Dataset | MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations |
Category | transcriptomics |
Type | gene perturbation |
Description | gene perturbation identified as [gene symbol]_[perturbation or condition] (Molecular Signatures Database) |
External Link | http://www.broadinstitute.org/gsea/msigdb/cards/E2F1_UP.V1_UP |
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380 genes differentially expressed following the E2F1_UP.V1 gene perturbation from the MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations dataset.
Symbol | Name |
---|---|
ACTN3 | actinin, alpha 3 (gene/pseudogene) |
ADA | adenosine deaminase |
ADCY6 | adenylate cyclase 6 |
ADIPOR2 | adiponectin receptor 2 |
AGO2 | argonaute RISC catalytic component 2 |
ARF3 | ADP-ribosylation factor 3 |
ARHGAP39 | Rho GTPase activating protein 39 |
ARHGAP8 | Rho GTPase activating protein 8 |
ARHGEF1 | Rho guanine nucleotide exchange factor (GEF) 1 |
ART3 | ADP-ribosyltransferase 3 |
ATP5D | ATP synthase, H+ transporting, mitochondrial F1 complex, delta subunit |
AURKB | aurora kinase B |
BCL2 | B-cell CLL/lymphoma 2 |
BOK | BCL2-related ovarian killer |
BOLA3 | bolA family member 3 |
BRCA2 | breast cancer 2, early onset |
BUB1 | BUB1 mitotic checkpoint serine/threonine kinase |
C4ORF27 | chromosome 4 open reading frame 27 |
CAD | carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase |
CAPRIN2 | caprin family member 2 |
CASP7 | caspase 7, apoptosis-related cysteine peptidase |
CCRN4L | CCR4 carbon catabolite repression 4-like (S. cerevisiae) |
CDK5R1 | cyclin-dependent kinase 5, regulatory subunit 1 (p35) |
CDR2L | cerebellar degeneration-related protein 2-like |
CDV3 | CDV3 homolog (mouse) |
CHAF1B | chromatin assembly factor 1, subunit B (p60) |
CHEK1 | checkpoint kinase 1 |
CLN6 | ceroid-lipofuscinosis, neuronal 6, late infantile, variant |
CMA1 | chymase 1, mast cell |
CNIH2 | cornichon family AMPA receptor auxiliary protein 2 |
CNOT7 | CCR4-NOT transcription complex, subunit 7 |
CRYZ | crystallin, zeta (quinone reductase) |
CSTF2 | cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa |
CYBA | cytochrome b-245, alpha polypeptide |
DBF4 | DBF4 zinc finger |
DCTPP1 | dCTP pyrophosphatase 1 |
DDB1 | damage-specific DNA binding protein 1, 127kDa |
DDX46 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 46 |
DFNA5 | deafness, autosomal dominant 5 |
DLGAP5 | discs, large (Drosophila) homolog-associated protein 5 |
DLX1 | distal-less homeobox 1 |
DMBT1 | deleted in malignant brain tumors 1 |
DNA2 | DNA replication helicase/nuclease 2 |
DNAJC2 | DnaJ (Hsp40) homolog, subfamily C, member 2 |
DNAJC21 | DnaJ (Hsp40) homolog, subfamily C, member 21 |
DRC1 | dynein regulatory complex subunit 1 |
E2F3 | E2F transcription factor 3 |
E2F8 | E2F transcription factor 8 |
EFNB2 | ephrin-B2 |
EIF6 | eukaryotic translation initiation factor 6 |
ELANE | elastase, neutrophil expressed |
ELAVL1 | ELAV like RNA binding protein 1 |
ERCC2 | excision repair cross-complementation group 2 |
ERMP1 | endoplasmic reticulum metallopeptidase 1 |
EVL | Enah/Vasp-like |
EZH2 | enhancer of zeste 2 polycomb repressive complex 2 subunit |
FAM60A | family with sequence similarity 60, member A |
FANCM | Fanconi anemia, complementation group M |
FEN1 | flap structure-specific endonuclease 1 |
FMNL3 | formin-like 3 |
FNBP1 | formin binding protein 1 |
FRAT2 | frequently rearranged in advanced T-cell lymphomas 2 |
GATA6 | GATA binding protein 6 |
GPN2 | GPN-loop GTPase 2 |
GPR19 | G protein-coupled receptor 19 |
GRSF1 | G-rich RNA sequence binding factor 1 |
GRWD1 | glutamate-rich WD repeat containing 1 |
GUF1 | GUF1 GTPase homolog (S. cerevisiae) |
HDGFRP2 | hepatoma-derived growth factor-related protein 2 |
HES1 | hes family bHLH transcription factor 1 |
HMGB3 | high mobility group box 3 |
HSPB2 | heat shock 27kDa protein 2 |
HSPBP1 | HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1 |
INO80C | INO80 complex subunit C |
INO80E | INO80 complex subunit E |
ITSN1 | intersectin 1 (SH3 domain protein) |
IVNS1ABP | influenza virus NS1A binding protein |
KANK3 | KN motif and ankyrin repeat domains 3 |
KIF2A | kinesin heavy chain member 2A |
KIFC1 | kinesin family member C1 |
KLHL21 | kelch-like family member 21 |
KPNA1 | karyopherin alpha 1 (importin alpha 5) |
KPNA3 | karyopherin alpha 3 (importin alpha 4) |
KRT72 | keratin 72, type II |
LARP4B | La ribonucleoprotein domain family, member 4B |
LMNB1 | lamin B1 |
LPIN2 | lipin 2 |
MAP3K11 | mitogen-activated protein kinase kinase kinase 11 |
MAP3K3 | mitogen-activated protein kinase kinase kinase 3 |
MAPK14 | mitogen-activated protein kinase 14 |
MASP1 | mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor) |
MCM10 | minichromosome maintenance complex component 10 |
MCM4 | minichromosome maintenance complex component 4 |
MED20 | mediator complex subunit 20 |
MFI2 | antigen p97 (melanoma associated) identified by monoclonal antibodies 133.2 and 96.5 |
MPG | N-methylpurine-DNA glycosylase |
MRPL46 | mitochondrial ribosomal protein L46 |
MSH3 | mutS homolog 3 |
MTSS1L | metastasis suppressor 1-like |
MXI1 | MAX interactor 1, dimerization protein |
NAB1 | NGFI-A binding protein 1 (EGR1 binding protein 1) |
NASP | nuclear autoantigenic sperm protein (histone-binding) |
NBL1 | neuroblastoma 1, DAN family BMP antagonist |
NCAPH | non-SMC condensin I complex, subunit H |
NDUFAF4 | NADH dehydrogenase (ubiquinone) complex I, assembly factor 4 |
NOLC1 | nucleolar and coiled-body phosphoprotein 1 |
NOP56 | NOP56 ribonucleoprotein |
NUP43 | nucleoporin 43kDa |
PACS1 | phosphofurin acidic cluster sorting protein 1 |
PAIP2B | poly(A) binding protein interacting protein 2B |
PARP1 | poly (ADP-ribose) polymerase 1 |
PARP16 | poly (ADP-ribose) polymerase family, member 16 |
PBX3 | pre-B-cell leukemia homeobox 3 |
PHF12 | PHD finger protein 12 |
PIGA | phosphatidylinositol glycan anchor biosynthesis, class A |
PIM1 | Pim-1 proto-oncogene, serine/threonine kinase |
PIP4K2A | phosphatidylinositol-5-phosphate 4-kinase, type II, alpha |
PITPNM1 | phosphatidylinositol transfer protein, membrane-associated 1 |
PKP4 | plakophilin 4 |
PLK4 | polo-like kinase 4 |
POLA2 | polymerase (DNA directed), alpha 2, accessory subunit |
PPM1M | protein phosphatase, Mg2+/Mn2+ dependent, 1M |
PRADC1 | protease-associated domain containing 1 |
PRC1 | protein regulator of cytokinesis 1 |
PRIM2 | primase, DNA, polypeptide 2 (58kDa) |
PRM1 | protamine 1 |
PSME3 | proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki) |
PTPN21 | protein tyrosine phosphatase, non-receptor type 21 |
PTPRU | protein tyrosine phosphatase, receptor type, U |
RB1 | retinoblastoma 1 |
RBM15 | RNA binding motif protein 15 |
RBM22 | RNA binding motif protein 22 |
RDH13 | retinol dehydrogenase 13 (all-trans/9-cis) |
RELL1 | RELT-like 1 |
RHBDL3 | rhomboid, veinlet-like 3 (Drosophila) |
RND2 | Rho family GTPase 2 |
RRM1 | ribonucleotide reductase M1 |
RRP1B | ribosomal RNA processing 1B |
SDCCAG3 | serologically defined colon cancer antigen 3 |
SGOL1 | shugoshin-like 1 (S. pombe) |
SHBG | sex hormone-binding globulin |
SIRPA | signal-regulatory protein alpha |
SLBP | stem-loop binding protein |
SLC20A1 | solute carrier family 20 (phosphate transporter), member 1 |
SLC35E1 | solute carrier family 35, member E1 |
SLC7A1 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 |
SLC9A3R1 | solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1 |
SMAD1 | SMAD family member 1 |
SMC2 | structural maintenance of chromosomes 2 |
SOCS2 | suppressor of cytokine signaling 2 |
SPEF1 | sperm flagellar 1 |
SRSF4 | serine/arginine-rich splicing factor 4 |
SSX2IP | synovial sarcoma, X breakpoint 2 interacting protein |
STIL | SCL/TAL1 interrupting locus |
TAF6 | TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa |
TAF9 | TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 32kDa |
TBP | TATA box binding protein |
TFAM | transcription factor A, mitochondrial |
THOP1 | thimet oligopeptidase 1 |
TINF2 | TERF1 (TRF1)-interacting nuclear factor 2 |
TK1 | thymidine kinase 1, soluble |
TLE4 | transducin-like enhancer of split 4 |
TLX2 | T-cell leukemia homeobox 2 |
TOP2A | topoisomerase (DNA) II alpha 170kDa |
TPD52 | tumor protein D52 |
TPM2 | tropomyosin 2 (beta) |
TRAF3 | TNF receptor-associated factor 3 |
TRNT1 | tRNA nucleotidyl transferase, CCA-adding, 1 |
TYMS | thymidylate synthetase |
TYRO3 | TYRO3 protein tyrosine kinase |
UBE2T | ubiquitin-conjugating enzyme E2T |
UBN1 | ubinuclein 1 |
UBR2 | ubiquitin protein ligase E3 component n-recognin 2 |
UCK2 | uridine-cytidine kinase 2 |
UPK2 | uroplakin 2 |
UQCC1 | ubiquinol-cytochrome c reductase complex assembly factor 1 |
USF2 | upstream transcription factor 2, c-fos interacting |
USP10 | ubiquitin specific peptidase 10 |
USP39 | ubiquitin specific peptidase 39 |
VEGFA | vascular endothelial growth factor A |
VPRBP | Vpr (HIV-1) binding protein |
VPREB3 | pre-B lymphocyte 3 |
VPS37B | vacuolar protein sorting 37 homolog B (S. cerevisiae) |
WBP11 | WW domain binding protein 11 |
WDHD1 | WD repeat and HMG-box DNA binding protein 1 |
WRN | Werner syndrome, RecQ helicase-like |
ZFPM1 | zinc finger protein, FOG family member 1 |
ZSWIM7 | zinc finger, SWIM-type containing 7 |
Symbol | Name |
---|---|
A4GALT | alpha 1,4-galactosyltransferase |
ABLIM1 | actin binding LIM protein 1 |
ACKR3 | atypical chemokine receptor 3 |
ACOX1 | acyl-CoA oxidase 1, palmitoyl |
ADAMTS1 | ADAM metallopeptidase with thrombospondin type 1 motif, 1 |
ADARB1 | adenosine deaminase, RNA-specific, B1 |
AJUBA | ajuba LIM protein |
ALAS2 | 5'-aminolevulinate synthase 2 |
ALDH1A1 | aldehyde dehydrogenase 1 family, member A1 |
ALDH3A1 | aldehyde dehydrogenase 3 family, member A1 |
AMPD3 | adenosine monophosphate deaminase 3 |
ANGPTL4 | angiopoietin-like 4 |
ANKHD1 | ankyrin repeat and KH domain containing 1 |
ANXA1 | annexin A1 |
ANXA4 | annexin A4 |
ANXA8 | annexin A8 |
APBB1IP | amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein |
APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 |
APC2 | adenomatosis polyposis coli 2 |
AQP8 | aquaporin 8 |
ARL4D | ADP-ribosylation factor-like 4D |
ASL | argininosuccinate lyase |
ATP2A3 | ATPase, Ca++ transporting, ubiquitous |
AVPI1 | arginine vasopressin-induced 1 |
B4GALT3 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 3 |
BAG3 | BCL2-associated athanogene 3 |
BCL6 | B-cell CLL/lymphoma 6 |
C18ORF8 | chromosome 18 open reading frame 8 |
C3 | complement component 3 |
CALML4 | calmodulin-like 4 |
CAPN2 | calpain 2, (m/II) large subunit |
CCL2 | chemokine (C-C motif) ligand 2 |
CCND2 | cyclin D2 |
CCNG2 | cyclin G2 |
CD3E | CD3e molecule, epsilon (CD3-TCR complex) |
CD47 | CD47 molecule |
CHRNA7 | cholinergic receptor, nicotinic, alpha 7 (neuronal) |
CIRBP | cold inducible RNA binding protein |
COL11A1 | collagen, type XI, alpha 1 |
COL3A1 | collagen, type III, alpha 1 |
CPT1A | carnitine palmitoyltransferase 1A (liver) |
CREBRF | CREB3 regulatory factor |
CRIP2 | cysteine-rich protein 2 |
CSF1 | colony stimulating factor 1 (macrophage) |
CXCL1 | chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) |
CXCL5 | chemokine (C-X-C motif) ligand 5 |
CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 |
CYTIP | cytohesin 1 interacting protein |
DAB2 | Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila) |
DCAF8 | DDB1 and CUL4 associated factor 8 |
DOK1 | docking protein 1, 62kDa (downstream of tyrosine kinase 1) |
DTX2 | deltex 2, E3 ubiquitin ligase |
EBF1 | early B-cell factor 1 |
EFNA4 | ephrin-A4 |
ENTPD6 | ectonucleoside triphosphate diphosphohydrolase 6 (putative) |
EPS8 | epidermal growth factor receptor pathway substrate 8 |
ERBB3 | erb-b2 receptor tyrosine kinase 3 |
EVI2A | ecotropic viral integration site 2A |
F3 | coagulation factor III (thromboplastin, tissue factor) |
FAS | Fas cell surface death receptor |
FCHO1 | FCH domain only 1 |
FER | fer (fps/fes related) tyrosine kinase |
FGF19 | fibroblast growth factor 19 |
FMO3 | flavin containing monooxygenase 3 |
GADD45A | growth arrest and DNA-damage-inducible, alpha |
GBP2 | guanylate binding protein 2, interferon-inducible |
GFRA1 | GDNF family receptor alpha 1 |
GHR | growth hormone receptor |
GSTA4 | glutathione S-transferase alpha 4 |
HBG2 | hemoglobin, gamma G |
HES6 | hes family bHLH transcription factor 6 |
HLA-E | major histocompatibility complex, class I, E |
HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) |
IDH1 | isocitrate dehydrogenase 1 (NADP+), soluble |
IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 |
IFT20 | intraflagellar transport 20 |
IL18 | interleukin 18 |
IL1R1 | interleukin 1 receptor, type I |
IL1RL1 | interleukin 1 receptor-like 1 |
IL6ST | interleukin 6 signal transducer |
ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 |
KLF2 | Kruppel-like factor 2 |
KLF3 | Kruppel-like factor 3 (basic) |
KMT2E | lysine (K)-specific methyltransferase 2E |
KXD1 | KxDL motif containing 1 |
LAMA4 | laminin, alpha 4 |
LBP | lipopolysaccharide binding protein |
LCLAT1 | lysocardiolipin acyltransferase 1 |
LGALS2 | lectin, galactoside-binding, soluble, 2 |
LIMA1 | LIM domain and actin binding 1 |
LIPE | lipase, hormone-sensitive |
LRIG1 | leucine-rich repeats and immunoglobulin-like domains 1 |
LXN | latexin |
MARC2 | mitochondrial amidoxime reducing component 2 |
MCL1 | myeloid cell leukemia 1 |
MDK | midkine (neurite growth-promoting factor 2) |
MDN1 | MDN1, midasin homolog (yeast) |
MLX | MLX, MAX dimerization protein |
MMP7 | matrix metallopeptidase 7 |
MX1 | MX dynamin-like GTPase 1 |
MYC | v-myc avian myelocytomatosis viral oncogene homolog |
NDRG4 | NDRG family member 4 |
NEAT1 | nuclear paraspeckle assembly transcript 1 (non-protein coding) |
NFKB1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 |
NFKBIZ | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta |
NHSL1 | NHS-like 1 |
NOTCH2 | notch 2 |
NPR1 | natriuretic peptide receptor 1 |
NUMA1 | nuclear mitotic apparatus protein 1 |
PAK3 | p21 protein (Cdc42/Rac)-activated kinase 3 |
PDE4DIP | phosphodiesterase 4D interacting protein |
PDGFRA | platelet-derived growth factor receptor, alpha polypeptide |
PDZK1IP1 | PDZK1 interacting protein 1 |
PGD | phosphogluconate dehydrogenase |
PHLDA1 | pleckstrin homology-like domain, family A, member 1 |
PKD1 | polycystic kidney disease 1 (autosomal dominant) |
PLA2G4A | phospholipase A2, group IVA (cytosolic, calcium-dependent) |
PLAT | plasminogen activator, tissue |
PLET1 | placenta expressed transcript 1 |
PLIN2 | perilipin 2 |
PLK2 | polo-like kinase 2 |
PLXND1 | plexin D1 |
POLD4 | polymerase (DNA-directed), delta 4, accessory subunit |
POU5F1 | POU class 5 homeobox 1 |
PPP3CA | protein phosphatase 3, catalytic subunit, alpha isozyme |
PPTC7 | PTC7 protein phosphatase homolog (S. cerevisiae) |
PSEN2 | presenilin 2 |
PTDSS2 | phosphatidylserine synthase 2 |
PTGS1 | prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) |
PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) |
RAB11FIP5 | RAB11 family interacting protein 5 (class I) |
RAB9A | RAB9A, member RAS oncogene family |
RALGDS | ral guanine nucleotide dissociation stimulator |
RAP2B | RAP2B, member of RAS oncogene family |
RASA3 | RAS p21 protein activator 3 |
RGS2 | regulator of G-protein signaling 2 |
RSRP1 | arginine/serine-rich protein 1 |
RTKN | rhotekin |
RUNX1T1 | runt-related transcription factor 1; translocated to, 1 (cyclin D-related) |
RUNX2 | runt-related transcription factor 2 |
SAMD10 | sterile alpha motif domain containing 10 |
SASH1 | SAM and SH3 domain containing 1 |
SCAMP1 | secretory carrier membrane protein 1 |
SDPR | serum deprivation response |
SEC23A | Sec23 homolog A (S. cerevisiae) |
SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B |
SERAC1 | serine active site containing 1 |
SERPINA3 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 |
SERTAD1 | SERTA domain containing 1 |
SGK1 | serum/glucocorticoid regulated kinase 1 |
SIX5 | SIX homeobox 5 |
SLC11A2 | solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2 |
SLC1A1 | solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1 |
SLC35E4 | solute carrier family 35, member E4 |
SLC6A8 | solute carrier family 6 (neurotransmitter transporter), member 8 |
SLPI | secretory leukocyte peptidase inhibitor |
SNAI1 | snail family zinc finger 1 |
SNAPC3 | small nuclear RNA activating complex, polypeptide 3, 50kDa |
ST3GAL4 | ST3 beta-galactoside alpha-2,3-sialyltransferase 4 |
STAC | SH3 and cysteine rich domain |
STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) |
STAT6 | signal transducer and activator of transcription 6, interleukin-4 induced |
STOM | stomatin |
STX4 | syntaxin 4 |
SYNPO | synaptopodin |
TANK | TRAF family member-associated NFKB activator |
TCF4 | transcription factor 4 |
TGFB1I1 | transforming growth factor beta 1 induced transcript 1 |
TGFB3 | transforming growth factor, beta 3 |
TGM2 | transglutaminase 2 |
TMEM45A | transmembrane protein 45A |
TNXB | tenascin XB |
TRAF3IP2 | TRAF3 interacting protein 2 |
TRAPPC4 | trafficking protein particle complex 4 |
TRIB3 | tribbles pseudokinase 3 |
TRIM41 | tripartite motif containing 41 |
TSHR | thyroid stimulating hormone receptor |
TUBG2 | tubulin, gamma 2 |
UBE2H | ubiquitin-conjugating enzyme E2H |
UNC93B1 | unc-93 homolog B1 (C. elegans) |
UQCC3 | ubiquinol-cytochrome c reductase complex assembly factor 3 |
USP19 | ubiquitin specific peptidase 19 |
VCAN | versican |
VPS45 | vacuolar protein sorting 45 homolog (S. cerevisiae) |
WDFY2 | WD repeat and FYVE domain containing 2 |
WDR26 | WD repeat domain 26 |
XBP1 | X-box binding protein 1 |
XPR1 | xenotropic and polytropic retrovirus receptor 1 |
ZBTB20 | zinc finger and BTB domain containing 20 |
ZC3H12A | zinc finger CCCH-type containing 12A |
ZFR2 | zinc finger RNA binding protein 2 |
ZMYND8 | zinc finger, MYND-type containing 8 |