Drospirenone_COLO 205 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Drospirenone perturbation in COLO 205 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Drospirenone_COLO 205 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 0.122757
MYH9 myosin, heavy chain 9, non-muscle 0.105617
ARGLU1 arginine and glutamate rich 1 0.103269
SRRM2 serine/arginine repetitive matrix 2 0.0906457
EZR ezrin 0.0878611
MLPH melanophilin 0.08283
HLA-B major histocompatibility complex, class I, B 0.0738253
FOS FBJ murine osteosarcoma viral oncogene homolog 0.0730527
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0697509
VEGFA vascular endothelial growth factor A 0.0686279
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0668885
TRIO trio Rho guanine nucleotide exchange factor 0.0660507
LOC112694756 uncharaterized LOC112694756 0.0652283
SQSTM1 sequestosome 1 0.0633346
JUN jun proto-oncogene 0.0626486
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0554045
APOL1 apolipoprotein L, 1 0.0529676
BHLHE40 basic helix-loop-helix family, member e40 0.0526232
AFF1 AF4/FMR2 family, member 1 0.0515361
EPHB2 EPH receptor B2 0.0507449
IGFBP3 insulin-like growth factor binding protein 3 0.0501231
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.048997
DST dystonin 0.0489916
NCOR2 nuclear receptor corepressor 2 0.0482763
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0479188
KRT8 keratin 8, type II 0.0473222
LMO7 LIM domain 7 0.0468241
NONO non-POU domain containing, octamer-binding 0.0459303
FTH1 ferritin, heavy polypeptide 1 0.045655
HDAC4 histone deacetylase 4 0.045645
DSCAM Down syndrome cell adhesion molecule 0.0452401
IGF1R insulin-like growth factor 1 receptor 0.0451703
HLA-A major histocompatibility complex, class I, A 0.0447767
ZKSCAN1 zinc finger with KRAB and SCAN domains 1 0.0445528
SMAD3 SMAD family member 3 0.0432835
CDHR2 cadherin-related family member 2 0.043187
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa 0.0424686
SH3PXD2A SH3 and PX domains 2A 0.0424428
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.041874
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0415556
CMIP c-Maf inducing protein 0.0411205
STYXL2 serine/threonine/tyrosine interacting like 2 0.0407739
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta 0.0395649
MBNL2 muscleblind-like splicing regulator 2 0.0394554
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.0391026
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0389787
FAT1 FAT atypical cadherin 1 0.0384534
NDRG1 N-myc downstream regulated 1 0.0384489
ABHD2 abhydrolase domain containing 2 0.0374809
MINK1 misshapen-like kinase 1 0.0373543
DSPP dentin sialophosphoprotein 0.0372996
SREBF2 sterol regulatory element binding transcription factor 2 0.0371684
CGN cingulin 0.0369861
SFTPA2 surfactant protein A2 0.0363124
KRT18 keratin 18, type I 0.0362317
YBX3 Y box binding protein 3 0.0360896
MPRIP myosin phosphatase Rho interacting protein 0.0355216
SLC22A23 solute carrier family 22, member 23 0.0354867
ACIN1 apoptotic chromatin condensation inducer 1 0.0352036
CDK5RAP3 CDK5 regulatory subunit associated protein 3 0.0350985
AKAP13 A kinase (PRKA) anchor protein 13 0.0350242
EEF2 eukaryotic translation elongation factor 2 0.0350194
APOL2 apolipoprotein L, 2 0.0347892
TSHZ2 teashirt zinc finger homeobox 2 0.0345433
TNIP1 TNFAIP3 interacting protein 1 0.0345027
SUPT6H suppressor of Ty 6 homolog (S. cerevisiae) 0.0341591
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble) 0.034057
EGR1 early growth response 1 0.0339665
DNM2 dynamin 2 0.0338966
KIF16B kinesin family member 16B 0.0337377
NEDD9 neural precursor cell expressed, developmentally down-regulated 9 0.0335459
ANXA2 annexin A2 0.0331283
NUMA1 nuclear mitotic apparatus protein 1 0.0326585
ACTG1 actin gamma 1 0.0326327
SHB Src homology 2 domain containing adaptor protein B 0.0321552
PADI1 peptidyl arginine deiminase, type I 0.0320599
MORF4L2 mortality factor 4 like 2 0.0320325
DUSP10 dual specificity phosphatase 10 0.0317272
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid) 0.031603
RAPGEF1 Rap guanine nucleotide exchange factor (GEF) 1 0.0310508
ANXA1 annexin A1 0.0308688
APP amyloid beta (A4) precursor protein 0.0308152
ATP11A ATPase, class VI, type 11A 0.0306992
FOSL2 FOS-like antigen 2 0.0304938
MYO18A myosin XVIIIA 0.0301481
DSCAML1 Down syndrome cell adhesion molecule like 1 0.0299677
TUFT1 tuftelin 1 0.0293968
TMSB4X thymosin beta 4, X-linked 0.0292028
ITGA6 integrin, alpha 6 0.0291604
ARHGEF10L Rho guanine nucleotide exchange factor (GEF) 10-like 0.0287625
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0283481
CPNE1 copine I 0.0280053
RPL3 ribosomal protein L3 0.0279762
SEPTIN9 septin 9 0.0276827
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0276696
MAML2 mastermind-like 2 (Drosophila) 0.0275879
EFHD2 EF-hand domain family, member D2 0.0275787
CREB3L2 cAMP responsive element binding protein 3-like 2 0.0272155
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae) 0.0269631
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0267864

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.169729
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0903123
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0903111
PDIA3 protein disulfide isomerase family A, member 3 -0.0717071
FNDC3A fibronectin type III domain containing 3A -0.0694379
TXNIP thioredoxin interacting protein -0.0631068
C6ORF132 chromosome 6 open reading frame 132 -0.0627567
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0624582
TPT1 tumor protein, translationally-controlled 1 -0.0597141
ZBTB20 zinc finger and BTB domain containing 20 -0.0576015
PTBP3 polypyrimidine tract binding protein 3 -0.0572877
PAN3 PAN3 poly(A) specific ribonuclease subunit -0.0536318
AHI1 Abelson helper integration site 1 -0.0519022
SP100 SP100 nuclear antigen -0.0517954
IFI6 interferon, alpha-inducible protein 6 -0.0506393
XAF1 XIAP associated factor 1 -0.0499097
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0470409
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.043346
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 -0.0428892
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0422574
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0415621
BTBD9 BTB (POZ) domain containing 9 -0.0409231
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0395763
PLSCR1 phospholipid scramblase 1 -0.0382818
UBR2 ubiquitin protein ligase E3 component n-recognin 2 -0.0379886
EPSTI1 epithelial stromal interaction 1 (breast) -0.0371784
CD2AP CD2-associated protein -0.034036
VCL vinculin -0.0337277
UFM1 ubiquitin-fold modifier 1 -0.033352
MEIS2 Meis homeobox 2 -0.0333088
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0329151
MTDH metadherin -0.0316597
NT5C2 5'-nucleotidase, cytosolic II -0.030915
TM9SF2 transmembrane 9 superfamily member 2 -0.0307901
WSB1 WD repeat and SOCS box containing 1 -0.03055
N4BP2L2 NEDD4 binding protein 2-like 2 -0.0301293
DSTN destrin (actin depolymerizing factor) -0.0299547
STAU1 staufen double-stranded RNA binding protein 1 -0.0295283
RIGI RNA sensor RIG-I -0.029526
ZMYM2 zinc finger, MYM-type 2 -0.0294879
NCOA7 nuclear receptor coactivator 7 -0.0289812
GNAS GNAS complex locus -0.0276279
HMGB1 high mobility group box 1 -0.0271993
RABGAP1L RAB GTPase activating protein 1-like -0.0269776
RPL7L1 ribosomal protein L7-like 1 -0.0269685
GCC2 GRIP and coiled-coil domain containing 2 -0.0269211
SPATS2L spermatogenesis associated, serine-rich 2-like -0.0267183
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.026615
CPEB4 cytoplasmic polyadenylation element binding protein 4 -0.0265342
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0264455
NUCB2 nucleobindin 2 -0.0263303
PIBF1 progesterone immunomodulatory binding factor 1 -0.0262313
NRIP1 nuclear receptor interacting protein 1 -0.0255823
ANKRD12 ankyrin repeat domain 12 -0.0253556
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) -0.0250946
CDCP1 CUB domain containing protein 1 -0.0249974
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) -0.0249094
APOL6 apolipoprotein L, 6 -0.0249066
TJP1 tight junction protein 1 -0.0247358
TM4SF1 transmembrane 4 L six family member 1 -0.024466
ITFG1 integrin alpha FG-GAP repeat containing 1 -0.024168
SLC38A1 solute carrier family 38, member 1 -0.0240923
MBD5 methyl-CpG binding domain protein 5 -0.0239772
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0237797
RPLP1 ribosomal protein, large, P1 -0.0237543
TMEM87A transmembrane protein 87A -0.0234846
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0234006
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0232876
FAF1 Fas (TNFRSF6) associated factor 1 -0.0230217
LIMA1 LIM domain and actin binding 1 -0.0229756
RUNX1 runt-related transcription factor 1 -0.0229535
RHOBTB3 Rho-related BTB domain containing 3 -0.0229075
UGGT2 UDP-glucose glycoprotein glucosyltransferase 2 -0.0227894
PERP PERP, TP53 apoptosis effector -0.022721
TMEM123 transmembrane protein 123 -0.0227075
NIPBL Nipped-B homolog (Drosophila) -0.0226902
ZNFX1 zinc finger, NFX1-type containing 1 -0.022443
RTN3 reticulon 3 -0.022136
NCKAP5 NCK-associated protein 5 -0.0220927
NIPSNAP2 nipsnap homolog 2 -0.0218995
MPHOSPH8 M-phase phosphoprotein 8 -0.0217839
SEC62 SEC62 homolog (S. cerevisiae) -0.0215305
NFE2L2 nuclear factor, erythroid 2-like 2 -0.021462
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0211304
GORASP2 golgi reassembly stacking protein 2, 55kDa -0.0209954
EHF ets homologous factor -0.0209074
TM9SF3 transmembrane 9 superfamily member 3 -0.0208627
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0207488
SRP72 signal recognition particle 72kDa -0.0206813
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.020666
SEC31A SEC31 homolog A (S. cerevisiae) -0.0205757
ZNF207 zinc finger protein 207 -0.0205487
SPRED2 sprouty-related, EVH1 domain containing 2 -0.0205143
NDFIP2 Nedd4 family interacting protein 2 -0.0203421
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0202656
WWOX WW domain containing oxidoreductase -0.0201091
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0200602
CANX calnexin -0.0200561
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 -0.0198872
NEBL nebulette -0.019696