E2F4 Gene Set

Dataset JASPAR Predicted Transcription Factor Targets
Category genomics
Type transcription factor
Description E2F transcription factor 4, p107/p130-binding|The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein binds to all three of the tumor suppressor proteins pRB, p107 and p130, but with higher affinity to the last two. It plays an important role in the suppression of proliferation-associated genes, and its gene mutation and increased expression may be associated with human cancer. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 1874)
External Link http://www.ncbi.nlm.nih.gov/gene/1874
Similar Terms
Downloads & Tools

Genes

267 target genes of the E2F4 transcription factor predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset.

Symbol Name
ABCB10 ATP-binding cassette, sub-family B (MDR/TAP), member 10
ABHD16A abhydrolase domain containing 16A
AGO2 argonaute RISC catalytic component 2
AGPAT3 1-acylglycerol-3-phosphate O-acyltransferase 3
AJAP1 adherens junctions associated protein 1
ALOX5 arachidonate 5-lipoxygenase
ALX1 ALX homeobox 1
ANXA2R annexin A2 receptor
AP4M1 adaptor-related protein complex 4, mu 1 subunit
APOLD1 apolipoprotein L domain containing 1
ARGLU1 arginine and glutamate rich 1
ARHGAP11A Rho GTPase activating protein 11A
ARHGAP44 Rho GTPase activating protein 44
ARL4C ADP-ribosylation factor-like 4C
ASNSD1 asparagine synthetase domain containing 1
ATAD3A ATPase family, AAA domain containing 3A
ATAD5 ATPase family, AAA domain containing 5
ATG2A autophagy related 2A
ATP6V1H ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H
ATXN7L3 ataxin 7-like 3
AURKB aurora kinase B
BHLHB9 basic helix-loop-helix domain containing, class B, 9
BRPF3 bromodomain and PHD finger containing, 3
C17ORF80 chromosome 17 open reading frame 80
C18ORF32 chromosome 18 open reading frame 32
C1ORF131 chromosome 1 open reading frame 131
C3ORF14 chromosome 3 open reading frame 14
C8ORF34 chromosome 8 open reading frame 34
CASR calcium-sensing receptor
CCDC85C coiled-coil domain containing 85C
CCDC94 coiled-coil domain containing 94
CCND2 cyclin D2
CCNO cyclin O
CD47 CD47 molecule
CDCA7 cell division cycle associated 7
CDK1 cyclin-dependent kinase 1
CDK10 cyclin-dependent kinase 10
CENPI centromere protein I
CENPU centromere protein U
CEP112 centrosomal protein 112kDa
CEP57 centrosomal protein 57kDa
CEP68 centrosomal protein 68kDa
CEP83 centrosomal protein 83kDa
CGNL1 cingulin-like 1
CHEK1 checkpoint kinase 1
CHID1 chitinase domain containing 1
CHMP1B charged multivesicular body protein 1B
CIZ1 CDKN1A interacting zinc finger protein 1
CNPY4 canopy FGF signaling regulator 4
CNTN4 contactin 4
COL18A1 collagen, type XVIII, alpha 1
COPRS coordinator of PRMT5, differentiation stimulator
COX7C cytochrome c oxidase subunit VIIc
CREBZF CREB/ATF bZIP transcription factor
CXCL5 chemokine (C-X-C motif) ligand 5
CYB5R4 cytochrome b5 reductase 4
CYP7B1 cytochrome P450, family 7, subfamily B, polypeptide 1
DAZAP1 DAZ associated protein 1
DDX46 DEAD (Asp-Glu-Ala-Asp) box polypeptide 46
DIP2B DIP2 disco-interacting protein 2 homolog B (Drosophila)
DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila)
DMTF1 cyclin D binding myb-like transcription factor 1
DNAJC5G DnaJ (Hsp40) homolog, subfamily C, member 5 gamma
DPYSL2 dihydropyrimidinase-like 2
DPYSL3 dihydropyrimidinase-like 3
DSTYK dual serine/threonine and tyrosine protein kinase
DUOXA2 dual oxidase maturation factor 2
E2F1 E2F transcription factor 1
E2F2 E2F transcription factor 2
E2F8 E2F transcription factor 8
EAF2 ELL associated factor 2
EARS2 glutamyl-tRNA synthetase 2, mitochondrial
EBF2 early B-cell factor 2
EFCAB2 EF-hand calcium binding domain 2
ELOVL2 ELOVL fatty acid elongase 2
ENKUR enkurin, TRPC channel interacting protein
ENSA endosulfine alpha
ESX1 ESX homeobox 1
EXO1 exonuclease 1
EXTL3 exostosin-like glycosyltransferase 3
FAAH fatty acid amide hydrolase
FAM111B family with sequence similarity 111, member B
FAM183A family with sequence similarity 183, member A
FAM207A family with sequence similarity 207, member A
FAM222A family with sequence similarity 222, member A
FAM73B family with sequence similarity 73, member B
FAM76B family with sequence similarity 76, member B
FANCC Fanconi anemia, complementation group C
FBXL16 F-box and leucine-rich repeat protein 16
FGFR1 fibroblast growth factor receptor 1
FMN2 formin 2
FOXM1 forkhead box M1
FUNDC1 FUN14 domain containing 1
FXYD7 FXYD domain containing ion transport regulator 7
FYTTD1 forty-two-three domain containing 1
GARS glycyl-tRNA synthetase
GEMIN4 gem (nuclear organelle) associated protein 4
GEN1 GEN1 Holliday junction 5' flap endonuclease
GIN1 gypsy retrotransposon integrase 1
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class)
GPR148 G protein-coupled receptor 148
GPRASP1 G protein-coupled receptor associated sorting protein 1
GTF2A1 general transcription factor IIA, 1, 19/37kDa
HCFC1 host cell factor C1
HIST1H2AG histone cluster 1, H2ag
HIST1H2AI histone cluster 1, H2ai
HIST1H2AL histone cluster 1, H2al
HIST1H2AM histone cluster 1, H2am
HIST1H2BJ histone cluster 1, H2bj
HIST1H2BK histone cluster 1, H2bk
HIST1H2BL histone cluster 1, H2bl
HIST1H2BO histone cluster 1, H2bo
HIST1H3F histone cluster 1, H3f
HIST1H3H histone cluster 1, H3h
HLCS holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase)
HLTF helicase-like transcription factor
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2)
HSD17B1 hydroxysteroid (17-beta) dehydrogenase 1
HSF4 heat shock transcription factor 4
HSPB11 heat shock protein family B (small), member 11
IFT38 intraflagellar transport 38
IKZF1 IKAROS family zinc finger 1 (Ikaros)
KBTBD2 kelch repeat and BTB (POZ) domain containing 2
KBTBD6 kelch repeat and BTB (POZ) domain containing 6
KBTBD7 kelch repeat and BTB (POZ) domain containing 7
KCNMB1 potassium channel subfamily M regulatory beta subunit 1
KLHL36 kelch-like family member 36
KRTAP2-4 keratin associated protein 2-4
LBX2 ladybird homeobox 2
LHX5 LIM homeobox 5
LIG4 ligase IV, DNA, ATP-dependent
LPCAT3 lysophosphatidylcholine acyltransferase 3
LRRC42 leucine rich repeat containing 42
LRRC49 leucine rich repeat containing 49
MAN1A2 mannosidase, alpha, class 1A, member 2
MANBAL mannosidase, beta A, lysosomal-like
MAZ MYC-associated zinc finger protein (purine-binding transcription factor)
MBTPS1 membrane-bound transcription factor peptidase, site 1
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MCM7 minichromosome maintenance complex component 7
METTL20 methyltransferase like 20
MFAP1 microfibrillar-associated protein 1
MGST3 microsomal glutathione S-transferase 3
MKKS McKusick-Kaufman syndrome
MOB3A MOB kinase activator 3A
MRPL18 mitochondrial ribosomal protein L18
MYBPC2 myosin binding protein C, fast type
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog
MYOCD myocardin
NARFL nuclear prelamin A recognition factor-like
NAT9 N-acetyltransferase 9 (GCN5-related, putative)
NDFIP2 Nedd4 family interacting protein 2
NEUROD1 neuronal differentiation 1
NEUROG1 neurogenin 1
NIPAL3 NIPA-like domain containing 3
NKAIN2 Na+/K+ transporting ATPase interacting 2
NMT1 N-myristoyltransferase 1
NUBP1 nucleotide binding protein 1
ORC2 origin recognition complex, subunit 2
OXGR1 oxoglutarate (alpha-ketoglutarate) receptor 1
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PAQR4 progestin and adipoQ receptor family member IV
PDE1A phosphodiesterase 1A, calmodulin-dependent
PDXK pyridoxal (pyridoxine, vitamin B6) kinase
PEG3 paternally expressed 3
PEX10 peroxisomal biogenesis factor 10
PHACTR2 phosphatase and actin regulator 2
PHF11 PHD finger protein 11
PLAA phospholipase A2-activating protein
POLA2 polymerase (DNA directed), alpha 2, accessory subunit
POMC proopiomelanocortin
PPP2R5A protein phosphatase 2, regulatory subunit B', alpha
PRPF40A PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae)
PRTN3 proteinase 3
PTCHD1 patched domain containing 1
PTGR2 prostaglandin reductase 2
PYGO2 pygopus family PHD finger 2
RAB12 RAB12, member RAS oncogene family
RABGAP1L RAB GTPase activating protein 1-like
RAD21L1 RAD21-like 1 (S. pombe)
RASSF6 Ras association (RalGDS/AF-6) domain family member 6
RBL1 retinoblastoma-like 1
RBM44 RNA binding motif protein 44
RBM46 RNA binding motif protein 46
RBPJ recombination signal binding protein for immunoglobulin kappa J region
RBSN rabenosyn, RAB effector
RMDN3 regulator of microtubule dynamics 3
RPA2 replication protein A2, 32kDa
RPLP2 ribosomal protein, large, P2
RPS18 ribosomal protein S18
RRP7A ribosomal RNA processing 7 homolog A (S. cerevisiae)
S1PR1 sphingosine-1-phosphate receptor 1
S1PR2 sphingosine-1-phosphate receptor 2
SAC3D1 SAC3 domain containing 1
SACM1L SAC1 suppressor of actin mutations 1-like (yeast)
SCO2 SCO2 cytochrome c oxidase assembly protein
SERINC5 serine incorporator 5
SERPIND1 serpin peptidase inhibitor, clade D (heparin cofactor), member 1
SFMBT1 Scm-like with four mbt domains 1
SHISA5 shisa family member 5
SIAH1 siah E3 ubiquitin protein ligase 1
SLC16A6 solute carrier family 16, member 6
SLC1A5 solute carrier family 1 (neutral amino acid transporter), member 5
SLC25A14 solute carrier family 25 (mitochondrial carrier, brain), member 14
SLC35A3 solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3
SLC40A1 solute carrier family 40 (iron-regulated transporter), member 1
SLX1A SLX1 structure-specific endonuclease subunit homolog A (S. cerevisiae)
SLX1B SLX1 structure-specific endonuclease subunit homolog B (S. cerevisiae)
SMC3 structural maintenance of chromosomes 3
SMC6 structural maintenance of chromosomes 6
SMG7 SMG7 nonsense mediated mRNA decay factor
SNRNP70 small nuclear ribonucleoprotein 70kDa (U1)
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SOX14 SRY (sex determining region Y)-box 14
SPHK1 sphingosine kinase 1
SPRYD7 SPRY domain containing 7
SRSF1 serine/arginine-rich splicing factor 1
SSBP3 single stranded DNA binding protein 3
STAU1 staufen double-stranded RNA binding protein 1
STEAP1 six transmembrane epithelial antigen of the prostate 1
STEAP2 STEAP family member 2, metalloreductase
STPG1 sperm-tail PG-rich repeat containing 1
STXBP6 syntaxin binding protein 6 (amisyn)
TARSL2 threonyl-tRNA synthetase-like 2
TCP1 t-complex 1
TESC tescalcin
TFDP1 transcription factor Dp-1
THAP10 THAP domain containing 10
TIGAR TP53 induced glycolysis regulatory phosphatase
TIPIN TIMELESS interacting protein
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TMEM104 transmembrane protein 104
TMEM109 transmembrane protein 109
TMEM165 transmembrane protein 165
TMEM187 transmembrane protein 187
TMEM215 transmembrane protein 215
TMX1 thioredoxin-related transmembrane protein 1
TOPBP1 topoisomerase (DNA) II binding protein 1
TRAPPC11 trafficking protein particle complex 11
TRIM26 tripartite motif containing 26
TRIM37 tripartite motif containing 37
TUBB2B tubulin, beta 2B class IIb
TWISTNB TWIST neighbor
UBE2Q1 ubiquitin-conjugating enzyme E2Q family member 1
UBFD1 ubiquitin family domain containing 1
UHRF1 ubiquitin-like with PHD and ring finger domains 1
UHRF2 ubiquitin-like with PHD and ring finger domains 2, E3 ubiquitin protein ligase
USP51 ubiquitin specific peptidase 51
VAX1 ventral anterior homeobox 1
VPS13A vacuolar protein sorting 13 homolog A (S. cerevisiae)
VTA1 vesicle (multivesicular body) trafficking 1
WAPAL wings apart-like homolog (Drosophila)
WBP2 WW domain binding protein 2
XRCC1 X-ray repair complementing defective repair in Chinese hamster cells 1
ZAK sterile alpha motif and leucine zipper containing kinase AZK
ZCCHC16 zinc finger, CCHC domain containing 16
ZDHHC17 zinc finger, DHHC-type containing 17
ZIC3 Zic family member 3
ZIM2 zinc finger, imprinted 2
ZNF260 zinc finger protein 260
ZNF367 zinc finger protein 367
ZNF565 zinc finger protein 565
ZNF577 zinc finger protein 577
ZNF74 zinc finger protein 74
ZPBP2 zona pellucida binding protein 2
ZSCAN22 zinc finger and SCAN domain containing 22