| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Drospirenone perturbation in HS-578T cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Drospirenone_HS-578T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| COL6A3 | collagen, type VI, alpha 3 | 0.506576 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.267305 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.195836 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0989635 |
| VEGFA | vascular endothelial growth factor A | 0.0948247 |
| PLEC | plectin | 0.0900047 |
| ITGA5 | integrin, alpha 5 (fibronectin receptor, alpha polypeptide) | 0.079753 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0786525 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0713808 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0641551 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0603467 |
| CALR | calreticulin | 0.0514794 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0493131 |
| FLNA | filamin A, alpha | 0.0422976 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0421274 |
| HLA-B | major histocompatibility complex, class I, B | 0.0420581 |
| TMSB4X | thymosin beta 4, X-linked | 0.0394562 |
| SLC6A6 | solute carrier family 6 (neurotransmitter transporter), member 6 | 0.0361053 |
| APP | amyloid beta (A4) precursor protein | 0.0353346 |
| COL7A1 | collagen, type VII, alpha 1 | 0.033989 |
| SMAD3 | SMAD family member 3 | 0.0338564 |
| RPL3 | ribosomal protein L3 | 0.0333266 |
| HLA-C | major histocompatibility complex, class I, C | 0.0329699 |
| YBX1 | Y box binding protein 1 | 0.0288707 |
| LDHA | lactate dehydrogenase A | 0.028324 |
| MT1X | metallothionein 1X | 0.0265307 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.025571 |
| PTTG1IP | pituitary tumor-transforming 1 interacting protein | 0.0245984 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0244766 |
| TRAM2 | translocation associated membrane protein 2 | 0.0242731 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0242627 |
| ATP13A3 | ATPase type 13A3 | 0.023858 |
| CAMTA1 | calmodulin binding transcription activator 1 | 0.0235787 |
| MED15 | mediator complex subunit 15 | 0.0232392 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0227078 |
| CNOT12 | CCR4-NOT transcription complex subunit 12 | 0.0226968 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0224995 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | 0.0222918 |
| NUMA1 | nuclear mitotic apparatus protein 1 | 0.0219543 |
| CD59 | CD59 molecule, complement regulatory protein | 0.0218749 |
| TNS1 | tensin 1 | 0.0217963 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0217613 |
| FN1 | fibronectin 1 | 0.0215955 |
| PPP1R18 | protein phosphatase 1, regulatory subunit 18 | 0.0214806 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0212039 |
| SREBF2 | sterol regulatory element binding transcription factor 2 | 0.0209398 |
| EIF4H | eukaryotic translation initiation factor 4H | 0.0208052 |
| NONO | non-POU domain containing, octamer-binding | 0.0205369 |
| HYOU1 | hypoxia up-regulated 1 | 0.0203825 |
| NFKBIZ | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta | 0.0203304 |
| RAD21 | RAD21 homolog (S. pombe) | 0.0200998 |
| NCOR2 | nuclear receptor corepressor 2 | 0.0200384 |
| P4HA2 | prolyl 4-hydroxylase, alpha polypeptide II | 0.019859 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0198267 |
| SHB | Src homology 2 domain containing adaptor protein B | 0.0197737 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0194637 |
| JUN | jun proto-oncogene | 0.0188889 |
| CAVIN1 | caveolae associated protein 1 | 0.0186227 |
| ITPR3 | inositol 1,4,5-trisphosphate receptor, type 3 | 0.0185185 |
| AHDC1 | AT hook, DNA binding motif, containing 1 | 0.0180612 |
| ANXA2 | annexin A2 | 0.0180051 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0178737 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | 0.0178064 |
| SUPT5H | suppressor of Ty 5 homolog (S. cerevisiae) | 0.0176814 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0175522 |
| SDC2 | syndecan 2 | 0.0174871 |
| CABIN1 | calcineurin binding protein 1 | 0.0173703 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0172805 |
| CPNE1 | copine I | 0.0170911 |
| ACTN1 | actinin, alpha 1 | 0.0168478 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0168291 |
| CAP1 | CAP, adenylate cyclase-associated protein 1 (yeast) | 0.0168107 |
| AP2M1 | adaptor-related protein complex 2, mu 1 subunit | 0.0167607 |
| COL4A1 | collagen, type IV, alpha 1 | 0.016736 |
| YWHAQ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta | 0.0163799 |
| ADM | adrenomedullin | 0.0163174 |
| B2M | beta-2-microglobulin | 0.0160464 |
| COPG1 | coatomer protein complex, subunit gamma 1 | 0.0159479 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0158312 |
| SEPTIN2 | septin 2 | 0.0158242 |
| SF3B1 | splicing factor 3b, subunit 1, 155kDa | 0.0157904 |
| SFTPA2 | surfactant protein A2 | 0.0156697 |
| SLC39A14 | solute carrier family 39 (zinc transporter), member 14 | 0.0156278 |
| CEP250 | centrosomal protein 250kDa | 0.0155046 |
| OPTN | optineurin | 0.0153369 |
| ARRDC3 | arrestin domain containing 3 | 0.0152499 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0152298 |
| PRKAR1A | protein kinase, cAMP-dependent, regulatory, type I, alpha | 0.0151173 |
| APOL2 | apolipoprotein L, 2 | 0.0150772 |
| CCDC9 | coiled-coil domain containing 9 | 0.0149938 |
| FDFT1 | farnesyl-diphosphate farnesyltransferase 1 | 0.0149687 |
| UBR4 | ubiquitin protein ligase E3 component n-recognin 4 | 0.0149511 |
| OGA | O-GlcNAcase | 0.0148885 |
| HRNR | hornerin | 0.0146974 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.014654 |
| MSN | moesin | 0.0144444 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0143372 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0142249 |
| NAV2 | neuron navigator 2 | 0.0141279 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0140097 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.178254 |
| COL1A1 | collagen, type I, alpha 1 | -0.132727 |
| CDH13 | cadherin 13 | -0.131299 |
| CD44 | CD44 molecule (Indian blood group) | -0.0884889 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.0875923 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.086751 |
| VIM | vimentin | -0.0807853 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0790253 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0783736 |
| NKAIN3 | Na+/K+ transporting ATPase interacting 3 | -0.0761113 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0755831 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.0749442 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0695793 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0683938 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0653382 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | -0.0638284 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0604524 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0599178 |
| FBN1 | fibrillin 1 | -0.0561863 |
| LIMS1 | LIM and senescent cell antigen-like domains 1 | -0.0503663 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | -0.0482494 |
| TRPS1 | trichorhinophalangeal syndrome I | -0.0474863 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0472431 |
| VCAN | versican | -0.0463899 |
| STC1 | stanniocalcin 1 | -0.0455548 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.045453 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.043767 |
| COL1A2 | collagen, type I, alpha 2 | -0.0435404 |
| MAP4 | microtubule-associated protein 4 | -0.0434827 |
| ASPH | aspartate beta-hydroxylase | -0.043045 |
| GOLGB1 | golgin B1 | -0.0410547 |
| TMEM158 | transmembrane protein 158 (gene/pseudogene) | -0.0395944 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | -0.0388629 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0385887 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0379788 |
| LOX | lysyl oxidase | -0.036534 |
| MTDH | metadherin | -0.0362833 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0358907 |
| GLIS3 | GLIS family zinc finger 3 | -0.0350516 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | -0.0347037 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.034468 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | -0.0334565 |
| IER3 | immediate early response 3 | -0.0333523 |
| EFNA5 | ephrin-A5 | -0.0312839 |
| INHBA | inhibin, beta A | -0.0312563 |
| MBNL1 | muscleblind-like splicing regulator 1 | -0.0301548 |
| EGFR | epidermal growth factor receptor | -0.0297335 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0295509 |
| JARID2 | jumonji, AT rich interactive domain 2 | -0.0294066 |
| RPS8 | ribosomal protein S8 | -0.0291726 |
| CLMP | CXADR-like membrane protein | -0.0290659 |
| LTBP1 | latent transforming growth factor beta binding protein 1 | -0.0289374 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | -0.0287391 |
| RPS2 | ribosomal protein S2 | -0.0285307 |
| IL6 | interleukin 6 | -0.0284454 |
| HMGA2 | high mobility group AT-hook 2 | -0.0279434 |
| PTK2 | protein tyrosine kinase 2 | -0.0271274 |
| ADAM12 | ADAM metallopeptidase domain 12 | -0.027044 |
| IL6ST | interleukin 6 signal transducer | -0.026978 |
| FOXP1 | forkhead box P1 | -0.0265284 |
| RUNX1 | runt-related transcription factor 1 | -0.026381 |
| SUPT3H | suppressor of Ty 3 homolog (S. cerevisiae) | -0.0257752 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0257741 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0255791 |
| CNTN5 | contactin 5 | -0.0252404 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0251551 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | -0.0249233 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | -0.0242401 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0242393 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0236642 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0235438 |
| FBXL13 | F-box and leucine-rich repeat protein 13 | -0.0235227 |
| PDE10A | phosphodiesterase 10A | -0.0234839 |
| COL3A1 | collagen, type III, alpha 1 | -0.0232681 |
| EDIL3 | EGF-like repeats and discoidin I-like domains 3 | -0.0232021 |
| NRP1 | neuropilin 1 | -0.0230284 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0228696 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0225664 |
| GOLGA4 | golgin A4 | -0.0224762 |
| CALD1 | caldesmon 1 | -0.0220052 |
| ABI3BP | ABI family, member 3 (NESH) binding protein | -0.0219436 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0216007 |
| ANKRD12 | ankyrin repeat domain 12 | -0.0215816 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0211814 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0207813 |
| VMP1 | vacuole membrane protein 1 | -0.0207111 |
| RAB2A | RAB2A, member RAS oncogene family | -0.0206535 |
| CDK13 | cyclin-dependent kinase 13 | -0.0206332 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | -0.020624 |
| OXR1 | oxidation resistance 1 | -0.0205732 |
| ZFPM2 | zinc finger protein, FOG family member 2 | -0.0204146 |
| POTEF | POTE ankyrin domain family, member F | -0.0201283 |
| ATXN1 | ataxin 1 | -0.0200893 |
| TTC3 | tetratricopeptide repeat domain 3 | -0.0200741 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0198478 |
| BBS9 | Bardet-Biedl syndrome 9 | -0.0196404 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0194817 |
| HYCC1 | hyccin PI4KA lipid kinase complex subunit 1 | -0.0194817 |
| ANTXR2 | anthrax toxin receptor 2 | -0.0194574 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0192563 |
