Drospirenone_NCI-H2347 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Drospirenone perturbation in NCI-H2347 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Drospirenone_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
NDRG1 N-myc downstream regulated 1 0.179865
PLEC plectin 0.1214
MYH9 myosin, heavy chain 9, non-muscle 0.11162
TSC22D2 TSC22 domain family, member 2 0.098517
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0822978
BHLHE40 basic helix-loop-helix family, member e40 0.0772482
EEF2 eukaryotic translation elongation factor 2 0.0740642
ASPH aspartate beta-hydroxylase 0.0711599
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta 0.0694875
LAMC2 laminin, gamma 2 0.0681047
LOC112694756 uncharaterized LOC112694756 0.0652253
VEGFA vascular endothelial growth factor A 0.0609423
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.059074
ELL2 elongation factor, RNA polymerase II, 2 0.0579404
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0572705
GRB10 growth factor receptor-bound protein 10 0.0562783
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0558771
MSN moesin 0.0541121
TRIO trio Rho guanine nucleotide exchange factor 0.050111
SDC4 syndecan 4 0.0476459
TNIP1 TNFAIP3 interacting protein 1 0.0471644
MAL2 mal, T-cell differentiation protein 2 (gene/pseudogene) 0.0459094
LAMB3 laminin, beta 3 0.0451763
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0450758
RPL3 ribosomal protein L3 0.0424022
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0423626
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0421125
RNF145 ring finger protein 145 0.0416516
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0411725
PGK1 phosphoglycerate kinase 1 0.0407202
KRT8 keratin 8, type II 0.0393864
HSPA8 heat shock 70kDa protein 8 0.039254
USP3 ubiquitin specific peptidase 3 0.0380826
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0376563
RAD21 RAD21 homolog (S. pombe) 0.0374167
MARCHF6 membrane associated ring-CH-type finger 6 0.0372846
UBA6 ubiquitin-like modifier activating enzyme 6 0.0372734
CALR calreticulin 0.0370811
FAM13A family with sequence similarity 13, member A 0.0362469
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0355718
DDIT4 DNA-damage-inducible transcript 4 0.0341789
CNBP CCHC-type zinc finger, nucleic acid binding protein 0.0340733
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B 0.0338897
NAMPT nicotinamide phosphoribosyltransferase 0.0338724
MYO5B myosin VB 0.0333838
NONO non-POU domain containing, octamer-binding 0.0333421
NUMA1 nuclear mitotic apparatus protein 1 0.0321688
TFG TRK-fused gene 0.0315525
DUSP10 dual specificity phosphatase 10 0.0308782
IGFBP3 insulin-like growth factor binding protein 3 0.0305468
EZR ezrin 0.0304247
SFTPA2 surfactant protein A2 0.0302144
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 0.0301732
YBX3 Y box binding protein 3 0.0301564
FXR1 fragile X mental retardation, autosomal homolog 1 0.0301274
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0300251
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0297116
PLAU plasminogen activator, urokinase 0.0294722
RAD23B RAD23 homolog B (S. cerevisiae) 0.0291534
ADAM9 ADAM metallopeptidase domain 9 0.0289553
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.0284459
KDM3A lysine (K)-specific demethylase 3A 0.0284009
TMSB4X thymosin beta 4, X-linked 0.0281666
MXD1 MAX dimerization protein 1 0.0280589
FLNA filamin A, alpha 0.0280229
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) 0.0278252
APP amyloid beta (A4) precursor protein 0.0275198
ANXA5 annexin A5 0.0269144
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0263312
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.0263098
FAM3C family with sequence similarity 3, member C 0.0262936
YTHDC1 YTH domain containing 1 0.0258438
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0257168
NUP58 nucleoporin 58 0.025479
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae) 0.0249831
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.0249531
AHDC1 AT hook, DNA binding motif, containing 1 0.0248599
UGCG UDP-glucose ceramide glucosyltransferase 0.0248155
ATP13A3 ATPase type 13A3 0.0245049
TSPAN15 tetraspanin 15 0.0244769
PUM1 pumilio RNA-binding family member 1 0.0244681
HLA-B major histocompatibility complex, class I, B 0.0244343
TRA2B transformer 2 beta homolog (Drosophila) 0.0243532
LRATD2 LRAT domain containing 2 0.0242052
CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2 0.0240509
ANXA11 annexin A11 0.0238491
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0238462
SF1 splicing factor 1 0.0234942
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9 0.0234363
MPRIP myosin phosphatase Rho interacting protein 0.0230045
FOSL1 FOS-like antigen 1 0.0227685
ARRDC3 arrestin domain containing 3 0.0227015
MSMO1 methylsterol monooxygenase 1 0.0226395
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0226087
CCNL1 cyclin L1 0.0226036
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0224638
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha 0.0223573
CLIP4 CAP-GLY domain containing linker protein family, member 4 0.0221239
PCBP2 poly(rC) binding protein 2 0.0219675
HRNR hornerin 0.0217339

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.170646
LPP LIM domain containing preferred translocation partner in lipoma -0.144264
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.143992
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.140593
EXT1 exostosin glycosyltransferase 1 -0.114793
SAMD4A sterile alpha motif domain containing 4A -0.108253
ZSWIM6 zinc finger, SWIM-type containing 6 -0.105124
PTMA prothymosin, alpha -0.0952411
EFNA5 ephrin-A5 -0.0913104
LIMCH1 LIM and calponin homology domains 1 -0.0829918
CCND1 cyclin D1 -0.0753607
TPT1 tumor protein, translationally-controlled 1 -0.0699789
TMSB10 thymosin beta 10 -0.0675272
ALCAM activated leukocyte cell adhesion molecule -0.060023
FBXO32 F-box protein 32 -0.0595635
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0565491
GOLGB1 golgin B1 -0.0556358
GNAS GNAS complex locus -0.0551092
SEC31A SEC31 homolog A (S. cerevisiae) -0.055067
IFI16 interferon, gamma-inducible protein 16 -0.0541106
TM4SF1 transmembrane 4 L six family member 1 -0.0538136
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.052156
FNIP1 folliculin interacting protein 1 -0.0519985
PDLIM5 PDZ and LIM domain 5 -0.0515941
VCL vinculin -0.0492963
RPL34 ribosomal protein L34 -0.049204
MYO1E myosin IE -0.048779
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0484127
MAP4 microtubule-associated protein 4 -0.0478303
FTL ferritin, light polypeptide -0.0472106
RAI14 retinoic acid induced 14 -0.0471444
CANX calnexin -0.0469599
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0456076
FBXO34 F-box protein 34 -0.0453978
TTC3 tetratricopeptide repeat domain 3 -0.0443651
ERBIN erbb2 interacting protein -0.0443526
GOLGA4 golgin A4 -0.0432479
RPL35A ribosomal protein L35a -0.0426375
ZBTB20 zinc finger and BTB domain containing 20 -0.0426
RPS8 ribosomal protein S8 -0.042112
ARHGAP20 Rho GTPase activating protein 20 -0.0419754
WSB1 WD repeat and SOCS box containing 1 -0.041853
MAP3K13 mitogen-activated protein kinase kinase kinase 13 -0.0415879
CEP350 centrosomal protein 350kDa -0.0414607
SOX4 SRY (sex determining region Y)-box 4 -0.0411512
NF1 neurofibromin 1 -0.0391009
RAB11FIP1 RAB11 family interacting protein 1 (class I) -0.037826
MCU mitochondrial calcium uniporter -0.0376951
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0376801
RPS25 ribosomal protein S25 -0.0375594
PALLD palladin, cytoskeletal associated protein -0.037535
RPLP1 ribosomal protein, large, P1 -0.03752
RCOR1 REST corepressor 1 -0.0375154
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3 -0.0373881
RPS23 ribosomal protein S23 -0.0373642
S100A10 S100 calcium binding protein A10 -0.037324
RBM47 RNA binding motif protein 47 -0.037245
RPS13 ribosomal protein S13 -0.0370479
RAB7A RAB7A, member RAS oncogene family -0.0366123
ANKIB1 ankyrin repeat and IBR domain containing 1 -0.0365032
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0363048
RPL9 ribosomal protein L9 -0.0362361
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0358173
INTS6 integrator complex subunit 6 -0.0357905
CDK13 cyclin-dependent kinase 13 -0.0357219
IFIH1 interferon induced with helicase C domain 1 -0.0355717
ETV6 ets variant 6 -0.0355482
RPS24 ribosomal protein S24 -0.0352744
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 -0.0352375
ISG15 ISG15 ubiquitin-like modifier -0.0350841
CSTB cystatin B (stefin B) -0.0350075
RPLP2 ribosomal protein, large, P2 -0.0349173
TMEM165 transmembrane protein 165 -0.0348323
TIMP2 TIMP metallopeptidase inhibitor 2 -0.0348013
KDM2A lysine (K)-specific demethylase 2A -0.034705
SH3KBP1 SH3-domain kinase binding protein 1 -0.0346522
CD2AP CD2-associated protein -0.0344818
FBXL20 F-box and leucine-rich repeat protein 20 -0.0343352
NIPBL Nipped-B homolog (Drosophila) -0.0342937
EIF1 eukaryotic translation initiation factor 1 -0.033911
RPS29 ribosomal protein S29 -0.0338938
IFI27 interferon, alpha-inducible protein 27 -0.0338889
AHNAK AHNAK nucleoprotein -0.0338809
IFI6 interferon, alpha-inducible protein 6 -0.0337912
TPM4 tropomyosin 4 -0.0336527
MYO6 myosin VI -0.0334652
ARHGAP5 Rho GTPase activating protein 5 -0.0334451
MAP1B microtubule-associated protein 1B -0.0333825
ANKRD12 ankyrin repeat domain 12 -0.0324006
BLZF1 basic leucine zipper nuclear factor 1 -0.0323653
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0312481
PLSCR1 phospholipid scramblase 1 -0.0312186
BBX bobby sox homolog (Drosophila) -0.0309781
NUMB numb homolog (Drosophila) -0.030951
ANKRD17 ankyrin repeat domain 17 -0.0307942
RIGI RNA sensor RIG-I -0.0307878
SCFD1 sec1 family domain containing 1 -0.0307279
MDK midkine (neurite growth-promoting factor 2) -0.0307126
MON2 MON2 homolog (S. cerevisiae) -0.030449
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.0304312