Doxycycline (monohydrate)_SW 900 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Doxycycline (monohydrate) perturbation in SW 900 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Doxycycline (monohydrate)_SW 900 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
NAMPT nicotinamide phosphoribosyltransferase 0.122036
TRIO trio Rho guanine nucleotide exchange factor 0.0966862
FNDC3B fibronectin type III domain containing 3B 0.0811184
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0809678
HMGA2 high mobility group AT-hook 2 0.0521939
PTK2 protein tyrosine kinase 2 0.0517434
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0482073
CXCL8 chemokine (C-X-C motif) ligand 8 0.0475165
ASPH aspartate beta-hydroxylase 0.0454131
ITGA1 integrin, alpha 1 0.0441491
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0434453
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0427051
NRG1 neuregulin 1 0.0415285
FAM13A family with sequence similarity 13, member A 0.0407525
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0369257
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0359096
AHR aryl hydrocarbon receptor 0.0337913
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.03372
EPS8 epidermal growth factor receptor pathway substrate 8 0.0307671
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0290337
SOD2 superoxide dismutase 2, mitochondrial 0.0283058
NDRG1 N-myc downstream regulated 1 0.0282238
ZNF292 zinc finger protein 292 0.0281984
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0281154
WAC WW domain containing adaptor with coiled-coil 0.0280033
TMEM156 transmembrane protein 156 0.0274174
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.0273915
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0273802
RNF145 ring finger protein 145 0.027351
NAP1L1 nucleosome assembly protein 1-like 1 0.0271036
CADM1 cell adhesion molecule 1 0.0269755
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0267704
DST dystonin 0.0263372
EFNA5 ephrin-A5 0.0262298
HELZ helicase with zinc finger 0.0259333
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 0.0258286
USP12 ubiquitin specific peptidase 12 0.025577
DOCK5 dedicator of cytokinesis 5 0.0250755
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0250511
EREG epiregulin 0.0248657
NEK7 NIMA-related kinase 7 0.0248242
ZFAND3 zinc finger, AN1-type domain 3 0.0238492
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0234167
RBM39 RNA binding motif protein 39 0.0230759
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0228481
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.0226173
PRELID2 PRELI domain containing 2 0.0224676
RICTOR RPTOR independent companion of MTOR, complex 2 0.0224498
ANXA5 annexin A5 0.0222478
SPAG9 sperm associated antigen 9 0.0221921
CD109 CD109 molecule 0.0219843
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0218668
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9 0.0215677
TXNRD1 thioredoxin reductase 1 0.0213525
ANKRD11 ankyrin repeat domain 11 0.0210484
MYOF myoferlin 0.0210366
MARCHF6 membrane associated ring-CH-type finger 6 0.0210153
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 0.020712
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.020676
FXR1 fragile X mental retardation, autosomal homolog 1 0.020273
TFG TRK-fused gene 0.020199
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0199456
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0199077
SMAD3 SMAD family member 3 0.0197516
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0197281
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0197245
HIPK2 homeodomain interacting protein kinase 2 0.0196294
LIMCH1 LIM and calponin homology domains 1 0.0194716
GRB10 growth factor receptor-bound protein 10 0.0193042
MATR3 matrin 3 0.0190364
RUNX2 runt-related transcription factor 2 0.0187042
IRAK3 interleukin-1 receptor-associated kinase 3 0.0186927
PGK1 phosphoglycerate kinase 1 0.0186679
PKM pyruvate kinase, muscle 0.0185302
LRMDA leucine rich melanocyte differentiation associated 0.0184133
RLF rearranged L-myc fusion 0.0183386
NBAS neuroblastoma amplified sequence 0.0183095
NUP58 nucleoporin 58 0.0181102
NRIP1 nuclear receptor interacting protein 1 0.0180732
LRRFIP2 leucine rich repeat (in FLII) interacting protein 2 0.0179827
PDE4D phosphodiesterase 4D, cAMP-specific 0.0179512
SFTPA2 surfactant protein A2 0.0179205
MYO1B myosin IB 0.0178234
PSD3 pleckstrin and Sec7 domain containing 3 0.0177793
SEPTIN7 septin 7 0.0174395
ACSL3 acyl-CoA synthetase long-chain family member 3 0.0172289
ADAM17 ADAM metallopeptidase domain 17 0.0171438
WDR43 WD repeat domain 43 0.0171387
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0170884
MACF1 microtubule-actin crosslinking factor 1 0.0170087
RAB1A RAB1A, member RAS oncogene family 0.0169833
SLTM SAFB-like, transcription modulator 0.0169585
ADAM9 ADAM metallopeptidase domain 9 0.0168713
KMT2C lysine (K)-specific methyltransferase 2C 0.0168602
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.016542
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0165297
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0164849
ZBTB20 zinc finger and BTB domain containing 20 0.0161992
SMG7 SMG7 nonsense mediated mRNA decay factor 0.0160618
SPATS2L spermatogenesis associated, serine-rich 2-like 0.0159891

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.185871
MT2A metallothionein 2A -0.0648229
VCL vinculin -0.0499533
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0486626
FTL ferritin, light polypeptide -0.047676
EXT1 exostosin glycosyltransferase 1 -0.0404383
NTN4 netrin 4 -0.0346659
RPS6 ribosomal protein S6 -0.0269888
TMSB10 thymosin beta 10 -0.0266382
SQSTM1 sequestosome 1 -0.0254858
PALLD palladin, cytoskeletal associated protein -0.025164
ZSWIM6 zinc finger, SWIM-type containing 6 -0.022769
RPS19 ribosomal protein S19 -0.0226798
VIM vimentin -0.0223163
RPL31 ribosomal protein L31 -0.0205194
RPL35A ribosomal protein L35a -0.0202725
RPS16 ribosomal protein S16 -0.0186041
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0184219
RPLP1 ribosomal protein, large, P1 -0.0183789
AKAP9 A kinase (PRKA) anchor protein 9 -0.0179527
PTMA prothymosin, alpha -0.0178914
KSR1 kinase suppressor of ras 1 -0.0175565
SOS1 son of sevenless homolog 1 (Drosophila) -0.0173443
INTS6 integrator complex subunit 6 -0.0171024
RPS27 ribosomal protein S27 -0.0169214
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0167033
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0165944
EGR1 early growth response 1 -0.016359
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0163409
GCC2 GRIP and coiled-coil domain containing 2 -0.0163346
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0160305
LOC102724023 ES1 protein homolog, mitochondrial -0.0159576
SEPTIN9 septin 9 -0.0158544
FHL2 four and a half LIM domains 2 -0.0158164
GLCCI1 glucocorticoid induced 1 -0.0158029
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 -0.0154959
RAB31 RAB31, member RAS oncogene family -0.0154106
VMP1 vacuole membrane protein 1 -0.0152435
RPL37A ribosomal protein L37a -0.0151191
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) -0.0147975
NPAS2 neuronal PAS domain protein 2 -0.0146289
RPS12 ribosomal protein S12 -0.0141275
CLIP2 CAP-GLY domain containing linker protein 2 -0.0140828
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0135079
RPS29 ribosomal protein S29 -0.0131824
CRK v-crk avian sarcoma virus CT10 oncogene homolog -0.0131724
RPL34 ribosomal protein L34 -0.0131634
AHRR aryl-hydrocarbon receptor repressor -0.0131289
EIF1 eukaryotic translation initiation factor 1 -0.0131152
RPLP2 ribosomal protein, large, P2 -0.012836
RPS8 ribosomal protein S8 -0.0121704
NXN nucleoredoxin -0.0120916
WSB1 WD repeat and SOCS box containing 1 -0.0120511
RPL12 ribosomal protein L12 -0.0119243
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0119195
RPL23 ribosomal protein L23 -0.0118268
SDC2 syndecan 2 -0.0118007
EPAS1 endothelial PAS domain protein 1 -0.0117386
LOC112694756 uncharaterized LOC112694756 -0.0117014
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) -0.0113618
ERN1 endoplasmic reticulum to nucleus signaling 1 -0.0113529
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) -0.0113096
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0113003
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -0.0111914
HLA-B major histocompatibility complex, class I, B -0.011148
GOLGB1 golgin B1 -0.0111369
RAB10 RAB10, member RAS oncogene family -0.0108738
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0107971
RPL18 ribosomal protein L18 -0.0107203
FNDC3A fibronectin type III domain containing 3A -0.0105926
TPR translocated promoter region, nuclear basket protein -0.0104576
BPTF bromodomain PHD finger transcription factor -0.0104319
MORF4L2 mortality factor 4 like 2 -0.0103983
YBX1 Y box binding protein 1 -0.0103897
RPL36 ribosomal protein L36 -0.0103722
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0102811
TGFB1 transforming growth factor, beta 1 -0.0102744
MAP4K3 mitogen-activated protein kinase kinase kinase kinase 3 -0.0100847
CEP350 centrosomal protein 350kDa -0.00999459
GON4L gon-4-like (C. elegans) -0.00997286
SP100 SP100 nuclear antigen -0.00985687
RBPMS RNA binding protein with multiple splicing -0.00981991
FBXO28 F-box protein 28 -0.00977956
CCDC138 coiled-coil domain containing 138 -0.00950911
ABLIM1 actin binding LIM protein 1 -0.00949384
UBXN4 UBX domain protein 4 -0.00945022
RPL8 ribosomal protein L8 -0.00937568
SLC38A2 solute carrier family 38, member 2 -0.00933821
SOX4 SRY (sex determining region Y)-box 4 -0.00932116
NCOA7 nuclear receptor coactivator 7 -0.0092352
RPS21 ribosomal protein S21 -0.00923061
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.00921816
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.00903574
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.00901378
SEC31A SEC31 homolog A (S. cerevisiae) -0.0090102
RPS28 ribosomal protein S28 -0.00894509
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2 -0.00888229
RPS20 ribosomal protein S20 -0.00884086
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.00882724
WDR59 WD repeat domain 59 -0.00879765