| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Doxycycline (monohydrate) perturbation in hTERT-HPNE cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Doxycycline (monohydrate)_hTERT-HPNE drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0532533 |
| SPAG9 | sperm associated antigen 9 | 0.0509027 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0482511 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0466734 |
| SMAD3 | SMAD family member 3 | 0.0325063 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.0300195 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | 0.0279728 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0272749 |
| ZNF292 | zinc finger protein 292 | 0.0268958 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0258677 |
| NUP58 | nucleoporin 58 | 0.022779 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.0215857 |
| PDE3A | phosphodiesterase 3A, cGMP-inhibited | 0.0212928 |
| MEIS1 | Meis homeobox 1 | 0.0212025 |
| RASA2 | RAS p21 protein activator 2 | 0.0209918 |
| RNF145 | ring finger protein 145 | 0.020735 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0207313 |
| PTK2 | protein tyrosine kinase 2 | 0.0201508 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | 0.0191303 |
| NCKAP1 | NCK-associated protein 1 | 0.0190733 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0187815 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.0184066 |
| TFG | TRK-fused gene | 0.0180124 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0176266 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.0175832 |
| ADGRB3 | adhesion G protein-coupled receptor B3 | 0.0175769 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | 0.017385 |
| LRRFIP2 | leucine rich repeat (in FLII) interacting protein 2 | 0.0167882 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | 0.0165726 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 0.0165554 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0165416 |
| USP12 | ubiquitin specific peptidase 12 | 0.0164052 |
| EXT1 | exostosin glycosyltransferase 1 | 0.01635 |
| ATP13A3 | ATPase type 13A3 | 0.0162428 |
| PHIP | pleckstrin homology domain interacting protein | 0.0161601 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0157174 |
| ANKRD11 | ankyrin repeat domain 11 | 0.015708 |
| USP3 | ubiquitin specific peptidase 3 | 0.0154621 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | 0.0154281 |
| SNX9 | sorting nexin 9 | 0.0151068 |
| ARHGEF12 | Rho guanine nucleotide exchange factor (GEF) 12 | 0.014917 |
| FAM13A | family with sequence similarity 13, member A | 0.0148624 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0143436 |
| PLPP3 | phospholipid phosphatase 3 | 0.0142664 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0142046 |
| NFKB1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | 0.0140641 |
| CRY1 | cryptochrome circadian clock 1 | 0.014064 |
| LOXL2 | lysyl oxidase-like 2 | 0.0139432 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | 0.0138553 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0138473 |
| ANXA5 | annexin A5 | 0.013804 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0137362 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | 0.0135371 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 0.0134182 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0133104 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0133007 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.0132743 |
| CCNL1 | cyclin L1 | 0.0129838 |
| PTPRG | protein tyrosine phosphatase, receptor type, G | 0.0126831 |
| QKI | QKI, KH domain containing, RNA binding | 0.0126635 |
| NUMB | numb homolog (Drosophila) | 0.0126385 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.0125514 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0124986 |
| ARRDC3 | arrestin domain containing 3 | 0.012277 |
| ZMYM2 | zinc finger, MYM-type 2 | 0.0122138 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.0122042 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | 0.0120455 |
| NBAS | neuroblastoma amplified sequence | 0.0119696 |
| RUNX1 | runt-related transcription factor 1 | 0.0119632 |
| PDE8A | phosphodiesterase 8A | 0.0119502 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | 0.0118058 |
| RAPGEF2 | Rap guanine nucleotide exchange factor (GEF) 2 | 0.0118002 |
| XPO1 | exportin 1 | 0.0117027 |
| BCLAF1 | BCL2-associated transcription factor 1 | 0.0116514 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0115877 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0112307 |
| BIRC2 | baculoviral IAP repeat containing 2 | 0.0111946 |
| CD59 | CD59 molecule, complement regulatory protein | 0.0110974 |
| FCHSD2 | FCH and double SH3 domains 2 | 0.0110361 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | 0.0108937 |
| ELF2 | E74-like factor 2 (ets domain transcription factor) | 0.0106671 |
| RAB8B | RAB8B, member RAS oncogene family | 0.0106402 |
| ARL8B | ADP-ribosylation factor-like 8B | 0.0105003 |
| WSB1 | WD repeat and SOCS box containing 1 | 0.010494 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0104651 |
| PID1 | phosphotyrosine interaction domain containing 1 | 0.0104645 |
| PSMD14 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 | 0.0104595 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | 0.0104514 |
| MAP4K5 | mitogen-activated protein kinase kinase kinase kinase 5 | 0.0104507 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0103424 |
| RYBP | RING1 and YY1 binding protein | 0.0103371 |
| PTEN | phosphatase and tensin homolog | 0.0102791 |
| ARID2 | AT rich interactive domain 2 (ARID, RFX-like) | 0.0101753 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0101622 |
| OTUD4 | OTU deubiquitinase 4 | 0.0101406 |
| ZEB1 | zinc finger E-box binding homeobox 1 | 0.0101301 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | 0.0101228 |
| CDK17 | cyclin-dependent kinase 17 | 0.0101212 |
| TXNRD1 | thioredoxin reductase 1 | 0.0100427 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0100045 |
| Symbol | Name | Standardized Value |
|---|---|---|
| VIM | vimentin | -0.332944 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.151923 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.133135 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.12603 |
| FN1 | fibronectin 1 | -0.109842 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0934994 |
| STC1 | stanniocalcin 1 | -0.087165 |
| MMP1 | matrix metallopeptidase 1 | -0.0758729 |
| HLA-B | major histocompatibility complex, class I, B | -0.0735762 |
| TMSB10 | thymosin beta 10 | -0.0638288 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0622352 |
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | -0.0578752 |
| INHBA | inhibin, beta A | -0.0550709 |
| FTL | ferritin, light polypeptide | -0.053554 |
| HMGA2 | high mobility group AT-hook 2 | -0.0534399 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0468454 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | -0.0437625 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0436625 |
| COL1A1 | collagen, type I, alpha 1 | -0.0419371 |
| LIMS1 | LIM and senescent cell antigen-like domains 1 | -0.0415548 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.0375512 |
| CALR | calreticulin | -0.037545 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0369348 |
| ACTG1 | actin gamma 1 | -0.03546 |
| ADM | adrenomedullin | -0.0346603 |
| RPS6 | ribosomal protein S6 | -0.0346439 |
| B2M | beta-2-microglobulin | -0.0344189 |
| COL6A1 | collagen, type VI, alpha 1 | -0.0343367 |
| PAPPA | pregnancy-associated plasma protein A, pappalysin 1 | -0.0341767 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0338442 |
| CANX | calnexin | -0.033712 |
| COL6A2 | collagen, type VI, alpha 2 | -0.0335064 |
| TPM4 | tropomyosin 4 | -0.033143 |
| ENO1 | enolase 1, (alpha) | -0.0329407 |
| MMP12 | matrix metallopeptidase 12 | -0.0311343 |
| RPS8 | ribosomal protein S8 | -0.0305563 |
| CAVIN1 | caveolae associated protein 1 | -0.0302667 |
| COL1A2 | collagen, type I, alpha 2 | -0.0300996 |
| LOX | lysyl oxidase | -0.0293116 |
| EMP1 | epithelial membrane protein 1 | -0.029179 |
| AHNAK | AHNAK nucleoprotein | -0.0290931 |
| RPLP1 | ribosomal protein, large, P1 | -0.0289541 |
| TTC3 | tetratricopeptide repeat domain 3 | -0.0285621 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0279459 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0262622 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0256653 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0256461 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0251252 |
| LGALS1 | lectin, galactoside-binding, soluble, 1 | -0.0250484 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.024677 |
| HLA-A | major histocompatibility complex, class I, A | -0.0244959 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0235772 |
| GREM1 | gremlin 1, DAN family BMP antagonist | -0.0234095 |
| RPL37A | ribosomal protein L37a | -0.0228536 |
| JARID2 | jumonji, AT rich interactive domain 2 | -0.022791 |
| RPL34 | ribosomal protein L34 | -0.0225632 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.022277 |
| TMEM165 | transmembrane protein 165 | -0.0215968 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | -0.0215102 |
| S100A6 | S100 calcium binding protein A6 | -0.0213212 |
| RPL35A | ribosomal protein L35a | -0.0212563 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0205327 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0200219 |
| HILPDA | hypoxia inducible lipid droplet-associated | -0.0199198 |
| RRBP1 | ribosome binding protein 1 | -0.0195835 |
| RAI14 | retinoic acid induced 14 | -0.0194895 |
| RACK1 | receptor for activated C kinase 1 | -0.0194049 |
| REV3L | REV3-like, polymerase (DNA directed), zeta, catalytic subunit | -0.0193018 |
| TMEM158 | transmembrane protein 158 (gene/pseudogene) | -0.0192987 |
| AFF3 | AF4/FMR2 family, member 3 | -0.0192259 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | -0.0188569 |
| HDLBP | high density lipoprotein binding protein | -0.018824 |
| ADAMTS12 | ADAM metallopeptidase with thrombospondin type 1 motif, 12 | -0.0185676 |
| RPL12 | ribosomal protein L12 | -0.0184701 |
| TMSB4X | thymosin beta 4, X-linked | -0.0183153 |
| RPS19 | ribosomal protein S19 | -0.0179925 |
| RPS13 | ribosomal protein S13 | -0.0178864 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0177838 |
| HLA-E | major histocompatibility complex, class I, E | -0.017782 |
| GOLGB1 | golgin B1 | -0.0177687 |
| NCKAP5 | NCK-associated protein 5 | -0.0175878 |
| FBN1 | fibrillin 1 | -0.0175749 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0175569 |
| RPL31 | ribosomal protein L31 | -0.0175521 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | -0.0174872 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0174198 |
| S100A9 | S100 calcium binding protein A9 | -0.0173777 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0172363 |
| MAP1B | microtubule-associated protein 1B | -0.0171766 |
| RPLP2 | ribosomal protein, large, P2 | -0.0171568 |
| RPL23 | ribosomal protein L23 | -0.0166845 |
| ARHGAP22 | Rho GTPase activating protein 22 | -0.0166522 |
| ANXA2 | annexin A2 | -0.0166216 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0164795 |
| NAV1 | neuron navigator 1 | -0.016352 |
| PTMA | prothymosin, alpha | -0.0163501 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | -0.0163322 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | -0.016264 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.0162438 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.0161296 |
