Drospirenone_NCI-H2122 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Drospirenone perturbation in NCI-H2122 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Drospirenone_NCI-H2122 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
KMT2E lysine (K)-specific methyltransferase 2E 0.0978747
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.091126
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0866405
ZFAND3 zinc finger, AN1-type domain 3 0.0839781
DST dystonin 0.0757934
GSK3B glycogen synthase kinase 3 beta 0.075175
HMGA2 high mobility group AT-hook 2 0.0729509
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.072132
PGK1 phosphoglycerate kinase 1 0.0717445
EEF2 eukaryotic translation elongation factor 2 0.0716745
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0673463
VMP1 vacuole membrane protein 1 0.0645687
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta 0.0635472
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0625806
VCL vinculin 0.0619077
PDE4B phosphodiesterase 4B, cAMP-specific 0.059066
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0579787
RUNX1 runt-related transcription factor 1 0.0571662
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.05703
MACC1 metastasis associated in colon cancer 1 0.0569757
GARS1 glycyl-tRNA synthetase 1 0.0560854
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0559696
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.055595
NUP58 nucleoporin 58 0.0550931
PRRC2B proline-rich coiled-coil 2B 0.0535055
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0527316
ANKRD10 ankyrin repeat domain 10 0.0523297
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0522933
ZNF292 zinc finger protein 292 0.0522733
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0512653
WAC WW domain containing adaptor with coiled-coil 0.0508244
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0480109
CSDE1 cold shock domain containing E1, RNA-binding 0.0475014
FMNL2 formin-like 2 0.0461683
TJP1 tight junction protein 1 0.045978
FAT1 FAT atypical cadherin 1 0.0457722
SOS1 son of sevenless homolog 1 (Drosophila) 0.0451245
ARHGAP32 Rho GTPase activating protein 32 0.0449132
SREBF2 sterol regulatory element binding transcription factor 2 0.0444161
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.044129
MTMR3 myotubularin related protein 3 0.0435637
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0433553
MYH9 myosin, heavy chain 9, non-muscle 0.0432397
ELL2 elongation factor, RNA polymerase II, 2 0.0432182
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0431757
SRRM2 serine/arginine repetitive matrix 2 0.0431752
PDPK1 3-phosphoinositide dependent protein kinase 1 0.0429739
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0429262
KYNU kynureninase 0.0429115
SNX9 sorting nexin 9 0.0428223
LPP LIM domain containing preferred translocation partner in lipoma 0.0427149
MPRIP myosin phosphatase Rho interacting protein 0.0423092
ITPRID2 ITPR interacting domain containing 2 0.0412458
OSBPL9 oxysterol binding protein-like 9 0.0410966
AFF1 AF4/FMR2 family, member 1 0.0407122
FNBP4 formin binding protein 4 0.0406308
AFF4 AF4/FMR2 family, member 4 0.0405605
ZC3H11A zinc finger CCCH-type containing 11A 0.0400698
FYN FYN proto-oncogene, Src family tyrosine kinase 0.0398877
NCKAP1 NCK-associated protein 1 0.0394823
RAP1B RAP1B, member of RAS oncogene family 0.0394554
CHD1 chromodomain helicase DNA binding protein 1 0.0394382
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0394115
DIAPH2 diaphanous-related formin 2 0.0393476
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0391359
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0389624
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0389335
PCDH7 protocadherin 7 0.0383269
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0381057
NKD1 naked cuticle homolog 1 (Drosophila) 0.0380713
USP9X ubiquitin specific peptidase 9, X-linked 0.0380527
BPTF bromodomain PHD finger transcription factor 0.0375587
OSBPL10 oxysterol binding protein-like 10 0.0373396
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase 0.0366682
IGFBP3 insulin-like growth factor binding protein 3 0.0365968
PLEC plectin 0.0363251
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.036302
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0360433
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0359984
ATP13A3 ATPase type 13A3 0.0358871
ANKHD1 ankyrin repeat and KH domain containing 1 0.0356498
CSNK2A2 casein kinase 2, alpha prime polypeptide 0.0356179
PATJ PATJ crumbs cell polarity complex component 0.0354549
HM13 histocompatibility (minor) 13 0.0353947
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0353217
PAPOLA poly(A) polymerase alpha 0.0352077
ATXN1 ataxin 1 0.0349262
NLGN1 neuroligin 1 0.0347169
PRELID2 PRELI domain containing 2 0.0343105
SCAF11 SR-related CTD-associated factor 11 0.0339463
NPAS2 neuronal PAS domain protein 2 0.0338349
KLC1 kinesin light chain 1 0.032958
RNMT RNA (guanine-7-) methyltransferase 0.0328001
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0319177
MED13 mediator complex subunit 13 0.0310977
SNX14 sorting nexin 14 0.0310845
RPL3 ribosomal protein L3 0.0310751
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0310554
PRRC2C proline-rich coiled-coil 2C 0.0310306
YBX1 Y box binding protein 1 0.0310099

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.136363
MT2A metallothionein 2A -0.122933
VIM vimentin -0.108126
TMSB10 thymosin beta 10 -0.106467
AK1 adenylate kinase 1 -0.0919006
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0916936
ATP2C2 ATPase, Ca++ transporting, type 2C, member 2 -0.0915784
B2M beta-2-microglobulin -0.0905098
PRKCA protein kinase C, alpha -0.0866793
BACE2 beta-site APP-cleaving enzyme 2 -0.08375
FTL ferritin, light polypeptide -0.0833288
RPL19 ribosomal protein L19 -0.0798879
NAP1L1 nucleosome assembly protein 1-like 1 -0.0784728
ATOSA atos homolog A -0.0777446
CALU calumenin -0.0769416
TM4SF1 transmembrane 4 L six family member 1 -0.0752957
PKM pyruvate kinase, muscle -0.0752175
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0709421
JMJD1C jumonji domain containing 1C -0.0697912
RIGI RNA sensor RIG-I -0.0690547
CD44 CD44 molecule (Indian blood group) -0.0684571
TPT1 tumor protein, translationally-controlled 1 -0.0671772
METTL15 methyltransferase like 15 -0.062509
TMEM165 transmembrane protein 165 -0.0619838
MXD1 MAX dimerization protein 1 -0.0593358
FNDC3B fibronectin type III domain containing 3B -0.0589737
LAMB3 laminin, beta 3 -0.0585096
MARCHF6 membrane associated ring-CH-type finger 6 -0.0584607
KRT19 keratin 19, type I -0.0582849
S100A10 S100 calcium binding protein A10 -0.0576146
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) -0.0570307
ARHGAP12 Rho GTPase activating protein 12 -0.0569732
RPLP1 ribosomal protein, large, P1 -0.0549029
HLA-B major histocompatibility complex, class I, B -0.0546616
CDCP1 CUB domain containing protein 1 -0.0524071
ESYT2 extended synaptotagmin-like protein 2 -0.0521172
TBC1D5 TBC1 domain family, member 5 -0.0519997
RPL34 ribosomal protein L34 -0.0518422
ZNFX1 zinc finger, NFX1-type containing 1 -0.0516024
MBNL2 muscleblind-like splicing regulator 2 -0.0504479
TMPRSS4 transmembrane protease, serine 4 -0.0494655
RPS11 ribosomal protein S11 -0.0488145
NPEPPS aminopeptidase puromycin sensitive -0.0479366
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 -0.0477362
ZNF638 zinc finger protein 638 -0.0469321
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 -0.0466799
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 -0.0465526
SEC31A SEC31 homolog A (S. cerevisiae) -0.04644
MAP2K1 mitogen-activated protein kinase kinase 1 -0.0461862
NF1 neurofibromin 1 -0.045939
RPS21 ribosomal protein S21 -0.0459358
CEMIP cell migration inducing protein, hyaluronan binding -0.0458366
RPL35A ribosomal protein L35a -0.0456941
RNF149 ring finger protein 149 -0.0454876
KLF6 Kruppel-like factor 6 -0.0454663
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0454656
CSTB cystatin B (stefin B) -0.0452306
RPS3 ribosomal protein S3 -0.0451946
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 -0.0451444
RPS19 ribosomal protein S19 -0.0447541
ENO1 enolase 1, (alpha) -0.0447278
MAP4 microtubule-associated protein 4 -0.0446471
PTMA prothymosin, alpha -0.0445512
CAPN2 calpain 2, (m/II) large subunit -0.0444664
WSB1 WD repeat and SOCS box containing 1 -0.0443522
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0438596
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.043496
CMIP c-Maf inducing protein -0.0429656
S100A9 S100 calcium binding protein A9 -0.0429649
LIMA1 LIM domain and actin binding 1 -0.0418604
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0417665
RNF213 ring finger protein 213 -0.0416472
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) -0.041565
TPI1 triosephosphate isomerase 1 -0.0413408
ANTXR2 anthrax toxin receptor 2 -0.0412654
AKAP13 A kinase (PRKA) anchor protein 13 -0.0411325
CANX calnexin -0.0410131
GNAS GNAS complex locus -0.0409544
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0407125
AFAP1 actin filament associated protein 1 -0.0406208
MCTP2 multiple C2 domains, transmembrane 2 -0.0404616
EPS15 epidermal growth factor receptor pathway substrate 15 -0.0403299
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0397134
RAB22A RAB22A, member RAS oncogene family -0.0393546
SAMD4A sterile alpha motif domain containing 4A -0.0391804
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0391218
RORA RAR-related orphan receptor A -0.0380343
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 -0.0373413
PDIA3 protein disulfide isomerase family A, member 3 -0.0364988
RRBP1 ribosome binding protein 1 -0.0363355
KATNBL1 katanin p80 subunit B-like 1 -0.0356304
MTDH metadherin -0.035427
STAU1 staufen double-stranded RNA binding protein 1 -0.0352403
RTN4 reticulon 4 -0.0352262
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0351984
DLG1 discs, large homolog 1 (Drosophila) -0.0347994
HLA-A major histocompatibility complex, class I, A -0.034653
FOXP1 forkhead box P1 -0.0340165
ARHGAP21 Rho GTPase activating protein 21 -0.0338884
ZMYND8 zinc finger, MYND-type containing 8 -0.0338531