Dysentery Gene Set

Dataset DISEASES Text-mining Gene-Disease Association Evidence Scores 2025
Category disease or phenotype associations
Type disease
Description An intestinal infectious disease that involves inflammation of the intestines, especially colon, due to chemical irritants, bacteria, protozoa, or parasitic worms, which results in severe diarrhea with passage of mucus and blood. (Human Disease Ontology, DOID_12384)
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Genes

390 genes co-occuring with the disease Dysentery in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.

Symbol Name Standardized Value
STX2 syntaxin 2 2.65
ST8SIA2 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2 2.615
STX1A syntaxin 1A (brain) 2.59
IL1B interleukin 1, beta 2.499
IL6 interleukin 6 2.46
TNF tumor necrosis factor 2.44
ALB albumin 2.287
IL10 interleukin 10 2.272
MGAM maltase-glucoamylase 2.217
SI sucrase-isomaltase (alpha-glucosidase) 2.208
VIPR1 vasoactive intestinal peptide receptor 1 2.197
IFNG interferon, gamma 2.196
LTF lactotransferrin 2.168
AMY2A amylase, alpha 2A (pancreatic) 2.168
ATP12A ATPase, H+/K+ transporting, nongastric, alpha polypeptide 2.13
ATP4A ATPase, H+/K+ exchanging, alpha polypeptide 2.126
TLR4 toll-like receptor 4 2.115
CD4 CD4 molecule 2.105
CXCL8 chemokine (C-X-C motif) ligand 8 2.093
CASP3 caspase 3, apoptosis-related cysteine peptidase 2.09
AMY2B amylase, alpha 2B (pancreatic) 2.065
OCLN occludin 2.057
RNF112 ring finger protein 112 2.057
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 2.043
AMY1B amylase, alpha 1B (salivary) 2.036
GPT glutamic-pyruvate transaminase (alanine aminotransferase) 2.034
AKT1 v-akt murine thymoma viral oncogene homolog 1 2.012
IL4 interleukin 4 1.994
BCL2 B-cell CLL/lymphoma 2 1.979
INS insulin 1.973
MPO myeloperoxidase 1.967
IL17A interleukin 17A 1.964
SLC9A3 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 1.942
TJP1 tight junction protein 1 1.933
CRP C-reactive protein, pentraxin-related 1.919
STH saitohin 1.902
MUC2 mucin 2, oligomeric mucus/gel-forming 1.884
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 1.881
GPX7 glutathione peroxidase 7 1.881
GPX5 glutathione peroxidase 5 1.881
GPX6 glutathione peroxidase 6 1.876
GPX8 glutathione peroxidase 8 (putative) 1.875
GPX3 glutathione peroxidase 3 1.871
GPX2 glutathione peroxidase 2 1.865
ACTB actin, beta 1.859
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 1.854
IL1A interleukin 1, alpha 1.849
TLR2 toll-like receptor 2 1.841
JUN jun proto-oncogene 1.839
EMD emerin 1.819
CD8A CD8a molecule 1.809
MYD88 myeloid differentiation primary response 88 1.807
CASP9 caspase 9, apoptosis-related cysteine peptidase 1.806
PRSS57 protease, serine, 57 1.794
TGFB1 transforming growth factor, beta 1 1.793
HMOX1 heme oxygenase 1 1.792
PPARG peroxisome proliferator-activated receptor gamma 1.782
CLDN7 claudin 7 1.779
IL2 interleukin 2 1.773
ACHE acetylcholinesterase (Yt blood group) 1.768
PXDNL peroxidasin-like 1.761
PXDN peroxidasin 1.76
SLC26A3 solute carrier family 26 (anion exchanger), member 3 1.758
CLDN1 claudin 1 1.753
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta 1.75
BAX BCL2-associated X protein 1.75
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma 1.75
ANXA5 annexin A5 1.747
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta 1.746
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 1.746
CYCS cytochrome c, somatic 1.745
AIG1 androgen-induced 1 1.74
GAPDH glyceraldehyde-3-phosphate dehydrogenase 1.732
MXI1 MAX interactor 1, dimerization protein 1.73
ESPL1 extra spindle pole bodies homolog 1 (S. cerevisiae) 1.728
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha 1.725
TP53 tumor protein p53 1.721
MTOR mechanistic target of rapamycin (serine/threonine kinase) 1.719
IL18 interleukin 18 1.714
CASP8 caspase 8, apoptosis-related cysteine peptidase 1.697
CPA5 carboxypeptidase A5 1.689
CCL2 chemokine (C-C motif) ligand 2 1.679
CASP1 caspase 1, apoptosis-related cysteine peptidase 1.671
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) 1.671
PNLIP pancreatic lipase 1.662
BCHE butyrylcholinesterase 1.64
MAPK3 mitogen-activated protein kinase 3 1.637
IL13 interleukin 13 1.632
MMP9 matrix metallopeptidase 9 1.628
TYR tyrosinase 1.626
ACE angiotensin I converting enzyme 1.62
CTRB2 chymotrypsinogen B2 1.61
IL22 interleukin 22 1.607
CTRB1 chymotrypsinogen B1 1.604
GALP galanin-like peptide 1.596
FOS FBJ murine osteosarcoma viral oncogene homolog 1.581
CABP5 calcium binding protein 5 1.579
IL5 interleukin 5 1.574
CLPP caseinolytic mitochondrial matrix peptidase proteolytic subunit 1.573
XDH xanthine dehydrogenase 1.561
GPT2 glutamic pyruvate transaminase (alanine aminotransferase) 2 1.549
ERVW-1 endogenous retrovirus group W, member 1 1.546
FOXP3 forkhead box P3 1.531
ACE2 angiotensin I converting enzyme 2 1.531
TLR5 toll-like receptor 5 1.511
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) 1.503
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase) 1.502
SLC9A2 solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2 1.501
SLC2A4 solute carrier family 2 (facilitated glucose transporter), member 4 1.5
RAD51 RAD51 recombinase 1.499
PTPN1 protein tyrosine phosphatase, non-receptor type 1 1.494
WASL Wiskott-Aldrich syndrome-like 1.492
HSPD1 heat shock 60kDa protein 1 (chaperonin) 1.49
CPE carboxypeptidase E 1.481
GSR glutathione reductase 1.48
SPI1 Spi-1 proto-oncogene 1.478
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4 1.477
CDK2AP1 cyclin-dependent kinase 2 associated protein 1 1.475
ERV3-1 endogenous retrovirus group 3, member 1 1.47
ERVFRD-1 endogenous retrovirus group FRD, member 1 1.47
SLC5A1 solute carrier family 5 (sodium/glucose cotransporter), member 1 1.468
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 1.459
FUT2 fucosyltransferase 2 (secretor status included) 1.458
NOD2 nucleotide-binding oligomerization domain containing 2 1.458
CD248 CD248 molecule, endosialin 1.453
NLRP3 NLR family, pyrin domain containing 3 1.441
REG3G regenerating islet-derived 3 gamma 1.438
NFE2L2 nuclear factor, erythroid 2-like 2 1.438
NOD1 nucleotide-binding oligomerization domain containing 1 1.437
NQO1 NAD(P)H dehydrogenase, quinone 1 1.436
ICAM1 intercellular adhesion molecule 1 1.435
TAC1 tachykinin, precursor 1 1.434
KIR2DL4 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 4 1.432
TLR9 toll-like receptor 9 1.427
CWC15 CWC15 spliceosome-associated protein 1.426
CREB1 cAMP responsive element binding protein 1 1.426
PPIG peptidylprolyl isomerase G (cyclophilin G) 1.425
CSF2 colony stimulating factor 2 (granulocyte-macrophage) 1.425
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1 1.423
MAOA monoamine oxidase A 1.416
GUCA2B guanylate cyclase activator 2B (uroguanylin) 1.411
CAMP cathelicidin antimicrobial peptide 1.41
CYP1A2 cytochrome P450, family 1, subfamily A, polypeptide 2 1.41
GUCY2C guanylate cyclase 2C 1.407
MAOB monoamine oxidase B 1.406
TPI1 triosephosphate isomerase 1 1.403
MAPK8 mitogen-activated protein kinase 8 1.396
KNG1 kininogen 1 1.395
HP haptoglobin 1.393
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta 1.385
BCL2L1 BCL2-like 1 1.384
EGF epidermal growth factor 1.38
MDH2 malate dehydrogenase 2, NAD (mitochondrial) 1.374
LEP leptin 1.372
NOS2 nitric oxide synthase 2, inducible 1.372
KEAP1 kelch-like ECH-associated protein 1 1.371
OPRM1 opioid receptor, mu 1 1.37
CCND1 cyclin D1 1.368
CLDN2 claudin 2 1.365
MYO1C myosin IC 1.358
SRC SRC proto-oncogene, non-receptor tyrosine kinase 1.357
MMP2 matrix metallopeptidase 2 1.354
ASZ1 ankyrin repeat, SAM and basic leucine zipper domain containing 1 1.354
STAT1 signal transducer and activator of transcription 1, 91kDa 1.349
VIP vasoactive intestinal peptide 1.345
TBL1X transducin (beta)-like 1X-linked 1.345
FN1 fibronectin 1 1.34
MARVELD2 MARVEL domain containing 2 1.339
GCG glucagon 1.337
CDC42 cell division cycle 42 1.332
CDH1 cadherin 1, type 1, E-cadherin (epithelial) 1.331
CALM3 calmodulin 3 (phosphorylase kinase, delta) 1.328
IGLL5 immunoglobulin lambda-like polypeptide 5 1.327
ATG5 autophagy related 5 1.324
DEFB4A defensin, beta 4A 1.321
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 1.315
PIGR polymeric immunoglobulin receptor 1.314
CTTNBP2 cortactin binding protein 2 1.314
FFAR2 free fatty acid receptor 2 1.31
GUCA2A guanylate cyclase activator 2A (guanylin) 1.309
DPP4 dipeptidyl-peptidase 4 1.309
CCK cholecystokinin 1.306
AHR aryl hydrocarbon receptor 1.302
HSPA4 heat shock 70kDa protein 4 1.302
EGFR epidermal growth factor receptor 1.299
TLR3 toll-like receptor 3 1.295
PARP1 poly (ADP-ribose) polymerase 1 1.295
JAK2 Janus kinase 2 1.29
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3 1.289
CALML4 calmodulin-like 4 1.288
CALML6 calmodulin-like 6 1.288
BDNF brain-derived neurotrophic factor 1.287
CALML3 calmodulin-like 3 1.286
CALML5 calmodulin-like 5 1.285
ESR1 estrogen receptor 1 1.284
CHUK conserved helix-loop-helix ubiquitous kinase 1.283
CLDN4 claudin 4 1.28
NPR3 natriuretic peptide receptor 3 1.279
TJP2 tight junction protein 2 1.275
GPKOW G patch domain and KOW motifs 1.274
CLCA1 chloride channel accessory 1 1.271
GUCY2D guanylate cyclase 2D, membrane (retina-specific) 1.268
MUC5AC mucin 5AC, oligomeric mucus/gel-forming 1.264
ELANE elastase, neutrophil expressed 1.264
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 1.262
CXCL10 chemokine (C-X-C motif) ligand 10 1.261
GAL galanin/GMAP prepropeptide 1.258
WAS Wiskott-Aldrich syndrome 1.255
GRPEL1 GrpE-like 1, mitochondrial (E. coli) 1.255
G6PC3 glucose 6 phosphatase, catalytic, 3 1.252
SIRT1 sirtuin 1 1.248
CLCA2 chloride channel accessory 2 1.248
VCAM1 vascular cell adhesion molecule 1 1.248
GUSB glucuronidase, beta 1.247
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma 1.244
TFF3 trefoil factor 3 (intestinal) 1.241
FURIN furin (paired basic amino acid cleaving enzyme) 1.24
ZNF224 zinc finger protein 224 1.239
ODC1 ornithine decarboxylase 1 1.238
OXA1L oxidase (cytochrome c) assembly 1-like 1.235
REL v-rel avian reticuloendotheliosis viral oncogene homolog 1.234
CPB1 carboxypeptidase B1 (tissue) 1.233
PIK3C3 phosphatidylinositol 3-kinase, catalytic subunit type 3 1.231
FABP2 fatty acid binding protein 2, intestinal 1.23
G6PC2 glucose-6-phosphatase, catalytic, 2 1.229
IGF1 insulin-like growth factor 1 (somatomedin C) 1.227
IFNB1 interferon, beta 1, fibroblast 1.226
GSK3B glycogen synthase kinase 3 beta 1.226
CCL5 chemokine (C-C motif) ligand 5 1.226
CCL3 chemokine (C-C motif) ligand 3 1.225
DEFB1 defensin, beta 1 1.221
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 1.219
MYH14 myosin, heavy chain 14, non-muscle 1.216
APAF1 apoptotic peptidase activating factor 1 1.216
LY96 lymphocyte antigen 96 1.213
GAST gastrin 1.213
CLCA4 chloride channel accessory 4 1.213
MYC v-myc avian myelocytomatosis viral oncogene homolog 1.212
IFNA1 interferon, alpha 1 1.21
BECN1 beclin 1, autophagy related 1.21
ADCY10 adenylate cyclase 10 (soluble) 1.209
TXN thioredoxin 1.208
AOC1 amine oxidase, copper containing 1 1.208
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 1.208
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 1.207
CSF3 colony stimulating factor 3 (granulocyte) 1.202
DNAH8 dynein, axonemal, heavy chain 8 1.201
CCL20 chemokine (C-C motif) ligand 20 1.201
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase 1.196
CD40 CD40 molecule, TNF receptor superfamily member 5 1.196
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 1.195
GOLPH3 golgi phosphoprotein 3 (coat-protein) 1.192
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9 1.192
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6 1.191
NLRC4 NLR family, CARD domain containing 4 1.189
SH2D3A SH2 domain containing 3A 1.187
PRKACG protein kinase, cAMP-dependent, catalytic, gamma 1.182
F3 coagulation factor III (thromboplastin, tissue factor) 1.182
SREBF1 sterol regulatory element binding transcription factor 1 1.181
REG3A regenerating islet-derived 3 alpha 1.18
CDK2 cyclin-dependent kinase 2 1.179
PCNA proliferating cell nuclear antigen 1.179
BIRC5 baculoviral IAP repeat containing 5 1.177
PRKACA protein kinase, cAMP-dependent, catalytic, alpha 1.176
PPARA peroxisome proliferator-activated receptor alpha 1.175
PRKACB protein kinase, cAMP-dependent, catalytic, beta 1.172
SHF Src homology 2 domain containing F 1.167
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 1.165
RPL3 ribosomal protein L3 1.162
QTRT1 queuine tRNA-ribosyltransferase 1 1.162
LOX lysyl oxidase 1.161
RPS16 ribosomal protein S16 1.16
SH2D3C SH2 domain containing 3C 1.159
PAPSS1 3'-phosphoadenosine 5'-phosphosulfate synthase 1 1.159
RHOA ras homolog family member A 1.158
ZNF185 zinc finger protein 185 (LIM domain) 1.156
CASP7 caspase 7, apoptosis-related cysteine peptidase 1.152
CBS cystathionine-beta-synthase 1.151
SLCO6A1 solute carrier organic anion transporter family, member 6A1 1.151
ANKRD49 ankyrin repeat domain 49 1.148
CYBB cytochrome b-245, beta polypeptide 1.148
SLC9A8 solute carrier family 9, subfamily A (NHE8, cation proton antiporter 8), member 8 1.147
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase 1.147
MMP3 matrix metallopeptidase 3 1.145
PPP1CA protein phosphatase 1, catalytic subunit, alpha isozyme 1.143
HRH2 histamine receptor H2 1.141
RPS23 ribosomal protein S23 1.138
TLR7 toll-like receptor 7 1.136
ALOX5 arachidonate 5-lipoxygenase 1.134
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 1.127
ATG16L1 autophagy related 16-like 1 (S. cerevisiae) 1.127
CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19 1.126
SDSL serine dehydratase-like 1.124
SLC2A2 solute carrier family 2 (facilitated glucose transporter), member 2 1.123
SETD1A SET domain containing 1A 1.123
DIABLO diablo, IAP-binding mitochondrial protein 1.122
H1-1 H1.1 linker histone, cluster member 1.122
NR1H4 nuclear receptor subfamily 1, group H, member 4 1.119
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A 1.117
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit) 1.116
VCL vinculin 1.114
NOS3 nitric oxide synthase 3 (endothelial cell) 1.113
PYY peptide YY 1.112
NR1I2 nuclear receptor subfamily 1, group I, member 2 1.111
MUC4 mucin 4, cell surface associated 1.111
NCF1 neutrophil cytosolic factor 1 1.11
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene) 1.109
HMGB1 high mobility group box 1 1.109
FASLG Fas ligand (TNF superfamily, member 6) 1.108
LMLN leishmanolysin-like (metallopeptidase M8 family) 1.105
TRPV1 transient receptor potential cation channel, subfamily V, member 1 1.101
GSDMD gasdermin D 1.1
MLN motilin 1.097
MYO1B myosin IB 1.096
TNFSF11 tumor necrosis factor (ligand) superfamily, member 11 1.096
SST somatostatin 1.092
ALPI alkaline phosphatase, intestinal 1.092
POMC proopiomelanocortin 1.089
IRF3 interferon regulatory factor 3 1.089
CTRL chymotrypsin-like 1.089
ITGAX integrin, alpha X (complement component 3 receptor 4 subunit) 1.089
FFAR3 free fatty acid receptor 3 1.087
CCNL2 cyclin L2 1.086
REG1B regenerating islet-derived 1 beta 1.08
SYK spleen tyrosine kinase 1.078
INSR insulin receptor 1.078
CD86 CD86 molecule 1.075
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase 1.074
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1 1.071
DNAJC28 DnaJ (Hsp40) homolog, subfamily C, member 28 1.071
ARF6 ADP-ribosylation factor 6 1.07
CLDN3 claudin 3 1.068
LPO lactoperoxidase 1.066
MGAM2 maltase-glucoamylase 2 (putative) 1.066
TMPRSS2 transmembrane protease, serine 2 1.064
ADIPOQ adiponectin, C1Q and collagen domain containing 1.062
SUN5 Sad1 and UNC84 domain containing 5 1.061
CGN cingulin 1.059
MMP1 matrix metallopeptidase 1 1.059
LALBA lactalbumin, alpha- 1.059
CLEC7A C-type lectin domain family 7, member A 1.058
CCL4 chemokine (C-C motif) ligand 4 1.057
BACE1 beta-site APP-cleaving enzyme 1 1.057
PFN4 profilin family, member 4 1.055
ORM2 orosomucoid 2 1.053
SLC35A2 solute carrier family 35 (UDP-galactose transporter), member A2 1.053
DHFR dihydrofolate reductase 1.051
PFN3 profilin 3 1.05
CD40LG CD40 ligand 1.049
LCN2 lipocalin 2 1.047
GP2 glycoprotein 2 (zymogen granule membrane) 1.046
APP amyloid beta (A4) precursor protein 1.045
TTR transthyretin 1.045
RAB5A RAB5A, member RAS oncogene family 1.044
SERPINF2 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2 1.042
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8) 1.041
HAMP hepcidin antimicrobial peptide 1.04
IL7 interleukin 7 1.039
HCAR2 hydroxycarboxylic acid receptor 2 1.039
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group) 1.036
ANO1 anoctamin 1, calcium activated chloride channel 1.034
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 1.034
PTGER3 prostaglandin E receptor 3 (subtype EP3) 1.033
ATG12 autophagy related 12 1.028
RAB7B RAB7B, member RAS oncogene family 1.026
LSR lipolysis stimulated lipoprotein receptor 1.026
DEFB103A defensin, beta 103A 1.022
VIL1 villin 1 1.02
ORM1 orosomucoid 1 1.019
TFRC transferrin receptor 1.018
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 1.017
TRPT1 tRNA phosphotransferase 1 1.016
CCNA2 cyclin A2 1.015
GALM galactose mutarotase (aldose 1-epimerase) 1.015
KDR kinase insert domain receptor 1.015
RNF103 ring finger protein 103 1.014
SETD1B SET domain containing 1B 1.012
CCNB1 cyclin B1 1.011
IL9 interleukin 9 1.01
CLDN15 claudin 15 1.009
NFE2 nuclear factor, erythroid 2 1.008
H6PD hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase) 1.007
TYRP1 tyrosinase-related protein 1 1.006
CTSB cathepsin B 1.005
CYP7A1 cytochrome P450, family 7, subfamily A, polypeptide 1 1.005
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 1.003
CYTH1 cytohesin 1 1.002
MYLK3 myosin light chain kinase 3 1.002
R3HCC1L R3H domain and coiled-coil containing 1-like 1.001
LPL lipoprotein lipase 1.001