| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Drospirenone perturbation in HepG2/C3A cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Drospirenone_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.311759 |
| VEGFA | vascular endothelial growth factor A | 0.122214 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.10376 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.100625 |
| DSPP | dentin sialophosphoprotein | 0.0998864 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0880581 |
| PEG3 | paternally expressed 3 | 0.0798351 |
| SDC4 | syndecan 4 | 0.0760568 |
| RPL3 | ribosomal protein L3 | 0.0738781 |
| PTTG1IP | pituitary tumor-transforming 1 interacting protein | 0.0633743 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0613557 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0541469 |
| AFDN | afadin, adherens junction formation factor | 0.0528892 |
| SORL1 | sortilin-related receptor, L(DLR class) A repeats containing | 0.0503449 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0500987 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0485038 |
| TNS1 | tensin 1 | 0.0484644 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0475719 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0458247 |
| C3 | complement component 3 | 0.045196 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0451532 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.044344 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0426799 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0405364 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0387472 |
| CLTB | clathrin, light chain B | 0.0373618 |
| KRT8 | keratin 8, type II | 0.0369726 |
| PLEC | plectin | 0.0354965 |
| NONO | non-POU domain containing, octamer-binding | 0.0351965 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0350244 |
| NEDD9 | neural precursor cell expressed, developmentally down-regulated 9 | 0.0349318 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0348561 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.034665 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0342719 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0335478 |
| KIZ | kizuna centrosomal protein | 0.0330784 |
| CFB | complement factor B | 0.0322862 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.0321476 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | 0.0304748 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0289663 |
| NOLC1 | nucleolar and coiled-body phosphoprotein 1 | 0.0289463 |
| AHSG | alpha-2-HS-glycoprotein | 0.0288109 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0285369 |
| TF | transferrin | 0.0277737 |
| NKD1 | naked cuticle homolog 1 (Drosophila) | 0.0277543 |
| NFKBIZ | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta | 0.0277087 |
| LDHA | lactate dehydrogenase A | 0.0271358 |
| NCOR2 | nuclear receptor corepressor 2 | 0.0270286 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0270095 |
| CP | ceruloplasmin (ferroxidase) | 0.0266767 |
| EPB41L2 | erythrocyte membrane protein band 4.1-like 2 | 0.0265311 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0264903 |
| CEP250 | centrosomal protein 250kDa | 0.026341 |
| APOE | apolipoprotein E | 0.0259926 |
| PCBP2 | poly(rC) binding protein 2 | 0.0257398 |
| SESTD1 | SEC14 and spectrin domains 1 | 0.0256108 |
| PRKAR1A | protein kinase, cAMP-dependent, regulatory, type I, alpha | 0.025403 |
| IGF1R | insulin-like growth factor 1 receptor | 0.0253247 |
| BCL3 | B-cell CLL/lymphoma 3 | 0.0250729 |
| KRT18 | keratin 18, type I | 0.0242953 |
| MLLT10 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 | 0.02419 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 0.0241383 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0240417 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | 0.0240363 |
| SEPTIN9 | septin 9 | 0.0239076 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0237527 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0235653 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | 0.0233602 |
| SERPINA5 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5 | 0.023193 |
| FLNB | filamin B, beta | 0.0229819 |
| OGA | O-GlcNAcase | 0.0227728 |
| INSIG2 | insulin induced gene 2 | 0.0225234 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.0222343 |
| RAB6A | RAB6A, member RAS oncogene family | 0.0217587 |
| DBN1 | drebrin 1 | 0.0214688 |
| YBX1 | Y box binding protein 1 | 0.0213957 |
| HNRNPF | heterogeneous nuclear ribonucleoprotein F | 0.021195 |
| ARGLU1 | arginine and glutamate rich 1 | 0.021172 |
| CPNE1 | copine I | 0.0208735 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0206364 |
| MED15 | mediator complex subunit 15 | 0.0206173 |
| SET | SET nuclear proto-oncogene | 0.0202833 |
| DNAJB1 | DnaJ (Hsp40) homolog, subfamily B, member 1 | 0.0202391 |
| CALR | calreticulin | 0.0199171 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0197982 |
| TPM3 | tropomyosin 3 | 0.0195624 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0195423 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0194479 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.0192386 |
| RAPGEF1 | Rap guanine nucleotide exchange factor (GEF) 1 | 0.0192255 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0191546 |
| HNRNPA3 | heterogeneous nuclear ribonucleoprotein A3 | 0.0191277 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | 0.0190956 |
| EFHD2 | EF-hand domain family, member D2 | 0.0190511 |
| SFTPA2 | surfactant protein A2 | 0.018943 |
| HSPA1A | heat shock 70kDa protein 1A | 0.0189293 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0189197 |
| EML4 | echinoderm microtubule associated protein like 4 | 0.0188839 |
| SF3B1 | splicing factor 3b, subunit 1, 155kDa | 0.0186914 |
| GIGYF2 | GRB10 interacting GYF protein 2 | 0.0182826 |
| Symbol | Name | Standardized Value |
|---|---|---|
| IGF2 | insulin-like growth factor 2 | -0.31485 |
| SERPINA1 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | -0.276167 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.177135 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.149761 |
| MT2A | metallothionein 2A | -0.12848 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | -0.114149 |
| SLC38A2 | solute carrier family 38, member 2 | -0.113492 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | -0.105705 |
| APOB | apolipoprotein B | -0.0947343 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0899718 |
| GPC3 | glypican 3 | -0.0871052 |
| IGFBP1 | insulin-like growth factor binding protein 1 | -0.0732621 |
| RPS8 | ribosomal protein S8 | -0.0646942 |
| EHBP1 | EH domain binding protein 1 | -0.0586967 |
| RPLP1 | ribosomal protein, large, P1 | -0.0582752 |
| FN1 | fibronectin 1 | -0.0571447 |
| RPS12 | ribosomal protein S12 | -0.0564906 |
| RPS24 | ribosomal protein S24 | -0.0559598 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.053154 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0529398 |
| APOA2 | apolipoprotein A-II | -0.0507675 |
| GPC6 | glypican 6 | -0.0504667 |
| RPL37A | ribosomal protein L37a | -0.0477902 |
| SERPINA3 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 | -0.0472771 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0460042 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0456313 |
| SVIL | supervillin | -0.0453518 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0443075 |
| VCL | vinculin | -0.0427501 |
| ATXN1 | ataxin 1 | -0.041826 |
| RPLP2 | ribosomal protein, large, P2 | -0.0417191 |
| RPS23 | ribosomal protein S23 | -0.0400525 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0400101 |
| RPS29 | ribosomal protein S29 | -0.0394881 |
| CCL20 | chemokine (C-C motif) ligand 20 | -0.0394811 |
| RPL26 | ribosomal protein L26 | -0.0369523 |
| RPLP0 | ribosomal protein, large, P0 | -0.0366143 |
| RPL34 | ribosomal protein L34 | -0.0363261 |
| RPS13 | ribosomal protein S13 | -0.0363099 |
| MAN1A1 | mannosidase, alpha, class 1A, member 1 | -0.0354102 |
| JMJD1C | jumonji domain containing 1C | -0.0353304 |
| DHRS2 | dehydrogenase/reductase (SDR family) member 2 | -0.0346443 |
| IER3 | immediate early response 3 | -0.0335553 |
| EGR1 | early growth response 1 | -0.0333159 |
| RPS15 | ribosomal protein S15 | -0.0331114 |
| RPS3 | ribosomal protein S3 | -0.0325064 |
| RPS10 | ribosomal protein S10 | -0.0324788 |
| RPS21 | ribosomal protein S21 | -0.0324726 |
| RPS6 | ribosomal protein S6 | -0.0317684 |
| HMGA1 | high mobility group AT-hook 1 | -0.0313032 |
| RPL32 | ribosomal protein L32 | -0.0303901 |
| SPATS2L | spermatogenesis associated, serine-rich 2-like | -0.0303048 |
| TM9SF3 | transmembrane 9 superfamily member 3 | -0.0295098 |
| RPS19 | ribosomal protein S19 | -0.0288113 |
| RPL10A | ribosomal protein L10a | -0.0287086 |
| RPL11 | ribosomal protein L11 | -0.0282521 |
| IRF2BP2 | interferon regulatory factor 2 binding protein 2 | -0.0278426 |
| FTL | ferritin, light polypeptide | -0.0277431 |
| RPS5 | ribosomal protein S5 | -0.0275022 |
| RPS27A | ribosomal protein S27a | -0.0274353 |
| RPL5 | ribosomal protein L5 | -0.0270916 |
| MALRD1 | MAM and LDL receptor class A domain containing 1 | -0.0262803 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0261941 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | -0.0260583 |
| RPL31 | ribosomal protein L31 | -0.025851 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0258093 |
| ITGAV | integrin, alpha V | -0.025571 |
| ACSL4 | acyl-CoA synthetase long-chain family member 4 | -0.0253973 |
| ASPH | aspartate beta-hydroxylase | -0.0248128 |
| MBD5 | methyl-CpG binding domain protein 5 | -0.0245384 |
| RPS25 | ribosomal protein S25 | -0.0241419 |
| TMEM123 | transmembrane protein 123 | -0.023882 |
| RPS16 | ribosomal protein S16 | -0.0236451 |
| ISG15 | ISG15 ubiquitin-like modifier | -0.0235398 |
| KIF21A | kinesin family member 21A | -0.0232719 |
| PTCHD4 | patched domain containing 4 | -0.0231265 |
| HS2ST1 | heparan sulfate 2-O-sulfotransferase 1 | -0.0231239 |
| DEK | DEK proto-oncogene | -0.0228729 |
| MCL1 | myeloid cell leukemia 1 | -0.0227441 |
| SLC16A3 | solute carrier family 16 (monocarboxylate transporter), member 3 | -0.0226175 |
| ROCK2 | Rho-associated, coiled-coil containing protein kinase 2 | -0.0224641 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | -0.0222891 |
| MBNL3 | muscleblind-like splicing regulator 3 | -0.0222819 |
| RPS11 | ribosomal protein S11 | -0.0218812 |
| SOS1 | son of sevenless homolog 1 (Drosophila) | -0.0217421 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0215299 |
| TGFBR2 | transforming growth factor, beta receptor II (70/80kDa) | -0.0211254 |
| STAU1 | staufen double-stranded RNA binding protein 1 | -0.0209113 |
| RPL23 | ribosomal protein L23 | -0.0208513 |
| PHF3 | PHD finger protein 3 | -0.0208491 |
| RPL27 | ribosomal protein L27 | -0.020753 |
| RPL30 | ribosomal protein L30 | -0.0205782 |
| RTN4 | reticulon 4 | -0.0204108 |
| TXNIP | thioredoxin interacting protein | -0.0203507 |
| PNRC1 | proline-rich nuclear receptor coactivator 1 | -0.0199933 |
| FOXP1 | forkhead box P1 | -0.0199131 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.019815 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0196391 |
| ID1 | inhibitor of DNA binding 1, dominant negative helix-loop-helix protein | -0.0191924 |
| FRMD5 | FERM domain containing 5 | -0.0191102 |
