E2F1_UP.V1 Gene Set

Dataset MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations
Category transcriptomics
Type gene perturbation
Description gene perturbation identified as [gene symbol]_[perturbation or condition] (Molecular Signatures Database)
External Link http://www.broadinstitute.org/gsea/msigdb/cards/E2F1_UP.V1_UP
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Genes

380 genes differentially expressed following the E2F1_UP.V1 gene perturbation from the MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations dataset.

increased expression

Symbol Name
ACTN3 actinin, alpha 3 (gene/pseudogene)
ADA adenosine deaminase
ADCY6 adenylate cyclase 6
ADIPOR2 adiponectin receptor 2
AGO2 argonaute RISC catalytic component 2
ARF3 ADP-ribosylation factor 3
ARHGAP39 Rho GTPase activating protein 39
ARHGAP8 Rho GTPase activating protein 8
ARHGEF1 Rho guanine nucleotide exchange factor (GEF) 1
ART3 ADP-ribosyltransferase 3
ATP5D ATP synthase, H+ transporting, mitochondrial F1 complex, delta subunit
AURKB aurora kinase B
BCL2 B-cell CLL/lymphoma 2
BOK BCL2-related ovarian killer
BOLA3 bolA family member 3
BRCA2 breast cancer 2, early onset
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
C4ORF27 chromosome 4 open reading frame 27
CAD carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
CAPRIN2 caprin family member 2
CASP7 caspase 7, apoptosis-related cysteine peptidase
CCRN4L CCR4 carbon catabolite repression 4-like (S. cerevisiae)
CDK5R1 cyclin-dependent kinase 5, regulatory subunit 1 (p35)
CDR2L cerebellar degeneration-related protein 2-like
CDV3 CDV3 homolog (mouse)
CHAF1B chromatin assembly factor 1, subunit B (p60)
CHEK1 checkpoint kinase 1
CLN6 ceroid-lipofuscinosis, neuronal 6, late infantile, variant
CMA1 chymase 1, mast cell
CNIH2 cornichon family AMPA receptor auxiliary protein 2
CNOT7 CCR4-NOT transcription complex, subunit 7
CRYZ crystallin, zeta (quinone reductase)
CSTF2 cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa
CYBA cytochrome b-245, alpha polypeptide
DBF4 DBF4 zinc finger
DCTPP1 dCTP pyrophosphatase 1
DDB1 damage-specific DNA binding protein 1, 127kDa
DDX46 DEAD (Asp-Glu-Ala-Asp) box polypeptide 46
DFNA5 deafness, autosomal dominant 5
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DLX1 distal-less homeobox 1
DMBT1 deleted in malignant brain tumors 1
DNA2 DNA replication helicase/nuclease 2
DNAJC2 DnaJ (Hsp40) homolog, subfamily C, member 2
DNAJC21 DnaJ (Hsp40) homolog, subfamily C, member 21
DRC1 dynein regulatory complex subunit 1
E2F3 E2F transcription factor 3
E2F8 E2F transcription factor 8
EFNB2 ephrin-B2
EIF6 eukaryotic translation initiation factor 6
ELANE elastase, neutrophil expressed
ELAVL1 ELAV like RNA binding protein 1
ERCC2 excision repair cross-complementation group 2
ERMP1 endoplasmic reticulum metallopeptidase 1
EVL Enah/Vasp-like
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FAM60A family with sequence similarity 60, member A
FANCM Fanconi anemia, complementation group M
FEN1 flap structure-specific endonuclease 1
FMNL3 formin-like 3
FNBP1 formin binding protein 1
FRAT2 frequently rearranged in advanced T-cell lymphomas 2
GATA6 GATA binding protein 6
GPN2 GPN-loop GTPase 2
GPR19 G protein-coupled receptor 19
GRSF1 G-rich RNA sequence binding factor 1
GRWD1 glutamate-rich WD repeat containing 1
GUF1 GUF1 GTPase homolog (S. cerevisiae)
HDGFRP2 hepatoma-derived growth factor-related protein 2
HES1 hes family bHLH transcription factor 1
HMGB3 high mobility group box 3
HSPB2 heat shock 27kDa protein 2
HSPBP1 HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1
INO80C INO80 complex subunit C
INO80E INO80 complex subunit E
ITSN1 intersectin 1 (SH3 domain protein)
IVNS1ABP influenza virus NS1A binding protein
KANK3 KN motif and ankyrin repeat domains 3
KIF2A kinesin heavy chain member 2A
KIFC1 kinesin family member C1
KLHL21 kelch-like family member 21
KPNA1 karyopherin alpha 1 (importin alpha 5)
KPNA3 karyopherin alpha 3 (importin alpha 4)
KRT72 keratin 72, type II
LARP4B La ribonucleoprotein domain family, member 4B
LMNB1 lamin B1
LPIN2 lipin 2
MAP3K11 mitogen-activated protein kinase kinase kinase 11
MAP3K3 mitogen-activated protein kinase kinase kinase 3
MAPK14 mitogen-activated protein kinase 14
MASP1 mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor)
MCM10 minichromosome maintenance complex component 10
MCM4 minichromosome maintenance complex component 4
MED20 mediator complex subunit 20
MFI2 antigen p97 (melanoma associated) identified by monoclonal antibodies 133.2 and 96.5
MPG N-methylpurine-DNA glycosylase
MRPL46 mitochondrial ribosomal protein L46
MSH3 mutS homolog 3
MTSS1L metastasis suppressor 1-like
MXI1 MAX interactor 1, dimerization protein
NAB1 NGFI-A binding protein 1 (EGR1 binding protein 1)
NASP nuclear autoantigenic sperm protein (histone-binding)
NBL1 neuroblastoma 1, DAN family BMP antagonist
NCAPH non-SMC condensin I complex, subunit H
NDUFAF4 NADH dehydrogenase (ubiquinone) complex I, assembly factor 4
NOLC1 nucleolar and coiled-body phosphoprotein 1
NOP56 NOP56 ribonucleoprotein
NUP43 nucleoporin 43kDa
PACS1 phosphofurin acidic cluster sorting protein 1
PAIP2B poly(A) binding protein interacting protein 2B
PARP1 poly (ADP-ribose) polymerase 1
PARP16 poly (ADP-ribose) polymerase family, member 16
PBX3 pre-B-cell leukemia homeobox 3
PHF12 PHD finger protein 12
PIGA phosphatidylinositol glycan anchor biosynthesis, class A
PIM1 Pim-1 proto-oncogene, serine/threonine kinase
PIP4K2A phosphatidylinositol-5-phosphate 4-kinase, type II, alpha
PITPNM1 phosphatidylinositol transfer protein, membrane-associated 1
PKP4 plakophilin 4
PLK4 polo-like kinase 4
POLA2 polymerase (DNA directed), alpha 2, accessory subunit
PPM1M protein phosphatase, Mg2+/Mn2+ dependent, 1M
PRADC1 protease-associated domain containing 1
PRC1 protein regulator of cytokinesis 1
PRIM2 primase, DNA, polypeptide 2 (58kDa)
PRM1 protamine 1
PSME3 proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki)
PTPN21 protein tyrosine phosphatase, non-receptor type 21
PTPRU protein tyrosine phosphatase, receptor type, U
RB1 retinoblastoma 1
RBM15 RNA binding motif protein 15
RBM22 RNA binding motif protein 22
RDH13 retinol dehydrogenase 13 (all-trans/9-cis)
RELL1 RELT-like 1
RHBDL3 rhomboid, veinlet-like 3 (Drosophila)
RND2 Rho family GTPase 2
RRM1 ribonucleotide reductase M1
RRP1B ribosomal RNA processing 1B
SDCCAG3 serologically defined colon cancer antigen 3
SGOL1 shugoshin-like 1 (S. pombe)
SHBG sex hormone-binding globulin
SIRPA signal-regulatory protein alpha
SLBP stem-loop binding protein
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SLC35E1 solute carrier family 35, member E1
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
SMAD1 SMAD family member 1
SMC2 structural maintenance of chromosomes 2
SOCS2 suppressor of cytokine signaling 2
SPEF1 sperm flagellar 1
SRSF4 serine/arginine-rich splicing factor 4
SSX2IP synovial sarcoma, X breakpoint 2 interacting protein
STIL SCL/TAL1 interrupting locus
TAF6 TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa
TAF9 TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 32kDa
TBP TATA box binding protein
TFAM transcription factor A, mitochondrial
THOP1 thimet oligopeptidase 1
TINF2 TERF1 (TRF1)-interacting nuclear factor 2
TK1 thymidine kinase 1, soluble
TLE4 transducin-like enhancer of split 4
TLX2 T-cell leukemia homeobox 2
TOP2A topoisomerase (DNA) II alpha 170kDa
TPD52 tumor protein D52
TPM2 tropomyosin 2 (beta)
TRAF3 TNF receptor-associated factor 3
TRNT1 tRNA nucleotidyl transferase, CCA-adding, 1
TYMS thymidylate synthetase
TYRO3 TYRO3 protein tyrosine kinase
UBE2T ubiquitin-conjugating enzyme E2T
UBN1 ubinuclein 1
UBR2 ubiquitin protein ligase E3 component n-recognin 2
UCK2 uridine-cytidine kinase 2
UPK2 uroplakin 2
UQCC1 ubiquinol-cytochrome c reductase complex assembly factor 1
USF2 upstream transcription factor 2, c-fos interacting
USP10 ubiquitin specific peptidase 10
USP39 ubiquitin specific peptidase 39
VEGFA vascular endothelial growth factor A
VPRBP Vpr (HIV-1) binding protein
VPREB3 pre-B lymphocyte 3
VPS37B vacuolar protein sorting 37 homolog B (S. cerevisiae)
WBP11 WW domain binding protein 11
WDHD1 WD repeat and HMG-box DNA binding protein 1
WRN Werner syndrome, RecQ helicase-like
ZFPM1 zinc finger protein, FOG family member 1
ZSWIM7 zinc finger, SWIM-type containing 7

decreased expression

Symbol Name
A4GALT alpha 1,4-galactosyltransferase
ABLIM1 actin binding LIM protein 1
ACKR3 atypical chemokine receptor 3
ACOX1 acyl-CoA oxidase 1, palmitoyl
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ADARB1 adenosine deaminase, RNA-specific, B1
AJUBA ajuba LIM protein
ALAS2 5'-aminolevulinate synthase 2
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
AMPD3 adenosine monophosphate deaminase 3
ANGPTL4 angiopoietin-like 4
ANKHD1 ankyrin repeat and KH domain containing 1
ANXA1 annexin A1
ANXA4 annexin A4
ANXA8 annexin A8
APBB1IP amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
APC2 adenomatosis polyposis coli 2
AQP8 aquaporin 8
ARL4D ADP-ribosylation factor-like 4D
ASL argininosuccinate lyase
ATP2A3 ATPase, Ca++ transporting, ubiquitous
AVPI1 arginine vasopressin-induced 1
B4GALT3 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 3
BAG3 BCL2-associated athanogene 3
BCL6 B-cell CLL/lymphoma 6
C18ORF8 chromosome 18 open reading frame 8
C3 complement component 3
CALML4 calmodulin-like 4
CAPN2 calpain 2, (m/II) large subunit
CCL2 chemokine (C-C motif) ligand 2
CCND2 cyclin D2
CCNG2 cyclin G2
CD3E CD3e molecule, epsilon (CD3-TCR complex)
CD47 CD47 molecule
CHRNA7 cholinergic receptor, nicotinic, alpha 7 (neuronal)
CIRBP cold inducible RNA binding protein
COL11A1 collagen, type XI, alpha 1
COL3A1 collagen, type III, alpha 1
CPT1A carnitine palmitoyltransferase 1A (liver)
CREBRF CREB3 regulatory factor
CRIP2 cysteine-rich protein 2
CSF1 colony stimulating factor 1 (macrophage)
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL5 chemokine (C-X-C motif) ligand 5
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYTIP cytohesin 1 interacting protein
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DCAF8 DDB1 and CUL4 associated factor 8
DOK1 docking protein 1, 62kDa (downstream of tyrosine kinase 1)
DTX2 deltex 2, E3 ubiquitin ligase
EBF1 early B-cell factor 1
EFNA4 ephrin-A4
ENTPD6 ectonucleoside triphosphate diphosphohydrolase 6 (putative)
EPS8 epidermal growth factor receptor pathway substrate 8
ERBB3 erb-b2 receptor tyrosine kinase 3
EVI2A ecotropic viral integration site 2A
F3 coagulation factor III (thromboplastin, tissue factor)
FAS Fas cell surface death receptor
FCHO1 FCH domain only 1
FER fer (fps/fes related) tyrosine kinase
FGF19 fibroblast growth factor 19
FMO3 flavin containing monooxygenase 3
GADD45A growth arrest and DNA-damage-inducible, alpha
GBP2 guanylate binding protein 2, interferon-inducible
GFRA1 GDNF family receptor alpha 1
GHR growth hormone receptor
GSTA4 glutathione S-transferase alpha 4
HBG2 hemoglobin, gamma G
HES6 hes family bHLH transcription factor 6
HLA-E major histocompatibility complex, class I, E
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IFIT2 interferon-induced protein with tetratricopeptide repeats 2
IFT20 intraflagellar transport 20
IL18 interleukin 18
IL1R1 interleukin 1 receptor, type I
IL1RL1 interleukin 1 receptor-like 1
IL6ST interleukin 6 signal transducer
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2
KLF2 Kruppel-like factor 2
KLF3 Kruppel-like factor 3 (basic)
KMT2E lysine (K)-specific methyltransferase 2E
KXD1 KxDL motif containing 1
LAMA4 laminin, alpha 4
LBP lipopolysaccharide binding protein
LCLAT1 lysocardiolipin acyltransferase 1
LGALS2 lectin, galactoside-binding, soluble, 2
LIMA1 LIM domain and actin binding 1
LIPE lipase, hormone-sensitive
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
LXN latexin
MARC2 mitochondrial amidoxime reducing component 2
MCL1 myeloid cell leukemia 1
MDK midkine (neurite growth-promoting factor 2)
MDN1 MDN1, midasin homolog (yeast)
MLX MLX, MAX dimerization protein
MMP7 matrix metallopeptidase 7
MX1 MX dynamin-like GTPase 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
NDRG4 NDRG family member 4
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta
NHSL1 NHS-like 1
NOTCH2 notch 2
NPR1 natriuretic peptide receptor 1
NUMA1 nuclear mitotic apparatus protein 1
PAK3 p21 protein (Cdc42/Rac)-activated kinase 3
PDE4DIP phosphodiesterase 4D interacting protein
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PDZK1IP1 PDZK1 interacting protein 1
PGD phosphogluconate dehydrogenase
PHLDA1 pleckstrin homology-like domain, family A, member 1
PKD1 polycystic kidney disease 1 (autosomal dominant)
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)
PLAT plasminogen activator, tissue
PLET1 placenta expressed transcript 1
PLIN2 perilipin 2
PLK2 polo-like kinase 2
PLXND1 plexin D1
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
POU5F1 POU class 5 homeobox 1
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme
PPTC7 PTC7 protein phosphatase homolog (S. cerevisiae)
PSEN2 presenilin 2
PTDSS2 phosphatidylserine synthase 2
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RAB11FIP5 RAB11 family interacting protein 5 (class I)
RAB9A RAB9A, member RAS oncogene family
RALGDS ral guanine nucleotide dissociation stimulator
RAP2B RAP2B, member of RAS oncogene family
RASA3 RAS p21 protein activator 3
RGS2 regulator of G-protein signaling 2
RSRP1 arginine/serine-rich protein 1
RTKN rhotekin
RUNX1T1 runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
RUNX2 runt-related transcription factor 2
SAMD10 sterile alpha motif domain containing 10
SASH1 SAM and SH3 domain containing 1
SCAMP1 secretory carrier membrane protein 1
SDPR serum deprivation response
SEC23A Sec23 homolog A (S. cerevisiae)
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B
SERAC1 serine active site containing 1
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERTAD1 SERTA domain containing 1
SGK1 serum/glucocorticoid regulated kinase 1
SIX5 SIX homeobox 5
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC35E4 solute carrier family 35, member E4
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SLPI secretory leukocyte peptidase inhibitor
SNAI1 snail family zinc finger 1
SNAPC3 small nuclear RNA activating complex, polypeptide 3, 50kDa
ST3GAL4 ST3 beta-galactoside alpha-2,3-sialyltransferase 4
STAC SH3 and cysteine rich domain
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced
STOM stomatin
STX4 syntaxin 4
SYNPO synaptopodin
TANK TRAF family member-associated NFKB activator
TCF4 transcription factor 4
TGFB1I1 transforming growth factor beta 1 induced transcript 1
TGFB3 transforming growth factor, beta 3
TGM2 transglutaminase 2
TMEM45A transmembrane protein 45A
TNXB tenascin XB
TRAF3IP2 TRAF3 interacting protein 2
TRAPPC4 trafficking protein particle complex 4
TRIB3 tribbles pseudokinase 3
TRIM41 tripartite motif containing 41
TSHR thyroid stimulating hormone receptor
TUBG2 tubulin, gamma 2
UBE2H ubiquitin-conjugating enzyme E2H
UNC93B1 unc-93 homolog B1 (C. elegans)
UQCC3 ubiquinol-cytochrome c reductase complex assembly factor 3
USP19 ubiquitin specific peptidase 19
VCAN versican
VPS45 vacuolar protein sorting 45 homolog (S. cerevisiae)
WDFY2 WD repeat and FYVE domain containing 2
WDR26 WD repeat domain 26
XBP1 X-box binding protein 1
XPR1 xenotropic and polytropic retrovirus receptor 1
ZBTB20 zinc finger and BTB domain containing 20
ZC3H12A zinc finger CCCH-type containing 12A
ZFR2 zinc finger RNA binding protein 2
ZMYND8 zinc finger, MYND-type containing 8