Doxycycline (monohydrate)_SHP-77 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Doxycycline (monohydrate) perturbation in SHP-77 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Doxycycline (monohydrate)_SHP-77 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
NALF1 NALCN channel auxiliary factor 1 0.0915214
GPC6 glypican 6 0.0557002
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.0354548
KCND2 potassium channel, voltage gated Shal related subfamily D, member 2 0.030855
CACNA1D calcium channel, voltage-dependent, L type, alpha 1D subunit 0.02763
DTNA dystrobrevin, alpha 0.027002
NRG1 neuregulin 1 0.0256371
ESRRG estrogen-related receptor gamma 0.0251122
KCNB2 potassium channel, voltage gated Shab related subfamily B, member 2 0.0247377
GRB10 growth factor receptor-bound protein 10 0.0238262
PELI2 pellino E3 ubiquitin protein ligase family member 2 0.0236272
PDE4B phosphodiesterase 4B, cAMP-specific 0.0229405
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0208357
RPTOR regulatory associated protein of MTOR, complex 1 0.0204783
MBNL2 muscleblind-like splicing regulator 2 0.020119
RORA RAR-related orphan receptor A 0.0200681
RAD51B RAD51 paralog B 0.0198403
ADARB2 adenosine deaminase, RNA-specific, B2 (non-functional) 0.0191733
NBAS neuroblastoma amplified sequence 0.0187794
ADGRL2 adhesion G protein-coupled receptor L2 0.0187329
SMYD3 SET and MYND domain containing 3 0.0186384
ADGRL3 adhesion G protein-coupled receptor L3 0.0183836
RIT2 Ras-like without CAAX 2 0.0182941
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0179529
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 0.0178255
NKAIN2 Na+/K+ transporting ATPase interacting 2 0.0176801
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1 0.0176587
JAZF1 JAZF zinc finger 1 0.0172955
MSI2 musashi RNA-binding protein 2 0.0170158
MED13L mediator complex subunit 13-like 0.0170142
ZBTB20 zinc finger and BTB domain containing 20 0.0168828
KCTD8 potassium channel tetramerization domain containing 8 0.0166291
PSD3 pleckstrin and Sec7 domain containing 3 0.0164901
EPHA6 EPH receptor A6 0.0164459
SNTG1 syntrophin, gamma 1 0.0162013
SLC35F4 solute carrier family 35, member F4 0.0161255
KIF26B kinesin family member 26B 0.0159974
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0157264
CAMK1D calcium/calmodulin-dependent protein kinase ID 0.0157169
FGF14 fibroblast growth factor 14 0.0150804
AUTS2 autism susceptibility candidate 2 0.0148981
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 0.0148319
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0145071
CHD7 chromodomain helicase DNA binding protein 7 0.0143911
NDRG1 N-myc downstream regulated 1 0.0143785
EFNA5 ephrin-A5 0.0143636
TSHZ2 teashirt zinc finger homeobox 2 0.0141721
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) 0.0140065
GPC5 glypican 5 0.0140014
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.013805
AGMO alkylglycerol monooxygenase 0.0135429
KCNMB3 potassium channel subfamily M regulatory beta subunit 3 0.0133571
DACH1 dachshund family transcription factor 1 0.0132126
BCL2 B-cell CLL/lymphoma 2 0.0131963
EYA2 EYA transcriptional coactivator and phosphatase 2 0.013127
LINGO2 leucine rich repeat and Ig domain containing 2 0.0130033
NCAM1 neural cell adhesion molecule 1 0.0129004
DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila) 0.0128986
PCDH9 protocadherin 9 0.0128121
NUP58 nucleoporin 58 0.0128057
PCBP3 poly(rC) binding protein 3 0.012278
PTK2 protein tyrosine kinase 2 0.0122047
SERGEF secretion regulating guanine nucleotide exchange factor 0.0122023
FNIP1 folliculin interacting protein 1 0.0121217
MYT1L myelin transcription factor 1-like 0.0120889
LSAMP limbic system-associated membrane protein 0.0115876
GSE1 Gse1 coiled-coil protein 0.0115039
TPD52 tumor protein D52 0.0113729
MACF1 microtubule-actin crosslinking factor 1 0.0113473
RIMS2 regulating synaptic membrane exocytosis 2 0.0112787
CDH10 cadherin 10, type 2 (T2-cadherin) 0.0111889
POLR2B polymerase (RNA) II (DNA directed) polypeptide B, 140kDa 0.0110208
ITGAV integrin, alpha V 0.0110152
TRIO trio Rho guanine nucleotide exchange factor 0.0108684
NELL1 NEL-like 1 (chicken) 0.0108663
ZNF407 zinc finger protein 407 0.0107521
FSTL5 follistatin-like 5 0.0106139
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.0105356
BCLAF1 BCL2-associated transcription factor 1 0.0105268
FAF1 Fas (TNFRSF6) associated factor 1 0.0103602
CCNY cyclin Y 0.0102979
CDK5RAP2 CDK5 regulatory subunit associated protein 2 0.0102909
AVL9 AVL9 homolog (S. cerevisiase) 0.00994768
GIGYF2 GRB10 interacting GYF protein 2 0.00992781
ANKRD28 ankyrin repeat domain 28 0.00992701
PRKD1 protein kinase D1 0.00988874
IGFBP5 insulin-like growth factor binding protein 5 0.00982293
FKBP9 FK506 binding protein 9, 63 kDa 0.00980191
HDAC9 histone deacetylase 9 0.00979187
RIMBP2 RIMS binding protein 2 0.00966469
DGKB diacylglycerol kinase, beta 90kDa 0.00956006
PEX5L peroxisomal biogenesis factor 5-like 0.00950399
SCAF8 SR-related CTD-associated factor 8 0.00950377
TPP2 tripeptidyl peptidase II 0.0094603
SNX13 sorting nexin 13 0.00945009
FHIT fragile histidine triad 0.00939037
SSBP2 single-stranded DNA binding protein 2 0.00930343
BIRC6 baculoviral IAP repeat containing 6 0.00924401
SLCO3A1 solute carrier organic anion transporter family, member 3A1 0.00919168
NCKAP5 NCK-associated protein 5 0.00916691

decreased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha -0.141384
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.135321
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.103624
FTL ferritin, light polypeptide -0.0835995
CALCA calcitonin-related polypeptide alpha -0.0759094
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0570874
RPS6 ribosomal protein S6 -0.0532007
MT2A metallothionein 2A -0.0527149
RPLP1 ribosomal protein, large, P1 -0.0516735
RPS21 ribosomal protein S21 -0.0503466
RPS8 ribosomal protein S8 -0.050258
ENO1 enolase 1, (alpha) -0.0470125
RPS3 ribosomal protein S3 -0.0433885
VGF VGF nerve growth factor inducible -0.0415393
RPL8 ribosomal protein L8 -0.0414118
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0411488
RPL26 ribosomal protein L26 -0.0406095
RPL37A ribosomal protein L37a -0.040066
RPL11 ribosomal protein L11 -0.0376956
INHBA inhibin, beta A -0.037261
RPL23 ribosomal protein L23 -0.0371358
ACTG1 actin gamma 1 -0.0363429
IFI6 interferon, alpha-inducible protein 6 -0.0358224
RPS27A ribosomal protein S27a -0.034428
ATP5F1E ATP synthase F1 subunit epsilon -0.0338707
S100A9 S100 calcium binding protein A9 -0.0335783
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0330573
RPS19 ribosomal protein S19 -0.032912
RPL19 ribosomal protein L19 -0.0326566
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0322603
LOC112694756 uncharaterized LOC112694756 -0.0317098
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0313822
STC1 stanniocalcin 1 -0.0312458
SNAP25 synaptosomal-associated protein, 25kDa -0.0308465
RPS16 ribosomal protein S16 -0.0306879
RPL35 ribosomal protein L35 -0.0302577
RPS27 ribosomal protein S27 -0.0299032
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0293608
TMSB10 thymosin beta 10 -0.0290815
RPL38 ribosomal protein L38 -0.0280663
RPL37 ribosomal protein L37 -0.0280582
RPL7 ribosomal protein L7 -0.0276904
RPS25 ribosomal protein S25 -0.0274748
RPS12 ribosomal protein S12 -0.0272798
RPL31 ribosomal protein L31 -0.0266062
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 -0.0263566
TPT1 tumor protein, translationally-controlled 1 -0.0260331
UBB ubiquitin B -0.0259396
RPLP0 ribosomal protein, large, P0 -0.0257554
RPL12 ribosomal protein L12 -0.0256543
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0252355
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0249829
CHGA chromogranin A -0.0247768
EIF1 eukaryotic translation initiation factor 1 -0.0247453
GNAS GNAS complex locus -0.0244869
SF3B2 splicing factor 3b, subunit 2, 145kDa -0.0242468
H1-0 H1.0 linker histone -0.0240456
RPL36 ribosomal protein L36 -0.0240097
FNDC3A fibronectin type III domain containing 3A -0.0238126
ISG15 ISG15 ubiquitin-like modifier -0.0234652
RPL30 ribosomal protein L30 -0.0231485
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0230816
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0226509
RPS29 ribosomal protein S29 -0.0224421
IRS2 insulin receptor substrate 2 -0.022302
RPL7A ribosomal protein L7a -0.0217834
SCG2 secretogranin II -0.0217433
SEPTIN7 septin 7 -0.0216878
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0216153
RPS5 ribosomal protein S5 -0.0214606
RACK1 receptor for activated C kinase 1 -0.0213432
RPL35A ribosomal protein L35a -0.0213017
RPL28 ribosomal protein L28 -0.0212435
B2M beta-2-microglobulin -0.020767
RPL5 ribosomal protein L5 -0.0205916
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0205008
KPNB1 karyopherin (importin) beta 1 -0.0204272
RPL32 ribosomal protein L32 -0.0204092
RPLP2 ribosomal protein, large, P2 -0.0203303
RPL34 ribosomal protein L34 -0.0202475
TUBB4B tubulin, beta 4B class IVb -0.0201999
YBX1 Y box binding protein 1 -0.0201583
UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1 -0.01998
RPL36AL ribosomal protein L36a-like -0.0199018
HMGB1 high mobility group box 1 -0.019532
RPS23 ribosomal protein S23 -0.0194669
RPS11 ribosomal protein S11 -0.0193893
DEK DEK proto-oncogene -0.0192584
RPS17 ribosomal protein S17 -0.0192446
IGFBP2 insulin-like growth factor binding protein 2, 36kDa -0.0192149
PCSK1 proprotein convertase subtilisin/kexin type 1 -0.019169
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0188567
HMGB2 high mobility group box 2 -0.018659
SEZ6L2 seizure related 6 homolog (mouse)-like 2 -0.0185661
FOXC1 forkhead box C1 -0.018346
SOX4 SRY (sex determining region Y)-box 4 -0.018335
RPS14 ribosomal protein S14 -0.0182358
CPE carboxypeptidase E -0.0177336
RPS20 ribosomal protein S20 -0.0176937
DSTN destrin (actin depolymerizing factor) -0.0176823