EBF4 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description early B-cell factor 4|EBF4 belongs to the conserved Olf/EBF family of helix-loop-helix transcription factors, members of which play important roles in neural development and B-cell maturation (Wang et al., 2002 [PubMed 12139918]).[supplied by OMIM, Mar 2008] (NCBI Entrez Gene Database, 57593)
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Genes

312 genes differentially expressed following the EBF4 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
B3GNT6 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 6 3.71149
IZUMO3 IZUMO family member 3 3.71149
SDR9C7 short chain dehydrogenase/reductase family 9C, member 7 3.71149
OR52A5 olfactory receptor, family 52, subfamily A, member 5 3.71149
PCDHB6 protocadherin beta 6 3.71149
PKP1 plakophilin 1 3.71149
PGBDF plakoglobin binding and degradation factor 3.71149
GRXCR2 glutaredoxin, cysteine rich 2 3.71149
TM4SF20 transmembrane 4 L six family member 20 3.71149
PI15 peptidase inhibitor 15 3.71149
USP26 ubiquitin specific peptidase 26 3.71149
TSSK4 testis-specific serine kinase 4 3.71149
FOLR1 folate receptor 1 (adult) 3.71149
CD5 CD5 molecule 3.71149
NYAP2 neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 2 3.71149
MYO7B myosin VIIB 3.71149
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4 3.71149
CARD16 caspase recruitment domain family, member 16 3.71149
ZNF503 zinc finger protein 503 3.71149
EPB42 erythrocyte membrane protein band 4.2 3.71149
SKOR1 SKI family transcriptional corepressor 1 3.71149
C19ORF67 chromosome 19 open reading frame 67 3.71149
NRROS negative regulator of reactive oxygen species 3.71149
GNAT1 guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 1 3.71149
OR1L6 olfactory receptor, family 1, subfamily L, member 6 3.71149
RGPD4 RANBP2-like and GRIP domain containing 4 3.71149
KCNE4 potassium channel, voltage gated subfamily E regulatory beta subunit 4 3.71149
PRSS36 protease, serine, 36 3.71149
C1GALT1C1L C1GALT1-specific chaperone 1 like 3.71149
TAS2R1 taste receptor, type 2, member 1 3.71149
LBP lipopolysaccharide binding protein 3.71149
GJB5 gap junction protein, beta 5, 31.1kDa 3.71149
GJB2 gap junction protein, beta 2, 26kDa 3.71149
PAX3 paired box 3 3.71149
APOA2 apolipoprotein A-II 3.71149
BATF basic leucine zipper transcription factor, ATF-like 3.71149
NFAM1 NFAT activating protein with ITAM motif 1 3.71149
NEU4 sialidase 4 3.71149
GABRA2 gamma-aminobutyric acid (GABA) A receptor, alpha 2 3.71149
CETN1 centrin, EF-hand protein, 1 3.71149
SLC22A16 solute carrier family 22 (organic cation/carnitine transporter), member 16 3.71149
PTH1R parathyroid hormone 1 receptor 3.71149
YIPF7 Yip1 domain family, member 7 3.71149
OPRM1 opioid receptor, mu 1 3.71149
MYH6 myosin, heavy chain 6, cardiac muscle, alpha 3.71149
GRAP GRB2-related adaptor protein 3.71149
FAM228A family with sequence similarity 228, member A 3.71149
CLEC6A C-type lectin domain family 6, member A 3.71149
OSTN osteocrin 3.71149
ELFN2 extracellular leucine-rich repeat and fibronectin type III domain containing 2 3.71149
DERPC DERPC proline and glycine rich nuclear protein 3.71149
LRRC8C-DT LRRC8C divergent transcript 3.71149
LOC124902436 talanin 3.71149
H1-8 H1.8 linker histone 3.71149
TMEM273 transmembrane protein 273 3.71149
CFAP141 cilia and flagella associated protein 141 3.71149
CBLIF cobalamin binding intrinsic factor 3.71149
CCDC198 coiled-coil domain containing 198 3.71149
PYDC5 pyrin domain containing 5 3.71149
CCDC42 coiled-coil domain containing 42 3.71149
LTK leukocyte receptor tyrosine kinase 3.71149
OR11A1 olfactory receptor, family 11, subfamily A, member 1 3.71149
CD79A CD79a molecule, immunoglobulin-associated alpha 3.71149
IL31RA interleukin 31 receptor A 3.71149
PTGDR2 prostaglandin D2 receptor 2 3.71149
REG4 regenerating islet-derived family, member 4 3.71149
ACOT4 acyl-CoA thioesterase 4 3.71149
ATP13A5 ATPase type 13A5 3.71149
CES1 carboxylesterase 1 3.71149
TACSTD2 tumor-associated calcium signal transducer 2 3.71149
OVOL3 ovo-like zinc finger 3 3.71149
ROPN1 rhophilin associated tail protein 1 3.71149
NPIPB8 nuclear pore complex interacting protein family, member B8 3.71149
SAMD11 sterile alpha motif domain containing 11 3.71149
PTH parathyroid hormone 3.71149
TACR2 tachykinin receptor 2 3.71149
SBSN suprabasin 3.71149
KCNT1 potassium channel, sodium activated subfamily T, member 1 3.71149
KLRF1 killer cell lectin-like receptor subfamily F, member 1 3.71149
SCPPPQ1 secretory calcium-binding phosphoprotein proline-glutamine rich 1 3.71149
ATOH7 atonal homolog 7 (Drosophila) 3.71149
OR2T12 olfactory receptor, family 2, subfamily T, member 12 3.71149
CST1 cystatin SN 3.71149
THTPA thiamine triphosphatase 3.71149
ADAM7 ADAM metallopeptidase domain 7 3.71149
F2RL3 coagulation factor II (thrombin) receptor-like 3 3.71149
SERINC4 serine incorporator 4 3.71149
ANGPTL4 angiopoietin-like 4 3.71149
MMP12 matrix metallopeptidase 12 3.71149
CDCP2 CUB domain containing protein 2 3.71149
CGB7 chorionic gonadotropin, beta polypeptide 7 3.71149
TBXA2R thromboxane A2 receptor 3.71149
SERPINC1 serpin peptidase inhibitor, clade C (antithrombin), member 1 3.71149
ZPLD1 zona pellucida-like domain containing 1 3.71149
OR10G3 olfactory receptor, family 10, subfamily G, member 3 3.71149
THEM5 thioesterase superfamily member 5 3.71149
CABP5 calcium binding protein 5 3.71149
RORC RAR-related orphan receptor C 3.71149
ANKRD62 ankyrin repeat domain 62 3.71149
PRF1 perforin 1 (pore forming protein) 3.71149
SLFN12L schlafen family member 12-like 3.71149
HGFAC HGF activator 3.71149
KIF4B kinesin family member 4B 3.71149
EPX eosinophil peroxidase 3.71149
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha) 3.71149
ZNF132 zinc finger protein 132 3.71149
ABCG8 ATP-binding cassette, sub-family G (WHITE), member 8 3.71149
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5 3.71149
GPR119 G protein-coupled receptor 119 3.71149
PLA1A phospholipase A1 member A 3.71149
CLCF1 cardiotrophin-like cytokine factor 1 3.71149
CSF1R colony stimulating factor 1 receptor 3.71149
ORM2 orosomucoid 2 3.71149
MS4A4A membrane-spanning 4-domains, subfamily A, member 4A 3.71149
RBBP8NL RBBP8 N-terminal like 3.71149
SP5 Sp5 transcription factor 3.71149
LAMB4 laminin, beta 4 3.71149
ZAP70 zeta-chain (TCR) associated protein kinase 70kDa 3.71149
MEPE matrix extracellular phosphoglycoprotein 3.71149
CLEC18A C-type lectin domain family 18, member A 3.71149
ADH6 alcohol dehydrogenase 6 (class V) 3.71149
TAS2R10 taste receptor, type 2, member 10 3.71149
QRFP pyroglutamylated RFamide peptide 3.71149
LHX5 LIM homeobox 5 3.71149
CACNG3 calcium channel, voltage-dependent, gamma subunit 3 3.71149
MUC7 mucin 7, secreted 3.71149
PLAC8 placenta-specific 8 3.71149
IP6K3 inositol hexakisphosphate kinase 3 3.71149
TMEM52B transmembrane protein 52B 3.71149
WFDC10A WAP four-disulfide core domain 10A 3.71149
ADGRD1 adhesion G protein-coupled receptor D1 3.71149
GALP galanin-like peptide 3.71149
HIGD2B HIG1 hypoxia inducible domain family, member 2B 3.71149
FXYD3 FXYD domain containing ion transport regulator 3 3.71149
PFKFB1 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 3.71149
OR51I2 olfactory receptor, family 51, subfamily I, member 2 3.71149
PAQR6 progestin and adipoQ receptor family member VI 3.64861
DKK2 dickkopf WNT signaling pathway inhibitor 2 3.64861
PSEN1 presenilin 1 3.5653
KCTD1 potassium channel tetramerization domain containing 1 3.21534
TWNK twinkle mtDNA helicase 3.19196
SNX3 sorting nexin 3 3.19144
FNDC3B fibronectin type III domain containing 3B 2.96919
C2 complement component 2 2.95668
CLDN20 claudin 20 2.95668
ZNF619 zinc finger protein 619 2.95668
ADAP2 ArfGAP with dual PH domains 2 2.95668
CTDNEP1 CTD nuclear envelope phosphatase 1 2.78749
SCNN1D sodium channel, non voltage gated 1 delta subunit 2.73272
SCARF1 scavenger receptor class F, member 1 2.73272
TMEM139 transmembrane protein 139 2.73272
IFI35 interferon-induced protein 35 2.73272
C19ORF38 chromosome 19 open reading frame 38 2.73272
F11 coagulation factor XI 2.73272
ADRA2B adrenoceptor alpha 2B 2.73272
MED1 mediator complex subunit 1 2.66766
REX1BD required for excision 1-B domain containing 2.65335
GLCCI1 glucocorticoid induced 1 2.58456
BCL7A B-cell CLL/lymphoma 7A 2.49773
CNOT2 CCR4-NOT transcription complex, subunit 2 2.49576
RPSA ribosomal protein SA 2.47022
PITRM1 pitrilysin metallopeptidase 1 2.41861
SRSF4 serine/arginine-rich splicing factor 4 2.41861
PPP1R9A protein phosphatase 1, regulatory subunit 9A 2.41562
GNG5 guanine nucleotide binding protein (G protein), gamma 5 2.38481
KIAA2012 KIAA2012 2.3215
GPX3 glutathione peroxidase 3 2.29749
DHFR dihydrofolate reductase 2.26252
THAP12 THAP domain containing 12 2.24066
GRIP2 glutamate receptor interacting protein 2 2.23682
SPC25 SPC25, NDC80 kinetochore complex component 2.22892
HSD17B4 hydroxysteroid (17-beta) dehydrogenase 4 2.22892
DPP6 dipeptidyl-peptidase 6 2.22318
DDX11 DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11 2.20646
CFAP36 cilia and flagella associated protein 36 2.18757
TRPC4 transient receptor potential cation channel, subfamily C, member 4 2.1767
DEF8 differentially expressed in FDCP 8 homolog (mouse) 2.16956
C5ORF63 chromosome 5 open reading frame 63 2.16073
KIAA0040 KIAA0040 2.16073
C11ORF58 chromosome 11 open reading frame 58 2.15959
CD320 CD320 molecule 2.15526
ACAP3 ArfGAP with coiled-coil, ankyrin repeat and PH domains 3 2.13874
LRRN1 leucine rich repeat neuronal 1 2.13864
CA11 carbonic anhydrase XI 2.13859
CFAP251 cilia and flagella associated protein 251 2.13709
INSYN2A inhibitory synaptic factor 2A 2.13668
MRPL16 mitochondrial ribosomal protein L16 2.11859
PFDN1 prefoldin subunit 1 2.11547
ZCCHC2 zinc finger, CCHC domain containing 2 2.11246
PLK2 polo-like kinase 2 2.10553
ANKS1B ankyrin repeat and sterile alpha motif domain containing 1B 2.08388
HMGN1 high mobility group nucleosome binding domain 1 2.06732
DESI1 desumoylating isopeptidase 1 2.05226
ZNF48 zinc finger protein 48 2.04467
TMEM106A transmembrane protein 106A 2.03993
ZBTB41 zinc finger and BTB domain containing 41 2.03953
TMEM43 transmembrane protein 43 2.03901
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 2.03806
ABHD12B abhydrolase domain containing 12B 2.03218
NCKAP5L NCK-associated protein 5-like 2.00779

decreased expression

Symbol Name Standardized Value
TUBA8 tubulin, alpha 8 -3.71149
H4C11 H4 clustered histone 11 -3.71149
STEAP3 STEAP family member 3, metalloreductase -3.71149
C11ORF42 chromosome 11 open reading frame 42 -3.71149
CSAG3 CSAG family, member 3 -3.71149
TRPV3 transient receptor potential cation channel, subfamily V, member 3 -3.71149
TRPV2 transient receptor potential cation channel, subfamily V, member 2 -3.71149
MCM3 minichromosome maintenance complex component 3 -3.71149
CYP2U1 cytochrome P450, family 2, subfamily U, polypeptide 1 -3.71149
CIMAP1D CIMAP1 family member D -3.64069
WAS Wiskott-Aldrich syndrome -3.64069
ST8SIA4 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 -3.64069
C16ORF54 chromosome 16 open reading frame 54 -3.64069
ASCL5 achaete-scute family bHLH transcription factor 5 -3.64069
PADI3 peptidyl arginine deiminase, type III -3.64069
CYP3A43 cytochrome P450, family 3, subfamily A, polypeptide 43 -3.64069
G0S2 G0/G1 switch 2 -3.64069
PRR22 proline rich 22 -3.64069
RNF39 ring finger protein 39 -3.64069
MYL4 myosin, light chain 4, alkali; atrial, embryonic -3.64069
TMEM272 transmembrane protein 272 -3.64069
EPOP elongin BC and polycomb repressive complex 2 associated protein -3.64069
RSPH4A radial spoke head 4 homolog A (Chlamydomonas) -3.64069
TBX10 T-box 10 -3.64069
FRK fyn-related Src family tyrosine kinase -3.64069
NPIPB9 nuclear pore complex interacting protein family, member B9 -3.64069
CARD18 caspase recruitment domain family, member 18 -3.64069
OPRL1 opiate receptor-like 1 -3.64069
RGL4 ral guanine nucleotide dissociation stimulator-like 4 -3.64069
PLK5 polo-like kinase 5 -3.64069
FOXP2 forkhead box P2 -3.64069
LOC114841035 uncharacterized LOC114841035 -3.64069
LRRIQ3 leucine-rich repeats and IQ motif containing 3 -3.64069
FAIM2 Fas apoptotic inhibitory molecule 2 -3.64069
CITED1 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1 -3.64069
ERVV-2 endogenous retrovirus group V, member 2 -3.64069
ELMOD1 ELMO/CED-12 domain containing 1 -3.61365
FNDC11 fibronectin type III domain containing 11 -3.53213
LYPD1 LY6/PLAUR domain containing 1 -3.53213
DSC3 desmocollin 3 -3.49852
IPCEF1 interaction protein for cytohesin exchange factors 1 -3.49852
DACT1 dishevelled-binding antagonist of beta-catenin 1 -3.44723
PPP1R3B protein phosphatase 1, regulatory subunit 3B -3.27732
TRIM46 tripartite motif containing 46 -3.14639
KLC3 kinesin light chain 3 -3.03093
MYL5 myosin, light chain 5, regulatory -3.02905
BTBD17 BTB (POZ) domain containing 17 -3.00193
PCMT1 protein-L-isoaspartate (D-aspartate) O-methyltransferase -2.86816
CTIF CBP80/20-dependent translation initiation factor -2.73272
TAF4B TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa -2.7049
NUP160 nucleoporin 160kDa -2.69165
SHARPIN SHANK-associated RH domain interactor -2.63713
OSBPL9 oxysterol binding protein-like 9 -2.53395
IFNAR1 interferon (alpha, beta and omega) receptor 1 -2.49514
SLC16A12 solute carrier family 16, member 12 -2.47022
ACSL6 acyl-CoA synthetase long-chain family member 6 -2.47022
RFC3 replication factor C (activator 1) 3, 38kDa -2.47022
CCNA1 cyclin A1 -2.47022
LONRF2 LON peptidase N-terminal domain and ring finger 2 -2.47022
CENPM centromere protein M -2.44931
SLC23A2 solute carrier family 23 (ascorbic acid transporter), member 2 -2.44322
NCBP2 nuclear cap binding protein subunit 2, 20kDa -2.41861
B9D1 B9 protein domain 1 -2.41062
NSUN2 NOP2/Sun RNA methyltransferase family, member 2 -2.39002
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 -2.38963
NOX4 NADPH oxidase 4 -2.38762
LETMD1 LETM1 domain containing 1 -2.3487
AKAP3 A kinase (PRKA) anchor protein 3 -2.3215
TNFRSF19 tumor necrosis factor receptor superfamily, member 19 -2.3215
RAB36 RAB36, member RAS oncogene family -2.3215
BCL2L10 BCL2-like 10 (apoptosis facilitator) -2.29836
BPTF bromodomain PHD finger transcription factor -2.29464
FHL2 four and a half LIM domains 2 -2.26252
FAM217A family with sequence similarity 217, member A -2.26252
SPINK5 serine peptidase inhibitor, Kazal type 5 -2.25292
PRSS3 protease, serine, 3 -2.2504
LDOC1 leucine zipper, down-regulated in cancer 1 -2.2504
WDR72 WD repeat domain 72 -2.24419
ARC activity-regulated cytoskeleton-associated protein -2.24419
VEGFB vascular endothelial growth factor B -2.23682
SOCS2 suppressor of cytokine signaling 2 -2.21651
RHOBTB2 Rho-related BTB domain containing 2 -2.20968
DAP death-associated protein -2.19238
MED10 mediator complex subunit 10 -2.18568
ZNF439 zinc finger protein 439 -2.1767
F2RL1 coagulation factor II (thrombin) receptor-like 1 -2.1622
ADAT1 adenosine deaminase, tRNA-specific 1 -2.15939
PSMC5 proteasome (prosome, macropain) 26S subunit, ATPase, 5 -2.14523
RASAL2 RAS protein activator like 2 -2.14147
ZNF324 zinc finger protein 324 -2.13859
RELN reelin -2.13859
RSPH14 radial spoke head 14 homolog (Chlamydomonas) -2.13859
CCDC63 coiled-coil domain containing 63 -2.13859
GCK glucokinase (hexokinase 4) -2.13709
FBXO31 F-box protein 31 -2.13668
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 -2.13575
H3C11 H3 clustered histone 11 -2.12893
ORC1 origin recognition complex, subunit 1 -2.11859
PRXL2A peroxiredoxin like 2A -2.11345
PRDM10 PR domain containing 10 -2.10993
USE1 unconventional SNARE in the ER 1 homolog (S. cerevisiae) -2.08172
LYRM7 LYR motif containing 7 -2.07999
ACP1 acid phosphatase 1, soluble -2.06511
SUGCT succinyl-CoA:glutarate-CoA transferase -2.05548
PDCL3 phosducin-like 3 -2.05281
FRZB frizzled-related protein -2.03953
SLC12A5 solute carrier family 12 (potassium/chloride transporter), member 5 -2.03953
APOBEC2 apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 2 -2.03806
MCF2 MCF.2 cell line derived transforming sequence -2.03806
IGDCC4 immunoglobulin superfamily, DCC subclass, member 4 -2.03011
SAMD1 sterile alpha motif domain containing 1 -2.0277
MTPAP mitochondrial poly(A) polymerase -2.02073