EGFR Gene Set

Dataset Kinase Library Tyrosine Kinome Atlas
Category proteomics
Type kinase
Description epidermal growth factor receptor|The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor. Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation. Mutations in this gene are associated with lung cancer. Multiple alternatively spliced transcript variants that encode different protein isoforms have been found for this gene. [provided by RefSeq, Jul 2010] (NCBI Entrez Gene Database, 1956)
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100 substrates of the kinase EGFR from the Kinase Library Tyrosine Kinome Atlas dataset.

Symbol Name Standardized Value
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 100.0
PELP1 proline, glutamate and leucine rich protein 1 100.0
CEP43 centrosomal protein 43 99.98
DPF2 D4, zinc and double PHD fingers family 2 99.96
RNF2 ring finger protein 2 99.93
ARHGEF40 Rho guanine nucleotide exchange factor (GEF) 40 99.91
FAM107B family with sequence similarity 107, member B 99.89
MCC mutated in colorectal cancers 99.87
THEMIS2 thymocyte selection associated family member 2 99.82
KCTD12 potassium channel tetramerization domain containing 12 99.8
PDCD5 programmed cell death 5 99.65
SH2D1B SH2 domain containing 1B 99.63
ARID4B AT rich interactive domain 4B (RBP1-like) 99.61
IPO8 importin 8 99.41
NMT1 N-myristoyltransferase 1 99.34
POLR1A polymerase (RNA) I polypeptide A, 194kDa 99.3
GPATCH11 G patch domain containing 11 99.28
MARVELD3 MARVEL domain containing 3 99.26
DYNC1LI1 dynein, cytoplasmic 1, light intermediate chain 1 99.21
ARHGAP5 Rho GTPase activating protein 5 99.17
DDX41 DEAD (Asp-Glu-Ala-Asp) box polypeptide 41 99.115
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 99.1
CKAP4 cytoskeleton-associated protein 4 99.01
MLEC malectin 98.91
EPM2AIP1 EPM2A (laforin) interacting protein 1 98.88
ZSCAN25 zinc finger and SCAN domain containing 25 98.77
USP25 ubiquitin specific peptidase 25 98.71
SIPA1L1 signal-induced proliferation-associated 1 like 1 98.69
SEC14L3 SEC14-like 3 (S. cerevisiae) 98.66
SEC14L2 SEC14-like 2 (S. cerevisiae) 98.66
HTATSF1 HIV-1 Tat specific factor 1 98.6
ZNF598 zinc finger protein 598 98.53
PDS5B PDS5 cohesin associated factor B 98.51
GOLIM4 golgi integral membrane protein 4 98.49
ZNF169 zinc finger protein 169 98.4
F5 coagulation factor V (proaccelerin, labile factor) 98.38
TRIOBP TRIO and F-actin binding protein 98.37
GAB3 GRB2-associated binding protein 3 98.285
DMAP1 DNA methyltransferase 1 associated protein 1 98.27
BYSL bystin-like 98.27
HAVCR1 hepatitis A virus cellular receptor 1 98.16
LSM14B LSM14B, SCD6 homolog B (S. cerevisiae) 98.14
EIF1 eukaryotic translation initiation factor 1 98.12
EIF1B eukaryotic translation initiation factor 1B 98.12
RCN2 reticulocalbin 2, EF-hand calcium binding domain 98.09
MAT2A methionine adenosyltransferase II, alpha 98.07
IRS4 insulin receptor substrate 4 97.975
PGRMC2 progesterone receptor membrane component 2 97.96
CHAF1B chromatin assembly factor 1, subunit B (p60) 97.9
LURAP1L leucine rich adaptor protein 1-like 97.88
PTPN7 protein tyrosine phosphatase, non-receptor type 7 97.86
TRAF3IP2 TRAF3 interacting protein 2 97.81
SPRY4 sprouty homolog 4 (Drosophila) 97.77
DLG3 discs, large homolog 3 (Drosophila) 97.765
PM20D2 peptidase M20 domain containing 2 97.75
HAVCR2 hepatitis A virus cellular receptor 2 97.705
PRRC2B proline-rich coiled-coil 2B 97.7
RABL6 RAB, member RAS oncogene family-like 6 97.66
HBS1L HBS1-like translational GTPase 97.62
ALOX5 arachidonate 5-lipoxygenase 97.57
KCNB1 potassium channel, voltage gated Shab related subfamily B, member 1 97.55
ZNF326 zinc finger protein 326 97.53
CEP68 centrosomal protein 68kDa 97.48
IPO9 importin 9 97.37
CNOT2 CCR4-NOT transcription complex, subunit 2 97.29
EIF3I eukaryotic translation initiation factor 3, subunit I 97.27
SHROOM1 shroom family member 1 97.24
SF3A3 splicing factor 3a, subunit 3, 60kDa 97.18
OSTF1 osteoclast stimulating factor 1 97.16
EPB41L5 erythrocyte membrane protein band 4.1 like 5 97.13
SH3BP2 SH3-domain binding protein 2 96.98
IL7R interleukin 7 receptor 96.94
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 96.93
TRPV2 transient receptor potential cation channel, subfamily V, member 2 96.81
FHIT fragile histidine triad 96.69
YEATS2 YEATS domain containing 2 96.65
GSDMD gasdermin D 96.61
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform 96.59
CHRNB1 cholinergic receptor, nicotinic, beta 1 (muscle) 96.5
UBR4 ubiquitin protein ligase E3 component n-recognin 4 96.48
PWP2 PWP2 periodic tryptophan protein homolog (yeast) 96.39
SLITRK6 SLIT and NTRK-like family, member 6 96.28
MCEMP1 mast cell-expressed membrane protein 1 96.26
SPTLC2 serine palmitoyltransferase, long chain base subunit 2 96.21
ZRANB2 zinc finger, RAN-binding domain containing 2 96.135
NFYA nuclear transcription factor Y, alpha 96.13
CHD1 chromodomain helicase DNA binding protein 1 96.08
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa) 96.015
SLC12A5 solute carrier family 12 (potassium/chloride transporter), member 5 96.0
COPB2 coatomer protein complex, subunit beta 2 (beta prime) 95.99
TIGIT T cell immunoreceptor with Ig and ITIM domains 95.99
STK4 serine/threonine kinase 4 95.94
ARHGAP35 Rho GTPase activating protein 35 95.94
MRPS27 mitochondrial ribosomal protein S27 95.86
HAUS7 HAUS augmin-like complex, subunit 7 95.82
CBFB core-binding factor, beta subunit 95.8
BLNK B-cell linker 95.78
LNPEP leucyl/cystinyl aminopeptidase 95.745
HNRNPLL heterogeneous nuclear ribonucleoprotein L-like 95.73
PLD1 phospholipase D1, phosphatidylcholine-specific 95.69