Drospirenone_SW 1088 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Drospirenone perturbation in SW 1088 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Drospirenone_SW 1088 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
COL6A3 collagen, type VI, alpha 3 0.625639
MYH9 myosin, heavy chain 9, non-muscle 0.159471
FTH1 ferritin, heavy polypeptide 1 0.107389
LOC112694756 uncharaterized LOC112694756 0.100359
HLA-B major histocompatibility complex, class I, B 0.0952268
TNIP1 TNFAIP3 interacting protein 1 0.0791269
EEF2 eukaryotic translation elongation factor 2 0.0720394
SDC4 syndecan 4 0.0695202
NAMPT nicotinamide phosphoribosyltransferase 0.0617727
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 0.0600619
ARRDC3 arrestin domain containing 3 0.053825
SOD2 superoxide dismutase 2, mitochondrial 0.0530905
BHLHE40 basic helix-loop-helix family, member e40 0.0523314
HOOK2 hook microtubule-tethering protein 2 0.0495792
VEGFA vascular endothelial growth factor A 0.046117
ANXA2 annexin A2 0.0458983
FAM13A family with sequence similarity 13, member A 0.0456154
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II 0.0441324
PLEC plectin 0.0430382
B2M beta-2-microglobulin 0.0429523
SRRM2 serine/arginine repetitive matrix 2 0.0417728
MT2A metallothionein 2A 0.0407292
ELL2 elongation factor, RNA polymerase II, 2 0.040674
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.0400068
BACE2 beta-site APP-cleaving enzyme 2 0.0396889
EIF1 eukaryotic translation initiation factor 1 0.0389397
HILPDA hypoxia inducible lipid droplet-associated 0.0376215
FLNA filamin A, alpha 0.037106
LGALS1 lectin, galactoside-binding, soluble, 1 0.0365981
SPAG9 sperm associated antigen 9 0.0363193
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0351761
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta 0.0350799
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.034497
APP amyloid beta (A4) precursor protein 0.0343926
RPL3 ribosomal protein L3 0.0335566
RTN4 reticulon 4 0.0332435
STC1 stanniocalcin 1 0.0330522
RNF145 ring finger protein 145 0.0321017
NUMA1 nuclear mitotic apparatus protein 1 0.0315514
PLAUR plasminogen activator, urokinase receptor 0.0313265
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.0307242
YTHDC1 YTH domain containing 1 0.0304354
NIBAN2 niban apoptosis regulator 2 0.0301989
UGCG UDP-glucose ceramide glucosyltransferase 0.0298334
MED15 mediator complex subunit 15 0.0296254
PDPK1 3-phosphoinositide dependent protein kinase 1 0.0295357
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0294189
TLN1 talin 1 0.0287542
COL7A1 collagen, type VII, alpha 1 0.0281178
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 0.0278601
PGK1 phosphoglycerate kinase 1 0.0277522
OS9 osteosarcoma amplified 9, endoplasmic reticulum lectin 0.0273367
IGFBP3 insulin-like growth factor binding protein 3 0.0273118
SMTN smoothelin 0.0272859
PMM2 phosphomannomutase 2 0.0271433
ITGAV integrin, alpha V 0.0270204
ERRFI1 ERBB receptor feedback inhibitor 1 0.026906
COL4A1 collagen, type IV, alpha 1 0.026732
HYOU1 hypoxia up-regulated 1 0.0265333
SEPTIN9 septin 9 0.0264583
MT1X metallothionein 1X 0.0257853
HLA-C major histocompatibility complex, class I, C 0.0257419
NDRG1 N-myc downstream regulated 1 0.0256498
FOSL1 FOS-like antigen 1 0.0255349
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0251892
ANXA5 annexin A5 0.0251451
RARS1 arginyl-tRNA synthetase 1 0.02509
TMSB4X thymosin beta 4, X-linked 0.0248409
SETD5 SET domain containing 5 0.0245561
HDLBP high density lipoprotein binding protein 0.0243767
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0240718
DKK3 dickkopf WNT signaling pathway inhibitor 3 0.0237146
ADM adrenomedullin 0.0236894
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0234252
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0233459
APOL2 apolipoprotein L, 2 0.0231878
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0228815
S100A6 S100 calcium binding protein A6 0.0227694
DDIT4 DNA-damage-inducible transcript 4 0.0227511
ANKRD36 ankyrin repeat domain 36 0.0226837
SFTPA2 surfactant protein A2 0.0226099
SKIC3 SKI3 subunit of superkiller complex 0.0226097
MSN moesin 0.0225218
CALR calreticulin 0.0225163
CD59 CD59 molecule, complement regulatory protein 0.02251
SHB Src homology 2 domain containing adaptor protein B 0.022042
TNRC6A trinucleotide repeat containing 6A 0.0219765
GOLGA3 golgin A3 0.0218015
MORF4L2 mortality factor 4 like 2 0.0217684
JAG1 jagged 1 0.0212558
MARCHF6 membrane associated ring-CH-type finger 6 0.0211287
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0210552
CYLD cylindromatosis (turban tumor syndrome) 0.0209584
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0207333
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0207234
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0206049
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0205202
HPCAL1 hippocalcin-like 1 0.020396
COLEC11 collectin sub-family member 11 0.0203467
PTTG1IP pituitary tumor-transforming 1 interacting protein 0.0203158

decreased expression

Symbol Name Standardized Value
TIMP3 TIMP metallopeptidase inhibitor 3 -0.11965
TGFBI transforming growth factor, beta-induced, 68kDa -0.105787
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0891209
COL1A1 collagen, type I, alpha 1 -0.0853865
TMEM158 transmembrane protein 158 (gene/pseudogene) -0.0845659
PSD3 pleckstrin and Sec7 domain containing 3 -0.081472
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0755593
CDH13 cadherin 13 -0.074385
VIM vimentin -0.0724989
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -0.0561793
EXT1 exostosin glycosyltransferase 1 -0.0548441
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0521315
RAI14 retinoic acid induced 14 -0.0499876
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0493647
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0482262
POTEF POTE ankyrin domain family, member F -0.0478506
TPT1 tumor protein, translationally-controlled 1 -0.046911
VCL vinculin -0.0456787
DPYD dihydropyrimidine dehydrogenase -0.0456583
DST dystonin -0.0450532
TNS3 tensin 3 -0.0449603
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0409899
COL1A2 collagen, type I, alpha 2 -0.0408795
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0403803
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.039898
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.038434
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0381257
KAZN kazrin, periplakin interacting protein -0.037827
EGFR epidermal growth factor receptor -0.0376167
VEGFC vascular endothelial growth factor C -0.0367493
EXOC4 exocyst complex component 4 -0.0365644
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0363976
RASAL2 RAS protein activator like 2 -0.0363139
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0362461
GLIS3 GLIS family zinc finger 3 -0.0358944
MAP4 microtubule-associated protein 4 -0.0354909
ENO1 enolase 1, (alpha) -0.0348984
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) -0.0347969
CCND1 cyclin D1 -0.0345153
ACTG1 actin gamma 1 -0.0340441
EFNA5 ephrin-A5 -0.0332279
DNAH11 dynein, axonemal, heavy chain 11 -0.0332269
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0326572
CDK13 cyclin-dependent kinase 13 -0.0325593
F3 coagulation factor III (thromboplastin, tissue factor) -0.0324697
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.031651
NAV1 neuron navigator 1 -0.0314618
RAD51B RAD51 paralog B -0.0309462
SBF2 SET binding factor 2 -0.0300937
SEC24A SEC24 family member A -0.0300012
ASCC3 activating signal cointegrator 1 complex subunit 3 -0.0299023
WSB1 WD repeat and SOCS box containing 1 -0.0296616
HMGA2 high mobility group AT-hook 2 -0.0291991
KMT2C lysine (K)-specific methyltransferase 2C -0.0290451
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats -0.0288605
SEPTIN7 septin 7 -0.0287616
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0278052
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0275985
ZMYND8 zinc finger, MYND-type containing 8 -0.0264084
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0261918
ATXN1 ataxin 1 -0.0259464
PTPRK protein tyrosine phosphatase, receptor type, K -0.0257676
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0253801
GRIK5 glutamate receptor, ionotropic, kainate 5 -0.0249063
CDK6 cyclin-dependent kinase 6 -0.0248408
PRKCA protein kinase C, alpha -0.02482
AKT3 v-akt murine thymoma viral oncogene homolog 3 -0.0246489
COL6A1 collagen, type VI, alpha 1 -0.0245881
LIMS1 LIM and senescent cell antigen-like domains 1 -0.0244051
WNT5A wingless-type MMTV integration site family, member 5A -0.0243255
GNAS GNAS complex locus -0.0242047
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0241391
TPM4 tropomyosin 4 -0.0239604
NABP1 nucleic acid binding protein 1 -0.0238733
THBS1 thrombospondin 1 -0.0238707
LOX lysyl oxidase -0.0238081
CALD1 caldesmon 1 -0.0234082
GCC2 GRIP and coiled-coil domain containing 2 -0.0232127
COL3A1 collagen, type III, alpha 1 -0.0231925
IL6 interleukin 6 -0.0229633
PRSS23 protease, serine, 23 -0.0227229
ATRX alpha thalassemia/mental retardation syndrome X-linked -0.0226451
MBD5 methyl-CpG binding domain protein 5 -0.022463
ANKRD17 ankyrin repeat domain 17 -0.0224616
PDIA3 protein disulfide isomerase family A, member 3 -0.0224406
NALF1 NALCN channel auxiliary factor 1 -0.0222826
JMJD1C jumonji domain containing 1C -0.0218051
SDK1 sidekick cell adhesion molecule 1 -0.0217925
SMYD3 SET and MYND domain containing 3 -0.0217453
LARP1 La ribonucleoprotein domain family, member 1 -0.0216794
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) -0.0214152
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0212573
AKAP9 A kinase (PRKA) anchor protein 9 -0.0210989
LPP LIM domain containing preferred translocation partner in lipoma -0.020708
FHIT fragile histidine triad -0.0206795
BPTF bromodomain PHD finger transcription factor -0.0205728
BIRC6 baculoviral IAP repeat containing 6 -0.0204649
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0202828
PTPRF protein tyrosine phosphatase, receptor type, F -0.0202764
EIF5B eukaryotic translation initiation factor 5B -0.0202144