EED Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description embryonic ectoderm development|This gene encodes a member of the Polycomb-group (PcG) family. PcG family members form multimeric protein complexes, which are involved in maintaining the transcriptional repressive state of genes over successive cell generations. This protein interacts with enhancer of zeste 2, the cytoplasmic tail of integrin beta7, immunodeficiency virus type 1 (HIV-1) MA protein, and histone deacetylase proteins. This protein mediates repression of gene activity through histone deacetylation, and may act as a specific regulator of integrin function. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 8726)
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Genes

347 genes differentially expressed following the EED gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
CARD14 caspase recruitment domain family, member 14 3.41254
SLC25A45 solute carrier family 25, member 45 3.41254
CSH2 chorionic somatomammotropin hormone 2 3.41254
TMEM191B transmembrane protein 191B 3.41254
CCL5 chemokine (C-C motif) ligand 5 3.41254
GJB5 gap junction protein, beta 5, 31.1kDa 3.41254
LMO1 LIM domain only 1 (rhombotin 1) 3.41254
UCP3 uncoupling protein 3 (mitochondrial, proton carrier) 3.41254
CSTL1 cystatin-like 1 3.41254
OR2J2 olfactory receptor, family 2, subfamily J, member 2 3.41254
FETUB fetuin B 3.41254
CEP295NL CEP295 N-terminal like 3.41254
SIRPB2 signal-regulatory protein beta 2 3.41254
AZGP1 alpha-2-glycoprotein 1, zinc-binding 3.41254
CHRNG cholinergic receptor, nicotinic, gamma (muscle) 3.41254
FAM180A family with sequence similarity 180, member A 3.41254
WDR87 WD repeat domain 87 3.41254
ZSCAN5B zinc finger and SCAN domain containing 5B 3.41254
ZNF491 zinc finger protein 491 3.41254
OR52H1 olfactory receptor, family 52, subfamily H, member 1 3.41254
TMEM176A transmembrane protein 176A 3.41254
MAGEA9 melanoma antigen family A9 3.41254
TSGA13 testis specific, 13 3.41254
PCDHB7 protocadherin beta 7 3.41254
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 3.41254
SCNN1G sodium channel, non voltage gated 1 gamma subunit 3.41254
MUSK muscle, skeletal, receptor tyrosine kinase 3.41254
B3GNT8 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8 3.41254
ATOH7 atonal homolog 7 (Drosophila) 3.41254
TAS2R13 taste receptor, type 2, member 13 3.41254
SULT6B1 sulfotransferase family, cytosolic, 6B, member 1 3.41254
HMX1 H6 family homeobox 1 3.41254
CSNK2A3 casein kinase 2, alpha 3 polypeptide 3.41254
NMUR1 neuromedin U receptor 1 3.41254
SLC22A9 solute carrier family 22 (organic anion transporter), member 9 3.41254
FAM9B family with sequence similarity 9, member B 3.41254
STAP1 signal transducing adaptor family member 1 3.41254
RNASE6 ribonuclease, RNase A family, k6 3.41254
MUC22 mucin 22 3.41254
PDZD9 PDZ domain containing 9 3.41254
MFAP5 microfibrillar associated protein 5 3.41254
MYCT1 myc target 1 3.41254
TAL2 T-cell acute lymphocytic leukemia 2 3.41254
HCRTR2 hypocretin (orexin) receptor 2 3.41254
ADGB androglobin 3.41254
POSTN periostin, osteoblast specific factor 3.41254
NOTUM notum pectinacetylesterase homolog (Drosophila) 3.41254
GMFG glia maturation factor, gamma 3.41254
LCN12 lipocalin 12 3.41254
UBA7 ubiquitin-like modifier activating enzyme 7 3.41254
RGPD4 RANBP2-like and GRIP domain containing 4 3.41254
PRSS21 protease, serine, 21 (testisin) 3.41254
SLC6A1 solute carrier family 6 (neurotransmitter transporter), member 1 3.41254
COXFA4L2 cytochrome c oxidase hypoxia associated subunit FA4L2 3.41254
CAPN9 calpain 9 3.41254
CCER2 coiled-coil glutamate-rich protein 2 3.41254
CXCL13 chemokine (C-X-C motif) ligand 13 3.41254
SPEM1 spermatid maturation 1 3.41254
KRT81 keratin 81, type II 3.41254
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 3.41254
RSPH4A radial spoke head 4 homolog A (Chlamydomonas) 3.41254
IQCF1 IQ motif containing F1 3.41254
XKR3 XK, Kell blood group complex subunit-related family, member 3 3.41254
SPATA25 spermatogenesis associated 25 3.41254
GPR37L1 G protein-coupled receptor 37 like 1 3.41254
CLDN14 claudin 14 3.41254
ANKRD40CL ANKRD40 C-terminal like 3.41254
ZC3H11C zinc finger CCCH-type containing 11C 3.41254
C17ORF114 chromosome 17 open reading frame 114 3.41254
NOTCH2NLB notch 2 N-terminal like B 3.41254
TMA7B translation machinery associated 7 homolog B 3.41254
INSYN1 inhibitory synaptic factor 1 3.41254
SEPTIN12 septin 12 3.41254
GARIN1A golgi associated RAB2 interactor 1A 3.41254
CFAP141 cilia and flagella associated protein 141 3.41254
BNIP5 BCL2 interacting protein 5 3.41254
RTL9 retrotransposon Gag like 9 3.41254
CRACDL CRACD like 3.41254
GCSAM germinal center-associated, signaling and motility 3.41254
SELL selectin L 3.41254
ANXA13 annexin A13 3.41254
ZSWIM2 zinc finger, SWIM-type containing 2 3.41254
CCDC17 coiled-coil domain containing 17 3.41254
PCDHB10 protocadherin beta 10 3.41254
PCDHB13 protocadherin beta 13 3.41254
PTPRB protein tyrosine phosphatase, receptor type, B 3.41254
OR2A1 olfactory receptor, family 2, subfamily A, member 1 3.41254
LOC390937 Ets2 repressor factor-like 3.41254
ISM2 isthmin 2 3.41254
SLC22A11 solute carrier family 22 (organic anion/urate transporter), member 11 3.41254
TMPRSS11A transmembrane protease, serine 11A 3.41254
IDO2 indoleamine 2,3-dioxygenase 2 3.41254
TACSTD2 tumor-associated calcium signal transducer 2 3.41254
ABCA8 ATP-binding cassette, sub-family A (ABC1), member 8 3.41254
GATA2 GATA binding protein 2 3.41254
KL klotho 3.41254
LRRN4CL LRRN4 C-terminal like 3.41254
LRRC72 leucine rich repeat containing 72 3.41254
FMR1NB fragile X mental retardation 1 neighbor 3.41254
C6ORF118 chromosome 6 open reading frame 118 3.41254
C1QTNF9 C1q and tumor necrosis factor related protein 9 3.41254
ESR1 estrogen receptor 1 3.41254
TLR7 toll-like receptor 7 3.41254
NHLRC1 NHL repeat containing E3 ubiquitin protein ligase 1 3.41254
UPK3A uroplakin 3A 3.41254
GFI1B growth factor independent 1B transcription repressor 3.41254
MAB21L3 mab-21-like 3 (C. elegans) 3.41254
TTC9B tetratricopeptide repeat domain 9B 3.41254
PCDHGA3 protocadherin gamma subfamily A, 3 3.41254
HCLS1 hematopoietic cell-specific Lyn substrate 1 3.41254
ISLR immunoglobulin superfamily containing leucine-rich repeat 3.41254
IL1B interleukin 1, beta 3.41254
PPP1R14C protein phosphatase 1, regulatory (inhibitor) subunit 14C 3.41254
SLC22A24 solute carrier family 22, member 24 3.41254
DENND1A DENN/MADD domain containing 1A 3.41254
COL6A5 collagen, type VI, alpha 5 3.41254
CALHM1 calcium homeostasis modulator 1 3.41254
GOLGA6C golgin A6 family, member C 3.41254
TBC1D10C TBC1 domain family, member 10C 3.41254
CH25H cholesterol 25-hydroxylase 3.41254
EXTL1 exostosin-like glycosyltransferase 1 3.41254
HSD17B13 hydroxysteroid (17-beta) dehydrogenase 13 3.41254
HCRT hypocretin (orexin) neuropeptide precursor 3.41254
BTNL3 butyrophilin-like 3 3.41254
CRYBB3 crystallin, beta B3 3.41254
HSPA1L heat shock 70kDa protein 1-like 3.41254
MAP3K19 mitogen-activated protein kinase kinase kinase 19 3.41254
KLHL41 kelch-like family member 41 3.41254
BPIFB4 BPI fold containing family B, member 4 3.41254
CATIP ciliogenesis associated TTC17 interacting protein 3.41254
FBXO40 F-box protein 40 3.41254
ASTL astacin-like metallo-endopeptidase (M12 family) 3.41254
RBBP8NL RBBP8 N-terminal like 3.41254
ROS1 ROS proto-oncogene 1 , receptor tyrosine kinase 3.41254
GPR142 G protein-coupled receptor 142 3.41254
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 3.41254
KCNA7 potassium channel, voltage gated shaker related subfamily A, member 7 3.41254
LAMB3 laminin, beta 3 3.41254
ETV3L ets variant 3-like 3.41254
LMX1B LIM homeobox transcription factor 1, beta 3.41254
SFTA2 surfactant associated 2 3.41254
PHACTR3 phosphatase and actin regulator 3 3.41254
CFAP126 cilia and flagella associated protein 126 3.41254
TCAP titin-cap 3.41254
DLX1 distal-less homeobox 1 3.41254
LOC124905976 uncharacterized LOC124905976 3.41254
PABPN1L poly(A) binding protein, nuclear 1-like (cytoplasmic) 3.41254
TBX1 T-box 1 3.41254
CHIT1 chitinase 1 (chitotriosidase) 3.41254
IL9R interleukin 9 receptor 3.41254
FGG fibrinogen gamma chain 3.41254
RBM24 RNA binding motif protein 24 3.41254
ANKRD53 ankyrin repeat domain 53 3.41254
PDCD1LG2 programmed cell death 1 ligand 2 3.41254
SYNGR4 synaptogyrin 4 3.41254
PHOX2A paired-like homeobox 2a 3.41254
FCN3 ficolin (collagen/fibrinogen domain containing) 3 3.41254
ANGPTL5 angiopoietin-like 5 3.41254
PPP1R3G protein phosphatase 1, regulatory subunit 3G 3.41254
C5ORF46 chromosome 5 open reading frame 46 3.41254
OR14A2 olfactory receptor, family 14, subfamily A, member 2 3.41254
SLITRK1 SLIT and NTRK-like family, member 1 3.41254
POTEF POTE ankyrin domain family, member F 3.41254
AOC1 amine oxidase, copper containing 1 3.41254
CHRDL2 chordin-like 2 3.41254
RERGL RERG/RAS-like 3.41254
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa) 3.41254
OXER1 oxoeicosanoid (OXE) receptor 1 3.41254
SLC28A1 solute carrier family 28 (concentrative nucleoside transporter), member 1 3.41254
C10ORF90 chromosome 10 open reading frame 90 3.41254
ALLC allantoicase 3.41254
TGM3 transglutaminase 3 3.41254
FAF2 Fas associated factor family member 2 3.41254
SLC38A11 solute carrier family 38, member 11 3.41254
ANGPTL3 angiopoietin-like 3 3.41254
C5AR2 complement component 5a receptor 2 3.41254
CARD9 caspase recruitment domain family, member 9 3.41254
PRSS51 protease, serine, 51 3.41254
VPREB3 pre-B lymphocyte 3 3.41254
PITX2 paired-like homeodomain 2 3.41254
WDFY4 WDFY family member 4 3.41254
KRTAP13-4 keratin associated protein 13-4 3.41254
FCN1 ficolin (collagen/fibrinogen domain containing) 1 3.41254
CHTF8 CTF8, chromosome transmission fidelity factor 8 homolog (S. cerevisiae) 3.41254
MT1A metallothionein 1A 3.41254
SMCO3 single-pass membrane protein with coiled-coil domains 3 3.41254
IRX5 iroquois homeobox 5 3.41254
MICU3 mitochondrial calcium uptake family, member 3 2.98172
SLC35E1 solute carrier family 35, member E1 2.94391
PRSS36 protease, serine, 36 2.83547
MPST mercaptopyruvate sulfurtransferase 2.70086
NICN1 nicolin 1 2.68858
PSMC1 proteasome (prosome, macropain) 26S subunit, ATPase, 1 2.67853
SLTM SAFB-like, transcription modulator 2.67853
FAH fumarylacetoacetate hydrolase (fumarylacetoacetase) 2.63966
RASA2 RAS p21 protein activator 2 2.62267
STUM stum, mechanosensory transduction mediator homolog 2.60447
TTC8 tetratricopeptide repeat domain 8 2.56504
RBPJL recombination signal binding protein for immunoglobulin kappa J region-like 2.54177
PLAC8 placenta-specific 8 2.54177
ATP6V0D1 ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d1 2.54155
TTI1 TELO2 interacting protein 1 2.52502
CTBS chitobiase, di-N-acetyl- 2.5234
PPFIA3 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 3 2.52066
ZFAT zinc finger and AT hook domain containing 2.51848
XRRA1 X-ray radiation resistance associated 1 2.50472
KY kyphoscoliosis peptidase 2.47232
DCTN2 dynactin 2 (p50) 2.46825
LYRM2 LYR motif containing 2 2.44755
SLC35H1 solute carrier family 35 member H1 2.43682
RSPH1 radial spoke head 1 homolog (Chlamydomonas) 2.3574
FGF4 fibroblast growth factor 4 2.3574
SPINT2 serine peptidase inhibitor, Kunitz type, 2 2.35623
ARMC2 armadillo repeat containing 2 2.34663
SH3BP4 SH3-domain binding protein 4 2.33417
TSKS testis-specific serine kinase substrate 2.33394
FER1L6 fer-1-like family member 6 2.33394
SLC68A1 solute carrier family 68 member 1 2.30759
GPR52 G protein-coupled receptor 52 2.29193
CPHXL2 cytoplasmic polyadenylated homeobox like 2 2.29193
ZNF354B zinc finger protein 354B 2.25782
SMIM3 small integral membrane protein 3 2.20809
KANK3 KN motif and ankyrin repeat domains 3 2.20307
SPIRE1 spire-type actin nucleation factor 1 2.2029
SLC5A4 solute carrier family 5 (glucose activated ion channel), member 4 2.18018
MYO1H myosin IH 2.18018
SCRG1 stimulator of chondrogenesis 1 2.18018
GPRASP2 G protein-coupled receptor associated sorting protein 2 2.16901
TMEM144 transmembrane protein 144 2.16495
LEMD3 LEM domain containing 3 2.12594
FAM149A family with sequence similarity 149, member A 2.09235
NDUFB6 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 6, 17kDa 2.09116
DIPK1A divergent protein kinase domain 1A 2.09116
IGSF8 immunoglobulin superfamily, member 8 2.08673
RAB18 RAB18, member RAS oncogene family 2.08673
GDPD1 glycerophosphodiester phosphodiesterase domain containing 1 2.08673
MAPK7 mitogen-activated protein kinase 7 2.06563
RGS17 regulator of G-protein signaling 17 2.06563
FAHD1 fumarylacetoacetate hydrolase domain containing 1 2.05406
CCDC61 coiled-coil domain containing 61 2.04718
SELENOW selenoprotein W 2.04468
RADX RPA1 related single stranded DNA binding protein, X-linked 2.04279
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase 2.03167
SC5D sterol-C5-desaturase 2.02454
ZNF3 zinc finger protein 3 2.02454
GSTM4 glutathione S-transferase mu 4 2.01504
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 2.00539
IGLON5 IgLON family member 5 2.00234

decreased expression

Symbol Name Standardized Value
LIPT2-AS1 LIPT2 antisense RNA 1 -3.41254
SMPDL3A sphingomyelin phosphodiesterase, acid-like 3A -3.41254
DCAF4L1 DDB1 and CUL4 associated factor 4-like 1 -3.41254
PLXDC1 plexin domain containing 1 -3.41254
AADACL3 arylacetamide deacetylase-like 3 -3.41254
PRODH proline dehydrogenase (oxidase) 1 -3.41254
CR2 complement component (3d/Epstein Barr virus) receptor 2 -3.41254
FGF9 fibroblast growth factor 9 -3.41254
WAS Wiskott-Aldrich syndrome -3.41254
NFE2 nuclear factor, erythroid 2 -3.41254
SLC5A9 solute carrier family 5 (sodium/sugar cotransporter), member 9 -3.41254
ANGPTL4 angiopoietin-like 4 -3.41254
DPF3 D4, zinc and double PHD fingers, family 3 -3.41254
CRLF2 cytokine receptor-like factor 2 -3.41254
SYT15B synaptotagmin 15B -3.41254
CIMAP1D CIMAP1 family member D -3.41254
SPDYE10 speedy/RINGO cell cycle regulator family member E10 -3.41254
CABCOCO1 ciliary associated calcium binding coiled-coil 1 -3.41254
PLPP4 phospholipid phosphatase 4 -3.41254
NECTIN4 nectin cell adhesion molecule 4 -3.41254
SIM1 single-minded family bHLH transcription factor 1 -3.41254
LMNTD2 lamin tail domain containing 2 -3.41254
UBE2QL1 ubiquitin-conjugating enzyme E2Q family-like 1 -3.41254
DNAAF19 dynein axonemal assembly factor 19 -3.41254
ADGRG1 adhesion G protein-coupled receptor G1 -3.41254
PXT1 peroxisomal, testis specific 1 -3.41254
CAV2 caveolin 2 -3.41254
YPEL4 yippee-like 4 (Drosophila) -3.41254
KLHL11 kelch-like family member 11 -3.41254
DYDC1 DPY30 domain containing 1 -3.41254
PDK1 pyruvate dehydrogenase kinase, isozyme 1 -3.41254
BCO1 beta-carotene oxygenase 1 -3.41254
ADGRE5 adhesion G protein-coupled receptor E5 -3.1257
ZNF547 zinc finger protein 547 -3.1257
DDIT4 DNA-damage-inducible transcript 4 -3.0823
NPW neuropeptide W -2.97941
LTV1 LTV1 ribosome biogenesis factor -2.91577
PLPPR4 phospholipid phosphatase related 4 -2.91577
ZBTB46 zinc finger and BTB domain containing 46 -2.89913
CRYBG2 crystallin beta-gamma domain containing 2 -2.83998
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor) -2.82086
RPL35A ribosomal protein L35a -2.61514
ZNF324B zinc finger protein 324B -2.56509
PCDHGB7 protocadherin gamma subfamily B, 7 -2.56509
PLAC1 placenta-specific 1 -2.56509
NWD1 NACHT and WD repeat domain containing 1 -2.56509
BCDIN3D BCDIN3 domain containing -2.56066
NDUFA11 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 11, 14.7kDa -2.56043
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1 -2.56043
HSD17B1 hydroxysteroid (17-beta) dehydrogenase 1 -2.52754
MAPK3 mitogen-activated protein kinase 3 -2.52411
AIMP1 aminoacyl tRNA synthetase complex-interacting multifunctional protein 1 -2.51847
OGDHL oxoglutarate dehydrogenase-like -2.49222
LYPD6 LY6/PLAUR domain containing 6 -2.47498
COPS3 COP9 signalosome subunit 3 -2.46974
LAMTOR1 late endosomal/lysosomal adaptor, MAPK and MTOR activator 1 -2.46825
LMAN1 lectin, mannose-binding, 1 -2.44997
TINCR tissue differentiation-inducing non-protein coding RNA -2.4107
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -2.38106
UNC5CL unc-5 homolog C (C. elegans)-like -2.35032
ZNF397 zinc finger protein 397 -2.34289
VPS13B vacuolar protein sorting 13 homolog B (yeast) -2.33698
RNASEL ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent) -2.33031
VPS51 vacuolar protein sorting 51 homolog (S. cerevisiae) -2.32635
SLC22A23 solute carrier family 22, member 23 -2.30759
KHDRBS3 KH domain containing, RNA binding, signal transduction associated 3 -2.29521
WDR93 WD repeat domain 93 -2.29309
NIPAL3 NIPA-like domain containing 3 -2.23466
CDK12 cyclin-dependent kinase 12 -2.18337
DIAPH1 diaphanous-related formin 1 -2.18315
ANKRD28 ankyrin repeat domain 28 -2.18203
ZNF225 zinc finger protein 225 -2.17291
C21ORF58 chromosome 21 open reading frame 58 -2.15858
SEMA4G sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G -2.13981
RIPK4 receptor-interacting serine-threonine kinase 4 -2.12987
FAU Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed -2.11254
TM9SF3 transmembrane 9 superfamily member 3 -2.11091
ZFP41 ZFP41 zinc finger protein -2.10447
ZBTB8A zinc finger and BTB domain containing 8A -2.10215
AVL9 AVL9 homolog (S. cerevisiase) -2.09872
CHEK1 checkpoint kinase 1 -2.09872
LANCL2 LanC lantibiotic synthetase component C-like 2 (bacterial) -2.09116
NDUFB4 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 4, 15kDa -2.08673
FHIP2A FHF complex subunit HOOK interacting protein 2A -2.08228
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 -2.06792
SCRN2 secernin 2 -2.06428
COQ8B coenzyme Q8B -2.05026
MARCKS myristoylated alanine-rich protein kinase C substrate -2.04928
C16ORF96 chromosome 16 open reading frame 96 -2.04636
CCDC24 coiled-coil domain containing 24 -2.03417
SNX16 sorting nexin 16 -2.03183
NDUFB7 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 7, 18kDa -2.03183
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -2.02748
SEC61A1 Sec61 alpha 1 subunit (S. cerevisiae) -2.02284
AMZ2 archaelysin family metallopeptidase 2 -2.02082
CBX5 chromobox homolog 5 -2.01889
IL1RAP interleukin 1 receptor accessory protein -2.01504
BRD7 bromodomain containing 7 -2.01314
SDC2 syndecan 2 -2.00234