EDA Gene Set

Dataset LINCS L1000 CMAP CRISPR Knockout Consensus Signatures
Category transcriptomics
Type gene perturbation
Description ectodysplasin A|The protein encoded by this gene is a type II membrane protein that can be cleaved by furin to produce a secreted form. The encoded protein, which belongs to the tumor necrosis factor family, acts as a homotrimer and may be involved in cell-cell signaling during the development of ectodermal organs. Defects in this gene are a cause of ectodermal dysplasia, anhidrotic, which is also known as X-linked hypohidrotic ectodermal dysplasia. Several transcript variants encoding many different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 1896)
External Link https://ncbi.nlm.nih.gov/gene/1896
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Genes

500 genes differentially expressed following the EDA gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.

increased expression

Symbol Name Standardized Value
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 0.0195945
EIF1AY eukaryotic translation initiation factor 1A, Y-linked 0.0149982
APOD apolipoprotein D 0.01431
RPS4Y1 ribosomal protein S4, Y-linked 1 0.0133134
PCP4 Purkinje cell protein 4 0.0129516
MS4A1 membrane-spanning 4-domains, subfamily A, member 1 0.0119447
KDM5D lysine (K)-specific demethylase 5D 0.0118957
LBH limb bud and heart development 0.0105601
MLPH melanophilin 0.0102882
BCHE butyrylcholinesterase 0.00978537
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase) 0.00972522
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D 0.00948869
NPY neuropeptide Y 0.00938084
MT1X metallothionein 1X 0.00937072
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked 0.00919683
MT1G metallothionein 1G 0.0090846
SNAP25 synaptosomal-associated protein, 25kDa 0.00890629
TCL1A T-cell leukemia/lymphoma 1A 0.0088777
AZGP1 alpha-2-glycoprotein 1, zinc-binding 0.00884545
COG7 component of oligomeric golgi complex 7 0.00876204
CCL5 chemokine (C-C motif) ligand 5 0.00872684
TGFBI transforming growth factor, beta-induced, 68kDa 0.00867793
E2F2 E2F transcription factor 2 0.00866108
TM7SF2 transmembrane 7 superfamily member 2 0.00864233
MSMB microseminoprotein, beta- 0.00861084
BASP1 brain abundant, membrane attached signal protein 1 0.00852317
SPRED2 sprouty-related, EVH1 domain containing 2 0.00850201
CD79A CD79a molecule, immunoglobulin-associated alpha 0.0084799
HGD homogentisate 1,2-dioxygenase 0.00847779
ESR1 estrogen receptor 1 0.00844155
SFRP1 secreted frizzled-related protein 1 0.00841532
CD19 CD19 molecule 0.00840678
LTB lymphotoxin beta (TNF superfamily, member 3) 0.00836732
NPIPB3 nuclear pore complex interacting protein family, member B3 0.00835893
FLNA filamin A, alpha 0.00804974
DES desmin 0.00801292
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1 0.00800192
RAMP1 receptor (G protein-coupled) activity modifying protein 1 0.00794743
NKG7 natural killer cell granule protein 7 0.00785351
KLK2 kallikrein-related peptidase 2 0.00778512
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 0.00775985
CAPG capping protein (actin filament), gelsolin-like 0.00773359
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 0.00767735
TMEM158 transmembrane protein 158 (gene/pseudogene) 0.00762969
CTSD cathepsin D 0.0076277
GSDME gasdermin E 0.00760295
NUPR1 nuclear protein, transcriptional regulator, 1 0.00758439
ZFP36L1 ZFP36 ring finger protein-like 1 0.00753644
PEG10 paternally expressed 10 0.00749747
KRT81 keratin 81, type II 0.00742783
PTK2B protein tyrosine kinase 2 beta 0.00742441
ACSL1 acyl-CoA synthetase long-chain family member 1 0.007415
VPREB3 pre-B lymphocyte 3 0.00741491
FXYD2 FXYD domain containing ion transport regulator 2 0.00734539
LGALS3 lectin, galactoside-binding, soluble, 3 0.00732446
TRPV6 transient receptor potential cation channel, subfamily V, member 6 0.00729991
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 0.00722486
PAX5 paired box 5 0.00721668
ALOX15B arachidonate 15-lipoxygenase, type B 0.00707217
PPP1R3C protein phosphatase 1, regulatory subunit 3C 0.00697336
RNF167 ring finger protein 167 0.00696262
ACTG2 actin, gamma 2, smooth muscle, enteric 0.00695566
SRPX sushi-repeat containing protein, X-linked 0.00695121
PLAU plasminogen activator, urokinase 0.00694012
CRYM crystallin, mu 0.0068934
BANK1 B-cell scaffold protein with ankyrin repeats 1 0.00688537
NBEAL2 neurobeachin-like 2 0.00685469
PID1 phosphotyrosine interaction domain containing 1 0.00684632
GPNMB glycoprotein (transmembrane) nmb 0.00679817
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.00677003
TESC tescalcin 0.00676679
TSPYL5 TSPY-like 5 0.00676048
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 0.00674557
CTSB cathepsin B 0.00671056
CLCN7 chloride channel, voltage-sensitive 7 0.00670147
OAT ornithine aminotransferase 0.00668614
MUC5B mucin 5B, oligomeric mucus/gel-forming 0.00667376
IRS1 insulin receptor substrate 1 0.00667087
PDIA4 protein disulfide isomerase family A, member 4 0.00667041
RAB29 RAB29, member RAS oncogene family 0.00666677
MT1H metallothionein 1H 0.00663941
LCN2 lipocalin 2 0.00662034
CTSH cathepsin H 0.0066074
KLK3 kallikrein-related peptidase 3 0.00659484
FGB fibrinogen beta chain 0.0065701
KRT7 keratin 7, type II 0.00656474
PAGE4 P antigen family, member 4 (prostate associated) 0.00655193
CUEDC1 CUE domain containing 1 0.00652752
COCH cochlin 0.00652438
SYT17 synaptotagmin XVII 0.0064431
OSGIN1 oxidative stress induced growth inhibitor 1 0.00640173
CSRP1 cysteine and glycine-rich protein 1 0.00637304
FTH1 ferritin, heavy polypeptide 1 0.00636344
SKIV2L superkiller viralicidic activity 2-like (S. cerevisiae) 0.00633845
MT1F metallothionein 1F 0.00632745
DEGS1 delta(4)-desaturase, sphingolipid 1 0.00632322
HSPB1 heat shock 27kDa protein 1 0.00630357
SYT1 synaptotagmin I 0.00630043
EYA2 EYA transcriptional coactivator and phosphatase 2 0.00629525
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 0.00629212
ECM1 extracellular matrix protein 1 0.00628909
MMP14 matrix metallopeptidase 14 (membrane-inserted) 0.00626485
MT1E metallothionein 1E 0.00620402
DGKA diacylglycerol kinase, alpha 80kDa 0.0061488
WASHC4 WASH complex subunit 4 0.00609349
POU2AF1 POU class 2 associating factor 1 0.00607882
HS2ST1 heparan sulfate 2-O-sulfotransferase 1 0.00607659
PLA2G7 phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma) 0.00605242
SH3BGRL SH3 domain binding glutamate-rich protein like 0.00605076
APMAP adipocyte plasma membrane associated protein 0.00602384
IGFBP2 insulin-like growth factor binding protein 2, 36kDa 0.00599608
PTGDS prostaglandin D2 synthase 21kDa (brain) 0.00599125
SMTN smoothelin 0.00598102
RAPSN receptor-associated protein of the synapse 0.00597772
RDH11 retinol dehydrogenase 11 (all-trans/9-cis/11-cis) 0.00595106
CYP11B2 cytochrome P450, family 11, subfamily B, polypeptide 2 0.00593382
CD79B CD79b molecule, immunoglobulin-associated beta 0.00591842
SRRM2 serine/arginine repetitive matrix 2 0.00591263
SLC22A3 solute carrier family 22 (organic cation transporter), member 3 0.00590685
ALAS2 5'-aminolevulinate synthase 2 0.00589406
BTG1 B-cell translocation gene 1, anti-proliferative 0.00588968
NOTCH2NL notch 2 N-terminal like 0.00588669
FAM53B family with sequence similarity 53, member B 0.00588581
DCT dopachrome tautomerase 0.00588127
MAD1L1 MAD1 mitotic arrest deficient-like 1 (yeast) 0.00587797
CD1C CD1c molecule 0.00587225
ELAVL3 ELAV like neuron-specific RNA binding protein 3 0.0058633
G6PD glucose-6-phosphate dehydrogenase 0.00585727
IFI6 interferon, alpha-inducible protein 6 0.00585146
TBL1X transducin (beta)-like 1X-linked 0.00584097
FGL1 fibrinogen-like 1 0.00582695
PLA1A phospholipase A1 member A 0.00581497
GMPR guanosine monophosphate reductase 0.00579868
VEGFA vascular endothelial growth factor A 0.00578301
MT1HL1 metallothionein 1H-like 1 0.00575117
ABHD2 abhydrolase domain containing 2 0.00571727
AMIGO2 adhesion molecule with Ig-like domain 2 0.0056786
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein) 0.00566893
MMP9 matrix metallopeptidase 9 0.00564586
FGA fibrinogen alpha chain 0.00564584
MINK1 misshapen-like kinase 1 0.00561669
PTMS parathymosin 0.00560433
QSOX1 quiescin Q6 sulfhydryl oxidase 1 0.00559956
ZNF91 zinc finger protein 91 0.00558503
FAXDC2 fatty acid hydroxylase domain containing 2 0.00556479
TUFT1 tuftelin 1 0.00556356
ATG16L1 autophagy related 16-like 1 (S. cerevisiae) 0.00555648
LDOC1 leucine zipper, down-regulated in cancer 1 0.00551312
ATP2B2 ATPase, Ca++ transporting, plasma membrane 2 0.00549294
JAG1 jagged 1 0.00548556
LAMP1 lysosomal-associated membrane protein 1 0.00547212
DHRS1 dehydrogenase/reductase (SDR family) member 1 0.00544621
ARG1 arginase 1 0.00544096
IGFBP5 insulin-like growth factor binding protein 5 0.00543976
TARP TCR gamma alternate reading frame protein 0.00542674
NT5E 5'-nucleotidase, ecto (CD73) 0.00540038
CA12 carbonic anhydrase XII 0.00538836
IPO13 importin 13 0.0053877
RGS10 regulator of G-protein signaling 10 0.00538732
ABAT 4-aminobutyrate aminotransferase 0.00537458
TBX21 T-box 21 0.00537365
CD9 CD9 molecule 0.00537182
GP1BB glycoprotein Ib (platelet), beta polypeptide 0.00536912
P4HB prolyl 4-hydroxylase, beta polypeptide 0.00534359
TFF3 trefoil factor 3 (intestinal) 0.00533089
VGF VGF nerve growth factor inducible 0.0053222
MICAL1 microtubule associated monooxygenase, calponin and LIM domain containing 1 0.00532099
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.00530547
SPIB Spi-B transcription factor (Spi-1/PU.1 related) 0.00529182
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase) 0.00529073
UPK1A uroplakin 1A 0.00529009
NCF1C neutrophil cytosolic factor 1C pseudogene 0.00528891
LPPR1 lipid phosphate phosphatase-related protein type 1 0.00528486
NCAM1 neural cell adhesion molecule 1 0.00527216
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.00526326
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.00524272
CD22 CD22 molecule 0.00523709
ACTN1 actinin, alpha 1 0.00522091
ACP5 acid phosphatase 5, tartrate resistant 0.00521196
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1 0.00520901
EIF5A eukaryotic translation initiation factor 5A 0.00517179
DKK1 dickkopf WNT signaling pathway inhibitor 1 0.00516311
IGFBP4 insulin-like growth factor binding protein 4 0.00515908
LPP LIM domain containing preferred translocation partner in lipoma 0.00515602
SMG7 SMG7 nonsense mediated mRNA decay factor 0.00515535
KRT5 keratin 5, type II 0.0051527
VOPP1 vesicular, overexpressed in cancer, prosurvival protein 1 0.0051395
SORBS2 sorbin and SH3 domain containing 2 0.00513021
SIGLEC15 sialic acid binding Ig-like lectin 15 0.00512682
ZBTB20 zinc finger and BTB domain containing 20 0.00510281
FMOD fibromodulin 0.00507462
HTRA1 HtrA serine peptidase 1 0.00507304
FLNC filamin C, gamma 0.00506233
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 0.00506221
MKNK2 MAP kinase interacting serine/threonine kinase 2 0.0050572
ARHGEF1 Rho guanine nucleotide exchange factor (GEF) 1 0.0050544
TSC22D4 TSC22 domain family, member 4 0.00504016
ATP2A3 ATPase, Ca++ transporting, ubiquitous 0.00503702
AHSP alpha hemoglobin stabilizing protein 0.00502984
UBB ubiquitin B 0.00501084
OPLAH 5-oxoprolinase (ATP-hydrolysing) 0.00498636
TSPOAP1 TSPO associated protein 1 0.00498309
GPC1 glypican 1 0.00497893
PENK proenkephalin 0.00497854
PEBP1 phosphatidylethanolamine binding protein 1 0.00497609
ZNF205 zinc finger protein 205 0.0049706
STAG3 stromal antigen 3 0.0049703
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.00495405
GZMK granzyme K (granzyme 3; tryptase II) 0.00494538
POLR2J2 polymerase (RNA) II (DNA directed) polypeptide J2 0.0049277
CLSTN3 calsyntenin 3 0.00492486
KIAA0226L KIAA0226-like 0.00492357
RHCG Rh family, C glycoprotein 0.00492308
CLGN calmegin 0.00491705
ACAN aggrecan 0.00489951
ACAP1 ArfGAP with coiled-coil, ankyrin repeat and PH domains 1 0.00489448
SYNE1 spectrin repeat containing, nuclear envelope 1 0.00488441
NDRG2 NDRG family member 2 0.0048813
CRYBG1 crystallin beta-gamma domain containing 1 0.0048638
SCUBE2 signal peptide, CUB domain, EGF-like 2 0.00485095
RBM38 RNA binding motif protein 38 0.00484396
CHKB choline kinase beta 0.00484149
SCARB1 scavenger receptor class B, member 1 0.00483545
CLPTM1 cleft lip and palate associated transmembrane protein 1 0.00483492
INA internexin neuronal intermediate filament protein, alpha 0.0048272
BRD4 bromodomain containing 4 0.00481479
GADD45A growth arrest and DNA-damage-inducible, alpha 0.00480325
TMED9 transmembrane emp24 protein transport domain containing 9 0.00479562
SLC4A1 solute carrier family 4 (anion exchanger), member 1 (Diego blood group) 0.00479264
DAPK3 death-associated protein kinase 3 0.00478781
RRBP1 ribosome binding protein 1 0.00475542
PDLIM7 PDZ and LIM domain 7 (enigma) 0.00475439
FXR2 fragile X mental retardation, autosomal homolog 2 0.00475006
COL7A1 collagen, type VII, alpha 1 0.0047487
TPCN1 two pore segment channel 1 0.00474795
SPON2 spondin 2, extracellular matrix protein 0.00474651
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble 0.00474228
RBBP5 retinoblastoma binding protein 5 0.00473366
LMOD1 leiomodin 1 (smooth muscle) 0.00472189
ARL4D ADP-ribosylation factor-like 4D 0.00472136
POU2F2 POU class 2 homeobox 2 0.00470904
TNC tenascin C 0.00470383
STEAP3 STEAP family member 3, metalloreductase 0.00470125
UPK1B uroplakin 1B 0.00469735
STK26 serine/threonine protein kinase 26 0.0046971
CXCR5 chemokine (C-X-C motif) receptor 5 0.00469445
DUSP5 dual specificity phosphatase 5 0.00468956
CTF1 cardiotrophin 1 0.00467381
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic) 0.00467066
EVX1 even-skipped homeobox 1 0.00466993

decreased expression

Symbol Name Standardized Value
SSBP2 single-stranded DNA binding protein 2 -0.0280008
MAP7 microtubule-associated protein 7 -0.0152498
SMC1A structural maintenance of chromosomes 1A -0.0146584
XIC X chromosome inactivation center -0.0115964
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0115189
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2 -0.011195
TM4SF1 transmembrane 4 L six family member 1 -0.0105343
BEX4 brain expressed, X-linked 4 -0.0102897
ATF3 activating transcription factor 3 -0.0101049
PELI2 pellino E3 ubiquitin protein ligase family member 2 -0.0100556
PDZD2 PDZ domain containing 2 -0.00982011
AKR1C3 aldo-keto reductase family 1, member C3 -0.009809
CD14 CD14 molecule -0.00975957
CPE carboxypeptidase E -0.00941505
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5 -0.00939299
CD93 CD93 molecule -0.00935694
F2RL1 coagulation factor II (thrombin) receptor-like 1 -0.00920382
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32) -0.0090395
ATP9A ATPase, class II, type 9A -0.00900444
GIMAP6 GTPase, IMAP family member 6 -0.0090006
CLEC2B C-type lectin domain family 2, member B -0.00895953
ITM2A integral membrane protein 2A -0.00890665
TLR4 toll-like receptor 4 -0.00884984
MS4A4A membrane-spanning 4-domains, subfamily A, member 4A -0.00874067
FAR2 fatty acyl CoA reductase 2 -0.00867072
GAB2 GRB2-associated binding protein 2 -0.00866528
LMO2 LIM domain only 2 (rhombotin-like 1) -0.00862843
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1 -0.00856891
CD163 CD163 molecule -0.0085612
RGS5 regulator of G-protein signaling 5 -0.00848067
MTUS1 microtubule associated tumor suppressor 1 -0.00846428
GNAQ guanine nucleotide binding protein (G protein), q polypeptide -0.00840149
BHLHE41 basic helix-loop-helix family, member e41 -0.00835722
MNDA myeloid cell nuclear differentiation antigen -0.0082918
MRPS30 mitochondrial ribosomal protein S30 -0.00820966
CLIC5 chloride intracellular channel 5 -0.00815438
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1 -0.00814248
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21 -0.0081378
NPTX2 neuronal pentraxin II -0.00812487
GPR37 G protein-coupled receptor 37 (endothelin receptor type B-like) -0.00811615
MMP10 matrix metallopeptidase 10 -0.00809316
LIMCH1 LIM and calponin homology domains 1 -0.00800501
DLD dihydrolipoamide dehydrogenase -0.00795295
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2 -0.00792934
FUT1 fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group) -0.00792388
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 -0.0079132
ACKR3 atypical chemokine receptor 3 -0.00791202
GBP2 guanylate binding protein 2, interferon-inducible -0.00785734
S100A8 S100 calcium binding protein A8 -0.00782712
DAPK1 death-associated protein kinase 1 -0.00782337
TRAM1 translocation associated membrane protein 1 -0.00781874
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1 -0.00776994
SAMSN1 SAM domain, SH3 domain and nuclear localization signals 1 -0.00760152
ST6GALNAC5 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5 -0.00749565
ADM adrenomedullin -0.00747419
PCSK1 proprotein convertase subtilisin/kexin type 1 -0.00736928
HOXD1 homeobox D1 -0.00731978
SLC22A4 solute carrier family 22 (organic cation/zwitterion transporter), member 4 -0.00728772
CLNS1A chloride channel, nucleotide-sensitive, 1A -0.00725591
FAIM Fas apoptotic inhibitory molecule -0.00724752
OSBPL1A oxysterol binding protein-like 1A -0.00722409
ANOS1 anosmin 1 -0.00722323
MCL1 myeloid cell leukemia 1 -0.00722216
FRY furry homolog (Drosophila) -0.00714792
KLF4 Kruppel-like factor 4 (gut) -0.00711158
AMH anti-Mullerian hormone -0.00706128
AGTPBP1 ATP/GTP binding protein 1 -0.00705303
GATA6 GATA binding protein 6 -0.00702877
TOX thymocyte selection-associated high mobility group box -0.00702839
CA2 carbonic anhydrase II -0.00702557
SEPP1 selenoprotein P, plasma, 1 -0.00699892
MSLN mesothelin -0.00697265
EGR2 early growth response 2 -0.00697098
C1QB complement component 1, q subcomponent, B chain -0.00685983
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2 -0.00682728
TAF9B TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa -0.00674693
SELENOW selenoprotein W -0.00672978
KLK6 kallikrein-related peptidase 6 -0.00670557
ZNF165 zinc finger protein 165 -0.00669301
PXDN peroxidasin -0.00668372
ZNF207 zinc finger protein 207 -0.00666626
GPC4 glypican 4 -0.00664547
SLC27A6 solute carrier family 27 (fatty acid transporter), member 6 -0.00663748
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.00662518
C5AR1 complement component 5a receptor 1 -0.00661604
DOK5 docking protein 5 -0.00655005
RGCC regulator of cell cycle -0.00653173
PRRG1 proline rich Gla (G-carboxyglutamic acid) 1 -0.00649604
COMMD10 COMM domain containing 10 -0.00648703
IFIT1 interferon-induced protein with tetratricopeptide repeats 1 -0.00647399
AGPS alkylglycerone phosphate synthase -0.0064476
APOBEC3A apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3A -0.00639568
TNFAIP6 tumor necrosis factor, alpha-induced protein 6 -0.00637428
VSIG4 V-set and immunoglobulin domain containing 4 -0.0063702
CXADR coxsackie virus and adenovirus receptor -0.00636826
PLSCR4 phospholipid scramblase 4 -0.00635947
C10ORF10 chromosome 10 open reading frame 10 -0.0063582
FOXF1 forkhead box F1 -0.00631731
PLAAT3 phospholipase A and acyltransferase 3 -0.00631535
GCH1 GTP cyclohydrolase 1 -0.00628754
KLK10 kallikrein-related peptidase 10 -0.0062777
WARS1 tryptophanyl-tRNA synthetase 1 -0.00626151
MED21 mediator complex subunit 21 -0.00624195
TYROBP TYRO protein tyrosine kinase binding protein -0.00621443
LGALS13 lectin, galactoside-binding, soluble, 13 -0.00620634
TRIM36 tripartite motif containing 36 -0.00620609
GRK5 G protein-coupled receptor kinase 5 -0.00620537
CASP1 caspase 1, apoptosis-related cysteine peptidase -0.00620497
MS4A6A membrane-spanning 4-domains, subfamily A, member 6A -0.00617041
S100A9 S100 calcium binding protein A9 -0.00616935
MSR1 macrophage scavenger receptor 1 -0.00616304
DKK2 dickkopf WNT signaling pathway inhibitor 2 -0.00616227
PTBP3 polypyrimidine tract binding protein 3 -0.0061538
PRDX2 peroxiredoxin 2 -0.00611021
MTRR 5-methyltetrahydrofolate-homocysteine methyltransferase reductase -0.00610342
CHMP2B charged multivesicular body protein 2B -0.00605727
CFH complement factor H -0.00603413
CPB1 carboxypeptidase B1 (tissue) -0.00601737
ATP11B ATPase, class VI, type 11B -0.0059777
ZNF204P zinc finger protein 204, pseudogene -0.0059704
CBX1 chromobox homolog 1 -0.00595768
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 -0.00595626
L1TD1 LINE-1 type transposase domain containing 1 -0.00595104
CX3CR1 chemokine (C-X3-C motif) receptor 1 -0.00592908
TLR2 toll-like receptor 2 -0.00591927
MYO1D myosin ID -0.00591886
ERG v-ets avian erythroblastosis virus E26 oncogene homolog -0.00590127
IFRD2 interferon-related developmental regulator 2 -0.00589486
CGA glycoprotein hormones, alpha polypeptide -0.00589291
WDR7 WD repeat domain 7 -0.00589106
RPRD1A regulation of nuclear pre-mRNA domain containing 1A -0.00588715
MPZL2 myelin protein zero-like 2 -0.00588139
NRN1 neuritin 1 -0.00588021
PMM2 phosphomannomutase 2 -0.005876
DLAT dihydrolipoamide S-acetyltransferase -0.00587252
INSR insulin receptor -0.00587064
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein -0.0058668
RETREG1 reticulophagy regulator 1 -0.00585681
C5ORF30 chromosome 5 open reading frame 30 -0.00582993
NQO2 NAD(P)H dehydrogenase, quinone 2 -0.00582353
CXCR4 chemokine (C-X-C motif) receptor 4 -0.00582078
LAMP3 lysosomal-associated membrane protein 3 -0.00581974
ZSCAN31 zinc finger and SCAN domain containing 31 -0.00581948
EFNA1 ephrin-A1 -0.00581282
NREP neuronal regeneration related protein -0.00580598
CX3CL1 chemokine (C-X3-C motif) ligand 1 -0.00578096
PANX1 pannexin 1 -0.00575698
CPVL carboxypeptidase, vitellogenic-like -0.00574535
AUTS2 autism susceptibility candidate 2 -0.00573485
LY96 lymphocyte antigen 96 -0.00571088
CDH5 cadherin 5, type 2 (vascular endothelium) -0.00570892
FAT4 FAT atypical cadherin 4 -0.00568924
AHR aryl hydrocarbon receptor -0.00567968
CAVIN3 caveolae associated protein 3 -0.00566992
MN1 meningioma (disrupted in balanced translocation) 1 -0.00566904
HBB hemoglobin, beta -0.00566294
HIKESHI heat shock protein nuclear import factor hikeshi -0.0056538
VWF von Willebrand factor -0.00565307
PTHLH parathyroid hormone-like hormone -0.0056523
EMC2 ER membrane protein complex subunit 2 -0.00563926
B3GNT2 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2 -0.00563911
LYZ lysozyme -0.00563706
ADAM10 ADAM metallopeptidase domain 10 -0.00563333
BMP2 bone morphogenetic protein 2 -0.00561799
RAB40B RAB40B, member RAS oncogene family -0.00560604
APOLD1 apolipoprotein L domain containing 1 -0.00560187
F13A1 coagulation factor XIII, A1 polypeptide -0.0056018
ACD adrenocortical dysplasia homolog (mouse) -0.00555622
FLRT3 fibronectin leucine rich transmembrane protein 3 -0.0055333
FAM13A family with sequence similarity 13, member A -0.00552992
DMAC2L distal membrane arm assembly component 2 like -0.00551105
COPS7A COP9 signalosome subunit 7A -0.00550545
S100A12 S100 calcium binding protein A12 -0.0054986
MEF2A myocyte enhancer factor 2A -0.00549575
PCSK6 proprotein convertase subtilisin/kexin type 6 -0.00549347
ZMYND11 zinc finger, MYND-type containing 11 -0.00547614
FBXO3 F-box protein 3 -0.0054435
SLC35A5 solute carrier family 35, member A5 -0.00543618
ZNF22 zinc finger protein 22 -0.00543111
TRIM14 tripartite motif containing 14 -0.00542505
IRAK3 interleukin-1 receptor-associated kinase 3 -0.00542384
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma) -0.00542167
APC adenomatous polyposis coli -0.00541864
OXTR oxytocin receptor -0.00541465
CD53 CD53 molecule -0.00540978
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 -0.00540692
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 -0.00540007
NOX4 NADPH oxidase 4 -0.0053989
CHEK2 checkpoint kinase 2 -0.00539559
TMCO3 transmembrane and coiled-coil domains 3 -0.00539243
FOXF2 forkhead box F2 -0.00538928
CCL14 chemokine (C-C motif) ligand 14 -0.00538746
CD302 CD302 molecule -0.00538471
SLC25A6 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6 -0.00538288
HAT1 histone acetyltransferase 1 -0.00538086
SLPI secretory leukocyte peptidase inhibitor -0.00535451
RAD23B RAD23 homolog B (S. cerevisiae) -0.00534609
DPYD dihydropyrimidine dehydrogenase -0.00534188
RCHY1 ring finger and CHY zinc finger domain containing 1, E3 ubiquitin protein ligase -0.00532496
CD69 CD69 molecule -0.00532483
FBXO11 F-box protein 11 -0.00529842
TSPAN8 tetraspanin 8 -0.00529228
MMP3 matrix metallopeptidase 3 -0.00528329
ZFAND5 zinc finger, AN1-type domain 5 -0.00528104
HGF hepatocyte growth factor (hepapoietin A; scatter factor) -0.00527495
SET SET nuclear proto-oncogene -0.00526983
IL15 interleukin 15 -0.00526749
CXCL14 chemokine (C-X-C motif) ligand 14 -0.00526706
CCP110 centriolar coiled coil protein 110kDa -0.00526686
SMAD4 SMAD family member 4 -0.00525391
GPC3 glypican 3 -0.00525239
CASP4 caspase 4, apoptosis-related cysteine peptidase -0.0052485
ENPEP glutamyl aminopeptidase (aminopeptidase A) -0.00524004
TFDP1 transcription factor Dp-1 -0.00523962
DOCK9 dedicator of cytokinesis 9 -0.00522752
HEY1 hes-related family bHLH transcription factor with YRPW motif 1 -0.00522677
ADCY3 adenylate cyclase 3 -0.00521728
ICAM2 intercellular adhesion molecule 2 -0.00519597
NID1 nidogen 1 -0.00519128
FBXO21 F-box protein 21 -0.00519051
MTAP methylthioadenosine phosphorylase -0.00518907
KCNJ15 potassium channel, inwardly rectifying subfamily J, member 15 -0.00517265
TM2D3 TM2 domain containing 3 -0.00516257
PDGFD platelet derived growth factor D -0.00515117
MMRN1 multimerin 1 -0.00515039
SOX11 SRY (sex determining region Y)-box 11 -0.00514964
STOM stomatin -0.00513758
BTBD3 BTB (POZ) domain containing 3 -0.00513676
RUNX1 runt-related transcription factor 1 -0.00513325
KIF2A kinesin heavy chain member 2A -0.00512695
MCM5 minichromosome maintenance complex component 5 -0.00509162
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae) -0.00509085
WAPL WAPL cohesin release factor -0.00508507
PODXL podocalyxin-like -0.00508189
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7 -0.00507732
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta -0.00506776
BMX BMX non-receptor tyrosine kinase -0.00505436
PCDH8 protocadherin 8 -0.00505087
KRT18 keratin 18, type I -0.00504964
NUDT21 nudix (nucleoside diphosphate linked moiety X)-type motif 21 -0.00503932
RNASE1 ribonuclease, RNase A family, 1 (pancreatic) -0.00503341
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 -0.00502973
TADA2A transcriptional adaptor 2A -0.00502121
RTN2 reticulon 2 -0.005017
ELL2 elongation factor, RNA polymerase II, 2 -0.00501446
EIF5 eukaryotic translation initiation factor 5 -0.00500943
DCTN4 dynactin 4 (p62) -0.00500869
KCNS3 potassium voltage-gated channel, modifier subfamily S, member 3 -0.0050022
CXCL10 chemokine (C-X-C motif) ligand 10 -0.0050017
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F -0.00499835