| Dataset | DeepCoverMOA Drug Mechanisms of Action |
| Category | proteomics |
| Type | drug perturbation |
| External Link | https://pubchem.ncbi.nlm.nih.gov/compound/50905713 |
| Similar Terms | |
| Downloads & Tools |
198 proteins with high or low expression in Duvelisib relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PDCD4 | programmed cell death 4 (neoplastic transformation inhibitor) | 1.45 |
| NR4A2 | nuclear receptor subfamily 4, group A, member 2 | 1.27 |
| AZGP1 | alpha-2-glycoprotein 1, zinc-binding | 1.06 |
| FAM122B | family with sequence similarity 122B | 0.89 |
| HMGCR | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.82 |
| ERBB3 | erb-b2 receptor tyrosine kinase 3 | 0.75 |
| ABTB1 | ankyrin repeat and BTB (POZ) domain containing 1 | 0.74 |
| CTHRC1 | collagen triple helix repeat containing 1 | 0.73 |
| CYP24A1 | cytochrome P450, family 24, subfamily A, polypeptide 1 | 0.72 |
| FDFT1 | farnesyl-diphosphate farnesyltransferase 1 | 0.71 |
| RBL2 | retinoblastoma-like 2 | 0.71 |
| PCMTD2 | protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2 | 0.71 |
| PBXIP1 | pre-B-cell leukemia homeobox interacting protein 1 | 0.68 |
| SLC16A6 | solute carrier family 16, member 6 | 0.67 |
| COQ8A | coenzyme Q8A | 0.64 |
| MT2A | metallothionein 2A | 0.64 |
| ANKS6 | ankyrin repeat and sterile alpha motif domain containing 6 | 0.63 |
| HECA | headcase homolog (Drosophila) | 0.62 |
| IRS2 | insulin receptor substrate 2 | 0.6 |
| SQLE | squalene epoxidase | 0.59 |
| H1-0 | H1.0 linker histone | 0.59 |
| BCL6 | B-cell CLL/lymphoma 6 | 0.57 |
| OPTN | optineurin | 0.56 |
| ZNF236 | zinc finger protein 236 | 0.56 |
| CASTOR2 | cytosolic arginine sensor for mTORC1 subunit 2 | 0.56 |
| ULK1 | unc-51 like autophagy activating kinase 1 | 0.55 |
| CYP2U1 | cytochrome P450, family 2, subfamily U, polypeptide 1 | 0.55 |
| DOCK11 | dedicator of cytokinesis 11 | 0.55 |
| H6PD | hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase) | 0.53 |
| AHNAK2 | AHNAK nucleoprotein 2 | 0.52 |
| CALCOCO1 | calcium binding and coiled-coil domain 1 | 0.52 |
| PCMTD1 | protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 1 | 0.52 |
| GRB7 | growth factor receptor-bound protein 7 | 0.52 |
| TST | thiosulfate sulfurtransferase (rhodanese) | 0.52 |
| MAP2 | microtubule-associated protein 2 | 0.52 |
| ALDH3B1 | aldehyde dehydrogenase 3 family, member B1 | 0.51 |
| NR1D1 | nuclear receptor subfamily 1, group D, member 1 | 0.51 |
| PCSK9 | proprotein convertase subtilisin/kexin type 9 | 0.51 |
| TMC4 | transmembrane channel-like 4 | 0.5 |
| TRIB1 | tribbles pseudokinase 1 | 0.5 |
| SLC30A3 | solute carrier family 30 (zinc transporter), member 3 | 0.5 |
| APPL2 | adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2 | 0.5 |
| MSRB2 | methionine sulfoxide reductase B2 | 0.5 |
| PSMB9 | proteasome (prosome, macropain) subunit, beta type, 9 | 0.49 |
| ERG28 | ergosterol biosynthesis 28 homolog | 0.49 |
| PLEKHB1 | pleckstrin homology domain containing, family B (evectins) member 1 | 0.49 |
| AASS | aminoadipate-semialdehyde synthase | 0.48 |
| H1FX | H1 histone family, member X | 0.48 |
| RTN2 | reticulon 2 | 0.48 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.48 |
| DUSP6 | dual specificity phosphatase 6 | 0.48 |
| GGACT | gamma-glutamylamine cyclotransferase | 0.48 |
| CARHSP1 | calcium regulated heat stable protein 1, 24kDa | 0.47 |
| TBC1D17 | TBC1 domain family, member 17 | 0.47 |
| NUDT7 | nudix (nucleoside diphosphate linked moiety X)-type motif 7 | 0.46 |
| FAM117B | family with sequence similarity 117, member B | 0.46 |
| VWA5B2 | von Willebrand factor A domain containing 5B2 | 0.46 |
| IGF1R | insulin-like growth factor 1 receptor | 0.46 |
| FN1 | fibronectin 1 | 0.46 |
| DHTKD1 | dehydrogenase E1 and transketolase domain containing 1 | 0.46 |
| PDK3 | pyruvate dehydrogenase kinase, isozyme 3 | 0.46 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.45 |
| TMBIM6 | transmembrane BAX inhibitor motif containing 6 | 0.45 |
| WIPI1 | WD repeat domain, phosphoinositide interacting 1 | 0.45 |
| GRN | granulin | 0.45 |
| KLHL36 | kelch-like family member 36 | 0.45 |
| PWWP3B | PWWP domain containing 3B | 0.44 |
| LTBP3 | latent transforming growth factor beta binding protein 3 | 0.44 |
| PPL | periplakin | 0.44 |
| MAGI1 | membrane associated guanylate kinase, WW and PDZ domain containing 1 | 0.44 |
| FGB | fibrinogen beta chain | 0.44 |
| ITGA7 | integrin, alpha 7 | 0.43 |
| BOK | BCL2-related ovarian killer | 0.43 |
| OGFRL1 | opioid growth factor receptor-like 1 | 0.43 |
| HSD17B8 | hydroxysteroid (17-beta) dehydrogenase 8 | 0.42 |
| IDI1 | isopentenyl-diphosphate delta isomerase 1 | 0.42 |
| SYN1 | synapsin I | 0.42 |
| EPM2AIP1 | EPM2A (laforin) interacting protein 1 | 0.42 |
| ACAD10 | acyl-CoA dehydrogenase family, member 10 | 0.42 |
| VPS37C | vacuolar protein sorting 37 homolog C (S. cerevisiae) | 0.42 |
| CLDN3 | claudin 3 | 0.42 |
| TMEM87B | transmembrane protein 87B | 0.42 |
| NUDT6 | nudix (nucleoside diphosphate linked moiety X)-type motif 6 | 0.42 |
| ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) | 0.42 |
| ELF1 | E74-like factor 1 (ets domain transcription factor) | 0.42 |
| GNE | glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase | 0.41 |
| ZNF226 | zinc finger protein 226 | 0.41 |
| PDK2 | pyruvate dehydrogenase kinase, isozyme 2 | 0.41 |
| E2F1 | E2F transcription factor 1 | 0.41 |
| ALDH6A1 | aldehyde dehydrogenase 6 family, member A1 | 0.41 |
| PXYLP1 | 2-phosphoxylose phosphatase 1 | 0.4 |
| DNAH5 | dynein, axonemal, heavy chain 5 | 0.4 |
| NDRG1 | N-myc downstream regulated 1 | 0.4 |
| TCF7L2 | transcription factor 7-like 2 (T-cell specific, HMG-box) | 0.4 |
| STMN1 | stathmin 1 | 0.4 |
| MOSPD1 | motile sperm domain containing 1 | 0.4 |
| TMEM263 | transmembrane protein 263 | 0.4 |
| GALNT11 | polypeptide N-acetylgalactosaminyltransferase 11 | 0.4 |
| CNTNAP3 | contactin associated protein-like 3 | 0.4 |
| Symbol | Name | Standardized Value |
|---|---|---|
| MYO15B | myosin XVB | -2.56 |
| HECW2 | HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2 | -2.37 |
| KMT2B | lysine (K)-specific methyltransferase 2B | -1.9 |
| TEN1 | TEN1 CST complex subunit | -1.89 |
| AKR1C2 | aldo-keto reductase family 1, member C2 | -1.33 |
| MCOLN2 | mucolipin 2 | -1.28 |
| KLHL23 | kelch-like family member 23 | -1.27 |
| ATXN7L2 | ataxin 7-like 2 | -1.24 |
| CCDC73 | coiled-coil domain containing 73 | -1.06 |
| STC2 | stanniocalcin 2 | -1.02 |
| E2F8 | E2F transcription factor 8 | -0.93 |
| AEN | apoptosis enhancing nuclease | -0.91 |
| PHLDB3 | pleckstrin homology-like domain, family B, member 3 | -0.88 |
| SESN1 | sestrin 1 | -0.86 |
| DHRS4L1 | dehydrogenase/reductase (SDR family) member 4 like 1 | -0.84 |
| EED | embryonic ectoderm development | -0.79 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.78 |
| SESN2 | sestrin 2 | -0.78 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.76 |
| DCBLD1 | discoidin, CUB and LCCL domain containing 1 | -0.73 |
| MYH15 | myosin, heavy chain 15 | -0.73 |
| SEMA7A | semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group) | -0.72 |
| TRIB3 | tribbles pseudokinase 3 | -0.72 |
| PLD6 | phospholipase D family, member 6 | -0.7 |
| ANKRD13D | ankyrin repeat domain 13 family, member D | -0.67 |
| PSAT1 | phosphoserine aminotransferase 1 | -0.67 |
| AASDH | aminoadipate-semialdehyde dehydrogenase | -0.66 |
| SLC7A5 | solute carrier family 7 (amino acid transporter light chain, L system), member 5 | -0.63 |
| GLI4 | GLI family zinc finger 4 | -0.63 |
| TRIM16 | tripartite motif containing 16 | -0.62 |
| DNPH1 | 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 | -0.62 |
| BHLHA15 | basic helix-loop-helix family, member a15 | -0.61 |
| PBX3 | pre-B-cell leukemia homeobox 3 | -0.61 |
| MAGEA2 | melanoma antigen family A2 | -0.61 |
| UPP1 | uridine phosphorylase 1 | -0.59 |
| SYTL3 | synaptotagmin-like 3 | -0.59 |
| HOXB9 | homeobox B9 | -0.59 |
| LAGE3 | L antigen family, member 3 | -0.58 |
| CCNB1 | cyclin B1 | -0.58 |
| SHCBP1 | SHC SH2-domain binding protein 1 | -0.57 |
| PLK1 | polo-like kinase 1 | -0.57 |
| CDC20 | cell division cycle 20 | -0.57 |
| ZNF503 | zinc finger protein 503 | -0.56 |
| DES | desmin | -0.56 |
| FMNL3 | formin-like 3 | -0.56 |
| ZNF263 | zinc finger protein 263 | -0.56 |
| DEPDC7 | DEP domain containing 7 | -0.55 |
| SLC1A4 | solute carrier family 1 (glutamate/neutral amino acid transporter), member 4 | -0.55 |
| RNF19B | ring finger protein 19B | -0.55 |
| ZRANB1 | zinc finger, RAN-binding domain containing 1 | -0.55 |
| SLC1A5 | solute carrier family 1 (neutral amino acid transporter), member 5 | -0.54 |
| GPT2 | glutamic pyruvate transaminase (alanine aminotransferase) 2 | -0.52 |
| CDKN3 | cyclin-dependent kinase inhibitor 3 | -0.52 |
| RCOR1 | REST corepressor 1 | -0.52 |
| BTBD10 | BTB (POZ) domain containing 10 | -0.51 |
| MAGEA12 | melanoma antigen family A12 | -0.51 |
| SLC3A2 | solute carrier family 3 (amino acid transporter heavy chain), member 2 | -0.51 |
| SPRTN | SprT-like N-terminal domain | -0.51 |
| WNT10B | wingless-type MMTV integration site family, member 10B | -0.51 |
| ZUP1 | zinc finger containing ubiquitin peptidase 1 | -0.5 |
| TNFRSF10A | tumor necrosis factor receptor superfamily, member 10a | -0.5 |
| BLOC1S2 | biogenesis of lysosomal organelles complex-1, subunit 2 | -0.5 |
| KNSTRN | kinetochore-localized astrin/SPAG5 binding protein | -0.49 |
| GRB10 | growth factor receptor-bound protein 10 | -0.49 |
| SPATA7 | spermatogenesis associated 7 | -0.48 |
| ASNS | asparagine synthetase (glutamine-hydrolyzing) | -0.48 |
| SLC7A6 | solute carrier family 7 (amino acid transporter light chain, y+L system), member 6 | -0.47 |
| CDC42EP3 | CDC42 effector protein (Rho GTPase binding) 3 | -0.47 |
| TESC | tescalcin | -0.47 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.47 |
| CPA4 | carboxypeptidase A4 | -0.46 |
| ABHD17C | abhydrolase domain containing 17C | -0.46 |
| SMTN | smoothelin | -0.46 |
| PPP3CC | protein phosphatase 3, catalytic subunit, gamma isozyme | -0.46 |
| MICA | MHC class I polypeptide-related sequence A | -0.46 |
| KLF4 | Kruppel-like factor 4 (gut) | -0.46 |
| ARHGAP19 | Rho GTPase activating protein 19 | -0.46 |
| SPEG | SPEG complex locus | -0.45 |
| TPM4 | tropomyosin 4 | -0.45 |
| SOCS2 | suppressor of cytokine signaling 2 | -0.45 |
| PYROXD1 | pyridine nucleotide-disulphide oxidoreductase domain 1 | -0.45 |
| PTPDC1 | protein tyrosine phosphatase domain containing 1 | -0.45 |
| OSGIN1 | oxidative stress induced growth inhibitor 1 | -0.45 |
| ENO1 | enolase 1, (alpha) | -0.44 |
| IPPK | inositol 1,3,4,5,6-pentakisphosphate 2-kinase | -0.44 |
| PRKRIP1 | PRKR interacting protein 1 (IL11 inducible) | -0.44 |
| POLH | polymerase (DNA directed), eta | -0.44 |
| ARID5B | AT rich interactive domain 5B (MRF1-like) | -0.44 |
| RAET1G | retinoic acid early transcript 1G | -0.44 |
| FOXO3 | forkhead box O3 | -0.44 |
| SLC6A8 | solute carrier family 6 (neurotransmitter transporter), member 8 | -0.44 |
| EIF1AD | eukaryotic translation initiation factor 1A domain containing | -0.43 |
| PRR11 | proline rich 11 | -0.43 |
| KIF2C | kinesin family member 2C | -0.43 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | -0.42 |
| BAIAP2 | BAI1-associated protein 2 | -0.42 |
| CENPE | centromere protein E, 312kDa | -0.42 |
| KPNA5 | karyopherin alpha 5 (importin alpha 6) | -0.42 |
| KANK1 | KN motif and ankyrin repeat domains 1 | -0.42 |
