E2F5 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description E2F transcription factor 5, p130-binding|The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionarily conserved domains that are present in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein is differentially phosphorylated and is expressed in a wide variety of human tissues. It has higher identity to E2F4 than to other family members. Both this protein and E2F4 interact with tumor suppressor proteins p130 and p107, but not with pRB. Alternative splicing results in multiple variants encoding different isoforms. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 1875)
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Genes

357 genes differentially expressed following the E2F5 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
PHF24 PHD finger protein 24 3.30108
NLRC3 NLR family, CARD domain containing 3 3.30108
CD33 CD33 molecule 3.30108
MYLK2 myosin light chain kinase 2 3.30108
RFPL2 ret finger protein-like 2 3.30108
ZNF703 zinc finger protein 703 3.30108
LAMP3 lysosomal-associated membrane protein 3 3.30108
BRINP3 bone morphogenetic protein/retinoic acid inducible neural-specific 3 3.30108
ANGPTL6 angiopoietin-like 6 3.30108
CAPN14 calpain 14 3.30108
FOXN4 forkhead box N4 3.30108
VWC2L von Willebrand factor C domain containing protein 2-like 3.30108
MAP3K7CL MAP3K7 C-terminal like 3.30108
UFSP1 UFM1-specific peptidase 1 (non-functional) 3.30108
ABCA4 ATP-binding cassette, sub-family A (ABC1), member 4 3.30108
CD180 CD180 molecule 3.30108
LOC105378220 macrophage receptor MARCO-like 3.30108
DPRX divergent-paired related homeobox 3.30108
HPCA hippocalcin 3.30108
PTH2 parathyroid hormone 2 3.30108
ATOH1 atonal homolog 1 (Drosophila) 3.30108
GPRC6A G protein-coupled receptor, class C, group 6, member A 3.30108
DHRS9 dehydrogenase/reductase (SDR family) member 9 3.30108
RIMBP2 RIMS binding protein 2 3.24337
TM4SF1 transmembrane 4 L six family member 1 3.24337
PAX6 paired box 6 3.24337
TM4SF4 transmembrane 4 L six family member 4 3.24337
SKOR2 SKI family transcriptional corepressor 2 3.24337
UGT1A8 UDP glucuronosyltransferase 1 family, polypeptide A8 3.24337
RAX retina and anterior neural fold homeobox 3.24337
GPR55 G protein-coupled receptor 55 3.24337
SERPINA11 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 11 3.24337
SERPINA12 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 12 3.24337
SLC46A2 solute carrier family 46, member 2 3.24337
TNFRSF6B tumor necrosis factor receptor superfamily, member 6b, decoy 3.24337
EPS8L3 EPS8-like 3 3.24337
UGT1A1 UDP glucuronosyltransferase 1 family, polypeptide A1 3.24337
ARHGAP36 Rho GTPase activating protein 36 3.24337
CEP295NL CEP295 N-terminal like 3.24337
MAGED4 melanoma antigen family D4 3.24337
CCDC38 coiled-coil domain containing 38 3.24337
ZC3H11C zinc finger CCCH-type containing 11C 3.24337
DRGX dorsal root ganglia homeobox 3.24337
S100A1 S100 calcium binding protein A1 3.24337
CPLX3 complexin 3 3.24337
S100A5 S100 calcium binding protein A5 3.24337
NPIPA2 nuclear pore complex interacting protein family, member A2 3.24337
C2ORF78 chromosome 2 open reading frame 78 3.24337
DLX4 distal-less homeobox 4 3.24337
SLC28A3 solute carrier family 28 (concentrative nucleoside transporter), member 3 3.24337
DIRAS3 DIRAS family, GTP-binding RAS-like 3 3.24337
GIMAP4 GTPase, IMAP family member 4 3.24337
ARSF arylsulfatase F 3.24337
AVPR2 arginine vasopressin receptor 2 3.24337
CA7 carbonic anhydrase VII 3.24337
BHLHE40 basic helix-loop-helix family, member e40 3.24337
C3ORF22 chromosome 3 open reading frame 22 3.24337
GNAT3 guanine nucleotide binding protein, alpha transducing 3 3.24337
RGPD3 RANBP2-like and GRIP domain containing 3 3.24337
NWD2 NACHT and WD repeat domain containing 2 3.24337
IYD iodotyrosine deiodinase 3.24337
NOTCH2NLB notch 2 N-terminal like B 3.24337
ST6GALNAC1 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 3.24337
PNLIPRP1 pancreatic lipase-related protein 1 3.24337
BNC1 basonuclin 1 3.24337
SPI1 Spi-1 proto-oncogene 3.24337
HTRA4 HtrA serine peptidase 4 3.24337
DUSP9 dual specificity phosphatase 9 3.24337
CIMIP2B ciliary microtubule inner protein 2B 3.24337
BDKRB1 bradykinin receptor B1 3.24337
WNT16 wingless-type MMTV integration site family, member 16 3.24337
GRAP GRB2-related adaptor protein 3.24337
MCHR1 melanin-concentrating hormone receptor 1 3.24337
YIPF7 Yip1 domain family, member 7 3.24337
ZAR1 zygote arrest 1 3.24337
LOC124902436 talanin 3.24337
EZHIP EZH inhibitory protein 3.24337
CABCOCO1 ciliary associated calcium binding coiled-coil 1 3.24337
SPACA9 sperm acrosome associated 9 3.24337
GPRASP3 G protein-coupled receptor associated sorting protein family member 3 3.24337
MATCAP2 microtubule associated tyrosine carboxypeptidase 2 3.24337
ANGPTL8 angiopoietin like 8 3.24337
VSIR V-set immunoregulatory receptor 3.24337
STING1 stimulator of interferon response cGAMP interactor 1 3.24337
HAO2 hydroxyacid oxidase 2 (long chain) 3.24337
ZNF441 zinc finger protein 441 3.24337
RTL1 retrotransposon-like 1 3.24337
CLDN5 claudin 5 3.24337
PTPRC protein tyrosine phosphatase, receptor type, C 3.24337
LIPC lipase, hepatic 3.24337
RS1 retinoschisin 1 3.24337
LOC390937 Ets2 repressor factor-like 3.24337
SLC22A10 solute carrier family 22, member 10 3.24337
GPR6 G protein-coupled receptor 6 3.24337
TPBGL trophoblast glycoprotein-like 3.24337
GJA5 gap junction protein, alpha 5, 40kDa 3.24337
HLX H2.0-like homeobox 3.24337
MAG myelin associated glycoprotein 3.24337
NPIPB9 nuclear pore complex interacting protein family, member B9 3.24337
TLR7 toll-like receptor 7 3.24337
GATA4 GATA binding protein 4 3.24337
PRDM7 PR domain containing 7 3.24337
WNT9B wingless-type MMTV integration site family, member 9B 3.24337
FRK fyn-related Src family tyrosine kinase 3.24337
OR2D3 olfactory receptor, family 2, subfamily D, member 3 3.24337
ALG10B ALG10B, alpha-1,2-glucosyltransferase 3.24337
SPDYC speedy/RINGO cell cycle regulator family member C 3.24337
KCNT1 potassium channel, sodium activated subfamily T, member 1 3.24337
C1QTNF8 C1q and tumor necrosis factor related protein 8 3.24337
SLC9A4 solute carrier family 9, subfamily A (NHE4, cation proton antiporter 4), member 4 3.24337
NYAP2 neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 2 3.24337
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4 3.24337
NOX1 NADPH oxidase 1 3.24337
AQP8 aquaporin 8 3.24337
KLK7 kallikrein-related peptidase 7 3.24337
UBQLNL ubiquilin-like 3.24337
C20ORF173 chromosome 20 open reading frame 173 3.24337
SUPT20HL1 suppressor of Ty 20 homolog (S. cerevisiae)-like 1 3.24337
MRLN myoregulin 3.24337
KLK3 kallikrein-related peptidase 3 3.24337
GAL3ST2 galactose-3-O-sulfotransferase 2 3.24337
UTS2R urotensin 2 receptor 3.24337
PYHIN1 pyrin and HIN domain family, member 1 3.24337
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid) 3.24337
TNR tenascin R 3.24337
ITGB7 integrin, beta 7 3.24337
ACSBG2 acyl-CoA synthetase bubblegum family member 2 3.24337
OR1B1 olfactory receptor, family 1, subfamily B, member 1 (gene/pseudogene) 3.24337
TAGAP T-cell activation RhoGTPase activating protein 3.24337
CYP2A6 cytochrome P450, family 2, subfamily A, polypeptide 6 3.24337
C2ORF66 chromosome 2 open reading frame 66 3.24337
IFITM5 interferon induced transmembrane protein 5 3.24337
SHISA8 shisa family member 8 3.24337
URAD ureidoimidazoline (2-oxo-4-hydroxy-4-carboxy-5-) decarboxylase 3.24337
RANBP3L RAN binding protein 3-like 3.24337
POU2AF1 POU class 2 associating factor 1 3.24337
PDZRN4 PDZ domain containing ring finger 4 3.24337
ZNF142 zinc finger protein 142 3.24337
IL36R interleukin 36 receptor 3.24337
EGR2 early growth response 2 3.24337
CBX8 chromobox homolog 8 3.24337
CD244 CD244 molecule, natural killer cell receptor 2B4 3.24337
C16ORF78 chromosome 16 open reading frame 78 3.24337
SPATA7 spermatogenesis associated 7 3.24337
DVL2 dishevelled segment polarity protein 2 3.24337
WFDC9 WAP four-disulfide core domain 9 3.24337
EPGN epithelial mitogen 3.24337
TTC16 tetratricopeptide repeat domain 16 3.24337
CALML6 calmodulin-like 6 3.24337
SLC38A3 solute carrier family 38, member 3 3.24337
ITGA8 integrin, alpha 8 3.24337
OPALIN oligodendrocytic myelin paranodal and inner loop protein 3.24337
TTC36 tetratricopeptide repeat domain 36 3.24337
ANGPTL5 angiopoietin-like 5 3.24337
WFDC6 WAP four-disulfide core domain 6 3.24337
RP1 retinitis pigmentosa 1 (autosomal dominant) 3.24337
CNGB1 cyclic nucleotide gated channel beta 1 3.24337
NLRP8 NLR family, pyrin domain containing 8 3.24337
ICAM5 intercellular adhesion molecule 5, telencephalin 3.24337
PSD4 pleckstrin and Sec7 domain containing 4 3.24337
NPR3 natriuretic peptide receptor 3 3.24337
MB myoglobin 3.24337
SPDEF SAM pointed domain containing ETS transcription factor 3.24337
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1 3.24337
GOLGA8T golgin A8 family, member T 3.24337
FAM81B family with sequence similarity 81, member B 3.24337
PDK4 pyruvate dehydrogenase kinase, isozyme 4 3.24337
SLC10A5 solute carrier family 10, member 5 3.24337
LAMB4 laminin, beta 4 3.24337
GJB6 gap junction protein, beta 6, 30kDa 3.24337
FES FES proto-oncogene, tyrosine kinase 3.24337
CIB4 calcium and integrin binding family member 4 3.24337
CLCNKA chloride channel, voltage-sensitive Ka 3.24337
THEM5 thioesterase superfamily member 5 3.24337
ESPNL espin-like 3.24337
KCNA2 potassium channel, voltage gated shaker related subfamily A, member 2 3.24337
C10ORF90 chromosome 10 open reading frame 90 3.24337
CYTH4 cytohesin 4 3.24337
SLC7A4 solute carrier family 7, member 4 3.24337
PSMA8 proteasome (prosome, macropain) subunit, alpha type, 8 3.24337
SUN3 Sad1 and UNC84 domain containing 3 3.24337
CYP4Z1 cytochrome P450, family 4, subfamily Z, polypeptide 1 3.24337
ELN elastin 3.14931
SPEF2 sperm flagellar 2 3.13048
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1 2.96342
SSC5D scavenger receptor cysteine rich family, 5 domains 2.58903
TLCD2 TLC domain containing 2 2.58903
COL6A6 collagen, type VI, alpha 6 2.58903
H4C2 H4 clustered histone 2 2.56876
LGALS8 lectin, galactoside-binding, soluble, 8 2.5196
ZNF500 zinc finger protein 500 2.51279
WDR37 WD repeat domain 37 2.47929
CRMP1 collapsin response mediator protein 1 2.47114
ERCC6L excision repair cross-complementation group 6-like 2.4301
SLC6A2 solute carrier family 6 (neurotransmitter transporter), member 2 2.4301
FBXL22 F-box and leucine-rich repeat protein 22 2.41172
GINS4 GINS complex subunit 4 (Sld5 homolog) 2.38658
ZNF772 zinc finger protein 772 2.35786
ZNF160 zinc finger protein 160 2.35692
POLR3A polymerase (RNA) III (DNA directed) polypeptide A, 155kDa 2.34356
CNOT4 CCR4-NOT transcription complex, subunit 4 2.32947
ATXN1 ataxin 1 2.32936
FIG4 FIG4 phosphoinositide 5-phosphatase 2.31674
F8 coagulation factor VIII, procoagulant component 2.31674
BORCS6 BLOC-1 related complex subunit 6 2.31674
UGGT1 UDP-glucose glycoprotein glucosyltransferase 1 2.30153
KLF9 Kruppel-like factor 9 2.28736
CSPP1 centrosome and spindle pole associated protein 1 2.28723
PML promyelocytic leukemia 2.28188
RIN3 Ras and Rab interactor 3 2.26961
SELENOP selenoprotein P 2.26755
SHROOM2 shroom family member 2 2.26748
DNAJC18 DnaJ (Hsp40) homolog, subfamily C, member 18 2.24915
CPZ carboxypeptidase Z 2.24915
SEC62 SEC62 homolog (S. cerevisiae) 2.24915
ANAPC1 anaphase promoting complex subunit 1 2.24915
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1 2.24834
DUS4L dihydrouridine synthase 4-like (S. cerevisiae) 2.24037
PTK2 protein tyrosine kinase 2 2.19706
POLM polymerase (DNA directed), mu 2.19126
RYK receptor-like tyrosine kinase 2.17796
DIS3L DIS3 like exosome 3'-5' exoribonuclease 2.17796
IRGQ immunity-related GTPase family, Q 2.17401
OSBPL2 oxysterol binding protein-like 2 2.15157
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) 2.15085
CMIP c-Maf inducing protein 2.14537
KPNA7 karyopherin alpha 7 (importin alpha 8) 2.13672
TSHR thyroid stimulating hormone receptor 2.13672
ZBTB14 zinc finger and BTB domain containing 14 2.13672
APOB apolipoprotein B 2.13672
TMEM272 transmembrane protein 272 2.13672
STX19 syntaxin 19 2.13672
SMC1B structural maintenance of chromosomes 1B 2.13672
KMT2E lysine (K)-specific methyltransferase 2E 2.11782
PTDSS1 phosphatidylserine synthase 1 2.09794
SFI1 Sfi1 homolog, spindle assembly associated (yeast) 2.09794
ST3GAL2 ST3 beta-galactoside alpha-2,3-sialyltransferase 2 2.09205
CYBC1 cytochrome b-245 chaperone 1 2.08015
SECISBP2L SECIS binding protein 2-like 2.06714
GCLC glutamate-cysteine ligase, catalytic subunit 2.05902
ACP2 acid phosphatase 2, lysosomal 2.0573
ELK1 ELK1, member of ETS oncogene family 2.03675
LRRIQ1 leucine-rich repeats and IQ motif containing 1 2.02616
AQR aquarius intron-binding spliceosomal factor 2.02582
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain 2.01628
NDOR1 NADPH dependent diflavin oxidoreductase 1 2.01527
ESRRG estrogen-related receptor gamma 2.0136

decreased expression

Symbol Name Standardized Value
CREG2 cellular repressor of E1A-stimulated genes 2 -3.30108
LYG1 lysozyme G-like 1 -3.30108
IGSF23 immunoglobulin superfamily, member 23 -3.30108
ALX3 ALX homeobox 3 -3.30108
A4GALT alpha 1,4-galactosyltransferase -3.30108
MYLK4 myosin light chain kinase family, member 4 -3.30108
CCDC170 coiled-coil domain containing 170 -3.30108
CELF4 CUGBP, Elav-like family member 4 -3.24337
GCOM1 GRINL1A complex locus 1 -3.24337
IDO2 indoleamine 2,3-dioxygenase 2 -3.24337
MAN2A2 mannosidase, alpha, class 2A, member 2 -3.24337
KYNU kynureninase -3.24337
NIM1K NIM1 serine/threonine protein kinase -3.24337
FPR3 formyl peptide receptor 3 -3.24337
HRH4 histamine receptor H4 -3.24337
TRPV6 transient receptor potential cation channel, subfamily V, member 6 -3.24337
OR13A1 olfactory receptor, family 13, subfamily A, member 1 -3.24337
TSKS testis-specific serine kinase substrate -3.24337
MUC1 mucin 1, cell surface associated -3.24337
TOR4A torsin family 4, member A -3.24337
RUNX3 runt-related transcription factor 3 -3.24337
DRC5 dynein regulatory complex subunit 5 -3.24337
CFAP144 cilia and flagella associated protein 144 -3.24337
C17ORF113 chromosome 17 open reading frame 113 -3.24337
PCDH20 protocadherin 20 -3.24337
H2AC11 H2A clustered histone 11 -3.24337
UBE2L5 ubiquitin conjugating enzyme E2 L5 -3.24337
CLDN14 claudin 14 -3.24337
ADGRD1 adhesion G protein-coupled receptor D1 -3.24337
BMP8B bone morphogenetic protein 8b -3.24337
PLN phospholamban -3.24337
SCT secretin -3.24337
FAM209A family with sequence similarity 209, member A -3.24337
ZAN zonadhesin (gene/pseudogene) -3.24337
EMILIN2 elastin microfibril interfacer 2 -3.19803
CKB creatine kinase, brain -3.18169
SRSF7 serine/arginine-rich splicing factor 7 -3.06529
KTI12 KTI12 homolog, chromatin associated (S. cerevisiae) -3.05468
CILP2 cartilage intermediate layer protein 2 -2.84461
UQCRC1 ubiquinol-cytochrome c reductase core protein I -2.74222
ATP5PB ATP synthase peripheral stalk-membrane subunit b -2.69296
H3C2 H3 clustered histone 2 -2.68934
ARHGAP18 Rho GTPase activating protein 18 -2.6192
STAP2 signal transducing adaptor family member 2 -2.57358
CDK2 cyclin-dependent kinase 2 -2.55487
ZNF345 zinc finger protein 345 -2.5406
SOX10 SRY (sex determining region Y)-box 10 -2.53543
SMPDL3A sphingomyelin phosphodiesterase, acid-like 3A -2.53449
DHX57 DEAH (Asp-Glu-Ala-Asp/His) box polypeptide 57 -2.51754
STAG3 stromal antigen 3 -2.49615
PSPH phosphoserine phosphatase -2.48272
COL13A1 collagen, type XIII, alpha 1 -2.4819
WNT5A wingless-type MMTV integration site family, member 5A -2.4819
OVOL1 ovo-like zinc finger 1 -2.4819
PIF1 PIF1 5'-to-3' DNA helicase -2.47114
SAFB scaffold attachment factor B -2.46195
RAP1A RAP1A, member of RAS oncogene family -2.46083
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1) -2.43079
FAM32A family with sequence similarity 32, member A -2.4301
FCHSD2 FCH and double SH3 domains 2 -2.42795
CCDC51 coiled-coil domain containing 51 -2.41248
SLC6A11 solute carrier family 6 (neurotransmitter transporter), member 11 -2.37321
ZNF488 zinc finger protein 488 -2.36663
CHD2 chromodomain helicase DNA binding protein 2 -2.36537
LONRF1 LON peptidase N-terminal domain and ring finger 1 -2.35948
SPATA1 spermatogenesis associated 1 -2.32947
RBMS2 RNA binding motif, single stranded interacting protein 2 -2.32947
CDT1 chromatin licensing and DNA replication factor 1 -2.31185
METTL2A methyltransferase like 2A -2.29656
RPL7 ribosomal protein L7 -2.2824
DNAJC28 DnaJ (Hsp40) homolog, subfamily C, member 28 -2.2723
SYT15B synaptotagmin 15B -2.24915
SMYD2 SET and MYND domain containing 2 -2.24915
PSMB2 proteasome (prosome, macropain) subunit, beta type, 2 -2.24915
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2 -2.24915
CALY calcyon neuron-specific vesicular protein -2.24317
ADRA2B adrenoceptor alpha 2B -2.24317
IRF8 interferon regulatory factor 8 -2.24317
ZBTB8B zinc finger and BTB domain containing 8B -2.23495
REPS2 RALBP1 associated Eps domain containing 2 -2.23279
RPP40 ribonuclease P/MRP 40kDa subunit -2.22881
SUMO2 small ubiquitin-like modifier 2 -2.22881
FAM50B family with sequence similarity 50, member B -2.19892
COA3 cytochrome c oxidase assembly factor 3 -2.18406
KLHL32 kelch-like family member 32 -2.18201
FERRY3 FERRY endosomal RAB5 effector complex subunit 3 -2.17976
CPNE7 copine VII -2.16569
E2F2 E2F transcription factor 2 -2.15468
TIGAR TP53 induced glycolysis regulatory phosphatase -2.15468
SPRED1 sprouty-related, EVH1 domain containing 1 -2.15468
TMEM268 transmembrane protein 268 -2.14159
GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 -2.13278
QRFPR pyroglutamylated RFamide peptide receptor -2.12511
MED31 mediator complex subunit 31 -2.1141
DDX51 DEAD (Asp-Glu-Ala-Asp) box polypeptide 51 -2.11248
ACTN3 actinin, alpha 3 (gene/pseudogene) -2.09986
SARNP SAP domain containing ribonucleoprotein -2.09794
NTHL1 nth endonuclease III-like 1 (E. coli) -2.09205
C19ORF12 chromosome 19 open reading frame 12 -2.09205
ARSD arylsulfatase D -2.06714
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta -2.04467
ENTR1 endosome associated trafficking regulator 1 -2.04361
MKI67 marker of proliferation Ki-67 -2.04361
ADAMTS10 ADAM metallopeptidase with thrombospondin type 1 motif, 10 -2.02846
GTF2A2 general transcription factor IIA, 2, 12kDa -2.02817
CLTA clathrin, light chain A -2.02616
MTF1 metal-regulatory transcription factor 1 -2.00748
DCTPP1 dCTP pyrophosphatase 1 -2.00638
CEP97 centrosomal protein 97kDa -2.00638
HGS hepatocyte growth factor-regulated tyrosine kinase substrate -2.00638