Dysgammaglobulinemia Gene Set

Dataset DISEASES Text-mining Gene-Disease Association Evidence Scores 2025
Category disease or phenotype associations
Type disease
Description A selective immunoglobulin deficiency disease that is caused by a reduction in some types of gamma globulins. (Human Disease Ontology, DOID_11702)
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Genes

146 genes co-occuring with the disease Dysgammaglobulinemia in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.

Symbol Name Standardized Value
SH2D1A SH2 domain containing 1A 3.025
SLAMF1 signaling lymphocytic activation molecule family member 1 2.383
SLAMF6 SLAM family member 6 2.175
LY9 lymphocyte antigen 9 2.164
TNFRSF13B tumor necrosis factor receptor superfamily, member 13B 2.139
CLEC16A C-type lectin domain family 16, member A 2.131
CD84 CD84 molecule 2.127
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase 1.954
CD4 CD4 molecule 1.911
CD8A CD8a molecule 1.902
MAGT1 magnesium transporter 1 1.901
DEXI Dexi homolog (mouse) 1.871
CD244 CD244 molecule, natural killer cell receptor 2B4 1.856
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 1.826
SH2D1B SH2 domain containing 1B 1.792
STXBP2 syntaxin binding protein 2 1.782
CD27 CD27 molecule 1.773
CD19 CD19 molecule 1.743
TOR1A torsin family 1, member A (torsin A) 1.732
DOCK8 dedicator of cytokinesis 8 1.729
UNC13D unc-13 homolog D (C. elegans) 1.71
STX11 syntaxin 11 1.705
ITK IL2-inducible T-cell kinase 1.7
BTK Bruton agammaglobulinemia tyrosine kinase 1.668
PIGR polymeric immunoglobulin receptor 1.656
DCLRE1C DNA cross-link repair 1C 1.625
CD40LG CD40 ligand 1.622
CORO1A coronin, actin binding protein, 1A 1.622
CD48 CD48 molecule 1.612
NIPAL3 NIPA-like domain containing 3 1.597
ICOS inducible T-cell co-stimulator 1.597
NIPAL2 NIPA-like domain containing 2 1.578
TNFRSF25 tumor necrosis factor receptor superfamily, member 25 1.569
TGM2 transglutaminase 2 1.566
IKZF1 IKAROS family zinc finger 1 (Ikaros) 1.55
NIPAL1 NIPA-like domain containing 1 1.542
CR2 complement component (3d/Epstein Barr virus) receptor 2 1.541
WAS Wiskott-Aldrich syndrome 1.531
RAG1 recombination activating gene 1 1.528
AIRE autoimmune regulator 1.525
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1 1.507
SLAMF9 SLAM family member 9 1.49
LYST lysosomal trafficking regulator 1.487
STK4 serine/threonine kinase 4 1.484
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1 1.483
RAG2 recombination activating gene 2 1.465
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma 1.463
SLAMF7 SLAM family member 7 1.438
CXCR5 chemokine (C-X-C motif) receptor 5 1.431
TNFRSF13C tumor necrosis factor receptor superfamily, member 13C 1.421
FYN FYN proto-oncogene, Src family tyrosine kinase 1.413
CD70 CD70 molecule 1.404
NIPAL4 NIPA-like domain containing 4 1.404
CAVIN1 caveolae associated protein 1 1.394
RAB27A RAB27A, member RAS oncogene family 1.39
ADA2 adenosine deaminase 2 1.39
DOK2 docking protein 2, 56kDa 1.388
IFIH1 interferon induced with helicase C domain 1 1.37
CARD11 caspase recruitment domain family, member 11 1.369
SEC31B SEC31 homolog B (S. cerevisiae) 1.352
PLCG1 phospholipase C, gamma 1 1.352
PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific) 1.346
IL2 interleukin 2 1.341
IL2RG interleukin 2 receptor, gamma 1.333
DNHD1 dynein heavy chain domain 1 1.332
NIPA2 non imprinted in Prader-Willi/Angelman syndrome 2 1.326
ZNF341 zinc finger protein 341 1.318
KLRK1 killer cell lectin-like receptor subfamily K, member 1 1.316
ZAP70 zeta-chain (TCR) associated protein kinase 70kDa 1.314
PGM3 phosphoglucomutase 3 1.312
MSH5 mutS homolog 5 1.284
HLA-DRB1 major histocompatibility complex, class II, DR beta 1 1.283
NOD2 nucleotide-binding oligomerization domain containing 2 1.283
HLA-DQA2 major histocompatibility complex, class II, DQ alpha 2 1.282
CTPS1 CTP synthase 1 1.282
CD40 CD40 molecule, TNF receptor superfamily member 5 1.277
CTLA4 cytotoxic T-lymphocyte-associated protein 4 1.27
FOXP3 forkhead box P3 1.265
FHL2 four and a half LIM domains 2 1.265
NHEJ1 nonhomologous end-joining factor 1 1.252
PRF1 perforin 1 (pore forming protein) 1.251
GATA2 GATA binding protein 2 1.25
PROB1 proline-rich basic protein 1 1.228
CD28 CD28 molecule 1.227
HLA-B major histocompatibility complex, class I, B 1.226
IFNG interferon, gamma 1.226
ZBTB24 zinc finger and BTB domain containing 24 1.222
IL4 interleukin 4 1.215
FCGR3B Fc fragment of IgG, low affinity IIIb, receptor (CD16b) 1.215
IL21R interleukin 21 receptor 1.208
ARPC1B actin related protein 2/3 complex, subunit 1B, 41kDa 1.206
FCGR3A Fc fragment of IgG, low affinity IIIa, receptor (CD16a) 1.202
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) 1.194
FOXN1 forkhead box N1 1.192
LIG4 ligase IV, DNA, ATP-dependent 1.188
IL10 interleukin 10 1.177
LCK LCK proto-oncogene, Src family tyrosine kinase 1.176
SLAMF8 SLAM family member 8 1.175
AMBRA1 autophagy/beclin-1 regulator 1 1.17
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated) 1.169
NCAM1 neural cell adhesion molecule 1 1.164
TNF tumor necrosis factor 1.161
PRDM1 PR domain containing 1, with ZNF domain 1.16
PTPN11 protein tyrosine phosphatase, non-receptor type 11 1.158
DOCK2 dedicator of cytokinesis 2 1.153
TTC7A tetratricopeptide repeat domain 7A 1.141
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 1.138
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 1.133
JAK3 Janus kinase 3 1.132
LAT linker for activation of T cells 1.126
AICDA activation-induced cytidine deaminase 1.126
STXBP6 syntaxin binding protein 6 (amisyn) 1.123
IL6 interleukin 6 1.115
ADA adenosine deaminase 1.112
CD2 CD2 molecule 1.109
CAMLG calcium modulating ligand 1.098
PTPRC protein tyrosine phosphatase, receptor type, C 1.097
VWA7 von Willebrand factor A domain containing 7 1.096
RIPK2 receptor-interacting serine-threonine kinase 2 1.094
RFXANK regulatory factor X-associated ankyrin-containing protein 1.092
STAT1 signal transducer and activator of transcription 1, 91kDa 1.091
EDAR ectodysplasin A receptor 1.088
HIRA histone cell cycle regulator 1.082
STAT5B signal transducer and activator of transcription 5B 1.081
CARMIL2 capping protein regulator and myosin 1 linker 2 1.076
SRC SRC proto-oncogene, non-receptor tyrosine kinase 1.07
DAPP1 dual adaptor of phosphotyrosine and 3-phosphoinositides 1.063
ATM ATM serine/threonine kinase 1.057
NTN5 netrin 5 1.055
SERPINA9 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 9 1.054
AHI1 Abelson helper integration site 1 1.054
PLEK pleckstrin 1.052
CD38 CD38 molecule 1.049
ATG13 autophagy related 13 1.042
CD247 CD247 molecule 1.04
FCAR Fc fragment of IgA receptor 1.039
GPR149 G protein-coupled receptor 149 1.033
VAV1 vav 1 guanine nucleotide exchange factor 1.033
EDARADD EDAR-associated death domain 1.031
C22ORF42 chromosome 22 open reading frame 42 1.027
CD81 CD81 molecule 1.023
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) 1.023
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) 1.022
MALT1 MALT1 paracaspase 1.013
FASLG Fas ligand (TNF superfamily, member 6) 1.012
TNFSF13B tumor necrosis factor (ligand) superfamily, member 13b 1.007