Doxycycline (monohydrate)_SK-MEL-2 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Doxycycline (monohydrate) perturbation in SK-MEL-2 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Doxycycline (monohydrate)_SK-MEL-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.10075
SPAG9 sperm associated antigen 9 0.072611
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0645391
CXCL8 chemokine (C-X-C motif) ligand 8 0.0633416
FNDC3B fibronectin type III domain containing 3B 0.0601368
ZFAND3 zinc finger, AN1-type domain 3 0.0495843
NAMPT nicotinamide phosphoribosyltransferase 0.0417385
CHD1 chromodomain helicase DNA binding protein 1 0.0401313
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.038229
ADAM17 ADAM metallopeptidase domain 17 0.0380828
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0356895
CLIP4 CAP-GLY domain containing linker protein family, member 4 0.0331353
TXNRD1 thioredoxin reductase 1 0.0321639
CLINT1 clathrin interactor 1 0.0317429
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 0.0311399
ANKRD11 ankyrin repeat domain 11 0.031114
LINGO2 leucine rich repeat and Ig domain containing 2 0.0297816
QKI QKI, KH domain containing, RNA binding 0.0296835
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0292379
VMP1 vacuole membrane protein 1 0.028678
WAC WW domain containing adaptor with coiled-coil 0.0286353
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0283953
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0274824
SOD2 superoxide dismutase 2, mitochondrial 0.0274524
ATP13A3 ATPase type 13A3 0.0270235
TSC22D2 TSC22 domain family, member 2 0.0267981
MSN moesin 0.0267016
ZNF292 zinc finger protein 292 0.0266326
CAMTA1 calmodulin binding transcription activator 1 0.026595
ABI1 abl-interactor 1 0.0258982
GARS1 glycyl-tRNA synthetase 1 0.0254256
USP3 ubiquitin specific peptidase 3 0.0253772
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0253447
DSCAM Down syndrome cell adhesion molecule 0.0247122
PNPLA8 patatin-like phospholipase domain containing 8 0.0247051
TRIO trio Rho guanine nucleotide exchange factor 0.0245965
CDC73 cell division cycle 73 0.0244128
ELL2 elongation factor, RNA polymerase II, 2 0.0242784
RNF145 ring finger protein 145 0.0240134
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0238437
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.0231491
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0231439
EPS8 epidermal growth factor receptor pathway substrate 8 0.0231428
TFG TRK-fused gene 0.0229212
UBA6 ubiquitin-like modifier activating enzyme 6 0.0228474
OGA O-GlcNAcase 0.0228222
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.022765
AFDN afadin, adherens junction formation factor 0.022445
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0222863
NGLY1 N-glycanase 1 0.0220061
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0216721
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0216174
MATR3 matrin 3 0.0212535
CPEB2 cytoplasmic polyadenylation element binding protein 2 0.0212122
KMT2E lysine (K)-specific methyltransferase 2E 0.0209925
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0209312
SBF2 SET binding factor 2 0.020835
CORO1C coronin, actin binding protein, 1C 0.0205118
FMNL2 formin-like 2 0.0203123
GOLGA4 golgin A4 0.0200285
BHLHE40 basic helix-loop-helix family, member e40 0.0198301
CCNL1 cyclin L1 0.0198216
ANXA5 annexin A5 0.0198004
NAV2 neuron navigator 2 0.019653
GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 0.0195916
NCKAP1 NCK-associated protein 1 0.0195551
TRIM33 tripartite motif containing 33 0.0195369
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 0.0194638
NBAS neuroblastoma amplified sequence 0.0194362
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0193275
COPA coatomer protein complex, subunit alpha 0.0192855
RLF rearranged L-myc fusion 0.0191707
SREBF2 sterol regulatory element binding transcription factor 2 0.0191328
ARL15 ADP-ribosylation factor-like 15 0.0191144
NDRG1 N-myc downstream regulated 1 0.0189555
COG5 component of oligomeric golgi complex 5 0.0185041
GLS2 glutaminase 2 (liver, mitochondrial) 0.0184479
MARK3 MAP/microtubule affinity-regulating kinase 3 0.0184458
SNX9 sorting nexin 9 0.0183428
NUP58 nucleoporin 58 0.0182868
LRRFIP2 leucine rich repeat (in FLII) interacting protein 2 0.0182051
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0181126
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0180065
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0179049
ICAM1 intercellular adhesion molecule 1 0.0177752
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0177499
RTN4 reticulon 4 0.0177299
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.017666
RAB7A RAB7A, member RAS oncogene family 0.0176554
MEMO1 mediator of cell motility 1 0.0175909
MED13L mediator complex subunit 13-like 0.0175607
SLC39A11 solute carrier family 39, member 11 0.0174396
PUM2 pumilio RNA-binding family member 2 0.0173993
KMT2C lysine (K)-specific methyltransferase 2C 0.0173904
ZFAND6 zinc finger, AN1-type domain 6 0.0172515
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0172217
SLC25A26 solute carrier family 25 (S-adenosylmethionine carrier), member 26 0.0171547
ARRDC3 arrestin domain containing 3 0.0171247
PIK3C3 phosphatidylinositol 3-kinase, catalytic subunit type 3 0.0169069
AKAP13 A kinase (PRKA) anchor protein 13 0.016739

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.160288
NLGN1 neuroligin 1 -0.0681253
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0646229
RPS3 ribosomal protein S3 -0.0615342
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.054074
RPL35A ribosomal protein L35a -0.04663
MT2A metallothionein 2A -0.0458072
FTL ferritin, light polypeptide -0.044554
TMSB10 thymosin beta 10 -0.0420083
NRG3 neuregulin 3 -0.0415341
PTMA prothymosin, alpha -0.0410144
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0374426
IFI6 interferon, alpha-inducible protein 6 -0.0358512
RPS6 ribosomal protein S6 -0.0340924
RPLP1 ribosomal protein, large, P1 -0.0334067
AKAP12 A kinase (PRKA) anchor protein 12 -0.0322236
RPS8 ribosomal protein S8 -0.0305416
RPL37A ribosomal protein L37a -0.0290753
RPLP2 ribosomal protein, large, P2 -0.0274417
B2M beta-2-microglobulin -0.0273442
RPS12 ribosomal protein S12 -0.0269753
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 -0.0268665
RPL31 ribosomal protein L31 -0.0260028
RPL23 ribosomal protein L23 -0.0250583
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0241501
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0239778
FRMD4A FERM domain containing 4A -0.0238496
TPT1 tumor protein, translationally-controlled 1 -0.0231017
FN1 fibronectin 1 -0.022942
RPS13 ribosomal protein S13 -0.0226669
RPL11 ribosomal protein L11 -0.0223314
HLA-B major histocompatibility complex, class I, B -0.0221586
CCND1 cyclin D1 -0.0220923
S100A9 S100 calcium binding protein A9 -0.0218429
RPL34 ribosomal protein L34 -0.0210745
ENO1 enolase 1, (alpha) -0.0208767
FHIT fragile histidine triad -0.0207359
RPS14 ribosomal protein S14 -0.0202771
RPS19 ribosomal protein S19 -0.0201397
CDH13 cadherin 13 -0.0199971
EHBP1 EH domain binding protein 1 -0.0198776
RPL38 ribosomal protein L38 -0.0197409
ANGPTL4 angiopoietin-like 4 -0.0196661
RPS24 ribosomal protein S24 -0.0196517
TPI1 triosephosphate isomerase 1 -0.0194615
RPS29 ribosomal protein S29 -0.0192962
RPS27A ribosomal protein S27a -0.0192806
RPS21 ribosomal protein S21 -0.0190797
RRBP1 ribosome binding protein 1 -0.0187536
RPL19 ribosomal protein L19 -0.0186718
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0184393
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.018192
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 -0.0181822
VDAC1 voltage-dependent anion channel 1 -0.0180872
RPS16 ribosomal protein S16 -0.0177323
RPS23 ribosomal protein S23 -0.0174819
IFI16 interferon, gamma-inducible protein 16 -0.0173093
IFITM3 interferon induced transmembrane protein 3 -0.0168504
RPL12 ribosomal protein L12 -0.01681
FOXP1 forkhead box P1 -0.0166162
RPL36A ribosomal protein L36a -0.0165716
RACK1 receptor for activated C kinase 1 -0.0163879
PRAME preferentially expressed antigen in melanoma -0.0163431
APOD apolipoprotein D -0.0163214
ZMYND8 zinc finger, MYND-type containing 8 -0.016265
ACTG1 actin gamma 1 -0.016082
RPL36 ribosomal protein L36 -0.016016
RAD51B RAD51 paralog B -0.0157574
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0157108
TOB2 transducer of ERBB2, 2 -0.0156719
RPL9 ribosomal protein L9 -0.0155524
SQSTM1 sequestosome 1 -0.0154271
RPL27 ribosomal protein L27 -0.0152848
LITAF lipopolysaccharide-induced TNF factor -0.0152508
RPL32 ribosomal protein L32 -0.0149886
CENPF centromere protein F, 350/400kDa -0.0149524
ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) -0.0149336
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0148185
MAML3 mastermind-like 3 (Drosophila) -0.014445
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0141998
CBX3 chromobox homolog 3 -0.014178
RHOBTB3 Rho-related BTB domain containing 3 -0.0139309
SP100 SP100 nuclear antigen -0.0137508
RNF213 ring finger protein 213 -0.0136917
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0136124
RPS17 ribosomal protein S17 -0.0135902
RPL26 ribosomal protein L26 -0.0133469
RPS25 ribosomal protein S25 -0.0133381
ZBTB20 zinc finger and BTB domain containing 20 -0.0130691
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0129514
TMTC2 transmembrane and tetratricopeptide repeat containing 2 -0.0127676
KIAA1549L KIAA1549-like -0.0126511
IFIH1 interferon induced with helicase C domain 1 -0.012648
ARPC1B actin related protein 2/3 complex, subunit 1B, 41kDa -0.0125164
MT1X metallothionein 1X -0.0123383
RPL37 ribosomal protein L37 -0.0123356
CDK6 cyclin-dependent kinase 6 -0.0123239
CTSD cathepsin D -0.0122873
RPL30 ribosomal protein L30 -0.0122246
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0120809