Doxycycline (monohydrate)_SW1417 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Doxycycline (monohydrate) perturbation in SW1417 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Doxycycline (monohydrate)_SW1417 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0585317
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0336683
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 0.0285662
FXR1 fragile X mental retardation, autosomal homolog 1 0.0241989
ZNF292 zinc finger protein 292 0.0228742
USP3 ubiquitin specific peptidase 3 0.0225684
NCKAP1 NCK-associated protein 1 0.022474
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0214298
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0200237
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0194764
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B 0.0181767
STT3B STT3B, subunit of the oligosaccharyltransferase complex (catalytic) 0.0167084
CCNL1 cyclin L1 0.0165892
NAMPT nicotinamide phosphoribosyltransferase 0.016406
HSPA8 heat shock 70kDa protein 8 0.0155249
FAM3C family with sequence similarity 3, member C 0.0153641
KRT8 keratin 8, type II 0.0150846
MATR3 matrin 3 0.0148646
XPO1 exportin 1 0.0147131
KMT2E lysine (K)-specific methyltransferase 2E 0.0145988
KDM6A lysine (K)-specific demethylase 6A 0.0138882
WAC WW domain containing adaptor with coiled-coil 0.0137382
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0136773
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0134525
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) 0.013101
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.013082
PELI1 pellino E3 ubiquitin protein ligase 1 0.0125793
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta 0.0123373
ACSL3 acyl-CoA synthetase long-chain family member 3 0.0123325
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0122655
LMTK2 lemur tyrosine kinase 2 0.0122282
SMG7 SMG7 nonsense mediated mRNA decay factor 0.0119967
PUM2 pumilio RNA-binding family member 2 0.0118775
RAD23B RAD23 homolog B (S. cerevisiae) 0.0117219
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0115353
MTMR3 myotubularin related protein 3 0.0115106
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0115061
AFDN afadin, adherens junction formation factor 0.0115031
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0114332
UBQLN1 ubiquilin 1 0.0111743
FAR1 fatty acyl CoA reductase 1 0.0110745
HNRNPA3 heterogeneous nuclear ribonucleoprotein A3 0.010751
CCND1 cyclin D1 0.0105479
VMP1 vacuole membrane protein 1 0.0104623
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0104604
HBP1 HMG-box transcription factor 1 0.0100227
ADAM17 ADAM metallopeptidase domain 17 0.00992262
MYO5B myosin VB 0.00979077
ACTN4 actinin, alpha 4 0.00978524
EPS8 epidermal growth factor receptor pathway substrate 8 0.00965742
OLA1 Obg-like ATPase 1 0.00962609
PPME1 protein phosphatase methylesterase 1 0.00960748
PTPRJ protein tyrosine phosphatase, receptor type, J 0.00955535
EWSR1 EWS RNA-binding protein 1 0.00951042
PTK2 protein tyrosine kinase 2 0.00950299
RAD21 RAD21 homolog (S. pombe) 0.0094158
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.00936427
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.00931524
RYK receptor-like tyrosine kinase 0.00923064
LRRFIP2 leucine rich repeat (in FLII) interacting protein 2 0.0091889
OGA O-GlcNAcase 0.00918068
MIER1 mesoderm induction early response 1, transcriptional regulator 0.00916906
HOXA3 homeobox A3 0.00914562
TM9SF3 transmembrane 9 superfamily member 3 0.00912395
CNOT4 CCR4-NOT transcription complex, subunit 4 0.00911106
ANKRD28 ankyrin repeat domain 28 0.00905516
MYO10 myosin X 0.00900045
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.00879468
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.00875978
MARCHF6 membrane associated ring-CH-type finger 6 0.00869725
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.00863585
AGFG1 ArfGAP with FG repeats 1 0.00862828
GNA13 guanine nucleotide binding protein (G protein), alpha 13 0.00851864
TFG TRK-fused gene 0.00847711
TMEM39A transmembrane protein 39A 0.00824783
MSMO1 methylsterol monooxygenase 1 0.00824767
VAPA VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa 0.00821617
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.00813644
OSBPL9 oxysterol binding protein-like 9 0.0081282
ARHGAP12 Rho GTPase activating protein 12 0.00811116
MAT2A methionine adenosyltransferase II, alpha 0.00808521
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 0.00808313
RBM33 RNA binding motif protein 33 0.00804398
PPP1CB protein phosphatase 1, catalytic subunit, beta isozyme 0.00799923
ATL2 atlastin GTPase 2 0.00783361
BCLAF1 BCL2-associated transcription factor 1 0.00781107
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.00778187
LUC7L2 LUC7-like 2 (S. cerevisiae) 0.0077726
RBM39 RNA binding motif protein 39 0.00776655
PLEKHA1 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 0.00775171
RRAS2 related RAS viral (r-ras) oncogene homolog 2 0.00774817
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 0.00773379
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.00768417
FNBP1L formin binding protein 1-like 0.00756153
ARHGAP32 Rho GTPase activating protein 32 0.00754856
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked 0.00752608
TRA2B transformer 2 beta homolog (Drosophila) 0.00746634
ANKRD11 ankyrin repeat domain 11 0.00739163
U2SURP U2 snRNP-associated SURP domain containing 0.00738659
KCTD3 potassium channel tetramerization domain containing 3 0.00719669

decreased expression

Symbol Name Standardized Value
FTL ferritin, light polypeptide -0.115555
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0767135
TMSB10 thymosin beta 10 -0.063644
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0531455
PTMA prothymosin, alpha -0.0501046
RPL35A ribosomal protein L35a -0.0401341
RPS6 ribosomal protein S6 -0.040013
NCEH1 neutral cholesterol ester hydrolase 1 -0.0359008
RPLP1 ribosomal protein, large, P1 -0.0355333
LOC102724023 ES1 protein homolog, mitochondrial -0.0336051
RPL12 ribosomal protein L12 -0.0332387
EGR1 early growth response 1 -0.0328563
MAML2 mastermind-like 2 (Drosophila) -0.0313228
EIF1 eukaryotic translation initiation factor 1 -0.0309589
RPS21 ribosomal protein S21 -0.0303669
RPLP2 ribosomal protein, large, P2 -0.030321
RPS19 ribosomal protein S19 -0.0295515
GOLGA4 golgin A4 -0.0295424
RPS13 ribosomal protein S13 -0.0294912
RPL23 ribosomal protein L23 -0.0289335
RPL37A ribosomal protein L37a -0.0276585
B2M beta-2-microglobulin -0.0276547
TPT1 tumor protein, translationally-controlled 1 -0.0272544
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.027138
RPL28 ribosomal protein L28 -0.026292
RPL31 ribosomal protein L31 -0.0257286
RPL19 ribosomal protein L19 -0.0246172
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0241711
EZR ezrin -0.0238137
RPS12 ribosomal protein S12 -0.0235778
GOLGB1 golgin B1 -0.0233323
RPS3 ribosomal protein S3 -0.0233154
BCL2L1 BCL2-like 1 -0.022777
S100A9 S100 calcium binding protein A9 -0.0224539
RPS11 ribosomal protein S11 -0.0222791
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0222638
RPS5 ribosomal protein S5 -0.0220364
RPS25 ribosomal protein S25 -0.0215512
RPL18 ribosomal protein L18 -0.0212189
LOC112694756 uncharaterized LOC112694756 -0.0212034
SLC38A1 solute carrier family 38, member 1 -0.0211703
RPS8 ribosomal protein S8 -0.021144
MYO1E myosin IE -0.0208617
ACTG1 actin gamma 1 -0.0206634
RPL8 ribosomal protein L8 -0.0205461
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0202926
MACC1 metastasis associated in colon cancer 1 -0.0198895
LDHA lactate dehydrogenase A -0.0196002
ZMYND8 zinc finger, MYND-type containing 8 -0.0194175
RPL7A ribosomal protein L7a -0.0190329
ZBTB20 zinc finger and BTB domain containing 20 -0.0189563
NDRG1 N-myc downstream regulated 1 -0.0189554
AKAP9 A kinase (PRKA) anchor protein 9 -0.0187223
GNAS GNAS complex locus -0.018643
PCSK5 proprotein convertase subtilisin/kexin type 5 -0.01859
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0184612
HM13 histocompatibility (minor) 13 -0.0181399
RPS27A ribosomal protein S27a -0.0181293
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa -0.0181232
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0180715
RPL36 ribosomal protein L36 -0.0179425
RPL32 ribosomal protein L32 -0.0178224
IFITM3 interferon induced transmembrane protein 3 -0.0175417
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0175196
RPS29 ribosomal protein S29 -0.0173926
VCL vinculin -0.0171911
RALY RALY heterogeneous nuclear ribonucleoprotein -0.0170426
RPL37 ribosomal protein L37 -0.0170198
RPS17 ribosomal protein S17 -0.0169449
WWC1 WW and C2 domain containing 1 -0.0169325
RACK1 receptor for activated C kinase 1 -0.0167601
S100A6 S100 calcium binding protein A6 -0.0167036
RAB7A RAB7A, member RAS oncogene family -0.0165776
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0165583
DLG1 discs, large homolog 1 (Drosophila) -0.0165455
RPS14 ribosomal protein S14 -0.0162515
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0162463
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 -0.01606
STAU1 staufen double-stranded RNA binding protein 1 -0.0159047
PKM pyruvate kinase, muscle -0.0157364
RPL34 ribosomal protein L34 -0.0156947
ZBTB38 zinc finger and BTB domain containing 38 -0.0156041
RPLP0 ribosomal protein, large, P0 -0.0153535
CST3 cystatin C -0.0152378
S100A10 S100 calcium binding protein A10 -0.0150383
HLA-A major histocompatibility complex, class I, A -0.0149757
IFITM1 interferon induced transmembrane protein 1 -0.0149224
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0148785
GSTP1 glutathione S-transferase pi 1 -0.0141994
NIPBL Nipped-B homolog (Drosophila) -0.0140563
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0140423
RPS16 ribosomal protein S16 -0.0140204
RPL26 ribosomal protein L26 -0.0140104
RPS24 ribosomal protein S24 -0.0139888
SLC20A2 solute carrier family 20 (phosphate transporter), member 2 -0.0139865
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0139032
NEBL nebulette -0.013794
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -0.0136788
EHBP1 EH domain binding protein 1 -0.0135246
RPS27 ribosomal protein S27 -0.0134936