ECM-receptor interaction Gene Set

Dataset KEGG Pathways 2026
Category structural or functional annotations
Type pathway
Description The extracellular matrix (ECM) consists of a complex mixture of structural and functional macromolecules and serves an important role in tissue and organ morphogenesis and in the maintenance of cell and tissue structure and function. Specific interactions between cells and the ECM are mediated by transmembrane molecules, mainly integrins and perhaps also proteoglycans, CD36, or other cell-surface-associated components. These interactions lead to a direct or indirect control of cellular activities such as adhesion, migration, differentiation, proliferation, and apoptosis. In addition, integrins function as mechanoreceptors and provide a force-transmitting physical link between the ECM and the cytoskeleton. Integrins are a family of glycosylated, heterodimeric transmembrane adhesion receptors that consist of noncovalently bound alpha- and beta-subunits. (Kyoto Encyclopedia of Genes and Genomes, hsa04512)
External Link https://www.kegg.jp/entry/hsa04512
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Genes

88 proteins participating in the ECM-receptor interaction pathway from the KEGG Pathways 2026 dataset.

Symbol Name
AGRN agrin
CD36 CD36 molecule (thrombospondin receptor)
CD44 CD44 molecule (Indian blood group)
CD47 CD47 molecule
CHAD chondroadherin
COL1A1 collagen, type I, alpha 1
COL1A2 collagen, type I, alpha 2
COL2A1 collagen, type II, alpha 1
COL4A1 collagen, type IV, alpha 1
COL4A2 collagen, type IV, alpha 2
COL4A3 collagen, type IV, alpha 3 (Goodpasture antigen)
COL4A4 collagen, type IV, alpha 4
COL4A5 collagen, type IV, alpha 5
COL4A6 collagen, type IV, alpha 6
COL6A1 collagen, type VI, alpha 1
COL6A2 collagen, type VI, alpha 2
COL6A3 collagen, type VI, alpha 3
COL6A5 collagen, type VI, alpha 5
COL6A6 collagen, type VI, alpha 6
COL9A1 collagen, type IX, alpha 1
COL9A2 collagen, type IX, alpha 2
COL9A3 collagen, type IX, alpha 3
COMP cartilage oligomeric matrix protein
CXXC1 CXXC finger protein 1
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1)
DMTF1 cyclin D binding myb-like transcription factor 1
DSPP dentin sialophosphoprotein
FN1 fibronectin 1
FRAS1 Fraser extracellular matrix complex subunit 1
FREM1 FRAS1 related extracellular matrix 1
FREM2 FRAS1 related extracellular matrix protein 2
GP1BA glycoprotein Ib (platelet), alpha polypeptide
GP1BB glycoprotein Ib (platelet), beta polypeptide
GP5 glycoprotein V (platelet)
GP6 glycoprotein VI (platelet)
GP9 glycoprotein IX (platelet)
HMMR hyaluronan-mediated motility receptor (RHAMM)
HSPG2 heparan sulfate proteoglycan 2
IBSP integrin-binding sialoprotein
ITGA1 integrin, alpha 1
ITGA10 integrin, alpha 10
ITGA11 integrin, alpha 11
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
ITGA2B integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
ITGA6 integrin, alpha 6
ITGA7 integrin, alpha 7
ITGA8 integrin, alpha 8
ITGA9 integrin, alpha 9
ITGAV integrin, alpha V
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
ITGB4 integrin, beta 4
ITGB5 integrin, beta 5
ITGB6 integrin, beta 6
ITGB7 integrin, beta 7
ITGB8 integrin, beta 8
LAMA1 laminin, alpha 1
LAMA2 laminin, alpha 2
LAMA4 laminin, alpha 4
LAMA5 laminin, alpha 5
LAMB1 laminin, beta 1
LAMB3 laminin, beta 3
LAMB4 laminin, beta 4
LAMC1 laminin, gamma 1 (formerly LAMB2)
LAMC2 laminin, gamma 2
LAMC3 laminin, gamma 3
LMNB2 lamin B2
MEPE matrix extracellular phosphoglycoprotein
NPNT nephronectin
RELN reelin
SDC1 syndecan 1
SDC4 syndecan 4
SV2A synaptic vesicle glycoprotein 2A
SV2B synaptic vesicle glycoprotein 2B
SV2C synaptic vesicle glycoprotein 2C
THBS1 thrombospondin 1
THBS2 thrombospondin 2
THBS3 thrombospondin 3
THBS4 thrombospondin 4
TNN tenascin N
TNNC1 troponin C type 1 (slow)
TNR tenascin R
TNXB tenascin XB
VTN vitronectin
VWF von Willebrand factor