Drospirenone_NCI-H596 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Drospirenone perturbation in NCI-H596 cell line (Tahoe Therapeutics)
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Genes

113 genes differentially expressed following the Drospirenone_NCI-H596 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.175707
IGFBP3 insulin-like growth factor binding protein 3 0.172756
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.132021
FMN1 formin 1 0.11605
PTPRJ protein tyrosine phosphatase, receptor type, J 0.114861
ANKRD11 ankyrin repeat domain 11 0.110024
MATR3 matrin 3 0.106717
ATP13A3 ATPase type 13A3 0.103071
BACE2 beta-site APP-cleaving enzyme 2 0.103014
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.102594
ERRFI1 ERBB receptor feedback inhibitor 1 0.0964958
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0940977
PDE10A phosphodiesterase 10A 0.0935025
SGIP1 SH3-domain GRB2-like (endophilin) interacting protein 1 0.0895071
SPAG9 sperm associated antigen 9 0.0892031
ZNF292 zinc finger protein 292 0.0888157
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0886086
NAP1L1 nucleosome assembly protein 1-like 1 0.0818669
PDLIM5 PDZ and LIM domain 5 0.0756907
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0733591
RUNX1 runt-related transcription factor 1 0.0697272
NDRG1 N-myc downstream regulated 1 0.069597
TOP1 topoisomerase (DNA) I 0.0682617
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0660531
EXT1 exostosin glycosyltransferase 1 0.0652004
ELL2 elongation factor, RNA polymerase II, 2 0.0631089
NAMPT nicotinamide phosphoribosyltransferase 0.0605907
PDE4D phosphodiesterase 4D, cAMP-specific 0.0572435
PRKCA protein kinase C, alpha 0.0570484
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0562553
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0553647
RPS6 ribosomal protein S6 0.053334
SND1 staphylococcal nuclease and tudor domain containing 1 0.0526464
PSD3 pleckstrin and Sec7 domain containing 3 0.0524933
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) 0.0497455
PTPRM protein tyrosine phosphatase, receptor type, M 0.04963
RBM39 RNA binding motif protein 39 0.047932
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0472253
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.045198
ADARB2 adenosine deaminase, RNA-specific, B2 (non-functional) 0.0427045
MAML2 mastermind-like 2 (Drosophila) 0.0412606
FNDC3B fibronectin type III domain containing 3B 0.0403673
NKD1 naked cuticle homolog 1 (Drosophila) 0.0393906
PTMA prothymosin, alpha 0.0384598
EEF2 eukaryotic translation elongation factor 2 0.038065
SETD5 SET domain containing 5 0.0288077
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0286226
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0256533
FNDC3A fibronectin type III domain containing 3A 0.0222722
DTNA dystrobrevin, alpha 0.0191958
DSCAM Down syndrome cell adhesion molecule 0.0177712
TBC1D22A TBC1 domain family, member 22A 0.0164074
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0137682
NHSL1 NHS-like 1 0.012808
ASPH aspartate beta-hydroxylase 0.0124772
RORA RAR-related orphan receptor A 0.0120584
AKAP12 A kinase (PRKA) anchor protein 12 0.0114892
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.011252
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.00603617
PTK2 protein tyrosine kinase 2 0.00355337
ATXN1 ataxin 1 5.85024E-4

decreased expression

Symbol Name Standardized Value
EGFR epidermal growth factor receptor -0.327269
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.274335
FN1 fibronectin 1 -0.139815
TMSB10 thymosin beta 10 -0.128953
MYO1E myosin IE -0.125454
PDE3A phosphodiesterase 3A, cGMP-inhibited -0.107805
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type -0.106068
TRIO trio Rho guanine nucleotide exchange factor -0.101285
CD44 CD44 molecule (Indian blood group) -0.101155
LDHA lactate dehydrogenase A -0.0983301
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0966836
MYO6 myosin VI -0.0844553
USP34 ubiquitin specific peptidase 34 -0.0827021
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0811368
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0799683
COL6A3 collagen, type VI, alpha 3 -0.0791117
TPM4 tropomyosin 4 -0.0761447
MT2A metallothionein 2A -0.0698962
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0692453
RPS3 ribosomal protein S3 -0.0683211
MYOF myoferlin -0.067606
SBF2 SET binding factor 2 -0.0660579
FTL ferritin, light polypeptide -0.058739
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0568851
LIMS1 LIM and senescent cell antigen-like domains 1 -0.0540876
MED13L mediator complex subunit 13-like -0.0490571
NALF1 NALCN channel auxiliary factor 1 -0.0469505
INHBA inhibin, beta A -0.043651
SAMD4A sterile alpha motif domain containing 4A -0.0397692
SMYD3 SET and MYND domain containing 3 -0.0390129
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0357686
MAML3 mastermind-like 3 (Drosophila) -0.0355314
EFNA5 ephrin-A5 -0.0355025
VIM vimentin -0.0343842
DPP10 dipeptidyl-peptidase 10 (non-functional) -0.0309865
THSD4 thrombospondin, type I, domain containing 4 -0.0283363
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.0248876
GPC6 glypican 6 -0.0187637
COL6A1 collagen, type VI, alpha 1 -0.0178842
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0160889
DST dystonin -0.0147795
WSB1 WD repeat and SOCS box containing 1 -0.0144661
RAD51B RAD51 paralog B -0.0135423
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0131221
CDH13 cadherin 13 -0.012257
ESYT2 extended synaptotagmin-like protein 2 -0.0102156
FAM13A family with sequence similarity 13, member A -0.00947715
VCL vinculin -0.00944439
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.00829008
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.00772002
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.00699422
UBA6 ubiquitin-like modifier activating enzyme 6 -0.00162933