Drospirenone_NCI-H23 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Drospirenone perturbation in NCI-H23 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Drospirenone_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
EEF2 eukaryotic translation elongation factor 2 0.254947
YBX3 Y box binding protein 3 0.142371
TMSB10 thymosin beta 10 0.124647
GRAMD1B GRAM domain containing 1B 0.121017
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.109546
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0923757
MYH9 myosin, heavy chain 9, non-muscle 0.0900738
ACTG1 actin gamma 1 0.0898427
EGR1 early growth response 1 0.0897207
PLEC plectin 0.086958
KRT18 keratin 18, type I 0.0793938
TRIO trio Rho guanine nucleotide exchange factor 0.0781649
RPL37 ribosomal protein L37 0.0765782
SRRM2 serine/arginine repetitive matrix 2 0.0749212
TXNRD1 thioredoxin reductase 1 0.0733169
LOC112694756 uncharaterized LOC112694756 0.0733089
SMAD3 SMAD family member 3 0.072147
THSD4 thrombospondin, type I, domain containing 4 0.0698007
ADAR adenosine deaminase, RNA-specific 0.0695191
NONO non-POU domain containing, octamer-binding 0.0678185
RPL35A ribosomal protein L35a 0.0666642
IGF1R insulin-like growth factor 1 receptor 0.0665929
RPL3 ribosomal protein L3 0.0659218
MCL1 myeloid cell leukemia 1 0.0642464
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0615238
RPL23 ribosomal protein L23 0.0608602
CEP250 centrosomal protein 250kDa 0.0604523
ACTN1 actinin, alpha 1 0.0595282
KMT2D lysine (K)-specific methyltransferase 2D 0.0571429
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast) 0.056399
CPNE1 copine I 0.0561403
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.055334
VIM vimentin 0.0542045
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0541247
NUMA1 nuclear mitotic apparatus protein 1 0.0529691
RPL11 ribosomal protein L11 0.0512533
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0510194
PTPRF protein tyrosine phosphatase, receptor type, F 0.0509918
RPS27 ribosomal protein S27 0.0489803
EEF1G eukaryotic translation elongation factor 1 gamma 0.0485516
RNF213 ring finger protein 213 0.046595
VCL vinculin 0.046075
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0457642
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0455093
KRT8 keratin 8, type II 0.0448657
FLNA filamin A, alpha 0.0442427
TLN1 talin 1 0.043054
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0425957
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0424755
TPI1 triosephosphate isomerase 1 0.0420522
RPS4X ribosomal protein S4, X-linked 0.0413088
HSPA8 heat shock 70kDa protein 8 0.0410085
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0408331
PFKP phosphofructokinase, platelet 0.0406185
YBX1 Y box binding protein 1 0.0401263
PRELID3B PRELI domain containing 3B 0.04009
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0397957
NR4A1 nuclear receptor subfamily 4, group A, member 1 0.0390933
RPS3 ribosomal protein S3 0.0389323
FKBP4 FK506 binding protein 4, 59kDa 0.038668
PRRC2A proline-rich coiled-coil 2A 0.0384088
RPL13A ribosomal protein L13a 0.0378106
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.037725
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0376837
NOLC1 nucleolar and coiled-body phosphoprotein 1 0.0373057
ARID1A AT rich interactive domain 1A (SWI-like) 0.0372363
ZYX zyxin 0.0369807
EIF4B eukaryotic translation initiation factor 4B 0.0364153
RAD51B RAD51 paralog B 0.0362801
DIDO1 death inducer-obliterator 1 0.0360818
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0359593
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0358898
RPS19 ribosomal protein S19 0.035883
FUS FUS RNA binding protein 0.0356341
NCOR2 nuclear receptor corepressor 2 0.0356064
RPL31 ribosomal protein L31 0.0354855
PGK1 phosphoglycerate kinase 1 0.0351874
RPS21 ribosomal protein S21 0.0348402
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 0.0348005
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 0.0346778
ELL2 elongation factor, RNA polymerase II, 2 0.0346102
TPM2 tropomyosin 2 (beta) 0.0344714
BRD2 bromodomain containing 2 0.0343064
PTMA prothymosin, alpha 0.0339982
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0339173
RACK1 receptor for activated C kinase 1 0.0332517
UBAP2L ubiquitin associated protein 2-like 0.0325239
BSG basigin (Ok blood group) 0.032238
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 0.0322114
RPS14 ribosomal protein S14 0.0321245
RPL37A ribosomal protein L37a 0.0321129
SEPTIN2 septin 2 0.032053
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0319663
TCOF1 Treacher Collins-Franceschetti syndrome 1 0.0316053
HDAC4 histone deacetylase 4 0.0315574
ZNFX1 zinc finger, NFX1-type containing 1 0.0311988
SON SON DNA binding protein 0.0308664
NCAPD2 non-SMC condensin I complex, subunit D2 0.0307121
MARCHF4 membrane associated ring-CH-type finger 4 0.030706
ANKRD11 ankyrin repeat domain 11 0.0305889

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.11362
TFPI2 tissue factor pathway inhibitor 2 -0.112972
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0959418
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0756811
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0672576
KDM2A lysine (K)-specific demethylase 2A -0.0638378
NIPBL Nipped-B homolog (Drosophila) -0.0585434
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0537495
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 -0.0480041
RPS2 ribosomal protein S2 -0.0455668
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0437267
TAS2R14 taste receptor, type 2, member 14 -0.0421006
GOLGA4 golgin A4 -0.0411182
WDPCP WD repeat containing planar cell polarity effector -0.040317
ANKRD12 ankyrin repeat domain 12 -0.039687
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) -0.0396187
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0388707
PREPL prolyl endopeptidase-like -0.0388696
JMJD1C jumonji domain containing 1C -0.038685
PDIA3 protein disulfide isomerase family A, member 3 -0.035711
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0354939
ARID2 AT rich interactive domain 2 (ARID, RFX-like) -0.0348416
MBD5 methyl-CpG binding domain protein 5 -0.0343695
KTN1 kinectin 1 (kinesin receptor) -0.0341869
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0339476
CANX calnexin -0.0336532
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.0333896
XPO1 exportin 1 -0.0329091
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0321121
ZNF638 zinc finger protein 638 -0.0319767
TOP2A topoisomerase (DNA) II alpha 170kDa -0.031685
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0314858
RTN4 reticulon 4 -0.0309543
CAMKMT calmodulin-lysine N-methyltransferase -0.0301186
ZNF292 zinc finger protein 292 -0.0300578
ZNF207 zinc finger protein 207 -0.0299699
GOLGB1 golgin B1 -0.0296165
MAP4 microtubule-associated protein 4 -0.0284255
FNIP1 folliculin interacting protein 1 -0.0283633
NOP58 NOP58 ribonucleoprotein -0.0282798
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 -0.0281576
GPHN gephyrin -0.0276649
ZBTB20 zinc finger and BTB domain containing 20 -0.027598
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0275798
SCAF11 SR-related CTD-associated factor 11 -0.0273793
BBX bobby sox homolog (Drosophila) -0.0265674
SBF2 SET binding factor 2 -0.0263374
NF1 neurofibromin 1 -0.0262632
RB1CC1 RB1-inducible coiled-coil 1 -0.0257356
MNAT1 MNAT CDK-activating kinase assembly factor 1 -0.0257051
PRELID2 PRELI domain containing 2 -0.0255761
PPME1 protein phosphatase methylesterase 1 -0.0252361
USP34 ubiquitin specific peptidase 34 -0.0250707
TM4SF1 transmembrane 4 L six family member 1 -0.0250423
LRPPRC leucine-rich pentatricopeptide repeat containing -0.025032
RSF1 remodeling and spacing factor 1 -0.0250272
BIRC6 baculoviral IAP repeat containing 6 -0.024904
ZFR zinc finger RNA binding protein -0.024637
AP2B1 adaptor-related protein complex 2, beta 1 subunit -0.0244601
MON2 MON2 homolog (S. cerevisiae) -0.0244387
KMT2E lysine (K)-specific methyltransferase 2E -0.0240458
TMEM263 transmembrane protein 263 -0.0239054
AKAP9 A kinase (PRKA) anchor protein 9 -0.0238373
FCHSD2 FCH and double SH3 domains 2 -0.023617
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 -0.0233743
NAMPT nicotinamide phosphoribosyltransferase -0.0232195
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0231368
SRP54 signal recognition particle 54kDa -0.0231362
RALGAPA1 Ral GTPase activating protein, alpha subunit 1 (catalytic) -0.0228776
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0225058
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -0.0224861
RBM25 RNA binding motif protein 25 -0.0224474
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0221532
HELZ helicase with zinc finger -0.0220355
SRP72 signal recognition particle 72kDa -0.0219718
PDIA6 protein disulfide isomerase family A, member 6 -0.0218421
SOS2 son of sevenless homolog 2 (Drosophila) -0.0217217
IKBIP IKBKB interacting protein -0.0214544
DHX36 DEAH (Asp-Glu-Ala-His) box polypeptide 36 -0.0214186
SEPTIN7 septin 7 -0.0213611
ANKIB1 ankyrin repeat and IBR domain containing 1 -0.0213488
PPP4R3B protein phosphatase 4 regulatory subunit 3B -0.0213149
TFG TRK-fused gene -0.021206
SUCO SUN domain containing ossification factor -0.0211077
BRWD3 bromodomain and WD repeat domain containing 3 -0.0209598
SLMAP sarcolemma associated protein -0.0208132
RBM39 RNA binding motif protein 39 -0.0207253
TMEM165 transmembrane protein 165 -0.0207115
ACAP2 ArfGAP with coiled-coil, ankyrin repeat and PH domains 2 -0.0205797
BPNT2 3'(2'), 5'-bisphosphate nucleotidase 2 -0.0205786
AFF3 AF4/FMR2 family, member 3 -0.0204847
ZFC3H1 zinc finger, C3H1-type containing -0.0204006
BRWD1 bromodomain and WD repeat domain containing 1 -0.0203448
SEC24A SEC24 family member A -0.0203142
GLO1 glyoxalase I -0.0203092
DEK DEK proto-oncogene -0.0202581
TUT4 terminal uridylyl transferase 4 -0.0202264
MIS18BP1 MIS18 binding protein 1 -0.0201851
KDM7A lysine (K)-specific demethylase 7A -0.0201781
RSRC1 arginine/serine-rich coiled-coil 1 -0.0201288