Dysarthria Gene Set

Dataset CTD Gene-Disease Associations
Category disease or phenotype associations
Type disease
Description Dysarthric speech is a general description referring to a neurological speech disorder characterized by poor articulation. Depending on the involved neurological structures, dysarthria may be further classified as spastic, flaccid, ataxic, hyperkinetic and hypokinetic, or mixed. (Human Phenotype Ontology, HP_0001260)
External Link http://ctdbase.org/detail.go?type=disease&acc=MESH:D004401
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Genes

238 genes/proteins associated with the disease Dysarthria from the curated CTD Gene-Disease Associations dataset.

Symbol Name Standardized Value
PDE8B phosphodiesterase 8B 2.88009
NPC1 Niemann-Pick disease, type C1 2.88009
CASP3 caspase 3, apoptosis-related cysteine peptidase 2.43218
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4 2.38348
TNF tumor necrosis factor 2.30443
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 2.28346
BCL2 B-cell CLL/lymphoma 2 2.2023
FOS FBJ murine osteosarcoma viral oncogene homolog 2.11211
BAX BCL2-associated X protein 2.08846
IL6 interleukin 6 2.08104
KCNH2 potassium channel, voltage gated eag related subfamily H, member 2 2.05882
NOS2 nitric oxide synthase 2, inducible 2.04463
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6 2.01979
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 2.00261
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A 1.99365
PRL prolactin 1.96506
CAT catalase 1.9548
EGR1 early growth response 1 1.91684
HMOX1 heme oxygenase 1 1.90425
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9 1.86873
JUN jun proto-oncogene 1.85695
DUSP1 dual specificity phosphatase 1 1.85521
SLC22A2 solute carrier family 22 (organic cation transporter), member 2 1.84924
FAS Fas cell surface death receptor 1.84835
CASP8 caspase 8, apoptosis-related cysteine peptidase 1.83788
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 1.83414
IFNG interferon, gamma 1.81665
NR1I2 nuclear receptor subfamily 1, group I, member 2 1.81055
ABCB11 ATP-binding cassette, sub-family B (MDR/TAP), member 11 1.81017
CASP9 caspase 9, apoptosis-related cysteine peptidase 1.80397
MAPK8 mitogen-activated protein kinase 8 1.78854
SOD2 superoxide dismutase 2, mitochondrial 1.78227
MAPK1 mitogen-activated protein kinase 1 1.78129
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 1.74421
DRD2 dopamine receptor D2 1.73818
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 1.73373
DRD1 dopamine receptor D1 1.73048
CXCL8 chemokine (C-X-C motif) ligand 8 1.71214
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 1.69534
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4 1.67505
DDIT3 DNA-damage-inducible transcript 3 1.67051
CYP1A2 cytochrome P450, family 1, subfamily A, polypeptide 2 1.66792
MAPK3 mitogen-activated protein kinase 3 1.66555
TP53 tumor protein p53 1.6538
VEGFA vascular endothelial growth factor A 1.65159
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 1.63608
PARP1 poly (ADP-ribose) polymerase 1 1.63451
BDNF brain-derived neurotrophic factor 1.63161
INS insulin 1.62601
IL1B interleukin 1, beta 1.62335
GSK3B glycogen synthase kinase 3 beta 1.60711
AKT1 v-akt murine thymoma viral oncogene homolog 1 1.60082
IGF1 insulin-like growth factor 1 (somatomedin C) 1.59497
CDK5 cyclin-dependent kinase 5 1.59334
CASP7 caspase 7, apoptosis-related cysteine peptidase 1.59101
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase 1.56214
HTR2C 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled 1.56044
LDLR low density lipoprotein receptor 1.55971
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 1.53627
GDPD3 glycerophosphodiester phosphodiesterase domain containing 3 1.53456
CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19 1.53036
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 1.53036
BCL2L1 BCL2-like 1 1.51557
IL10 interleukin 10 1.50574
TAGLN transgelin 1.50018
NR0B2 nuclear receptor subfamily 0, group B, member 2 1.48454
S100A9 S100 calcium binding protein A9 1.48222
NFE2L2 nuclear factor, erythroid 2-like 2 1.48093
INHBE inhibin, beta E 1.44735
SLC22A3 solute carrier family 22 (organic cation transporter), member 3 1.43892
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 1.4332
PLAT plasminogen activator, tissue 1.42913
C10ORF10 chromosome 10 open reading frame 10 1.42293
CYP2B6 cytochrome P450, family 2, subfamily B, polypeptide 6 1.41965
WIPI1 WD repeat domain, phosphoinositide interacting 1 1.41884
GSTP1 glutathione S-transferase pi 1 1.41613
MPO myeloperoxidase 1.41532
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 1.41532
PDE4B phosphodiesterase 4B, cAMP-specific 1.41285
NUPR1 nuclear protein, transcriptional regulator, 1 1.41229
TIMP1 TIMP metallopeptidase inhibitor 1 1.4065
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8) 1.40204
SLC22A1 solute carrier family 22 (organic cation transporter), member 1 1.3931
GADD45A growth arrest and DNA-damage-inducible, alpha 1.39058
MMP2 matrix metallopeptidase 2 1.38724
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 1.36619
TGFB1 transforming growth factor, beta 1 1.35299
APP amyloid beta (A4) precursor protein 1.34926
RGS2 regulator of G-protein signaling 2 1.34606
S100A8 S100 calcium binding protein A8 1.34198
THBS1 thrombospondin 1 1.33553
MYC v-myc avian myelocytomatosis viral oncogene homolog 1.33346
HSPA8 heat shock 70kDa protein 8 1.32696
CCL2 chemokine (C-C motif) ligand 2 1.32607
FABP1 fatty acid binding protein 1, liver 1.32547
NPPB natriuretic peptide B 1.32547
INHA inhibin, alpha 1.3228
CAMK2A calcium/calmodulin-dependent protein kinase II alpha 1.31297
ICAM1 intercellular adhesion molecule 1 1.31208
CPSF6 cleavage and polyadenylation specific factor 6, 68kDa 1.30543
FASLG Fas ligand (TNF superfamily, member 6) 1.30543
BAK1 BCL2-antagonist/killer 1 1.30238
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 1.30056
SLC22A5 solute carrier family 22 (organic cation/carnitine transporter), member 5 1.2941
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 1.29133
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 1.28734
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group) 1.28303
MMP9 matrix metallopeptidase 9 1.27997
ATF2 activating transcription factor 2 1.27626
FNDC4 fibronectin type III domain containing 4 1.27162
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 1.27009
VCAM1 vascular cell adhesion molecule 1 1.2639
IL23A interleukin 23, alpha subunit p19 1.26298
BID BH3 interacting domain death agonist 1.26236
SLC17A6 solute carrier family 17 (vesicular glutamate transporter), member 6 1.25899
SREBF2 sterol regulatory element binding transcription factor 2 1.24905
CYP2C8 cytochrome P450, family 2, subfamily C, polypeptide 8 1.2437
REN renin 1.24181
AVP arginine vasopressin 1.2415
ATF3 activating transcription factor 3 1.23899
MAPK14 mitogen-activated protein kinase 14 1.23775
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 1.23296
SOD1 superoxide dismutase 1, soluble 1.23137
UGT1A1 UDP glucuronosyltransferase 1 family, polypeptide A1 1.22948
CALCA calcitonin-related polypeptide alpha 1.22177
CCND1 cyclin D1 1.21695
PRKCB protein kinase C, beta 1.2137
PENK proenkephalin 1.2137
RGS4 regulator of G-protein signaling 4 1.21337
HTR2A 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled 1.20946
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1 1.20427
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) 1.20328
ARC activity-regulated cytoskeleton-associated protein 1.19835
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 1.19835
CXCL2 chemokine (C-X-C motif) ligand 2 1.19412
ASNS asparagine synthetase (glutamine-hydrolyzing) 1.19345
CAMKK2 calcium/calmodulin-dependent protein kinase kinase 2, beta 1.19047
SLC22A7 solute carrier family 22 (organic anion transporter), member 7 1.18981
NPPA natriuretic peptide A 1.18948
CLU clusterin 1.18948
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit) 1.18783
CCNB2 cyclin B2 1.18587
CCND3 cyclin D3 1.18587
BIRC5 baculoviral IAP repeat containing 5 1.18456
MAP3K7 mitogen-activated protein kinase kinase kinase 7 1.17662
ACHE acetylcholinesterase (Yt blood group) 1.17596
MAOA monoamine oxidase A 1.17268
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) 1.17202
STAR steroidogenic acute regulatory protein 1.17034
PPARG peroxisome proliferator-activated receptor gamma 1.16666
FASN fatty acid synthase 1.16137
TH tyrosine hydroxylase 1.16137
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 1.1607
TAC1 tachykinin, precursor 1 1.16001
GOT2 glutamic-oxaloacetic transaminase 2, mitochondrial 1.15156
RB1 retinoblastoma 1 1.14885
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4 1.14507
GAD1 glutamate decarboxylase 1 (brain, 67kDa) 1.14268
GSTM1 glutathione S-transferase mu 1 1.14098
MMP3 matrix metallopeptidase 3 1.13793
NR1I3 nuclear receptor subfamily 1, group I, member 3 1.13347
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase) 1.13279
TXNRD1 thioredoxin reductase 1 1.12973
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 1.12872
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1 1.12668
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3 1.12599
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A 1.12599
EIF2S1 eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa 1.12599
FN1 fibronectin 1 1.12117
IL1A interleukin 1, alpha 1.11843
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 1.11741
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 1.11673
ASAH1 N-acylsphingosine amidohydrolase (acid ceramidase) 1 1.11396
NOS1 nitric oxide synthase 1 (neuronal) 1.1136
FOSB FBJ murine osteosarcoma viral oncogene homolog B 1.1122
TK2 thymidine kinase 2, mitochondrial 1.11116
MT1A metallothionein 1A 1.11046
CTSL cathepsin L 1.11011
EDN1 endothelin 1 1.10838
BMP4 bone morphogenetic protein 4 1.10769
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 1.10699
HSPD1 heat shock 60kDa protein 1 (chaperonin) 1.10596
PPP5C protein phosphatase 5, catalytic subunit 1.10493
DHFR dihydrofolate reductase 1.10353
CREB1 cAMP responsive element binding protein 1 1.10282
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 1.10282
MKI67 marker of proliferation Ki-67 1.08513
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 1.08513
CALR calreticulin 1.08442
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 1.08442
PRKCE protein kinase C, epsilon 1.0784
CASP6 caspase 6, apoptosis-related cysteine peptidase 1.0784
JUNB jun B proto-oncogene 1.07804
MAOB monoamine oxidase B 1.07625
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 1.07447
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1 1.07376
PTEN phosphatase and tensin homolog 1.07376
GJA1 gap junction protein, alpha 1, 43kDa 1.06661
NQO1 NAD(P)H dehydrogenase, quinone 1 1.06406
VIM vimentin 1.06406
DUSP6 dual specificity phosphatase 6 1.06261
CCNF cyclin F 1.06225
CCNG1 cyclin G1 1.0608
MCL1 myeloid cell leukemia 1 1.05721
SREBF1 sterol regulatory element binding transcription factor 1 1.05573
CRH corticotropin releasing hormone 1.05498
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase 1.05163
MAP2 microtubule-associated protein 2 1.05052
AP1S1 adaptor-related protein complex 1, sigma 1 subunit 1.04978
ATP6V1B2 ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B2 1.04904
ADIPOQ adiponectin, C1Q and collagen domain containing 1.04757
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 1.04611
PPP1R15A protein phosphatase 1, regulatory subunit 15A 1.04352
NPY neuropeptide Y 1.04163
AKT2 v-akt murine thymoma viral oncogene homolog 2 1.04163
FOSL2 FOS-like antigen 2 1.03641
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10 1.03456
SELE selectin E 1.03271
PTH parathyroid hormone 1.02858
SAT1 spermidine/spermine N1-acetyltransferase 1 1.02821
CXCL10 chemokine (C-X-C motif) ligand 10 1.02783
LHB luteinizing hormone beta polypeptide 1.02783
MMP13 matrix metallopeptidase 13 1.02746
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble) 1.02708
F3 coagulation factor III (thromboplastin, tissue factor) 1.02559
ENO1 enolase 1, (alpha) 1.02373
CYCS cytochrome c, somatic 1.02336
CCNE1 cyclin E1 1.02299
E2F1 E2F transcription factor 1 1.02225
FNBP1 formin binding protein 1 1.02077
CYP17A1 cytochrome P450, family 17, subfamily A, polypeptide 1 1.0204
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) 1.01814
CHEK1 checkpoint kinase 1 1.01701
MAPK9 mitogen-activated protein kinase 9 1.01663
MAP2K5 mitogen-activated protein kinase kinase 5 1.01625
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein 1.01361
CPT1A carnitine palmitoyltransferase 1A (liver) 1.01174
GPT glutamic-pyruvate transaminase (alanine aminotransferase) 1.01174