Doxycycline (monohydrate)_SNU-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Doxycycline (monohydrate) perturbation in SNU-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Doxycycline (monohydrate)_SNU-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ADAM10 ADAM metallopeptidase domain 10 0.057082
VCL vinculin 0.0467946
PDE4D phosphodiesterase 4D, cAMP-specific 0.0455322
EML4 echinoderm microtubule associated protein like 4 0.0452274
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0446173
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0377342
SOX6 SRY (sex determining region Y)-box 6 0.0370864
ZEB1 zinc finger E-box binding homeobox 1 0.0361635
PYGB phosphorylase, glycogen; brain 0.03515
HDAC9 histone deacetylase 9 0.0330398
AHNAK AHNAK nucleoprotein 0.0317953
FLNB filamin B, beta 0.0306824
ECT2 epithelial cell transforming 2 0.0303725
SSBP2 single-stranded DNA binding protein 2 0.0300971
PDGFC platelet derived growth factor C 0.0293926
RTN4 reticulon 4 0.0288818
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0287659
ZNF292 zinc finger protein 292 0.0287153
CAMTA1 calmodulin binding transcription activator 1 0.0282673
EGFR epidermal growth factor receptor 0.0277793
NBEA neurobeachin 0.0272436
PDE4B phosphodiesterase 4B, cAMP-specific 0.0271635
ZFAND3 zinc finger, AN1-type domain 3 0.0263529
KDM3A lysine (K)-specific demethylase 3A 0.0257693
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 0.0250039
CDC73 cell division cycle 73 0.0245524
GSK3B glycogen synthase kinase 3 beta 0.0244933
NAMPT nicotinamide phosphoribosyltransferase 0.0241251
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0233575
CNOT6L CCR4-NOT transcription complex, subunit 6-like 0.0232543
ENOX1 ecto-NOX disulfide-thiol exchanger 1 0.0229123
MINDY2 MINDY lysine 48 deubiquitinase 2 0.022877
TJP1 tight junction protein 1 0.0227949
RBM39 RNA binding motif protein 39 0.0226952
DSCAM Down syndrome cell adhesion molecule 0.0223568
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0223257
PICALM phosphatidylinositol binding clathrin assembly protein 0.0219284
LPP LIM domain containing preferred translocation partner in lipoma 0.021927
CACNB4 calcium channel, voltage-dependent, beta 4 subunit 0.021103
CCNL1 cyclin L1 0.0204229
NCKAP1 NCK-associated protein 1 0.0198977
NBAS neuroblastoma amplified sequence 0.0198104
TXNRD1 thioredoxin reductase 1 0.0197729
TGFBR3 transforming growth factor, beta receptor III 0.0197483
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0195399
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0194493
ADAM9 ADAM metallopeptidase domain 9 0.0193225
BRWD1 bromodomain and WD repeat domain containing 1 0.0179369
TMEM65 transmembrane protein 65 0.0179078
EZR ezrin 0.0177016
SPATS2L spermatogenesis associated, serine-rich 2-like 0.0175809
NUP58 nucleoporin 58 0.0175024
TBC1D5 TBC1 domain family, member 5 0.0174829
JMJD1C jumonji domain containing 1C 0.0173512
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0173066
QKI QKI, KH domain containing, RNA binding 0.0170753
USP3 ubiquitin specific peptidase 3 0.0169525
TFG TRK-fused gene 0.0168926
PUM2 pumilio RNA-binding family member 2 0.0162811
COG5 component of oligomeric golgi complex 5 0.015801
ANK2 ankyrin 2, neuronal 0.0157373
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0156651
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0152653
SAMD4A sterile alpha motif domain containing 4A 0.0149813
ANKRD11 ankyrin repeat domain 11 0.0148269
EVI5 ecotropic viral integration site 5 0.0147073
PTBP2 polypyrimidine tract binding protein 2 0.0145509
ATP9B ATPase, class II, type 9B 0.0144639
ZMYM2 zinc finger, MYM-type 2 0.0143841
MATR3 matrin 3 0.0141053
ATOSA atos homolog A 0.0140971
MARCHF6 membrane associated ring-CH-type finger 6 0.0139651
XPO1 exportin 1 0.0139524
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0135847
WAC WW domain containing adaptor with coiled-coil 0.0135578
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0135061
TMEM41B transmembrane protein 41B 0.0132854
SRPK2 SRSF protein kinase 2 0.0132233
ELOVL5 ELOVL fatty acid elongase 5 0.0131498
LUC7L2 LUC7-like 2 (S. cerevisiae) 0.0129308
SBF2 SET binding factor 2 0.0129215
TTC28 tetratricopeptide repeat domain 28 0.0126698
ZFC3H1 zinc finger, C3H1-type containing 0.0125729
DUSP4 dual specificity phosphatase 4 0.0124338
PARP4 poly (ADP-ribose) polymerase family, member 4 0.0124006
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0121311
GLI2 GLI family zinc finger 2 0.012015
DLG1 discs, large homolog 1 (Drosophila) 0.0120134
PUM1 pumilio RNA-binding family member 1 0.0119927
BMP2K BMP2 inducible kinase 0.0119632
EIF4A2 eukaryotic translation initiation factor 4A2 0.0119584
DENND5A DENN/MADD domain containing 5A 0.0118935
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0118922
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.0118121
NCOR1 nuclear receptor corepressor 1 0.0118016
KDM6A lysine (K)-specific demethylase 6A 0.0117336
SMYD3 SET and MYND domain containing 3 0.0117322
ARID2 AT rich interactive domain 2 (ARID, RFX-like) 0.0117205
EXOC4 exocyst complex component 4 0.0117165
FNDC3B fibronectin type III domain containing 3B 0.0116983

decreased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha -0.18347
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.15326
RPS6 ribosomal protein S6 -0.09025
RPS8 ribosomal protein S8 -0.0834377
RPL35A ribosomal protein L35a -0.0786471
TPT1 tumor protein, translationally-controlled 1 -0.069586
RPL31 ribosomal protein L31 -0.0565712
RPL37A ribosomal protein L37a -0.0490245
RPS3 ribosomal protein S3 -0.0474877
RPL9 ribosomal protein L9 -0.0465402
RPLP1 ribosomal protein, large, P1 -0.0439061
RPS19 ribosomal protein S19 -0.0435825
RPLP2 ribosomal protein, large, P2 -0.04237
RPL26 ribosomal protein L26 -0.0403095
RPS12 ribosomal protein S12 -0.0400803
RPL34 ribosomal protein L34 -0.0397374
RPS13 ribosomal protein S13 -0.0390871
RPL12 ribosomal protein L12 -0.0372336
RPL19 ribosomal protein L19 -0.0365796
FTL ferritin, light polypeptide -0.0351801
RPS25 ribosomal protein S25 -0.0351334
RPL23 ribosomal protein L23 -0.0343512
RPS23 ribosomal protein S23 -0.0330412
RPS27A ribosomal protein S27a -0.032594
RPL11 ribosomal protein L11 -0.0324981
PFN1 profilin 1 -0.0315639
TMSB10 thymosin beta 10 -0.0313875
ACTG1 actin gamma 1 -0.0313765
RPL36 ribosomal protein L36 -0.0312425
RPL7A ribosomal protein L7a -0.0303277
S100A9 S100 calcium binding protein A9 -0.0298941
RPS14 ribosomal protein S14 -0.0297894
RACK1 receptor for activated C kinase 1 -0.0284224
RPS29 ribosomal protein S29 -0.027986
VIM vimentin -0.0275611
RPS17 ribosomal protein S17 -0.0270479
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0265842
RPLP0 ribosomal protein, large, P0 -0.0263109
RPS16 ribosomal protein S16 -0.025463
RPL32 ribosomal protein L32 -0.0251259
RPL13A ribosomal protein L13a -0.024963
ARL4C ADP-ribosylation factor-like 4C -0.0246366
S100A6 S100 calcium binding protein A6 -0.0243499
RPS27 ribosomal protein S27 -0.024256
RPL37 ribosomal protein L37 -0.0224541
MT2A metallothionein 2A -0.0222573
RPS21 ribosomal protein S21 -0.0221835
RPS10 ribosomal protein S10 -0.0221688
HSPB1 heat shock 27kDa protein 1 -0.0217128
RPL30 ribosomal protein L30 -0.0211687
RPS11 ribosomal protein S11 -0.0205588
ENO1 enolase 1, (alpha) -0.0205484
RPL8 ribosomal protein L8 -0.0202222
RPL27A ribosomal protein L27a -0.0201402
ENO2 enolase 2 (gamma, neuronal) -0.0200497
PRDX2 peroxiredoxin 2 -0.0196815
RPL36A ribosomal protein L36a -0.0196271
EIF1 eukaryotic translation initiation factor 1 -0.0192631
RPL35 ribosomal protein L35 -0.0190594
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0185388
LOC102724023 ES1 protein homolog, mitochondrial -0.0184427
RPS20 ribosomal protein S20 -0.0180701
RPL18 ribosomal protein L18 -0.0180045
POTEF POTE ankyrin domain family, member F -0.017923
RPL15 ribosomal protein L15 -0.0175628
RPS5 ribosomal protein S5 -0.0174506
HLA-B major histocompatibility complex, class I, B -0.0173727
RPL5 ribosomal protein L5 -0.0172405
RPS24 ribosomal protein S24 -0.0172002
RPS15 ribosomal protein S15 -0.0171959
ATF4 activating transcription factor 4 -0.0170227
EEF1G eukaryotic translation elongation factor 1 gamma -0.0168969
RPL10A ribosomal protein L10a -0.0168887
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0166565
MYL12B myosin, light chain 12B, regulatory -0.0166041
TPI1 triosephosphate isomerase 1 -0.0161014
BMP10 bone morphogenetic protein 10 -0.0155127
NACA nascent polypeptide-associated complex alpha subunit -0.0154107
RPL38 ribosomal protein L38 -0.0153071
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0152176
RPL28 ribosomal protein L28 -0.0152096
COX4I1 cytochrome c oxidase subunit IV isoform 1 -0.0150655
RPL7 ribosomal protein L7 -0.014942
CENPF centromere protein F, 350/400kDa -0.0147943
RPS2 ribosomal protein S2 -0.0140732
IFITM3 interferon induced transmembrane protein 3 -0.0140414
RPL27 ribosomal protein L27 -0.013848
EIF5B eukaryotic translation initiation factor 5B -0.0137139
NDRG1 N-myc downstream regulated 1 -0.0134212
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0132114
RAN RAN, member RAS oncogene family -0.0130149
B2M beta-2-microglobulin -0.0129701
ASTN2 astrotactin 2 -0.0129617
S100A10 S100 calcium binding protein A10 -0.0126027
PDIA3 protein disulfide isomerase family A, member 3 -0.0125547
PKM pyruvate kinase, muscle -0.0125424
CPED1 cadherin-like and PC-esterase domain containing 1 -0.0125216
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 -0.0124616
S100A4 S100 calcium binding protein A4 -0.012349
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 -0.0123142