | 0.0191144 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0191137 |
| NCAM1 | neural cell adhesion molecule 1 | 0.0189061 |
| ACTR3 | ARP3 actin-related protein 3 homolog (yeast) | 0.0187286 |
| SNAP25 | synaptosomal-associated protein, 25kDa | 0.0185826 |
| RAB8B | RAB8B, member RAS oncogene family | 0.0185569 |
| SMAD3 | SMAD family member 3 | 0.0185282 |
| MYO1B | myosin IB | 0.0184156 |
| AFDN | afadin, adherens junction formation factor | 0.0182428 |
| CKAP2L | cytoskeleton associated protein 2-like | 0.0180785 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.0179879 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0178623 |
| U2SURP | U2 snRNP-associated SURP domain containing | 0.0178404 |
| PCBP2 | poly(rC) binding protein 2 | 0.0176938 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0176781 |
| STRN3 | striatin, calmodulin binding protein 3 | 0.0176157 |
| SGO2 | shugoshin 2 | 0.0175326 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0174636 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0171823 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 0.0171285 |
| CKAP2 | cytoskeleton associated protein 2 | 0.017087 |
| PPME1 | protein phosphatase methylesterase 1 | 0.017071 |
| MLLT10 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 | 0.0170385 |
| WSB1 | WD repeat and SOCS box containing 1 | 0.0168932 |
| PHC3 | polyhomeotic homolog 3 (Drosophila) | 0.0168571 |
| MATR3 | matrin 3 | 0.0168197 |
| Symbol | Name | Standardized Value |
|---|---|---|
| VIM | vimentin | -0.219104 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.120663 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.106067 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0938454 |
| CDH13 | cadherin 13 | -0.0871028 |
| HLA-B | major histocompatibility complex, class I, B | -0.0766217 |
| FTL | ferritin, light polypeptide | -0.0757589 |
| COL1A1 | collagen, type I, alpha 1 | -0.0740835 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | -0.0729686 |
| COL1A2 | collagen, type I, alpha 2 | -0.0619787 |
| ITPR1 | inositol 1,4,5-trisphosphate receptor, type 1 | -0.0618319 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0605527 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0564454 |
| EGR1 | early growth response 1 | -0.0547984 |
| MT2A | metallothionein 2A | -0.0496832 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0493452 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0485648 |
| LOXL2 | lysyl oxidase-like 2 | -0.047578 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | -0.0473351 |
| SP100 | SP100 nuclear antigen | -0.0461263 |
| NAV1 | neuron navigator 1 | -0.0458784 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0449881 |
| TENT5A | terminal nucleotidyltransferase 5A | -0.0440939 |
| COL6A2 | collagen, type VI, alpha 2 | -0.041812 |
| SLIT2 | slit homolog 2 (Drosophila) | -0.0416362 |
| B2M | beta-2-microglobulin | -0.0412135 |
| RPLP1 | ribosomal protein, large, P1 | -0.0401617 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0388977 |
| TMSB10 | thymosin beta 10 | -0.0387032 |
| RALY | RALY heterogeneous nuclear ribonucleoprotein | -0.0380609 |
| IER3 | immediate early response 3 | -0.0374816 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0368875 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0366156 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0362122 |
| PTMA | prothymosin, alpha | -0.0360747 |
| ANXA2 | annexin A2 | -0.0350283 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0349915 |
| COL5A1 | collagen, type V, alpha 1 | -0.0344212 |
| RRBP1 | ribosome binding protein 1 | -0.0334931 |
| HDLBP | high density lipoprotein binding protein | -0.0321752 |
| H1-0 | H1.0 linker histone | -0.0319164 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.0308351 |
| HLA-A | major histocompatibility complex, class I, A | -0.0299675 |
| TMEM178B | transmembrane protein 178B | -0.0295741 |
| ARL4C | ADP-ribosylation factor-like 4C | -0.0293832 |
| S100A10 | S100 calcium binding protein A10 | -0.0288419 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0286953 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0280364 |
| HDAC9 | histone deacetylase 9 | -0.0277979 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0276687 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0272271 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.0264717 |
| RPL35A | ribosomal protein L35a | -0.0263918 |
| LMNA | lamin A/C | -0.0262187 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | -0.0255487 |
| GRB10 | growth factor receptor-bound protein 10 | -0.0252872 |
| TNS3 | tensin 3 | -0.025287 |
| BZW2 | basic leucine zipper and W2 domains 2 | -0.0251233 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.024989 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0247113 |
| RPS8 | ribosomal protein S8 | -0.0245884 |
| IFI16 | interferon, gamma-inducible protein 16 | -0.0243625 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.024175 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | -0.0240652 |
| SQSTM1 | sequestosome 1 | -0.0237565 |
| ACTG1 | actin gamma 1 | -0.023632 |
| CAVIN1 | caveolae associated protein 1 | -0.0234554 |
| JUN | jun proto-oncogene | -0.0233656 |
| INHBA | inhibin, beta A | -0.0232717 |
| ADM | adrenomedullin | -0.0232383 |
| CADM1 | cell adhesion molecule 1 | -0.0227038 |
| UBC | ubiquitin C | -0.0225944 |
| PPIB | peptidylprolyl isomerase B (cyclophilin B) | -0.0223515 |
| INTS6 | integrator complex subunit 6 | -0.022001 |
| LGALS1 | lectin, galactoside-binding, soluble, 1 | -0.0217438 |
| LPCAT2 | lysophosphatidylcholine acyltransferase 2 | -0.0217217 |
| DIP2C | DIP2 disco-interacting protein 2 homolog C (Drosophila) | -0.0214654 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.021236 |
| EGFR | epidermal growth factor receptor | -0.0212302 |
| PFKFB4 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 | -0.0212041 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.0211468 |
| ZBTB38 | zinc finger and BTB domain containing 38 | -0.0210809 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.020837 |
| GNAS | GNAS complex locus | -0.0205633 |
| RPS21 | ribosomal protein S21 | -0.0205314 |
| MYO1E | myosin IE | -0.0204707 |
| IFITM3 | interferon induced transmembrane protein 3 | -0.02045 |
| HLA-C | major histocompatibility complex, class I, C | -0.0204065 |
| CALR | calreticulin | -0.0203546 |
| RPS19 | ribosomal protein S19 | -0.0202749 |
| RND3 | Rho family GTPase 3 | -0.0199467 |
| FHIT | fragile histidine triad | -0.0198664 |
| IFRD1 | interferon-related developmental regulator 1 | -0.0197236 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0196837 |
| JARID2 | jumonji, AT rich interactive domain 2 | -0.0195749 |
| MYDGF | myeloid-derived growth factor | -0.0195389 |
| NABP1 | nucleic acid binding protein 1 | -0.0195285 |
| RPL8 | ribosomal protein L8 | -0.0194056 |
| P4HA2 | prolyl 4-hydroxylase, alpha polypeptide II | -0.0193573 |
| S100A9 | S100 calcium binding protein A9 | -0.019183 |
