E2F5 Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description E2F transcription factor 5, p130-binding|The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionarily conserved domains that are present in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein is differentially phosphorylated and is expressed in a wide variety of human tissues. It has higher identity to E2F4 than to other family members. Both this protein and E2F4 interact with tumor suppressor proteins p130 and p107, but not with pRB. Alternative splicing results in multiple variants encoding different isoforms. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 1875)
External Link http://www.ncbi.nlm.nih.gov/gene/1875
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71 interacting proteins for E2F5 from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
ARID1A AT rich interactive domain 1A (SWI-like)
ARID1B AT rich interactive domain 1B (SWI1-like)
B2M beta-2-microglobulin
BIRC5 baculoviral IAP repeat containing 5
BRCC3 BRCA1/BRCA2-containing complex, subunit 3
CCNA2 cyclin A2
CCND1 cyclin D1
CCND2 cyclin D2
CCND3 cyclin D3
CCNE1 cyclin E1
CCNE2 cyclin E2
CDK1 cyclin-dependent kinase 1
CDK2 cyclin-dependent kinase 2
CDK4 cyclin-dependent kinase 4
CDK6 cyclin-dependent kinase 6
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CREBBP CREB binding protein
CSTB cystatin B (stefin B)
DNMT1 DNA (cytosine-5-)-methyltransferase 1
E2F1 E2F transcription factor 1
E2F4 E2F transcription factor 4, p107/p130-binding
EIF4H eukaryotic translation initiation factor 4H
EP300 E1A binding protein p300
GOLGA4 golgin A4
GSTM3 glutathione S-transferase mu 3 (brain)
HDAC1 histone deacetylase 1
HDAC2 histone deacetylase 2
HDAC3 histone deacetylase 3
HIST1H4F histone cluster 1, H4f
HNF4A hepatocyte nuclear factor 4, alpha
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1
HSBP1 heat shock factor binding protein 1
ISCU iron-sulfur cluster assembly enzyme
KAT5 K(lysine) acetyltransferase 5
KMT2D lysine (K)-specific methyltransferase 2D
LIN37 lin-37 DREAM MuvB core complex component
LIN52 lin-52 DREAM MuvB core complex component
LIN54 lin-54 DREAM MuvB core complex component
LIN9 lin-9 DREAM MuvB core complex component
MT1G metallothionein 1G
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
MYC v-myc avian myelocytomatosis viral oncogene homolog
NCOR1 nuclear receptor corepressor 1
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin)
NSFL1C NSFL1 (p97) cofactor (p47)
PARK7 parkinson protein 7
PDAP1 PDGFA associated protein 1
PRDX5 peroxiredoxin 5
RB1 retinoblastoma 1
RBBP4 retinoblastoma binding protein 4
RBL1 retinoblastoma-like 1
RBL2 retinoblastoma-like 2
RPLP2 ribosomal protein, large, P2
SIN3A SIN3 transcription regulator family member A
SLC4A2 solute carrier family 4 (anion exchanger), member 2
SMAD3 SMAD family member 3
SMAD4 SMAD family member 4
SMARCA2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1
SRP9 signal recognition particle 9kDa
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1
TFDP1 transcription factor Dp-1
TFDP2 transcription factor Dp-2 (E2F dimerization partner 2)
TMLHE trimethyllysine hydroxylase, epsilon
UBC ubiquitin C
XPO1 exportin 1