E2F4 Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description E2F transcription factor 4, p107/p130-binding|The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein binds to all three of the tumor suppressor proteins pRB, p107 and p130, but with higher affinity to the last two. It plays an important role in the suppression of proliferation-associated genes, and its gene mutation and increased expression may be associated with human cancer. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 1874)
External Link http://www.ncbi.nlm.nih.gov/gene/1874
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161 interacting proteins for E2F4 from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
ACR acrosin
ALG5 ALG5, dolichyl-phosphate beta-glucosyltransferase
ANAPC15 anaphase promoting complex subunit 15
AP3S2 adaptor-related protein complex 3, sigma 2 subunit
AR androgen receptor
ARID1A AT rich interactive domain 1A (SWI-like)
ARID1B AT rich interactive domain 1B (SWI1-like)
ARID3A AT rich interactive domain 3A (BRIGHT-like)
ASH2L ash2 (absent, small, or homeotic)-like (Drosophila)
ATAD2 ATPase family, AAA domain containing 2
B2M beta-2-microglobulin
BIRC5 baculoviral IAP repeat containing 5
BRCA1 breast cancer 1, early onset
BTRC beta-transducin repeat containing E3 ubiquitin protein ligase
C5ORF22 chromosome 5 open reading frame 22
CCNA2 cyclin A2
CCND1 cyclin D1
CCND2 cyclin D2
CCND3 cyclin D3
CCNE1 cyclin E1
CCNE2 cyclin E2
CCRL2 chemokine (C-C motif) receptor-like 2
CDC25C cell division cycle 25C
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDK1 cyclin-dependent kinase 1
CDK2 cyclin-dependent kinase 2
CDK4 cyclin-dependent kinase 4
CDK6 cyclin-dependent kinase 6
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CENPO centromere protein O
CHMP2A charged multivesicular body protein 2A
CSDE1 cold shock domain containing E1, RNA-binding
CSTB cystatin B (stefin B)
CSTF3 cleavage stimulation factor, 3' pre-RNA, subunit 3, 77kDa
CXCL10 chemokine (C-X-C motif) ligand 10
DBF4B DBF4 zinc finger B
DDX11 DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11
DDX28 DEAD (Asp-Glu-Ala-Asp) box polypeptide 28
DHPS deoxyhypusine synthase
DHX30 DEAH (Asp-Glu-Ala-His) box helicase 30
E2F1 E2F transcription factor 1
E2F5 E2F transcription factor 5, p130-binding
EFHC1 EF-hand domain (C-terminal) containing 1
EIF4H eukaryotic translation initiation factor 4H
EPAS1 endothelial PAS domain protein 1
FHL2 four and a half LIM domains 2
FOXD3 forkhead box D3
GOLGA4 golgin A4
GOLT1B golgi transport 1B
GSTM3 glutathione S-transferase mu 3 (brain)
GTF2H4 general transcription factor IIH, polypeptide 4, 52kDa
HCFC1 host cell factor C1
HDAC1 histone deacetylase 1
HDAC2 histone deacetylase 2
HDAC3 histone deacetylase 3
HIST1H2AB histone cluster 1, H2ab
HIST1H3B histone cluster 1, H3b
HIST1H4F histone cluster 1, H4f
HNF4A hepatocyte nuclear factor 4, alpha
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1
HOXA3 homeobox A3
HSBP1 heat shock factor binding protein 1
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
ISCU iron-sulfur cluster assembly enzyme
JMY junction mediating and regulatory protein, p53 cofactor
JPH2 junctophilin 2
KAT2A K(lysine) acetyltransferase 2A
KAT5 K(lysine) acetyltransferase 5
KMT2A lysine (K)-specific methyltransferase 2A
L3MBTL3 l(3)mbt-like 3 (Drosophila)
LACTB lactamase, beta
LIN37 lin-37 DREAM MuvB core complex component
LIN52 lin-52 DREAM MuvB core complex component
LIN54 lin-54 DREAM MuvB core complex component
LIN9 lin-9 DREAM MuvB core complex component
LMO7 LIM domain 7
METAP2 methionyl aminopeptidase 2
MFAP1 microfibrillar-associated protein 1
MGA MGA, MAX dimerization protein
MMP16 matrix metallopeptidase 16 (membrane-inserted)
MT1G metallothionein 1G
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric
MYLPF myosin light chain, phosphorylatable, fast skeletal muscle
NCOR1 nuclear receptor corepressor 1
NCOR2 nuclear receptor corepressor 2
NDN necdin, melanoma antigen (MAGE) family member
NOLC1 nucleolar and coiled-body phosphoprotein 1
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin)
NR2E3 nuclear receptor subfamily 2, group E, member 3
NSFL1C NSFL1 (p97) cofactor (p47)
NUSAP1 nucleolar and spindle associated protein 1
PARK7 parkinson protein 7
PBK PDZ binding kinase
PCCA propionyl CoA carboxylase, alpha polypeptide
PCM1 pericentriolar material 1
PCSK1N proprotein convertase subtilisin/kexin type 1 inhibitor
PDAP1 PDGFA associated protein 1
PDGFA platelet-derived growth factor alpha polypeptide
PGRMC1 progesterone receptor membrane component 1
PML promyelocytic leukemia
POLR1D polymerase (RNA) I polypeptide D, 16kDa
PRDX5 peroxiredoxin 5
PRR11 proline rich 11
PSMA4 proteasome (prosome, macropain) subunit, alpha type, 4
RAD54L RAD54-like (S. cerevisiae)
RB1 retinoblastoma 1
RBBP4 retinoblastoma binding protein 4
RBBP5 retinoblastoma binding protein 5
RBL1 retinoblastoma-like 1
RBL2 retinoblastoma-like 2
RECQL RecQ helicase-like
RNF144A ring finger protein 144A
RPA3 replication protein A3, 14kDa
RPLP1 ribosomal protein, large, P1
RPLP2 ribosomal protein, large, P2
RPS16 ribosomal protein S16
RYBP RING1 and YY1 binding protein
S100A7 S100 calcium binding protein A7
SIN3A SIN3 transcription regulator family member A
SLC1A2 solute carrier family 1 (glial high affinity glutamate transporter), member 2
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC4A2 solute carrier family 4 (anion exchanger), member 2
SMAD2 SMAD family member 2
SMAD3 SMAD family member 3
SMAD4 SMAD family member 4
SMARCA2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
SMARCA5 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1
SNRPC small nuclear ribonucleoprotein polypeptide C
SNRPD2 small nuclear ribonucleoprotein D2 polypeptide 16.5kDa
SOAT2 sterol O-acyltransferase 2
SPIB Spi-B transcription factor (Spi-1/PU.1 related)
SRP9 signal recognition particle 9kDa
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1
TFDP1 transcription factor Dp-1
TFDP2 transcription factor Dp-2 (E2F dimerization partner 2)
TMLHE trimethyllysine hydroxylase, epsilon
TMOD3 tropomodulin 3 (ubiquitous)
TP53RK TP53 regulating kinase
TRIM28 tripartite motif containing 28
TRIM55 tripartite motif containing 55
TRMT13 tRNA methyltransferase 13 homolog (S. cerevisiae)
TRRAP transformation/transcription domain-associated protein
TSNAX translin-associated factor X
TTK TTK protein kinase
TYMS thymidylate synthetase
UBC ubiquitin C
UBE2C ubiquitin-conjugating enzyme E2C
UXT ubiquitously-expressed, prefoldin-like chaperone
WDR76 WD repeat domain 76
XPO1 exportin 1