Doxycycline (monohydrate)_SW480 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Doxycycline (monohydrate) perturbation in SW480 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Doxycycline (monohydrate)_SW480 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
INTS6 integrator complex subunit 6 0.0441278
ASPH aspartate beta-hydroxylase 0.0379148
KDM6A lysine (K)-specific demethylase 6A 0.031433
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.030627
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0284211
RCOR1 REST corepressor 1 0.0269666
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0257647
PLEC plectin 0.0256521
SDK1 sidekick cell adhesion molecule 1 0.0248467
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0247777
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0244774
ZSWIM6 zinc finger, SWIM-type containing 6 0.021732
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.021589
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0215754
NUP58 nucleoporin 58 0.0215547
HSPA8 heat shock 70kDa protein 8 0.0215346
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) 0.0204102
MSN moesin 0.0189354
SAMD4A sterile alpha motif domain containing 4A 0.0182326
ADAM17 ADAM metallopeptidase domain 17 0.0179409
HSD17B12 hydroxysteroid (17-beta) dehydrogenase 12 0.0173601
HPCAL1 hippocalcin-like 1 0.0165754
HSPH1 heat shock 105kDa/110kDa protein 1 0.0164554
UBAP2 ubiquitin associated protein 2 0.0162095
ANO1 anoctamin 1, calcium activated chloride channel 0.01584
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0156918
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0148638
CLSTN2 calsyntenin 2 0.014522
NCAPG2 non-SMC condensin II complex, subunit G2 0.0144785
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0144756
WAC WW domain containing adaptor with coiled-coil 0.0144424
NCKAP1 NCK-associated protein 1 0.0143691
NPTN neuroplastin 0.0143336
SFPQ splicing factor proline/glutamine-rich 0.0143122
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 0.0142404
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0137333
NAV2 neuron navigator 2 0.0137271
PHC3 polyhomeotic homolog 3 (Drosophila) 0.0134348
RABGGTB Rab geranylgeranyltransferase, beta subunit 0.0131153
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.01276
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit 0.0126843
VCL vinculin 0.0126568
GULP1 GULP, engulfment adaptor PTB domain containing 1 0.0125818
FTH1 ferritin, heavy polypeptide 1 0.0125699
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0122657
FAT1 FAT atypical cadherin 1 0.01215
MRTFA myocardin related transcription factor A 0.0120563
TBC1D4 TBC1 domain family, member 4 0.0117751
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0117042
FLNA filamin A, alpha 0.0116495
BCAR3 breast cancer anti-estrogen resistance 3 0.0116451
CACNB4 calcium channel, voltage-dependent, beta 4 subunit 0.0115822
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide 0.0115606
UBA6 ubiquitin-like modifier activating enzyme 6 0.0114947
CD44 CD44 molecule (Indian blood group) 0.0112653
ABHD3 abhydrolase domain containing 3 0.011162
RPL3 ribosomal protein L3 0.0111502
SLMAP sarcolemma associated protein 0.0111286
EGFR epidermal growth factor receptor 0.01111
SMAD3 SMAD family member 3 0.0110842
ZMIZ1 zinc finger, MIZ-type containing 1 0.0108809
MYO5B myosin VB 0.010845
INPP5A inositol polyphosphate-5-phosphatase, 40kDa 0.0108191
PDLIM5 PDZ and LIM domain 5 0.0108054
ELK4 ELK4, ETS-domain protein (SRF accessory protein 1) 0.0107939
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0107812
PRKCA protein kinase C, alpha 0.0107431
FAR1 fatty acyl CoA reductase 1 0.0105801
ARRDC3 arrestin domain containing 3 0.0105505
MPZL2 myelin protein zero-like 2 0.0103822
NPLOC4 nuclear protein localization 4 homolog (S. cerevisiae) 0.0103478
ZNF704 zinc finger protein 704 0.0103401
FOSL2 FOS-like antigen 2 0.0103071
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0102562
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0102217
RTN4 reticulon 4 0.0101185
ZEB1 zinc finger E-box binding homeobox 1 0.0101185
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 0.0100931
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 0.00980053
UBE2G2 ubiquitin-conjugating enzyme E2G 2 0.00973253
FGD4 FYVE, RhoGEF and PH domain containing 4 0.00967608
TARDBP TAR DNA binding protein 0.00962321
FNIP1 folliculin interacting protein 1 0.00954872
MBNL1 muscleblind-like splicing regulator 1 0.00954127
TENT4A terminal nucleotidyltransferase 4A 0.00941221
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 0.00928981
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.00924148
SCAF4 SR-related CTD-associated factor 4 0.00922941
SNX29 sorting nexin 29 0.00899101
SORBS1 sorbin and SH3 domain containing 1 0.00897718
SLCO4A1 solute carrier organic anion transporter family, member 4A1 0.00897321
WDR20 WD repeat domain 20 0.00896438
C17ORF99 chromosome 17 open reading frame 99 0.00896019
RCC1 regulator of chromosome condensation 1 0.00895651
DIAPH1 diaphanous-related formin 1 0.00887274
UBE2E2 ubiquitin-conjugating enzyme E2E 2 0.00877252
RYBP RING1 and YY1 binding protein 0.00875689
OGDH oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) 0.00870533
UBXN7 UBX domain protein 7 0.00867237
LAMA5 laminin, alpha 5 0.00861888

decreased expression

Symbol Name Standardized Value
NKD1 naked cuticle homolog 1 (Drosophila) -0.242077
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.200526
TMSB10 thymosin beta 10 -0.126621
RPS6 ribosomal protein S6 -0.109822
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0974403
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0963499
KRT18 keratin 18, type I -0.091231
PTMA prothymosin, alpha -0.0903116
AKAP12 A kinase (PRKA) anchor protein 12 -0.0866388
PDE4D phosphodiesterase 4D, cAMP-specific -0.0811264
MAML2 mastermind-like 2 (Drosophila) -0.0765363
SYT1 synaptotagmin I -0.0748587
PGK1 phosphoglycerate kinase 1 -0.0727993
RPL35A ribosomal protein L35a -0.0707289
VIM vimentin -0.0684761
ACTG1 actin gamma 1 -0.067579
ENO1 enolase 1, (alpha) -0.0664085
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0663574
RPS3 ribosomal protein S3 -0.0661661
RPLP1 ribosomal protein, large, P1 -0.0640474
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0631594
CDK6 cyclin-dependent kinase 6 -0.0613744
RPS19 ribosomal protein S19 -0.060925
EIF1 eukaryotic translation initiation factor 1 -0.0608923
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) -0.0604571
CANX calnexin -0.0593579
RPL19 ribosomal protein L19 -0.0572224
TPT1 tumor protein, translationally-controlled 1 -0.0572167
CDH13 cadherin 13 -0.0564132
DST dystonin -0.056193
THOC2 THO complex 2 -0.0561406
RPL11 ribosomal protein L11 -0.0552274
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) -0.0542986
RPS8 ribosomal protein S8 -0.0542242
RPL26 ribosomal protein L26 -0.0540783
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0539522
MT2A metallothionein 2A -0.0534737
ZMYND8 zinc finger, MYND-type containing 8 -0.0521428
AKAP9 A kinase (PRKA) anchor protein 9 -0.0515924
OXR1 oxidation resistance 1 -0.0505076
RPS24 ribosomal protein S24 -0.0504886
LOC102724023 ES1 protein homolog, mitochondrial -0.0502018
H1-0 H1.0 linker histone -0.0498126
TMSB4X thymosin beta 4, X-linked -0.0496447
RPLP2 ribosomal protein, large, P2 -0.0491976
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase -0.0489012
KIZ kizuna centrosomal protein -0.0487483
RPS27A ribosomal protein S27a -0.0483068
RPL12 ribosomal protein L12 -0.0481335
ZBTB20 zinc finger and BTB domain containing 20 -0.0477302
BPTF bromodomain PHD finger transcription factor -0.0474662
RUNX1 runt-related transcription factor 1 -0.0469593
RPL23 ribosomal protein L23 -0.0467977
GCC2 GRIP and coiled-coil domain containing 2 -0.0462861
SLC38A1 solute carrier family 38, member 1 -0.046126
TTC3 tetratricopeptide repeat domain 3 -0.0455029
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0453836
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0448554
PROX1 prospero homeobox 1 -0.0445314
RPL32 ribosomal protein L32 -0.0436908
TMEM123 transmembrane protein 123 -0.0436569
RPL36A ribosomal protein L36a -0.0434633
RPS13 ribosomal protein S13 -0.0427258
RPL31 ribosomal protein L31 -0.0414993
PRRC2C proline-rich coiled-coil 2C -0.0414503
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.041364
IARS1 isoleucyl-tRNA synthetase 1 -0.0412978
RPS21 ribosomal protein S21 -0.0404392
KPNB1 karyopherin (importin) beta 1 -0.0404053
RPL5 ribosomal protein L5 -0.0399834
ATRX alpha thalassemia/mental retardation syndrome X-linked -0.0392004
RPLP0 ribosomal protein, large, P0 -0.0389578
RPL7A ribosomal protein L7a -0.0389569
SOX4 SRY (sex determining region Y)-box 4 -0.0382809
PCLO piccolo presynaptic cytomatrix protein -0.0380781
RACK1 receptor for activated C kinase 1 -0.0379397
RPS11 ribosomal protein S11 -0.0377738
RBM25 RNA binding motif protein 25 -0.0374366
TPI1 triosephosphate isomerase 1 -0.0373849
PERP PERP, TP53 apoptosis effector -0.0369809
LDHA lactate dehydrogenase A -0.036746
RPL37 ribosomal protein L37 -0.0365193
LIMS1 LIM and senescent cell antigen-like domains 1 -0.0363524
RPS23 ribosomal protein S23 -0.03614
SPATA13 spermatogenesis associated 13 -0.0360432
MACC1 metastasis associated in colon cancer 1 -0.0357319
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.0351623
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0350678
RPL8 ribosomal protein L8 -0.0347464
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0346353
MORF4L2 mortality factor 4 like 2 -0.0346241
PIBF1 progesterone immunomodulatory binding factor 1 -0.034019
DUSP6 dual specificity phosphatase 6 -0.0338097
RPL34 ribosomal protein L34 -0.0337829
TPM4 tropomyosin 4 -0.0336463
RPS4X ribosomal protein S4, X-linked -0.0335253
NUDT4 nudix (nucleoside diphosphate linked moiety X)-type motif 4 -0.0335171
UBB ubiquitin B -0.0328449
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0326959
CENPF centromere protein F, 350/400kDa -0.0325918