EFNA2 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description ephrin-A2|This gene encodes a member of the ephrin family. The protein is composed of a signal sequence, a receptor-binding region, a spacer region, and a hydrophobic region. The EPH and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. Posttranslational modifications determine whether this protein localizes to the nucleus or the cytoplasm. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 1943)
Similar Terms
Downloads & Tools

Genes

330 genes differentially expressed following the EFNA2 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
JSRP1 junctional sarcoplasmic reticulum protein 1 2.84057
TAF9B TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa 2.84057
RSPH4A radial spoke head 4 homolog A (Chlamydomonas) 2.84057
GALNT15 polypeptide N-acetylgalactosaminyltransferase 15 2.84057
OR1C1 olfactory receptor, family 1, subfamily C, member 1 2.84057
CNTNAP4 contactin associated protein-like 4 2.84057
C22ORF42 chromosome 22 open reading frame 42 2.84057
SULT2A1 sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1 2.84057
CFAP45 cilia and flagella associated protein 45 2.84057
C1QTNF9B C1q and tumor necrosis factor related protein 9B 2.84057
PRSS38 protease, serine, 38 2.84057
C22ORF31 chromosome 22 open reading frame 31 2.84057
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5 2.84057
C1ORF105 chromosome 1 open reading frame 105 2.84057
MEIKIN meiotic kinetochore factor 2.84057
P2RY6 pyrimidinergic receptor P2Y, G-protein coupled, 6 2.84057
CATSPERZ catsper channel auxiliary subunit zeta 2.84057
SCGB3A1 secretoglobin, family 3A, member 1 2.81989
TTLL8 tubulin tyrosine ligase-like family member 8 2.81989
GFRA4 GDNF family receptor alpha 4 2.81989
PKP1 plakophilin 1 2.81989
SSTR1 somatostatin receptor 1 2.81989
CLEC12A C-type lectin domain family 12, member A 2.81989
TMEM176A transmembrane protein 176A 2.81989
IL2RA interleukin 2 receptor, alpha 2.81989
NRN1 neuritin 1 2.81989
GPR4 G protein-coupled receptor 4 2.81989
SIX2 SIX homeobox 2 2.81989
SIX6 SIX homeobox 6 2.81989
SELPLG selectin P ligand 2.81989
KHDC3L KH domain containing 3-like, subcortical maternal complex member 2.81989
FBXL8 F-box and leucine-rich repeat protein 8 2.81989
A4GALT alpha 1,4-galactosyltransferase 2.81989
PGBDF plakoglobin binding and degradation factor 2.81989
GJB1 gap junction protein, beta 1, 32kDa 2.81989
SSTR5 somatostatin receptor 5 2.81989
ADAD2 adenosine deaminase domain containing 2 2.81989
LIM2 lens intrinsic membrane protein 2, 19kDa 2.81989
ALPK2 alpha-kinase 2 2.81989
UNC45B unc-45 homolog B (C. elegans) 2.81989
OTUD6B OTU domain containing 6B 2.81989
ADGB androglobin 2.81989
RAPSN receptor-associated protein of the synapse 2.81989
GUCY2D guanylate cyclase 2D, membrane (retina-specific) 2.81989
RSPO3 R-spondin 3 2.81989
STRIP1 striatin interacting protein 1 2.81989
OR10A5 olfactory receptor, family 10, subfamily A, member 5 2.81989
GSTM5 glutathione S-transferase mu 5 2.81989
SKOR1 SKI family transcriptional corepressor 1 2.81989
TMEM100 transmembrane protein 100 2.81989
CSTL1 cystatin-like 1 2.81989
MOGAT2 monoacylglycerol O-acyltransferase 2 2.81989
LCN12 lipocalin 12 2.81989
NOTUM notum pectinacetylesterase homolog (Drosophila) 2.81989
ADAMTSL4-AS2 ADAMTSL4 antisense RNA 2 2.81989
CAPN9 calpain 9 2.81989
HTRA4 HtrA serine peptidase 4 2.81989
RHCG Rh family, C glycoprotein 2.81989
DNAAF1 dynein, axonemal, assembly factor 1 2.81989
KRT80 keratin 80, type II 2.81989
LOC124906892 uncharacterized LOC124906892 2.81989
ANO3 anoctamin 3 2.81989
TMPRSS4 transmembrane protease, serine 4 2.81989
CLDN14 claudin 14 2.81989
GPX5 glutathione peroxidase 5 2.81989
NHERF4 NHERF family PDZ scaffold protein 4 2.81989
LOC124904411 uncharacterized LOC124904411 2.81989
ELOA2 elongin A2 2.81989
GMCL2 germ cell-less 2, spermatogenesis associated 2.81989
VSIR V-set immunoregulatory receptor 2.81989
H1-6 H1.6 linker histone, cluster member 2.81989
STING1 stimulator of interferon response cGAMP interactor 1 2.81989
OPRM1 opioid receptor, mu 1 2.81989
PPP2R2D protein phosphatase 2, regulatory subunit B, delta 2.81989
OR52E4 olfactory receptor, family 52, subfamily E, member 4 2.81989
KCND3 potassium channel, voltage gated Shal related subfamily D, member 3 2.81989
ZNF575 zinc finger protein 575 2.81989
DNASE2B deoxyribonuclease II beta 2.81989
MSX2 msh homeobox 2 2.81989
VSX2 visual system homeobox 2 2.81989
SNX20 sorting nexin 20 2.81989
ZNF280A zinc finger protein 280A 2.81989
KLHL33 kelch-like family member 33 2.81989
FPR3 formyl peptide receptor 3 2.81989
GZMM granzyme M (lymphocyte met-ase 1) 2.81989
NPFF neuropeptide FF-amide peptide precursor 2.81989
HTR3C 5-hydroxytryptamine (serotonin) receptor 3C, ionotropic 2.81989
MS4A5 membrane-spanning 4-domains, subfamily A, member 5 2.81989
NPIPB8 nuclear pore complex interacting protein family, member B8 2.81989
ZNF121 zinc finger protein 121 2.81989
PTH parathyroid hormone 2.81989
C6 complement component 6 2.81989
MS4A13 membrane-spanning 4-domains, subfamily A, member 13 2.81989
ATP2B3 ATPase, Ca++ transporting, plasma membrane 3 2.81989
RAET1E retinoic acid early transcript 1E 2.81989
SPACA5 sperm acrosome associated 5 2.81989
C9ORF64 chromosome 9 open reading frame 64 2.81989
FCN1 ficolin (collagen/fibrinogen domain containing) 1 2.81989
HSPB9 heat shock protein, alpha-crystallin-related, B9 2.81989
P2RX6 purinergic receptor P2X, ligand gated ion channel, 6 2.81989
EGR3 early growth response 3 2.81989
PRSS54 protease, serine, 54 2.81989
CALML5 calmodulin-like 5 2.81989
TEX12 testis expressed 12 2.81989
AWAT1 acyl-CoA wax alcohol acyltransferase 1 2.81989
MAPK11 mitogen-activated protein kinase 11 2.81989
EXOSC6 exosome component 6 2.81989
PRRX1 paired related homeobox 1 2.81989
MAEL maelstrom spermatogenic transposon silencer 2.81989
PRPH peripherin 2.81989
VAX1 ventral anterior homeobox 1 2.81989
PCDHGB4 protocadherin gamma subfamily B, 4 2.81989
GLYATL3 glycine-N-acyltransferase-like 3 2.81989
KCNS2 potassium voltage-gated channel, modifier subfamily S, member 2 2.81989
SERPINB12 serpin peptidase inhibitor, clade B (ovalbumin), member 12 2.81989
HOXD1 homeobox D1 2.81989
GPR12 G protein-coupled receptor 12 2.81989
LMOD3 leiomodin 3 (fetal) 2.81989
TESPA1 thymocyte expressed, positive selection associated 1 2.81989
LRTM2 leucine-rich repeats and transmembrane domains 2 2.81989
IFITM5 interferon induced transmembrane protein 5 2.81989
OR52K1 olfactory receptor, family 52, subfamily K, member 1 2.81989
SHOX2 short stature homeobox 2 2.81989
LYL1 lymphoblastic leukemia associated hematopoiesis regulator 1 2.81989
ZNF132 zinc finger protein 132 2.81989
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39) 2.81989
MMP1 matrix metallopeptidase 1 2.81989
FGF17 fibroblast growth factor 17 2.81989
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6 2.81989
ANGPTL6 angiopoietin-like 6 2.81989
TRIM7 tripartite motif containing 7 2.81989
BANF2 barrier to autointegration factor 2 2.81989
PLXNC1 plexin C1 2.81989
SLC22A7 solute carrier family 22 (organic anion transporter), member 7 2.81989
MNX1 motor neuron and pancreas homeobox 1 2.81989
CCDC80 coiled-coil domain containing 80 2.81989
TTC22 tetratricopeptide repeat domain 22 2.81989
GSC2 goosecoid homeobox 2 2.81989
SLN sarcolipin 2.81989
GCGR glucagon receptor 2.81989
SDSL serine dehydratase-like 2.81989
FRMPD1 FERM and PDZ domain containing 1 2.81989
SAMD9 sterile alpha motif domain containing 9 2.81989
NLRP9 NLR family, pyrin domain containing 9 2.81989
TF transferrin 2.81989
IP6K3 inositol hexakisphosphate kinase 3 2.81989
NOG noggin 2.81989
GPR61 G protein-coupled receptor 61 2.81989
IFNE interferon, epsilon 2.81989
SLCO1C1 solute carrier organic anion transporter family, member 1C1 2.81989
PGR progesterone receptor 2.81989
SMCO3 single-pass membrane protein with coiled-coil domains 3 2.81989
CALHM2 calcium homeostasis modulator 2 2.75458
OLFML1 olfactomedin-like 1 2.75458
DNAJC18 DnaJ (Hsp40) homolog, subfamily C, member 18 2.7169
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2 2.69368
SH3RF2 SH3 domain containing ring finger 2 2.64094
TATDN2 TatD DNase domain containing 2 2.63751
PPL periplakin 2.62655
AMBRA1 autophagy/beclin-1 regulator 1 2.61331
HS3ST5 heparan sulfate (glucosamine) 3-O-sulfotransferase 5 2.60262
ZPR1 ZPR1 zinc finger 2.58223
EFR3B EFR3 homolog B (S. cerevisiae) 2.57879
FOXRED2 FAD-dependent oxidoreductase domain containing 2 2.55632
TSEN34 TSEN34 tRNA splicing endonuclease subunit 2.55159
ARRDC2 arrestin domain containing 2 2.47346
B3GLCT beta 3-glucosyltransferase 2.4404
ATP2A3 ATPase, Ca++ transporting, ubiquitous 2.41238
NAP1L4 nucleosome assembly protein 1-like 4 2.38976
PCBP4 poly(rC) binding protein 4 2.37436
SETD2 SET domain containing 2 2.36981
TMEM237 transmembrane protein 237 2.36435
B4GALNT3 beta-1,4-N-acetyl-galactosaminyl transferase 3 2.35709
RPS6KL1 ribosomal protein S6 kinase-like 1 2.33226
NRF1 nuclear respiratory factor 1 2.33191
TIRAP toll-interleukin 1 receptor (TIR) domain containing adaptor protein 2.31839
KCNIP2 Kv channel interacting protein 2 2.31182
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein 2.28618
CRY2 cryptochrome circadian clock 2 2.27092
CCDC78 coiled-coil domain containing 78 2.2605
CIITA class II, major histocompatibility complex, transactivator 2.25844
ANKRD62 ankyrin repeat domain 62 2.25844
CLMP CXADR-like membrane protein 2.25844
ACYP2 acylphosphatase 2, muscle type 2.24811
SELENOV selenoprotein V 2.24782
FASTK Fas-activated serine/threonine kinase 2.24709
TM2D1 TM2 domain containing 1 2.24237
SH2D2A SH2 domain containing 2A 2.23875
CRAMP1 cramped chromatin regulator homolog 1 2.23875
C12ORF57 chromosome 12 open reading frame 57 2.2322
SGSH N-sulfoglucosamine sulfohydrolase 2.2296
POC1B-DUSP6 POC1B-DUSP6 readthrough 2.18023
SMARCD3 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3 2.15031
FANCE Fanconi anemia, complementation group E 2.12671
GOLGA3 golgin A3 2.11322
RPRD1A regulation of nuclear pre-mRNA domain containing 1A 2.10939
EDC3 enhancer of mRNA decapping 3 2.10179
FSD1 fibronectin type III and SPRY domain containing 1 2.07821
SSPN sarcospan 2.07821
NKAIN1 Na+/K+ transporting ATPase interacting 1 2.07294
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 2.0649
ZNF606 zinc finger protein 606 2.0629
TNIP2 TNFAIP3 interacting protein 2 2.04972
PIR pirin (iron-binding nuclear protein) 2.04501
DENND5B DENN/MADD domain containing 5B 2.04477
PDK1 pyruvate dehydrogenase kinase, isozyme 1 2.04477
TIMM44 translocase of inner mitochondrial membrane 44 homolog (yeast) 2.03673
BRMS1 breast cancer metastasis suppressor 1 2.03673
SMIM8 small integral membrane protein 8 2.02611
COL18A1 collagen, type XVIII, alpha 1 2.02437
GOLM1 golgi membrane protein 1 2.02411
ACACA acetyl-CoA carboxylase alpha 2.02162
NSUN3 NOP2/Sun domain family, member 3 2.02162
MYSM1 Myb-like, SWIRM and MPN domains 1 2.02162
CD320 CD320 molecule 2.02162
RAB2A RAB2A, member RAS oncogene family 2.02162
GLCE glucuronic acid epimerase 2.01926
PLCXD1 phosphatidylinositol-specific phospholipase C, X domain containing 1 2.01122
FBXL22 F-box and leucine-rich repeat protein 22 2.00738
ZNF267 zinc finger protein 267 2.00738
RADX RPA1 related single stranded DNA binding protein, X-linked 2.00149

decreased expression

Symbol Name Standardized Value
OPRK1 opioid receptor, kappa 1 -2.84057
AMH anti-Mullerian hormone -2.84057
GPRASP1 G protein-coupled receptor associated sorting protein 1 -2.84057
HSPB6 heat shock protein, alpha-crystallin-related, B6 -2.84057
ADAMTS18 ADAM metallopeptidase with thrombospondin type 1 motif, 18 -2.84057
TMEM236 transmembrane protein 236 -2.84057
TRPV2 transient receptor potential cation channel, subfamily V, member 2 -2.84057
SERAC1 serine active site containing 1 -2.84057
STRIT1 small transmembrane regulator of ion transport 1 -2.84057
MC5R melanocortin 5 receptor -2.81989
FOSB FBJ murine osteosarcoma viral oncogene homolog B -2.81989
MBOAT4 membrane bound O-acyltransferase domain containing 4 -2.81989
PCDHGB1 protocadherin gamma subfamily B, 1 -2.81989
RASSF10 Ras association (RalGDS/AF-6) domain family (N-terminal) member 10 -2.81989
GJB3 gap junction protein, beta 3, 31kDa -2.81989
SIDT1 SID1 transmembrane family, member 1 -2.81989
SLC2A14 solute carrier family 2 (facilitated glucose transporter), member 14 -2.81989
LCP1 lymphocyte cytosolic protein 1 (L-plastin) -2.81989
MYL7 myosin, light chain 7, regulatory -2.81989
RAB7B RAB7B, member RAS oncogene family -2.81989
TWIST2 twist family bHLH transcription factor 2 -2.81989
SERF1B small EDRK-rich factor 1B (centromeric) -2.81989
SPDEF SAM pointed domain containing ETS transcription factor -2.81989
MAGEA4 melanoma antigen family A4 -2.81989
LYG2 lysozyme G-like 2 -2.81989
CNTN3 contactin 3 (plasmacytoma associated) -2.81989
MYO19 myosin XIX -2.81989
TATDN3 TatD DNase domain containing 3 -2.81989
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4 -2.81989
TMEM255A transmembrane protein 255A -2.81989
ZBTB18 zinc finger and BTB domain containing 18 -2.81989
ACSBG2 acyl-CoA synthetase bubblegum family member 2 -2.81989
RBM20 RNA binding motif protein 20 -2.81989
PCDHB12 protocadherin beta 12 -2.81989
KLK5 kallikrein-related peptidase 5 -2.81989
OR2A25 olfactory receptor, family 2, subfamily A, member 25 -2.81989
ERAS ES cell expressed Ras -2.81989
SLC22A10 solute carrier family 22, member 10 -2.81989
F2RL2 coagulation factor II (thrombin) receptor-like 2 -2.81989
WFDC1 WAP four-disulfide core domain 1 -2.81989
SLC7A9 solute carrier family 7 (amino acid transporter light chain, bo,+ system), member 9 -2.81989
PNLIPRP2 pancreatic lipase-related protein 2 -2.81989
ZNF892 zinc finger protein 892 -2.76343
GCNT7 glucosaminyl (N-acetyl) transferase family member 7 -2.75458
TP53TG5 TP53 target 5 -2.73219
TMEM31 transmembrane protein 31 -2.73219
USP38 ubiquitin specific peptidase 38 -2.63179
TCAF1 TRPM8 channel-associated factor 1 -2.62236
SLFN13 schlafen family member 13 -2.61971
WNK4 WNK lysine deficient protein kinase 4 -2.61331
OAF OAF homolog (Drosophila) -2.61331
PEBP4 phosphatidylethanolamine-binding protein 4 -2.61331
MARCHF11 membrane associated ring-CH-type finger 11 -2.59391
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila) -2.56411
IL7 interleukin 7 -2.56411
TMEM200C transmembrane protein 200C -2.55454
TGFB1 transforming growth factor, beta 1 -2.53971
RPF2 ribosome production factor 2 homolog (S. cerevisiae) -2.50739
SLC30A5 solute carrier family 30 (zinc transporter), member 5 -2.50446
AEN apoptosis enhancing nuclease -2.47922
PLAAT3 phospholipase A and acyltransferase 3 -2.4607
C9ORF78 chromosome 9 open reading frame 78 -2.44573
GCNT4 glucosaminyl (N-acetyl) transferase 4, core 2 -2.42044
SLCO5A1 solute carrier organic anion transporter family, member 5A1 -2.41361
TBC1D22A TBC1 domain family, member 22A -2.41354
MAP7D3 MAP7 domain containing 3 -2.41354
RPS15A ribosomal protein S15a -2.40444
MTRF1L mitochondrial translational release factor 1-like -2.3802
SULT1A3 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 3 -2.37436
IDO2 indoleamine 2,3-dioxygenase 2 -2.37436
MANF mesencephalic astrocyte-derived neurotrophic factor -2.37436
TSKU tsukushi, small leucine rich proteoglycan -2.36692
VSTM2A V-set and transmembrane domain containing 2A -2.36692
MTR 5-methyltetrahydrofolate-homocysteine methyltransferase -2.3637
PON2 paraoxonase 2 -2.35065
JPT2 Jupiter microtubule associated homolog 2 -2.33973
PCYOX1L prenylcysteine oxidase 1 like -2.33226
AARD alanine and arginine rich domain containing protein -2.31932
C4ORF50 chromosome 4 open reading frame 50 -2.31839
TTC9 tetratricopeptide repeat domain 9 -2.29666
ZMYND12 zinc finger, MYND-type containing 12 -2.26501
AADAT aminoadipate aminotransferase -2.25954
SNX6 sorting nexin 6 -2.25844
SWAP70 SWAP switching B-cell complex 70kDa subunit -2.2383
GRIA4 glutamate receptor, ionotropic, AMPA 4 -2.20462
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog -2.18815
TMEM160 transmembrane protein 160 -2.1812
TNPO2 transportin 2 -2.16816
TMEM9 transmembrane protein 9 -2.15334
EYA4 EYA transcriptional coactivator and phosphatase 4 -2.1295
ANKFN1 ankyrin-repeat and fibronectin type III domain containing 1 -2.11828
OSBPL9 oxysterol binding protein-like 9 -2.11736
ATP5F1A ATP synthase F1 subunit alpha -2.10939
PLAGL2 pleiomorphic adenoma gene-like 2 -2.10179
TRIM36 tripartite motif containing 36 -2.07821
SMG8 SMG8 nonsense mediated mRNA decay factor -2.07614
ACTG1 actin gamma 1 -2.07614
MAPK7 mitogen-activated protein kinase 7 -2.07294
WDR36 WD repeat domain 36 -2.06746
HIGD2A HIG1 hypoxia inducible domain family, member 2A -2.04477
ANAPC11 anaphase promoting complex subunit 11 -2.04477
KTI12 KTI12 homolog, chromatin associated (S. cerevisiae) -2.04477
TBX6 T-box 6 -2.02437
MAN1C1 mannosidase, alpha, class 1C, member 1 -2.01908
KIF13A kinesin family member 13A -2.0132
SH3KBP1 SH3-domain kinase binding protein 1 -2.00738
PHF23 PHD finger protein 23 -2.00526
SGTB small glutamine-rich tetratricopeptide repeat (TPR)-containing, beta -2.00204
RHOG ras homolog family member G -2.00204