| Dataset | DeepCoverMOA Drug Mechanisms of Action |
| Category | proteomics |
| Type | drug perturbation |
| External Link | https://pubchem.ncbi.nlm.nih.gov/compound/208898 |
| Similar Terms | |
| Downloads & Tools |
197 proteins with high or low expression in Dronedarone relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| MYO3A | myosin IIIA | 1.28 |
| ZNF317 | zinc finger protein 317 | 1.19 |
| PIP | prolactin-induced protein | 1.08 |
| ZNF675 | zinc finger protein 675 | 1.0 |
| SEMG2 | semenogelin II | 0.79 |
| TERF2IP | telomeric repeat binding factor 2, interacting protein | 0.77 |
| MT2A | metallothionein 2A | 0.73 |
| MT1L | metallothionein 1L (gene/pseudogene) | 0.73 |
| RFFL | ring finger and FYVE-like domain containing E3 ubiquitin protein ligase | 0.73 |
| MT1E | metallothionein 1E | 0.7 |
| MAFF | v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F | 0.65 |
| PER2 | period circadian clock 2 | 0.59 |
| LGALSL | lectin, galactoside-binding-like | 0.58 |
| ABLIM3 | actin binding LIM protein family, member 3 | 0.56 |
| HECW2 | HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2 | 0.54 |
| CLCN5 | chloride channel, voltage-sensitive 5 | 0.54 |
| COL12A1 | collagen, type XII, alpha 1 | 0.53 |
| B3GALNT1 | beta-1,3-N-acetylgalactosaminyltransferase 1 (globoside blood group) | 0.52 |
| SET | SET nuclear proto-oncogene | 0.52 |
| IGFN1 | immunoglobulin-like and fibronectin type III domain containing 1 | 0.5 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.49 |
| ZNF584 | zinc finger protein 584 | 0.46 |
| PRELID1 | PRELI domain containing 1 | 0.46 |
| CCN1 | cellular communication network factor 1 | 0.46 |
| CCN3 | cellular communication network factor 3 | 0.46 |
| OTC | ornithine carbamoyltransferase | 0.45 |
| IFRD1 | interferon-related developmental regulator 1 | 0.45 |
| ALDOB | aldolase B, fructose-bisphosphate | 0.44 |
| MSMO1 | methylsterol monooxygenase 1 | 0.44 |
| HYKK | hydroxylysine kinase | 0.43 |
| CCNF | cyclin F | 0.43 |
| ODC1 | ornithine decarboxylase 1 | 0.43 |
| PLD6 | phospholipase D family, member 6 | 0.42 |
| TFR2 | transferrin receptor 2 | 0.42 |
| HSP90AB4P | heat shock protein 90kDa alpha (cytosolic), class B member 4, pseudogene | 0.42 |
| RPL26 | ribosomal protein L26 | 0.42 |
| MCL1 | myeloid cell leukemia 1 | 0.42 |
| CENPP | centromere protein P | 0.41 |
| PRKCQ | protein kinase C, theta | 0.41 |
| HMMR | hyaluronan-mediated motility receptor (RHAMM) | 0.4 |
| C16ORF72 | chromosome 16 open reading frame 72 | 0.39 |
| PANK3 | pantothenate kinase 3 | 0.39 |
| SLF1 | SMC5-SMC6 complex localization factor 1 | 0.39 |
| TLR3 | toll-like receptor 3 | 0.38 |
| RPS26 | ribosomal protein S26 | 0.37 |
| MCM9 | minichromosome maintenance complex component 9 | 0.37 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.37 |
| ABHD2 | abhydrolase domain containing 2 | 0.37 |
| PRNP | prion protein | 0.37 |
| TIMM23B | translocase of inner mitochondrial membrane 23 homolog B (yeast) | 0.36 |
| BAHD1 | bromo adjacent homology domain containing 1 | 0.36 |
| MYH3 | myosin, heavy chain 3, skeletal muscle, embryonic | 0.36 |
| SLC30A1 | solute carrier family 30 (zinc transporter), member 1 | 0.36 |
| DNAJC15 | DnaJ (Hsp40) homolog, subfamily C, member 15 | 0.36 |
| TRAF5 | TNF receptor-associated factor 5 | 0.36 |
| PBK | PDZ binding kinase | 0.36 |
| R3HDM1 | R3H domain containing 1 | 0.35 |
| ATG2A | autophagy related 2A | 0.35 |
| PRXL2C | peroxiredoxin like 2C | 0.35 |
| ZNF616 | zinc finger protein 616 | 0.35 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.35 |
| DIAPH3 | diaphanous-related formin 3 | 0.35 |
| HMGCR | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.34 |
| TTC39C | tetratricopeptide repeat domain 39C | 0.34 |
| CCDC170 | coiled-coil domain containing 170 | 0.34 |
| TMED3 | transmembrane emp24 protein transport domain containing 3 | 0.34 |
| TM2D3 | TM2 domain containing 3 | 0.34 |
| DEPDC7 | DEP domain containing 7 | 0.34 |
| AMD1 | adenosylmethionine decarboxylase 1 | 0.34 |
| KIAA0556 | KIAA0556 | 0.33 |
| MELK | maternal embryonic leucine zipper kinase | 0.33 |
| CEP55 | centrosomal protein 55kDa | 0.33 |
| ZNF431 | zinc finger protein 431 | 0.32 |
| NKAP | NFKB activating protein | 0.32 |
| KIF1B | kinesin family member 1B | 0.32 |
| NR2F2 | nuclear receptor subfamily 2, group F, member 2 | 0.32 |
| DEAF1 | DEAF1 transcription factor | 0.32 |
| C1D | C1D nuclear receptor corepressor | 0.32 |
| CEP83 | centrosomal protein 83kDa | 0.32 |
| COX16 | COX16 cytochrome c oxidase assembly homolog (S. cerevisiae) | 0.32 |
| CAMK4 | calcium/calmodulin-dependent protein kinase IV | 0.32 |
| RPGRIP1L | RPGRIP1-like | 0.32 |
| YBEY | ybeY metallopeptidase (putative) | 0.32 |
| CDC25C | cell division cycle 25C | 0.32 |
| CERK | ceramide kinase | 0.31 |
| RAB3B | RAB3B, member RAS oncogene family | 0.31 |
| SHPRH | SNF2 histone linker PHD RING helicase, E3 ubiquitin protein ligase | 0.31 |
| NOL7 | nucleolar protein 7, 27kDa | 0.31 |
| ZNF430 | zinc finger protein 430 | 0.31 |
| ELF4 | E74-like factor 4 (ets domain transcription factor) | 0.31 |
| BHMT | betaine--homocysteine S-methyltransferase | 0.3 |
| DPH5 | diphthamide biosynthesis 5 | 0.3 |
| GPD1 | glycerol-3-phosphate dehydrogenase 1 (soluble) | 0.3 |
| B4GALNT1 | beta-1,4-N-acetyl-galactosaminyl transferase 1 | 0.3 |
| NEDD8 | neural precursor cell expressed, developmentally down-regulated 8 | 0.3 |
| NADK | NAD kinase | 0.3 |
| LPIN1 | lipin 1 | 0.3 |
| KIF20B | kinesin family member 20B | 0.3 |
| ABHD15 | abhydrolase domain containing 15 | 0.3 |
| AP5M1 | adaptor-related protein complex 5, mu 1 subunit | 0.3 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HPS4 | Hermansky-Pudlak syndrome 4 | -1.65 |
| IKBKG | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma | -1.17 |
| COL2A1 | collagen, type II, alpha 1 | -1.16 |
| CNTLN | centlein, centrosomal protein | -1.13 |
| PSAP | prosaposin | -1.11 |
| DNAH5 | dynein, axonemal, heavy chain 5 | -1.09 |
| STMN2 | stathmin 2 | -1.05 |
| CDA | cytidine deaminase | -1.0 |
| RUNDC1 | RUN domain containing 1 | -0.98 |
| CCDC158 | coiled-coil domain containing 158 | -0.97 |
| CARHSP1 | calcium regulated heat stable protein 1, 24kDa | -0.97 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.92 |
| NR4A2 | nuclear receptor subfamily 4, group A, member 2 | -0.92 |
| ERICH5 | glutamate-rich 5 | -0.91 |
| WTAP | Wilms tumor 1 associated protein | -0.9 |
| MED8 | mediator complex subunit 8 | -0.87 |
| HPCAL4 | hippocalcin like 4 | -0.85 |
| STMN1 | stathmin 1 | -0.84 |
| PXN | paxillin | -0.81 |
| DDAH2 | dimethylarginine dimethylaminohydrolase 2 | -0.8 |
| BAG3 | BCL2-associated athanogene 3 | -0.78 |
| B2M | beta-2-microglobulin | -0.78 |
| BLOC1S3 | biogenesis of lysosomal organelles complex-1, subunit 3 | -0.77 |
| PAFAH1B2 | platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (30kDa) | -0.76 |
| IGBP1 | immunoglobulin (CD79A) binding protein 1 | -0.75 |
| SF3B4 | splicing factor 3b, subunit 4, 49kDa | -0.75 |
| HINT2 | histidine triad nucleotide binding protein 2 | -0.73 |
| CALB2 | calbindin 2 | -0.73 |
| PDCD5 | programmed cell death 5 | -0.73 |
| SOD1 | superoxide dismutase 1, soluble | -0.73 |
| CD2BP2 | CD2 (cytoplasmic tail) binding protein 2 | -0.72 |
| PDRG1 | p53 and DNA-damage regulated 1 | -0.72 |
| TANK | TRAF family member-associated NFKB activator | -0.72 |
| FKBP14 | FK506 binding protein 14, 22 kDa | -0.72 |
| TPM4 | tropomyosin 4 | -0.69 |
| PPP1R14B | protein phosphatase 1, regulatory (inhibitor) subunit 14B | -0.69 |
| PAH | phenylalanine hydroxylase | -0.68 |
| RCN1 | reticulocalbin 1, EF-hand calcium binding domain | -0.68 |
| JPT1 | Jupiter microtubule associated homolog 1 | -0.68 |
| CD58 | CD58 molecule | -0.67 |
| PSME1 | proteasome (prosome, macropain) activator subunit 1 (PA28 alpha) | -0.67 |
| ZNF524 | zinc finger protein 524 | -0.66 |
| LIFR | leukemia inhibitory factor receptor alpha | -0.66 |
| MCOLN1 | mucolipin 1 | -0.66 |
| CYB5B | cytochrome b5 type B (outer mitochondrial membrane) | -0.65 |
| IRGQ | immunity-related GTPase family, Q | -0.65 |
| IFT43 | intraflagellar transport 43 | -0.65 |
| DFFA | DNA fragmentation factor, 45kDa, alpha polypeptide | -0.65 |
| ZYX | zyxin | -0.64 |
| TMOD3 | tropomodulin 3 (ubiquitous) | -0.63 |
| AKT1S1 | AKT1 substrate 1 (proline-rich) | -0.63 |
| SUMF2 | sulfatase modifying factor 2 | -0.63 |
| KITLG | KIT ligand | -0.63 |
| CCS | copper chaperone for superoxide dismutase | -0.63 |
| HPCAL1 | hippocalcin-like 1 | -0.63 |
| MLH3 | mutL homolog 3 | -0.62 |
| RNF126 | ring finger protein 126 | -0.62 |
| MPZL2 | myelin protein zero-like 2 | -0.62 |
| OPTN | optineurin | -0.62 |
| SELENOF | selenoprotein F | -0.61 |
| VPS37A | vacuolar protein sorting 37 homolog A (S. cerevisiae) | -0.6 |
| S100A6 | S100 calcium binding protein A6 | -0.6 |
| POLR2M | polymerase (RNA) II (DNA directed) polypeptide M | -0.59 |
| PEX14 | peroxisomal biogenesis factor 14 | -0.59 |
| TYMP | thymidine phosphorylase | -0.59 |
| C1ORF52 | chromosome 1 open reading frame 52 | -0.59 |
| CDC37L1 | cell division cycle 37-like 1 | -0.58 |
| PGRMC1 | progesterone receptor membrane component 1 | -0.58 |
| NAA38 | N(alpha)-acetyltransferase 38, NatC auxiliary subunit | -0.58 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.58 |
| UBE2NL | ubiquitin-conjugating enzyme E2N-like (gene/pseudogene) | -0.58 |
| FAM114A1 | family with sequence similarity 114, member A1 | -0.57 |
| CDC26 | cell division cycle 26 | -0.57 |
| NSFL1C | NSFL1 (p97) cofactor (p47) | -0.57 |
| ACTBL2 | actin, beta-like 2 | -0.57 |
| DNAAF2 | dynein, axonemal, assembly factor 2 | -0.57 |
| ZC3H6 | zinc finger CCCH-type containing 6 | -0.57 |
| TOM1L2 | target of myb1-like 2 (chicken) | -0.57 |
| HINT1 | histidine triad nucleotide binding protein 1 | -0.57 |
| DERPC | DERPC proline and glycine rich nuclear protein | -0.56 |
| SEPTIN7 | septin 7 | -0.56 |
| LSM1 | LSM1, U6 small nuclear RNA associated | -0.55 |
| ZNF700 | zinc finger protein 700 | -0.55 |
| RXRG | retinoid X receptor, gamma | -0.55 |
| TSSC4 | tumor suppressing subtransferable candidate 4 | -0.55 |
| SGTB | small glutamine-rich tetratricopeptide repeat (TPR)-containing, beta | -0.55 |
| ATP5PD | ATP synthase peripheral stalk subunit d | -0.55 |
| PET117 | PET117 homolog (S. cerevisiae) | -0.55 |
| HSPB1 | heat shock 27kDa protein 1 | -0.54 |
| PRKCSH | protein kinase C substrate 80K-H | -0.54 |
| PON3 | paraoxonase 3 | -0.54 |
| LRP10 | low density lipoprotein receptor-related protein 10 | -0.54 |
| TPM3 | tropomyosin 3 | -0.54 |
| KHSRP | KH-type splicing regulatory protein | -0.54 |
| NDUFV2 | NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa | -0.53 |
| ACY1 | aminoacylase 1 | -0.53 |
| CSTF2T | cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa, tau variant | -0.53 |
