Doxycycline (monohydrate)_SNU-423 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Doxycycline (monohydrate) perturbation in SNU-423 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Doxycycline (monohydrate)_SNU-423 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SOD2 superoxide dismutase 2, mitochondrial 0.110731
FTH1 ferritin, heavy polypeptide 1 0.082898
VCAN versican 0.0695543
IGFBP3 insulin-like growth factor binding protein 3 0.064273
UBE2E2 ubiquitin-conjugating enzyme E2E 2 0.0588651
COL6A3 collagen, type VI, alpha 3 0.058779
CADM1 cell adhesion molecule 1 0.0544703
EXT1 exostosin glycosyltransferase 1 0.0536097
ZFAND3 zinc finger, AN1-type domain 3 0.0467986
GLIS3 GLIS family zinc finger 3 0.0467641
CDH13 cadherin 13 0.0416417
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0409723
FN1 fibronectin 1 0.038034
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A 0.0368016
ATP13A3 ATPase type 13A3 0.0366915
FNDC3B fibronectin type III domain containing 3B 0.0365021
ANKS1B ankyrin repeat and sterile alpha motif domain containing 1B 0.0346196
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0304296
CCBE1 collagen and calcium binding EGF domains 1 0.0299755
DENND5A DENN/MADD domain containing 5A 0.0296191
LPP LIM domain containing preferred translocation partner in lipoma 0.0293492
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0287456
DIAPH2 diaphanous-related formin 2 0.0281364
PAPPA pregnancy-associated plasma protein A, pappalysin 1 0.0273005
RAI14 retinoic acid induced 14 0.0272393
QKI QKI, KH domain containing, RNA binding 0.0271085
TSC22D2 TSC22 domain family, member 2 0.0270857
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 0.0256053
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0254607
PTPRK protein tyrosine phosphatase, receptor type, K 0.0250188
PTK2 protein tyrosine kinase 2 0.0248725
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0243851
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.0235757
TULP4 tubby like protein 4 0.0231954
EPS8 epidermal growth factor receptor pathway substrate 8 0.0222776
CNTN6 contactin 6 0.0219909
INHBA inhibin, beta A 0.0217328
PRKG1 protein kinase, cGMP-dependent, type I 0.0213195
HMGA2 high mobility group AT-hook 2 0.021121
PALM2AKAP2 PALM2 and AKAP2 fusion 0.021055
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0207063
FRMPD4 FERM and PDZ domain containing 4 0.0205678
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough 0.0202189
FRMD4A FERM domain containing 4A 0.0193616
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) 0.0189958
PARD3 par-3 family cell polarity regulator 0.0189405
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0186571
CTSC cathepsin C 0.0181735
IRAK2 interleukin-1 receptor-associated kinase 2 0.01816
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A 0.018159
USP3 ubiquitin specific peptidase 3 0.0180965
MBNL1 muscleblind-like splicing regulator 1 0.0179769
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.0179709
IGF1R insulin-like growth factor 1 receptor 0.0179676
PRR16 proline rich 16 0.017801
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0176574
USP9X ubiquitin specific peptidase 9, X-linked 0.0175938
PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 0.0167233
WAC WW domain containing adaptor with coiled-coil 0.0166834
DNER delta/notch-like EGF repeat containing 0.016433
PCCA propionyl CoA carboxylase, alpha polypeptide 0.0158983
NR3C2 nuclear receptor subfamily 3, group C, member 2 0.0155891
MAML2 mastermind-like 2 (Drosophila) 0.0154736
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0154586
IL6 interleukin 6 0.0153809
BNC2 basonuclin 2 0.0150989
SKIL SKI-like proto-oncogene 0.0150626
SAMD3 sterile alpha motif domain containing 3 0.0150557
KCNIP4 Kv channel interacting protein 4 0.0143181
TRRAP transformation/transcription domain-associated protein 0.0142713
CAMK1D calcium/calmodulin-dependent protein kinase ID 0.0140315
TFG TRK-fused gene 0.0140029
EDIL3 EGF-like repeats and discoidin I-like domains 3 0.0139974
SPDYA speedy/RINGO cell cycle regulator family member A 0.013894
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 0.0136027
PRKD3 protein kinase D3 0.0135902
SRSF3 serine/arginine-rich splicing factor 3 0.0135408
UBE2E1 ubiquitin-conjugating enzyme E2E 1 0.0135256
CPEB2 cytoplasmic polyadenylation element binding protein 2 0.0135124
RYK receptor-like tyrosine kinase 0.0134236
COL5A1 collagen, type V, alpha 1 0.0133337
TENM2 teneurin transmembrane protein 2 0.0131959
HPCAL1 hippocalcin-like 1 0.0131737
ANKRD11 ankyrin repeat domain 11 0.013117
HMGA1 high mobility group AT-hook 1 0.0131047
MAP4K3 mitogen-activated protein kinase kinase kinase kinase 3 0.012897
STRN3 striatin, calmodulin binding protein 3 0.0128951
TPM1 tropomyosin 1 (alpha) 0.0128936
ABR active BCR-related 0.0128853
GRB10 growth factor receptor-bound protein 10 0.0126999
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0126942
DSE dermatan sulfate epimerase 0.0125973
KDM6A lysine (K)-specific demethylase 6A 0.012519
LIF leukemia inhibitory factor 0.0124594
COL6A1 collagen, type VI, alpha 1 0.0123453
ADAMTS12 ADAM metallopeptidase with thrombospondin type 1 motif, 12 0.0120982
PPP4R4 protein phosphatase 4, regulatory subunit 4 0.0120844
ADAM12 ADAM metallopeptidase domain 12 0.0119849
CLMP CXADR-like membrane protein 0.0119165
CTBP2 C-terminal binding protein 2 0.0118931

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.168155
VIM vimentin -0.119502
NAMPT nicotinamide phosphoribosyltransferase -0.0993039
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0895275
MT2A metallothionein 2A -0.0891931
RPS6 ribosomal protein S6 -0.0858319
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.085084
HLA-B major histocompatibility complex, class I, B -0.0849834
CD44 CD44 molecule (Indian blood group) -0.0823869
MYH9 myosin, heavy chain 9, non-muscle -0.0822629
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0765912
RPS2 ribosomal protein S2 -0.0764388
STC1 stanniocalcin 1 -0.0742246
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0669426
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0605683
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.059809
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.059332
RPS3 ribosomal protein S3 -0.0586943
NAP1L1 nucleosome assembly protein 1-like 1 -0.0566623
RPL26 ribosomal protein L26 -0.0539136
RPS12 ribosomal protein S12 -0.0535865
EIF1 eukaryotic translation initiation factor 1 -0.0524249
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0523199
B2M beta-2-microglobulin -0.052124
FTL ferritin, light polypeptide -0.0519747
RPS8 ribosomal protein S8 -0.0512322
PTMA prothymosin, alpha -0.0507484
MKI67 marker of proliferation Ki-67 -0.0494742
ADM adrenomedullin -0.0492204
NDRG1 N-myc downstream regulated 1 -0.0470452
VEGFA vascular endothelial growth factor A -0.0465652
RPL7 ribosomal protein L7 -0.0451309
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.044942
GOLGA4 golgin A4 -0.0442952
TPT1 tumor protein, translationally-controlled 1 -0.0432161
CDCP1 CUB domain containing protein 1 -0.0430934
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0430802
UBC ubiquitin C -0.0430083
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0421774
RPL19 ribosomal protein L19 -0.0420915
RPL11 ribosomal protein L11 -0.042032
NAV2 neuron navigator 2 -0.0414538
RPLP2 ribosomal protein, large, P2 -0.0413
OGA O-GlcNAcase -0.0412599
MSN moesin -0.0411121
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0401605
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0401341
ARRDC3 arrestin domain containing 3 -0.0399361
RTN4 reticulon 4 -0.0392733
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0392369
RPL9 ribosomal protein L9 -0.0390476
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0389909
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0389239
BASP1 brain abundant, membrane attached signal protein 1 -0.0388679
ARFGEF3 ARFGEF family member 3 -0.0386554
GOLGB1 golgin B1 -0.038602
SFTPA2 surfactant protein A2 -0.0383247
RPL37A ribosomal protein L37a -0.0379863
ELL2 elongation factor, RNA polymerase II, 2 -0.0377508
RPS23 ribosomal protein S23 -0.0376486
LAMP2 lysosomal-associated membrane protein 2 -0.0376343
ANLN anillin, actin binding protein -0.0372916
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa -0.0369512
RPL36A ribosomal protein L36a -0.0362528
SQSTM1 sequestosome 1 -0.0361026
DUSP5 dual specificity phosphatase 5 -0.0359866
AKAP12 A kinase (PRKA) anchor protein 12 -0.0356963
MORF4L2 mortality factor 4 like 2 -0.0356256
DSCAM Down syndrome cell adhesion molecule -0.0353077
ANKRD12 ankyrin repeat domain 12 -0.0344201
CLTC clathrin, heavy chain (Hc) -0.0344139
RPL23 ribosomal protein L23 -0.034151
ZNF292 zinc finger protein 292 -0.0339575
RPL32 ribosomal protein L32 -0.0338035
TENT5A terminal nucleotidyltransferase 5A -0.0335136
MXI1 MAX interactor 1, dimerization protein -0.0334507
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0333455
ICAM1 intercellular adhesion molecule 1 -0.0332393
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0326745
MYOF myoferlin -0.0325437
RPL5 ribosomal protein L5 -0.0324104
PRRC2C proline-rich coiled-coil 2C -0.0320464
LDHA lactate dehydrogenase A -0.0320273
RB1CC1 RB1-inducible coiled-coil 1 -0.0316291
RPL38 ribosomal protein L38 -0.0315406
TMSB10 thymosin beta 10 -0.0314145
SF3B2 splicing factor 3b, subunit 2, 145kDa -0.0313314
CANX calnexin -0.0312118
RBM39 RNA binding motif protein 39 -0.0311586
ZBTB38 zinc finger and BTB domain containing 38 -0.0311355
IGFBP7 insulin-like growth factor binding protein 7 -0.0309508
TMSB4X thymosin beta 4, X-linked -0.0309397
VMP1 vacuole membrane protein 1 -0.0306219
CUL4B cullin 4B -0.0304756
ENO1 enolase 1, (alpha) -0.0304716
RPLP1 ribosomal protein, large, P1 -0.0302296
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 -0.0300874
PKM pyruvate kinase, muscle -0.0298348
SPTBN1 spectrin, beta, non-erythrocytic 1 -0.0295483
RPL12 ribosomal protein L12 -0.0291358